DK0985032T4 - Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner - Google Patents

Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Info

Publication number
DK0985032T4
DK0985032T4 DK98924468T DK98924468T DK0985032T4 DK 0985032 T4 DK0985032 T4 DK 0985032T4 DK 98924468 T DK98924468 T DK 98924468T DK 98924468 T DK98924468 T DK 98924468T DK 0985032 T4 DK0985032 T4 DK 0985032T4
Authority
DK
Denmark
Prior art keywords
complexes
protein
peptide
mrna
antibody
Prior art date
Application number
DK98924468T
Other languages
English (en)
Other versions
DK0985032T3 (da
Inventor
Michael John Taussig
Mingyue He
Original Assignee
Crescendo Biolog Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0985032(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9710829.4A external-priority patent/GB9710829D0/en
Priority claimed from GBGB9724850.4A external-priority patent/GB9724850D0/en
Priority claimed from GBGB9804195.7A external-priority patent/GB9804195D0/en
Application filed by Crescendo Biolog Ltd filed Critical Crescendo Biolog Ltd
Application granted granted Critical
Publication of DK0985032T3 publication Critical patent/DK0985032T3/da
Publication of DK0985032T4 publication Critical patent/DK0985032T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1041Ribosome/Polysome display, e.g. SPERT, ARM
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK98924468T 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner DK0985032T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710829.4A GB9710829D0 (en) 1997-05-28 1997-05-28 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9724850.4A GB9724850D0 (en) 1997-11-26 1997-11-26 Selection particles for in vitro display and evolution of antibody combining sites
GBGB9804195.7A GB9804195D0 (en) 1998-02-28 1998-02-28 Selection particles for in vitro display and evolution of antibody combining sites
PCT/GB1998/001564 WO1998054312A1 (en) 1997-05-28 1998-05-28 Ribosome complexes as selection particles for in vitro display and evolution of proteins

Publications (2)

Publication Number Publication Date
DK0985032T3 DK0985032T3 (da) 2004-02-02
DK0985032T4 true DK0985032T4 (da) 2009-08-31

Family

ID=27268863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98924468T DK0985032T4 (da) 1997-05-28 1998-05-28 Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner

Country Status (10)

