DK1019044T3 - Præparat og fremgangsmåder til behandling af Alzheimers sygdom og andre amyloidoser - Google Patents

Præparat og fremgangsmåder til behandling af Alzheimers sygdom og andre amyloidoser

Info

Publication number
DK1019044T3
DK1019044T3 DK98923529T DK98923529T DK1019044T3 DK 1019044 T3 DK1019044 T3 DK 1019044T3 DK 98923529 T DK98923529 T DK 98923529T DK 98923529 T DK98923529 T DK 98923529T DK 1019044 T3 DK1019044 T3 DK 1019044T3
Authority
DK
Denmark
Prior art keywords
disease
fibrils
amyloidoses
alzheimer
preparation
Prior art date
Application number
DK98923529T
Other languages
English (en)
Inventor
Gerardo Castillo
Alan D Snow
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21944344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1019044(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK1019044T3 publication Critical patent/DK1019044T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98923529T 1997-05-15 1998-05-15 Præparat og fremgangsmåder til behandling af Alzheimers sygdom og andre amyloidoser DK1019044T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4660297P 1997-05-15 1997-05-15
PCT/US1998/010239 WO1998051302A1 (en) 1997-05-15 1998-05-15 Composition and methods for treating alzheimer's disease and other amyloidoses

Publications (1)

Publication Number Publication Date
DK1019044T3 true DK1019044T3 (da) 2007-08-06

Family

ID=21944344

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98923529T DK1019044T3 (da) 1997-05-15 1998-05-15 Præparat og fremgangsmåder til behandling af Alzheimers sygdom og andre amyloidoser

Country Status (10)

Country Link
US (5) US6939570B1 (da)
EP (1) EP1019044B1 (da)
JP (1) JP4386470B2 (da)
AT (1) ATE359071T1 (da)
AU (1) AU7580098A (da)
CA (1) CA2289531C (da)
DE (1) DE69837551T2 (da)
DK (1) DK1019044T3 (da)
ES (1) ES2285772T3 (da)
WO (1) WO1998051302A1 (da)

