DK1027343T3 - Fremgangsmåde til fremstilling af hydroxysubstituerede gamma-butyrolactoner - Google Patents
Fremgangsmåde til fremstilling af hydroxysubstituerede gamma-butyrolactonerInfo
- Publication number
- DK1027343T3 DK1027343T3 DK98948584T DK98948584T DK1027343T3 DK 1027343 T3 DK1027343 T3 DK 1027343T3 DK 98948584 T DK98948584 T DK 98948584T DK 98948584 T DK98948584 T DK 98948584T DK 1027343 T3 DK1027343 T3 DK 1027343T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- butyrolactones
- hydroxy
- substituted gamma
- methyl ester
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- ARXKVVRQIIOZGF-UHFFFAOYSA-N 1,2,4-butanetriol Chemical compound OCCC(O)CO ARXKVVRQIIOZGF-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical class O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 abstract 1
- FUDDLSHBRSNCBV-UHFFFAOYSA-N 4-hydroxyoxolan-2-one Chemical compound OC1COC(=O)C1 FUDDLSHBRSNCBV-UHFFFAOYSA-N 0.000 abstract 1
- NSISJFFVIMQBRN-UHFFFAOYSA-N 5-(hydroxymethyl)oxolan-2-one Chemical compound OCC1CCC(=O)O1 NSISJFFVIMQBRN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 229930188620 butyrolactone Natural products 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- DKRLDWPGYHOBCX-UHFFFAOYSA-N methyl 4,5-dihydroxypentanoate Chemical compound COC(=O)CCC(O)CO DKRLDWPGYHOBCX-UHFFFAOYSA-N 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D315/00—Heterocyclic compounds containing rings having one oxygen atom as the only ring hetero atom according to more than one of groups C07D303/00 - C07D313/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/962,365 US5808107A (en) | 1997-10-31 | 1997-10-31 | Process for the preparation of hydroxy substituted gamma butyrolactones |
| PCT/US1998/020448 WO1999023086A1 (fr) | 1997-10-31 | 1998-09-29 | Procede de preparation de gamma butyrolactones a substitution hydroxy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1027343T3 true DK1027343T3 (da) | 2003-03-31 |
Family
ID=25505755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98948584T DK1027343T3 (da) | 1997-10-31 | 1998-09-29 | Fremgangsmåde til fremstilling af hydroxysubstituerede gamma-butyrolactoner |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5808107A (fr) |
| EP (1) | EP1027343B2 (fr) |
| JP (1) | JP3527706B2 (fr) |
| KR (1) | KR100369857B1 (fr) |
| AT (1) | ATE229013T1 (fr) |
| CA (1) | CA2304809C (fr) |
| DE (1) | DE69809962T3 (fr) |
| DK (1) | DK1027343T3 (fr) |
| ES (1) | ES2188017T5 (fr) |
| PT (1) | PT1027343E (fr) |
| WO (1) | WO1999023086A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618099D0 (en) | 1996-08-30 | 1996-10-09 | Zeneca Ltd | Process |
| IT1297120B1 (it) * | 1997-12-16 | 1999-08-03 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina |
| US6949684B2 (en) | 1998-03-03 | 2005-09-27 | Daiso Co., Ltd. | Process for preparing 1,2,4-butanetriol |
| EP1061060B1 (fr) * | 1998-03-03 | 2005-01-12 | Daiso Co., Ltd. | Procede de production de 1,2,4-butanetriol |
| US6084131A (en) * | 1998-06-01 | 2000-07-04 | Board Of Trustees Operating Michigan State University | Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof |
| US6040464A (en) * | 1998-06-01 | 2000-03-21 | Board Of Trustees Operating Michigan State University | Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof |
| ES2183587T3 (es) * | 1998-07-24 | 2003-03-16 | Samsung Fine Chemicals Co Ltd | Procedimiento continuo para la preparacion de derivados de acido (s) -3-4-dihidroxibutirico opticamente puros.. |