Country Link
US (1) US6620587B1 (da)
EP (1) EP0985032B2 (da)
JP (1) JP4060892B2 (da)
AT (1) ATE250668T1 (da)
CA (1) CA2291721C (da)
DE (1) DE69818458T3 (da)
DK (1) DK0985032T4 (da)
ES (1) ES2209145T5 (da)
PT (1) PT985032E (da)
WO (1) WO1998054312A1 (da)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4854999A (en) * 1998-07-02 2000-01-24 Invitro Diagnostics, Inc. Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
GB9917027D0 (en) * 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
IL150291A0 (en) 2000-01-11 2002-12-01 Maxygen Inc Integrated systems and methods for diversity generation and screening
EP1652919A1 (en) * 2000-03-31 2006-05-03 Cambridge Antibody Technology LTD Improvements to ribosome display
ES2253358T3 (es) * 2000-03-31 2006-06-01 Cambridge Antibody Technology Limited Mejoras en la visualizacion del ribosoma.
US7129326B2 (en) 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
DK1360500T3 (da) 2000-04-14 2010-05-25 Genencor Int Fremgangsmåde til selektiv målretning
CA2440649A1 (en) 2001-03-07 2002-09-19 Children's Medical Center Corporation Method to screen peptide display libraries using minicell display
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
DE10145226A1 (de) * 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
EP1487978B1 (en) * 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
US20050221318A1 (en) * 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
AU2003214033A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of transferring a functional entity
AU2003218629A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond uponreaction
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
JP4664677B2 (ja) * 2002-09-06 2011-04-06 イソゲニカ リミテッド イン・ビトロでのペプチド発現ライブラリー
PT2348125T (pt) 2002-10-30 2017-08-29 Nuevolution As Método para a síntese de um complexo bifuncional
EP2581383A1 (en) 2002-11-25 2013-04-17 Genencor International, Inc. Skin or hair binding peptides
AU2003291964A1 (en) * 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
US20070026397A1 (en) * 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
ES2326649T3 (es) * 2003-03-19 2009-10-16 Crescendo Biologics Ltd. Recuperacion de dna.
DE602004019764D1 (de) * 2003-03-20 2009-04-16 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
GB0316314D0 (en) * 2003-07-12 2003-08-13 Univ Belfast Method
EP1670939B1 (en) * 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
EP1723255B1 (en) * 2004-02-17 2010-12-29 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DE602005017370D1 (de) * 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
US20050250112A1 (en) * 2004-05-07 2005-11-10 Padmabandu Gothami A Nucleic acids, compositions, methods, and kits for detecting mycoplasma and acholeplasma species
US9006393B1 (en) 2004-08-26 2015-04-14 Patricia L. Clark Molecular constructs and uses thereof in ribosomal translational events
DE102004049479A1 (de) 2004-10-11 2006-04-13 Scil Proteins Gmbh Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
HUE056836T2 (hu) 2005-12-01 2022-03-28 Nuevolution As Enzimatikus kódolási eljárások nagy könyvtárak hatékony szintéziséhez
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
US7879974B2 (en) * 2006-06-29 2011-02-01 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7879975B2 (en) * 2006-06-29 2011-02-01 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7923533B2 (en) * 2006-06-29 2011-04-12 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7910695B2 (en) 2006-06-29 2011-03-22 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
US7777002B2 (en) * 2006-06-29 2010-08-17 The Invention Science Fund I, Llc Methods for arbitrary peptide synthesis
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
US8865179B2 (en) * 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
EP3629022A1 (en) 2008-07-25 2020-04-01 Richard W. Wagner Protein screening methods
MX2011003381A (es) * 2008-09-30 2011-04-21 Abbott Lab Metodo mejorado para despliegue de arn.
AU2010332932B2 (en) 2009-12-14 2013-01-17 Navigo Proteins Gmbh Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin
WO2011111832A1 (ja) 2010-03-11 2011-09-15 独立行政法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
EP2627781B1 (en) 2010-10-15 2017-02-22 Olink Bioscience AB Dynamic range methods
EP2466310A1 (en) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Means and methods for detecting double-strand breaks
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
WO2012161227A1 (ja) 2011-05-23 2012-11-29 独立行政法人理化学研究所 核酸構築物、核酸-蛋白質複合体、及びその利用
JP6146821B2 (ja) 2011-06-15 2017-06-14 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH 修飾ユビキチンに基づく二量体型結合タンパク質
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
US10421958B2 (en) 2014-02-05 2019-09-24 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
US20170306039A1 (en) * 2014-10-22 2017-10-26 Crescendo Biologics Limited Human vh domain scaffolds
JP6738340B2 (ja) 2015-02-06 2020-08-12 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH 新規なegfr結合タンパク質
AU2016293063B2 (en) 2015-07-16 2018-11-08 Navigo Proteins Gmbh Novel immunoglobulin-binding proteins and their use in affinity purification
JP2018520675A (ja) 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
KR20180085717A (ko) 2015-09-24 2018-07-27 에이비비트로, 엘엘씨 친화성-올리고뉴클레오타이드 콘쥬게이트 및 그것의 사용
EP3452097A1 (en) 2016-05-04 2019-03-13 Navigo Proteins GmbH Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
SG11201901066UA (en) 2016-08-11 2019-03-28 Navigo Proteins Gmbh Novel alkaline stable immunoglobulin-binding proteins
BR112019005748A2 (pt) 2016-09-24 2019-06-18 Abvitro Llc afinidade-conjugados de oligonucleotídeo e usos destes
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
MA54501A (fr) 2018-12-18 2021-10-27 Navigo Proteins Gmbh Nouvelles protéines de liaison spécifiques de folr1 pour le diagnostic et le traitement du cancer
BR112022002365A2 (pt) 2019-08-09 2022-04-26 Nutcracker Therapeutics Inc Métodos e aparelhos para fabricar e para remover material de uma composição terapêutica
EP4382534A1 (en) 2022-12-06 2024-06-12 Biomérieux Synthetic peptide for use in an immunomolecular assay
EP4655590A1 (en) 2023-01-27 2025-12-03 Biomerieux Modified immuno-molecular assay for faster biomarker detection
WO2025111396A1 (en) 2023-11-20 2025-05-30 Alamar Biosciences, Inc. Molecular barcode set and use thereof in multiplex proximity detection assays

