DK1025121T3 - Peptider, som er i stand til at hæmme interaktionen mellem preseniliner og peptidet beta-amyloid eller dets precursor - Google Patents

Peptider, som er i stand til at hæmme interaktionen mellem preseniliner og peptidet beta-amyloid eller dets precursor

Info

Publication number: DK1025121T3
Authority: DK; Denmark
Prior art keywords: beta; interaction; app; iii; amino acids
Prior art date: 1997-10-24

Application number

DK98951547.3T

Other languages

English (en)

Inventor

Christian Czech

Soline Reboul-Becquart

Luc Mercken

Laurent Pradier

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-23

Publication date

2011-11-28

1998-10-23 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

1998-10-23 Priority claimed from PCT/FR1998/002278 external-priority patent/WO1999021886A1/fr

2011-11-28 Application granted granted Critical

2011-11-28 Publication of DK1025121T3 publication Critical patent/DK1025121T3/da

Links

230000003993 interaction Effects 0.000 title abstract 5
102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
239000002243 precursor Substances 0.000 title abstract 2
108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 7
101710137189 Amyloid-beta A4 protein Proteins 0.000 abstract 6
101710151993 Amyloid-beta precursor protein Proteins 0.000 abstract 6
102100022704 Amyloid-beta precursor protein Human genes 0.000 abstract 6
102000015499 Presenilins Human genes 0.000 abstract 6
108010050254 Presenilins Proteins 0.000 abstract 6
101000741220 Barley stripe mosaic virus Capsid protein Proteins 0.000 abstract 4
150000007523 nucleic acids Chemical class 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
241000700605 Viruses Species 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002950 deficient Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Cell Biology (AREA)
General Physics & Mathematics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Food Science & Technology (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Peptides Or Proteins (AREA)

DK98951547.3T 1997-10-24 1998-10-23 Peptider, som er i stand til at hæmme interaktionen mellem preseniliner og peptidet beta-amyloid eller dets precursor DK1025121T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9713384A FR2770217B1 (fr)	1997-10-24	1997-10-24	Peptides capables d'inhiber l'interaction entre les presenilines et le precurseur du peptide b-amyloide et/ou le peptide b-amyloide
US9567198P	1998-08-07	1998-08-07
PCT/FR1998/002278 WO1999021886A1 (fr)	1997-10-24	1998-10-23	PEPTIDES CAPABLES D'INHIBER L'INTERACTION ENTRE LES PRESENILINES ET LE PEPTIDE β-AMYLOIDE OU SON PRECURSEUR

Publications (1)

Publication Number	Publication Date
DK1025121T3 true DK1025121T3 (da)	2011-11-28

Family

ID=9512632

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98951547.3T DK1025121T3 (da)	1997-10-24	1998-10-23	Peptider, som er i stand til at hæmme interaktionen mellem preseniliner og peptidet beta-amyloid eller dets precursor

Country Status (8)

Country	Link
AT (1)	ATE521630T1 (da)
DK (1)	DK1025121T3 (da)
ES (1)	ES2372586T3 (da)
FR (1)	FR2770217B1 (da)
PL (1)	PL198079B1 (da)
PT (1)	PT1025121E (da)
SI (1)	SI1025121T1 (da)
ZA (1)	ZA989745B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6815175B2 (en)	2001-03-16	2004-11-09	Cornell Research Foundation, Inc.	Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU652997B2 (en) *	1991-01-21	1994-09-15	Elan Pharmaceuticals, Inc.	Test and model for alzheimer's disease
US5986054A (en) *	1995-04-28	1999-11-16	The Hospital For Sick Children, Hsc Research And Development Limited Partnership	Genetic sequences and proteins related to alzheimer's disease
WO1997027296A1 (en) *	1996-01-26	1997-07-31	Hsc Research And Development Limited Partnership	Nucleic acids and proteins related to alzheimer's disease, and uses therefor

1997
- 1997-10-24 FR FR9713384A patent/FR2770217B1/fr not_active Expired - Fee Related
1998
- 1998-10-23 ES ES98951547T patent/ES2372586T3/es not_active Expired - Lifetime
- 1998-10-23 AT AT98951547T patent/ATE521630T1/de active
- 1998-10-23 PL PL340054A patent/PL198079B1/pl not_active IP Right Cessation
- 1998-10-23 PT PT98951547T patent/PT1025121E/pt unknown
- 1998-10-23 DK DK98951547.3T patent/DK1025121T3/da active
- 1998-10-23 SI SI9830931T patent/SI1025121T1/sl unknown
- 1998-10-26 ZA ZA989745A patent/ZA989745B/xx unknown

Also Published As

Publication number	Publication date
ES2372586T3 (es)	2012-01-24
PL198079B1 (pl)	2008-05-30
FR2770217A1 (fr)	1999-04-30
PT1025121E (pt)	2011-11-04
ATE521630T1 (de)	2011-09-15
SI1025121T1 (sl)	2011-12-30
FR2770217B1 (fr)	2001-12-07
ZA989745B (en)	1999-05-04
PL340054A1 (en)	2001-01-15

Publication	Publication Date	Title
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Anderson et al.	1989	Characterization of the adenovirus 2 virion protein, mu
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