| US6713290B2 (en) * | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| US6423850B1 (en) * | 1999-06-18 | 2002-07-23 | E.I. Du Pont De Nemours And Company | Preparation and use of gamma-butyrolactones as cross-linking agents |
| KR100645665B1 (ko) * | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (s)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| US6288239B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | 5-trityloxymethyl-oxazolidinones and process for the preparation thereof |
| US6288238B1 (en) | 2000-09-19 | 2001-09-11 | Board Of Trustees Operating Michigan State University | Process for the preparation of 5-hydroxymethyl 2-oxazolidinone and novel intermediate |
| JP4824874B2 (ja) | 2001-07-19 | 2011-11-30 | 高砂香料工業株式会社 | 光学活性γ−ブチロラクトンの製造方法 |
| EP1398312A1 (fr) * | 2002-09-13 | 2004-03-17 | Hong-Sun Uh | Gamma-butyrolactones substituées en position béta et procédé pour leur préparation |
| EP1558597B1 (fr) * | 2002-09-18 | 2008-05-07 | SK Holdings Co., Ltd. | Procede continu pour la production de (s)-beta hydroxy-gamma-butyrolactone de purete optique |
| WO2005068642A2 (fr) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Synthese d'enantiomeres 1,2,4-butanetriol issue de glucides |
| CN100335457C (zh) * | 2005-09-08 | 2007-09-05 | 上海交通大学 | 3-位手性羟基被保护的3,4-二羟基丁酸酯及其制备方法 |
| KR20070090833A (ko) * | 2006-03-02 | 2007-09-06 | 주식회사 엘지화학 | 가수분해효소를 이용한 s-hgb의 제조방법 |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| WO2008091288A2 (fr) * | 2006-07-19 | 2008-07-31 | Board Of Trustees Of Michigan State University | Synthèse microbienne du d-1,2,4-butanetriol |
| CN100441573C (zh) * | 2006-07-20 | 2008-12-10 | 厦门大学 | 一种合成s-(3)-羟基四氢呋喃的方法 |
| CA2791425A1 (fr) * | 2009-03-06 | 2010-09-10 | Massachusetts Institute Of Technology | Production microbienne de 3-hydroxyacides a partir du glucose et du glycolate |
| WO2012116307A1 (fr) | 2011-02-25 | 2012-08-30 | Massachusetts Institute Of Technology | Production microbienne de 3,4-dihydroxybutyrate (3,4-dhba), de 2,3-dihydroxybutyrate (2,3-dhba) et de 3-hydroxybutyrolactone (3-hbl) |
| MX2018010466A (es) * | 2016-03-15 | 2019-01-14 | Shionogi & Co | Metodo de produccion para derivados de fenoxietanol. |
| CA3097737A1 (fr) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Compositions pharmaceutiques comprenant un systeme formant un reseau polymere d'interpenetration flottant |
| WO2019126214A1 (fr) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Composition pharmaceutique comprenant des systèmes formant un radeau de rétention gastrique de ghb à libération de médicament par impulsions de déclenchement |
| CA3085941A1 (fr) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Compositions pharmaceutiques de ghb comprenant un systeme de formation de reseau polymere interpenetrant flottant |
| AU2018388577B2 (en) | 2017-12-18 | 2024-06-06 | Tris Pharma, Inc. | Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release |
| FR3088324B1 (fr) * | 2018-11-08 | 2020-10-09 | Inst Des Sciences Et Industries Du Vivant Et De Lenvironnement Agroparistech | Procede biocatalytique de production de 2h-hbo a partir de lgo utilisant une cyclohexanone monooxygenase |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| JP2026513019A (ja) | 2023-02-03 | 2026-04-22 | トリス・フアルマ・インコーポレーテツド | 1晩1回の低ナトリウムオキシベート組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3024250A (en) * | 1962-03-06 | Certificate of correction | ||
