DK1003750T3 - Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin - Google Patents

Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin

Info

Publication number: DK1003750T3
Authority: DK; Denmark
Prior art keywords: camptothecin; nitrocamptothecin; purifying; nitro; preparing
Prior art date: 1997-08-05

Application number

DK98933340T

Other languages

English (en)

Inventor

Zhisong Cao

Original Assignee

Stehlin Foundation For Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-05

Filing date

1998-07-10

Publication date

2008-07-21

1998-07-10 Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer

2008-07-21 Application granted granted Critical

2008-07-21 Publication of DK1003750T3 publication Critical patent/DK1003750T3/da

Links

229940127093 camptothecin Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 abstract 3
229950009213 rubitecan Drugs 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000004440 column chromatography Methods 0.000 abstract 1
OMBRFUXPXNIUCZ-UHFFFAOYSA-N dioxidonitrogen(1+) Chemical compound O=[N+]=O OMBRFUXPXNIUCZ-UHFFFAOYSA-N 0.000 abstract 1
229910001959 inorganic nitrate Inorganic materials 0.000 abstract 1
150000002823 nitrates Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK98933340T 1997-08-05 1998-07-10 Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin DK1003750T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/906,434 US5922877A (en)	1997-08-05	1997-08-05	Methods of preparing and purifying 9-nitro-20-camptothecin
PCT/US1998/014532 WO1999007709A1 (en)	1997-08-05	1998-07-10	Methods of preparing and purifying 9-nitro-20-camptothecin

Publications (1)

Publication Number	Publication Date
DK1003750T3 true DK1003750T3 (da)	2008-07-21

Family

ID=25422444

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98933340T DK1003750T3 (da)	1997-08-05	1998-07-10	Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin

Country Status (14)

Country	Link
US (1)	US5922877A (da)
EP (1)	EP1003750B1 (da)
JP (2)	JP3651778B2 (da)
CN (2)	CN1266435A (da)
AT (1)	ATE390429T1 (da)
AU (1)	AU736323B2 (da)
CA (1)	CA2296731C (da)
DE (1)	DE69839306T2 (da)
DK (1)	DK1003750T3 (da)
ES (1)	ES2303355T3 (da)
HU (1)	HUP0003206A3 (da)
IL (2)	IL134224A0 (da)
PT (1)	PT1003750E (da)
WO (1)	WO1999007709A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5527913A (en) *	1993-02-25	1996-06-18	The Stehlin Foundation For Cancer Research	Methods for purifying camptothecin compounds
US5731316A (en)	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en)	1996-01-30	2002-06-18	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6352996B1 (en)	1999-08-03	2002-03-05	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
DE10063766B4 (de) *	2000-12-21	2005-01-27	Daimlerchrysler Ag	Airbagvorrichtung für einen Personenkraftwagen
US6756381B2 (en) *	2002-02-21	2004-06-29	Supergen, Inc.	Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof
EP2316468A1 (en)	2002-02-22	2011-05-04	Shire LLC	Delivery system and methods for protecting and administering dextroamphetamine
US6703399B2 (en)	2002-05-06	2004-03-09	The Stehlin Foundation For Cancer Research	Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
US6699875B2 (en)	2002-05-06	2004-03-02	The Stehlin Foundation For Cancer Research	Cascade esters of camptothecins and methods of treating cancer using these compounds
US20040204435A1 (en) *	2003-04-09	2004-10-14	Joachim Liehr	Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CN1324032C (zh) *	2004-01-07	2007-07-04	重庆医药工业研究院有限责任公司	一种新的9－硝基喜树碱晶型和药物组合物
CN100334089C (zh) *	2004-07-21	2007-08-29	王洋	一种9－硝基喜树碱的生产方法
CN1312155C (zh) *	2005-01-21	2007-04-25	华东理工大学	一种分离纯化9－硝基喜树碱的方法
CN101522686A (zh) *	2006-08-11	2009-09-02	克里斯特斯斯特林癌症研究基金会	制备喜树碱酯的方法
US7572803B2 (en) *	2007-10-25	2009-08-11	The Christus Stehlin Foundation For Cancer Research	Hydrated crystalline esters of camptothecin
JP2012155651A (ja) *	2011-01-28	2012-08-16	Sony Corp	信号処理装置および方法、並びに、プログラム
CN104628737B (zh) *	2015-01-28	2017-06-06	华南理工大学	两种新晶型的9‑硝基喜树碱及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5527913A (en) *	1993-02-25	1996-06-18	The Stehlin Foundation For Cancer Research	Methods for purifying camptothecin compounds
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
US5731316A (en) *	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives

1997
- 1997-08-05 US US08/906,434 patent/US5922877A/en not_active Ceased
1998
- 1998-07-10 DK DK98933340T patent/DK1003750T3/da active
- 1998-07-10 EP EP98933340A patent/EP1003750B1/en not_active Expired - Lifetime
- 1998-07-10 PT PT98933340T patent/PT1003750E/pt unknown
- 1998-07-10 CN CN98807978A patent/CN1266435A/zh active Pending
- 1998-07-10 IL IL13422498A patent/IL134224A0/xx active IP Right Grant
- 1998-07-10 CN CNA2007101625950A patent/CN101186609A/zh active Pending
- 1998-07-10 AT AT98933340T patent/ATE390429T1/de not_active IP Right Cessation
- 1998-07-10 WO PCT/US1998/014532 patent/WO1999007709A1/en not_active Ceased
- 1998-07-10 CA CA002296731A patent/CA2296731C/en not_active Expired - Fee Related
- 1998-07-10 DE DE69839306T patent/DE69839306T2/de not_active Expired - Fee Related
- 1998-07-10 HU HU0003206A patent/HUP0003206A3/hu unknown
- 1998-07-10 JP JP2000506212A patent/JP3651778B2/ja not_active Expired - Fee Related
- 1998-07-10 ES ES98933340T patent/ES2303355T3/es not_active Expired - Lifetime
- 1998-07-10 AU AU83003/98A patent/AU736323B2/en not_active Ceased
2000
- 2000-01-26 IL IL134224A patent/IL134224A/en not_active IP Right Cessation
2004
- 2004-12-22 JP JP2004372250A patent/JP3842278B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001512732A (ja)	2001-08-28
CN101186609A (zh)	2008-05-28
ATE390429T1 (de)	2008-04-15
EP1003750B1 (en)	2008-03-26
JP3651778B2 (ja)	2005-05-25
CA2296731C (en)	2007-01-09
EP1003750A1 (en)	2000-05-31
HUP0003206A2 (hu)	2001-10-28
JP3842278B2 (ja)	2006-11-08
PT1003750E (pt)	2008-04-29
IL134224A (en)	2006-10-31
AU8300398A (en)	1999-03-01
DE69839306D1 (de)	2008-05-08
WO1999007709A1 (en)	1999-02-18
ES2303355T3 (es)	2008-08-01
CA2296731A1 (en)	1999-02-18
IL134224A0 (en)	2001-04-30
AU736323B2 (en)	2001-07-26
JP2005145981A (ja)	2005-06-09
US5922877A (en)	1999-07-13
CN1266435A (zh)	2000-09-13
DE69839306T2 (de)	2009-04-09
HUP0003206A3 (en)	2001-12-28

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