DK0996439T3 - Beta-alkoxyacrylater mod malaria - Google Patents

Beta-alkoxyacrylater mod malaria

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Publication number
DK0996439T3
DK0996439T3 DK98935020T DK98935020T DK0996439T3 DK 0996439 T3 DK0996439 T3 DK 0996439T3 DK 98935020 T DK98935020 T DK 98935020T DK 98935020 T DK98935020 T DK 98935020T DK 0996439 T3 DK0996439 T3 DK 0996439T3
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DK
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Prior art keywords
malaria
beta
alkoxy acrylates
acrylates
alkoxy
Prior art date
Application number
DK98935020T
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English (en)
Inventor
Jawad Alzeer
Jacques Chollet
Christian Hubschwerlen
Hugues Matile
Robert George Ridley
Original Assignee
Hoffmann La Roche
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Publication date
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Publication of DK0996439T3 publication Critical patent/DK0996439T3/da

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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK98935020T 1997-07-09 1998-07-06 Beta-alkoxyacrylater mod malaria DK0996439T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97111607 1997-07-09
PCT/EP1998/004162 WO1999002150A1 (en) 1997-07-09 1998-07-06 β-ALKOXYACRYLATES AGAINST MALARIA

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JP (1) JP2002511881A (da)
KR (1) KR20010014339A (da)
CN (1) CN1109544C (da)
AT (1) ATE230718T1 (da)
AU (1) AU748990B2 (da)
BR (1) BR9810556A (da)
CA (1) CA2294931A1 (da)
DE (1) DE69810629T2 (da)
DK (1) DK0996439T3 (da)
ES (1) ES2189206T3 (da)
PT (1) PT996439E (da)
TR (1) TR200000005T2 (da)
WO (1) WO1999002150A1 (da)

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US6713505B2 (en) * 2000-06-28 2004-03-30 Eli Lilly And Company spla2 inhibitors
CN100443463C (zh) * 2005-06-28 2008-12-17 沈阳化工研究院 取代的对三氟甲基苯醚类化合物及其制备与应用
KR20080111021A (ko) * 2006-03-29 2008-12-22 바스프 에스이 철 대사 장애의 치료를 위한 스트로빌루린의 용도
CN102510854A (zh) 2010-04-21 2012-06-20 奥斯考泰克公司 α-芳基甲氧基丙烯酸酯衍生物、其制备方法和包含所述衍生物的药物组合物
WO2015027863A1 (zh) 2013-08-27 2015-03-05 中国中化股份有限公司 含取代苄氧基的醚类化合物作为制备抗肿瘤药物的应用
CN103601716A (zh) * 2013-11-20 2014-02-26 厦门大学 一种苯并噻吩取代肟醚类化合物及其制备方法与应用
CN103980179A (zh) * 2014-05-29 2014-08-13 厦门大学 一种吲哚取代肟醚类化合物及其制备方法与应用
US10519098B2 (en) * 2014-10-21 2019-12-31 Council Of Scientific & Industrial Research Aromatic derivatives as anti-malarial
BR112017025824B1 (pt) * 2015-06-02 2022-10-18 Syngenta Participations Ag Uso não terapêutico de compostos de metoxiacrilato, meios integrados de controle de vetores de mosquitos, material polimérico incorporado com o referido composto, métodos para controle de mosquitos, kit e método para tratar uma fibra, fio, rede e trama revestindo-os com propriedades inseticidas, método de preparação de um material polimérico, rede incorporada com um composto e composto de metoxiacrilato

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NZ213630A (en) * 1984-10-19 1990-02-26 Ici Plc Acrylic acid derivatives and fungicidal compositions
DE3519280A1 (de) * 1985-05-30 1986-12-04 Basf Ag, 6700 Ludwigshafen Stilbenderivate und fungizide, die diese verbindungen enthalten
GB8617648D0 (en) * 1986-07-18 1986-08-28 Ici Plc Fungicides
EP0278595B2 (en) * 1987-02-09 2000-01-12 Zeneca Limited Fungicides
IL87020A (en) * 1987-07-11 1996-09-12 Schering Agrochemicals Ltd Acrylic acid derivatives and their use as pesticides
EP0370629B2 (en) * 1988-11-21 1998-01-07 Zeneca Limited Fungicides
EP0403618B2 (de) * 1988-12-29 2004-04-28 Bayer Aktiengesellschaft Aldimino- oder ketimino-oxy-ortho-tolylacrylsäure-methylester, ihre herstellung und diese enthaltende fungizide
DE3901607A1 (de) * 1989-01-20 1990-08-16 Basf Ag Schwefelhaltige acrylsaeureester und diese enthaltende fungizide
EP0433233B1 (de) * 1989-12-14 1995-01-25 Ciba-Geigy Ag Heterocyclische Verbindungen
PH11991042549B1 (da) * 1990-06-05 2000-12-04
DE59109047D1 (de) * 1990-06-27 1998-10-08 Basf Ag O-Benzyl-Oximether und diese Verbindungen enthaltende Pflanzenschutzmittel
DE4028391A1 (de) * 1990-09-07 1992-03-12 Basf Ag (alpha)-arylacrylsaeurederivate, ihre herstellung und verwendung zur bekaempfung von schaedlingen und pilzen
DE4029192A1 (de) * 1990-09-14 1992-03-19 Basf Ag Verwendung von (alpha)-arylacrylsaeurederivaten zur bekaempfung von schaedlingen
FR2670781B1 (fr) * 1990-12-21 1994-09-16 Roussel Uclaf Nouveaux derives de l'acide alpha-methylene 6-styryl phenyl acrylique, leur procede de preparation et leur application comme pesticides.
FR2670782A1 (fr) * 1990-12-24 1992-06-26 Valoris Chimie Fine Lab Ethers couronnes acridiniques et ethers couronnes acridinoniques.
DE4117371A1 (de) * 1991-05-28 1992-12-03 Basf Ag Antimykotische mittel, die phenylessigsaeurederivate enthalten
TW224042B (da) * 1992-04-04 1994-05-21 Basf Ag

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CN1262620A (zh) 2000-08-09
WO1999002150A1 (en) 1999-01-21
TR200000005T2 (tr) 2000-09-21
DE69810629D1 (de) 2003-02-13
CN1109544C (zh) 2003-05-28
KR20010014339A (ko) 2001-02-26
US6084120A (en) 2000-07-04
BR9810556A (pt) 2000-08-15
EP0996439B1 (en) 2003-01-08
AU8441198A (en) 1999-02-08
AU748990B2 (en) 2002-06-13
DE69810629T2 (de) 2003-10-16
PT996439E (pt) 2003-04-30
JP2002511881A (ja) 2002-04-16
CA2294931A1 (en) 1999-01-21
ES2189206T3 (es) 2003-07-01
ATE230718T1 (de) 2003-01-15
EP0996439A1 (en) 2000-05-03

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