| US2683721A (en) * | 1952-01-17 | 1954-07-13 | Hermann I Schlesinger | Method of reducing and hydrogenating chemical compounds by reacting with alkali metal borohydrides |
| US3997569A (en) * | 1972-11-08 | 1976-12-14 | Texaco Inc. | Method for preparing a lactone reaction product |
| US3868370A (en) * | 1973-02-09 | 1975-02-25 | Gen Electric | Process for making 4-butyrolactone |
| US4083809A (en) * | 1976-08-20 | 1978-04-11 | Gaf Corporation | Hydrogenation catalyst and method of producing same |
| GB1587198A (en) * | 1976-11-23 | 1981-04-01 | Ucb Sa | Process for the production of butane-1,4 diol and tetrahydrofuran |
| US4772729A (en) * | 1987-01-23 | 1988-09-20 | E. I. Du Pont De Nemours And Company | Hydrogenation of citric acid and substituted citric acids to 3-substituted tetrahydrofuran, 3- and 4-substituted butyrolactones and mixtures thereof |
| EP0304696B1 (fr) * | 1987-08-08 | 1992-04-29 | BASF Aktiengesellschaft | Procédé pour la préparation de 1,4-butanediol et/ou tétrahydrofuranne |
| CA1307796C (fr) * | 1988-04-27 | 1992-09-22 | Kenji Inoue | Methode pour la preparation de derives optiquement actifs de l'acide 3,4-dihydroxybutyrique |
| US5087751A (en) * | 1988-04-27 | 1992-02-11 | Kanegafuchi Kagaku Kogyo K.K. | Method of preparing optically active 3,4-dihydroxy butyric acid derivatives |
| CA2049536C (fr) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Procede d'obtention d'acide 3,4-dihydroxybutanoique et de ses sels |
| DE69225560T2 (de) * | 1991-11-18 | 1998-11-12 | Sagami Chem Res | Verfahren zur Herstellung von Lactonen |
| GB9618099D0 (en) † | 1996-08-30 | 1996-10-09 | Zeneca Ltd | Process |
-
1997
- 1997-10-31 US US08/962,365 patent/US5808107A/en not_active Ceased
-
1998
- 1998-09-29 WO PCT/US1998/020448 patent/WO1999023086A1/fr not_active Ceased
- 1998-09-29 PT PT98948584T patent/PT1027343E/pt unknown
- 1998-09-29 AT AT98948584T patent/ATE229013T1/de not_active IP Right Cessation
- 1998-09-29 ES ES98948584T patent/ES2188017T5/es not_active Expired - Lifetime
- 1998-09-29 DE DE69809962T patent/DE69809962T3/de not_active Expired - Fee Related
- 1998-09-29 DK DK98948584T patent/DK1027343T3/da active
- 1998-09-29 JP JP2000518957A patent/JP3527706B2/ja not_active Expired - Fee Related
- 1998-09-29 CA CA002304809A patent/CA2304809C/fr not_active Expired - Fee Related
- 1998-09-29 KR KR10-2000-7004510A patent/KR100369857B1/ko not_active Expired - Fee Related
- 1998-09-29 EP EP98948584A patent/EP1027343B2/fr not_active Expired - Lifetime
-
2002
- 2002-03-28 US US10/109,487 patent/USRE38324E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3527706B2 (ja) | 2004-05-17 |
| WO1999023086A1 (fr) | 1999-05-14 |
| EP1027343B2 (fr) | 2006-01-11 |
| CA2304809A1 (fr) | 1999-05-14 |
| EP1027343A4 (fr) | 2001-08-22 |
| ES2188017T5 (es) | 2006-07-16 |
| JP2001521931A (ja) | 2001-11-13 |
| ES2188017T3 (es) | 2003-06-16 |
| CA2304809C (fr) | 2006-08-01 |
| DE69809962T2 (de) | 2003-04-24 |
| EP1027343A1 (fr) | 2000-08-16 |
| US5808107A (en) | 1998-09-15 |
| USRE38324E1 (en) | 2003-11-18 |
| DE69809962D1 (de) | 2003-01-16 |
| KR100369857B1 (ko) | 2003-02-05 |
| PT1027343E (pt) | 2003-04-30 |
| EP1027343B1 (fr) | 2002-12-04 |
| DE69809962T3 (de) | 2006-12-14 |
| KR20010031475A (ko) | 2001-04-16 |
| ATE229013T1 (de) | 2002-12-15 |
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