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US20030017998A1 (en) * 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
US5985936A (en) * 1997-12-18 1999-11-16 Forbes Medi-Tech, Inc. Method of preventing and delaying onset of Alzheimer's disease and composition therefor
ATE337788T1 (de) * 1998-03-26 2006-09-15 Phytopharm Plc Steroidale saponine zur behandlung der alzheimerischen krankheit
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
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US6887898B1 (en) 1999-10-22 2005-05-03 Darrick S. H. L. Kim Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
AU2300001A (en) * 1999-10-22 2001-05-08 Board Of Trustees Of The University Of Illinois, The Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease
US7728043B2 (en) 1999-10-22 2010-06-01 Kim Darrick S H L Methods for treatment of beta-amyloid protein-induced ocular disease
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
JP3418724B2 (ja) * 2000-02-10 2003-06-23 国立医薬品食品衛生研究所長 セスキテルペノイド化合物及びそれを含む医薬
NZ544691A (en) * 2000-11-03 2007-12-21 Proteotech Inc Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
PT1372682E (pt) * 2001-03-15 2012-08-03 Proteotech Inc Catequinas para o tratamento de fibrilogénese em doença de alzheimer, doença de parkinson, amiloidose αa sistémica e outras perturbações amiloides
AU2002250117B2 (en) * 2001-03-15 2007-11-29 Cognitive Clarity Inc. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
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CA2499549C (en) * 2002-10-11 2012-01-24 Proteotech, Inc. Isolation, purification and synthesis of procyanidin b2 and uses thereof
DK1648952T3 (da) 2003-06-03 2018-05-28 The Us Gov As Represented By The Department Of Health And Human Services Kosttilskud og terapeutiske sammensætninger omfattende (R)-3-hydroxybutyrat-derivater
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KR101462825B1 (ko) 2004-05-03 2014-11-21 헤르메스 바이오사이언스, 인코포레이티드 약물 전달에 유용한 리포좀
BRPI0403688A (pt) * 2004-09-01 2006-05-02 Herbarium Lab Botan Ltda composto fitoterápico tópico para tratamento de herpes
US7446210B2 (en) * 2004-10-26 2008-11-04 Janssen Pharmaceutica N.V. Factor Xa compounds
CH697330B1 (de) * 2004-12-28 2008-08-29 Synthes Gmbh Zwischenwirbelprothese.
US8021701B1 (en) * 2005-04-13 2011-09-20 Perry Stephen C Composition to retard the onset of symptoms of alzheimer's disease
US8679738B2 (en) 2005-04-22 2014-03-25 The Hong Kong University Of Science And Technology Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin
US9279806B2 (en) 2005-04-22 2016-03-08 The Hong Kong University Of Science And Technology Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins
CN101437503A (zh) * 2006-02-21 2009-05-20 阿斯特鲁姆医疗有限公司 用于降低血糖水平和治疗糖尿病的组合物
EP2005171B1 (en) * 2006-03-23 2012-08-08 The General Hospital Corporation Inflammation-inhibitory serum factors and uses thereof
WO2009089144A1 (en) 2008-01-04 2009-07-16 Isis Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
ES2326065B1 (es) * 2008-03-28 2010-07-08 Consejo Superior De Investigaciones Cientificas (Csic) Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple.
EP2307440A4 (en) * 2008-07-01 2012-12-19 Zacharon Pharmaceuticals Inc HEPARAN SULFATE INHIBITORS
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
JP5334508B2 (ja) * 2008-09-10 2013-11-06 Ｔｏｗａ Ｃｏｒｐｏｒａｔｉｏｎ 株式会社 高活性ｐｏａの製法
US8137666B2 (en) * 2008-11-22 2012-03-20 Academia Sinica Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses
FR2941697A1 (fr) * 2009-02-02 2010-08-06 Pf Medicament Derives de tagitinine c et f comme agents anticancereux.
US9950019B2 (en) * 2009-06-12 2018-04-24 Generex Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of brain diseases and conditions
GB201002983D0 (en) 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
WO2014071389A1 (en) 2012-11-05 2014-05-08 Veech Richard L Ketone bodies to protect tissues from damage by ionizing radiation
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
GB2515603B (en) 2013-03-14 2015-10-14 Isis Innovation Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
AU2014101153A4 (en) * 2014-01-03 2014-10-23 Macau University Of Science And Technology A Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof
EP3261655B1 (en) 2015-02-27 2025-04-09 Cognitive Clarity Inc. Composition comprising an uncaria tomentosa extract and an oolong tea extract for use in the treatment of a tautopathy
ES3036518T3 (en) 2015-10-16 2025-09-19 Ipsen Biopharm Ltd Stabilizing camptothecin pharmaceutical compositions
US10391135B2 (en) * 2016-09-16 2019-08-27 University Of South Florida Inhibition of formation of amyloid β-protein fibrils using cactus mucilage extracts
US10946056B2 (en) 2016-09-16 2021-03-16 University Of South Florida Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts
CN107397906A (zh) * 2017-08-24 2017-11-28 王小军 一种治疗继发性系统性淀粉样变的中药
US10799551B2 (en) * 2017-09-25 2020-10-13 Amorepacific Corporation Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients
US10098922B1 (en) * 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
JP7037814B2 (ja) * 2018-03-28 2022-03-17 国立大学法人山口大学 ホルボールエステルを有効成分とする軸索の伸展剤
CA3122687A1 (en) * 2018-12-12 2020-06-18 Cognitive Clarity Inc. Compositions and methods for the treatment of "plaques and tangles" in humans and animals
KR102583195B1 (ko) * 2020-12-10 2023-09-26 경상국립대학교산학협력단 퀴노바산을 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물
KR102509211B1 (ko) * 2021-02-01 2023-03-10 가천대학교 산학협력단 이소미트라필린, 미트라필린, 또는 이들의 약제학적으로 허용 가능한 염을 포함하는 퇴행성 신경질환의 예방 또는 치료용 약제학적 조성물
CN113797204B (zh) * 2021-11-08 2023-07-28 辽宁大学 小檗胺在制备治疗阿尔兹海默症药物中的应用
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US6346280B1 (en) * 1997-05-15 2002-02-12 University Of Washington Composition and methods for inhibiting the formation of brain amyloid deposits
WO1998051302A1 (en) * 1997-05-15 1998-11-19 University Of Washington Composition and methods for treating alzheimer's disease and other amyloidoses
NZ544691A (en) * 2000-11-03 2007-12-21 Proteotech Inc Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants

Also Published As

Publication number Publication date
EP1019044A1 (en) 2000-07-19
US20040086585A1 (en) 2004-05-06
WO1998051302A1 (en) 1998-11-19
DE69837551D1 (de) 2007-05-24
EP1019044B1 (en) 2007-04-11
US20080206162A1 (en) 2008-08-28
ES2285772T3 (es) 2007-11-16
ATE359071T1 (de) 2007-05-15
US6607758B2 (en) 2003-08-19
JP2002508752A (ja) 2002-03-19
US20010055630A1 (en) 2001-12-27
US7029710B2 (en) 2006-04-18
CA2289531C (en) 2009-09-29
JP4386470B2 (ja) 2009-12-16
EP1019044A4 (en) 2004-01-07
AU7580098A (en) 1998-12-08
US7754250B2 (en) 2010-07-13
DE69837551T2 (de) 2007-12-20
US20040076698A1 (en) 2004-04-22
CA2289531A1 (en) 1998-11-19
US6939570B1 (en) 2005-09-06

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