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06178688A (ja) * 1992-12-11 1994-06-28 Mitsui Toatsu Chem Inc E型緑膿菌を抗原とするヒト抗体をコードする遺伝子
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
ES2253358T3 (es) 2000-03-31 2006-06-01 Cambridge Antibody Technology Limited Mejoras en la visualizacion del ribosoma.

Also Published As

Publication number Publication date
CA2291721C (en) 2011-08-09
DE69818458D1 (de) 2003-10-30
PT985032E (pt) 2004-02-27
AU725957B2 (en) 2000-10-26
EP0985032A1 (en) 2000-03-15
ES2209145T5 (es) 2009-10-30
US6620587B1 (en) 2003-09-16
CA2291721A1 (en) 1998-12-03
EP0985032B2 (en) 2009-06-03
AU7666698A (en) 1998-12-30
DK0985032T3 (da) 2004-02-02
WO1998054312A1 (en) 1998-12-03
DE69818458T2 (de) 2004-07-08
EP0985032B1 (en) 2003-09-24
ES2209145T3 (es) 2004-06-16
DE69818458T3 (de) 2009-12-17
ATE250668T1 (de) 2003-10-15
JP2002500514A (ja) 2002-01-08
JP4060892B2 (ja) 2008-03-12

Similar Documents

Publication Publication Date Title
DK0985032T3 (da) Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner
Stretton The first sequence: Fred Sanger and insulin
GB2338237A (en) In vitro peptide or protein expression library
DK1356023T3 (da) Isolering af bindingsproteiner med høj affinitet for ligander
AU2001268173A1 (en) Microarrays for performing proteomic analyses
WO2004005319A3 (en) Microarrays on mirrored substrates for performing proteomic analyses
ATE488586T1 (de) In vitro peptid-expressionsbank
Ding et al. Dual kinetically controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide
CA2419490A1 (en) Functional protein arrays
WO2005019409A3 (en) Combinatorial protein library screening by periplasmic expression
EP1530592B8 (en) Chimeric mhc protein and oligomer thereof
WO2001005808A3 (en) In vitro selection and optional identification of polypeptides using solid support carriers
WO2002005146A3 (en) Method for disigning protein libraries with altered immunogenicity
WO2005012531A3 (en) Antibody cdr polypeptide sequences with restricted diversity
NO20010362L (no) Nukleinsyrer kodende for proteiner som er involvert i sensorisk transduksjon
Levine et al. Chemoselective fragment condensation between peptide and peptidomimetic oligomers
DK1572994T3 (da) Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer
PT1551977E (pt) Activação local, selectiva, de membros da família de ligandos tnf de proteínas de fusão de ligando tnf nãoanticorpo, sistemicamente inactivas
DK0816377T3 (da) Peptider, som binder sig til prothrombin og thrombin
DE602004020776D1 (de) Ligierungsverfahren
AU2002322506A1 (en) Non-affinity based isotope tagged peptides and methods for using the same
CA2440399A1 (en) Epitope testing using hla
Schafer et al. A highly specific system for efficient enzymatic removal of tags from recombinant proteins
US20060210982A1 (en) Cleavable assigned molecules and screening method using the same
DK1512004T3 (da) Fremgangsmåde til kortlægning og eliminering af T-celleepitoper