DK1030697T3 - Bionedbrydeligt polymerskelet - Google Patents

Bionedbrydeligt polymerskelet

Info

Publication number
DK1030697T3
DK1030697T3 DK98954085T DK98954085T DK1030697T3 DK 1030697 T3 DK1030697 T3 DK 1030697T3 DK 98954085 T DK98954085 T DK 98954085T DK 98954085 T DK98954085 T DK 98954085T DK 1030697 T3 DK1030697 T3 DK 1030697T3
Authority
DK
Denmark
Prior art keywords
polymer
scaffold
polymer scaffold
particles
solvent
Prior art date
Application number
DK98954085T
Other languages
English (en)
Inventor
Chantal E Holy
Molly S Shoichet
John E Davies
Original Assignee
Bonetec Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonetec Corp filed Critical Bonetec Corp
Application granted granted Critical
Publication of DK1030697T3 publication Critical patent/DK1030697T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK98954085T 1997-11-14 1998-11-13 Bionedbrydeligt polymerskelet DK1030697T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002221195A CA2221195A1 (en) 1997-11-14 1997-11-14 Biodegradable polymer matrix
PCT/CA1998/001052 WO1999025391A2 (en) 1997-11-14 1998-11-13 Biodegradable polymer scaffold

Publications (1)

Publication Number Publication Date
DK1030697T3 true DK1030697T3 (da) 2003-12-29

Family

ID=4161772

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98954085T DK1030697T3 (da) 1997-11-14 1998-11-13 Bionedbrydeligt polymerskelet

Country Status (15)

Country Link
US (1) US6379962B1 (da)
EP (1) EP1030697B1 (da)
JP (1) JP4636684B2 (da)
KR (1) KR100664772B1 (da)
CN (1) CN1212866C (da)
AT (1) ATE247994T1 (da)
AU (2) AU749041B2 (da)
BR (1) BR9814036B1 (da)
CA (2) CA2221195A1 (da)
DE (1) DE69817600T2 (da)
DK (1) DK1030697T3 (da)
ES (1) ES2207861T3 (da)
IL (1) IL136093A0 (da)
NZ (1) NZ504973A (da)
WO (1) WO1999025391A2 (da)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR876M (da) 1960-10-12 1961-10-16
US7022522B2 (en) * 1998-11-13 2006-04-04 Limin Guan Macroporous polymer scaffold containing calcium phosphate particles
AU3844599A (en) * 1999-05-07 2000-11-21 Salviac Limited Biostable polyether polyurethane product
WO2000067815A1 (en) * 1999-05-07 2000-11-16 Salviac Limited A tissue engineering scaffold
JP3421741B2 (ja) * 2000-05-18 2003-06-30 筑波大学長 人工骨髄、血球細胞の増殖方法
US6835390B1 (en) * 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
DE10126137C1 (de) * 2001-05-29 2002-11-07 Andreas Haisch Verfahren zur Herstellung von Zellen, Geweben und Organen
WO2003004254A1 (en) * 2001-07-03 2003-01-16 The Regents Of The University Of California Microfabricated biopolymer scaffolds and method of making same
EP1293220B1 (en) * 2001-09-13 2006-11-08 Akira Myoi Porous calcium phosphate ceramics for in vivo use
US9969980B2 (en) 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
NL1019888C2 (nl) * 2002-02-01 2003-08-25 Univ Twente Werkwijze voor het vervaardigen van een poreuze polymeerstructuur.
WO2003104439A2 (en) * 2002-03-12 2003-12-18 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US20030181978A1 (en) 2002-03-25 2003-09-25 Brown Kelly R. Channeled biomedical foams and method for producing same
DE10392444T5 (de) * 2002-03-28 2005-05-25 Japan As Represented By President Of National Cardiovascular Center, Suita-Shi Stützgerüst für die Gewebsverarbeitung, künstliches Blutgefäß, Manschette und biologisches Implantat abdeckendes Glied
AU2003251874A1 (en) * 2002-07-12 2004-02-02 Dirk R. Albrecht Three dimensional cell patterned bioploymer scaffolds and method of making the same
EP2570440A3 (en) 2003-02-19 2014-06-11 Orteq B.V. Method for the preparation of new segmented polyurethanes with high tear and tensile strengths and method for making porous scaffolds
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
GB0311221D0 (en) * 2003-05-15 2003-06-18 Orthogem Ltd Biomaterial
EP1664168B1 (en) * 2003-08-29 2008-12-03 Mayo Foundation for Medical Education and Research Hydrogel porogens for fabricating biodegradable scaffolds
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
US20060024249A1 (en) * 2004-07-16 2006-02-02 Yelick Pamela C Methods and compositions for bioengineering a tooth
PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
PL1789063T3 (pl) * 2004-09-17 2012-05-31 Hampton Creek Inc Mięso do spożycia hodowane techniką inżynierii tkankowej i sposób wytwarzania mięsa do spożycia hodowanego techniką inżynierii tkankowej
WO2006053031A2 (en) * 2004-11-12 2006-05-18 Mayo Foundation For Medical Education And Research Photocrosslinkable poly(caprolactone fumarate)
JP4897699B2 (ja) * 2004-11-18 2012-03-14 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ ポリカプロラクトンとポリ（プロピレンフマレート）とのブロックコポリマー
US20080206186A1 (en) * 2005-04-26 2008-08-28 Rimon Therapeutics Ltd. Pro-Angiogenic Polymer Scaffolds
ATE511439T1 (de) * 2005-04-29 2011-06-15 Mayo Foundation Hydrophile/hydrophobe polymernetze auf der basis von poly(caprolactonfumarat), poly(ethylenglycolfumarat) und copolymere davon
CN100453124C (zh) * 2006-04-28 2009-01-21 武汉理工大学 多孔、分层、三维空间多级结构的组织支架材料及其制备方法
US8197930B1 (en) 2007-05-10 2012-06-12 Hrl Laboratories, Llc Three-dimensional ordered open-cellular structures
US8287895B1 (en) 2008-04-24 2012-10-16 Hrl Laboratories, Llc Three-dimensional biological scaffold compromising polymer waveguides
US8048857B2 (en) * 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US20080177378A1 (en) * 2007-01-19 2008-07-24 Civention Ag Partially bioabsorbable implant
US8092626B2 (en) * 2007-03-12 2012-01-10 University Of Washington Foaming methods for making cellular thermoplastic materials
US20090069904A1 (en) * 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
DE102008042401A1 (de) * 2008-09-26 2010-04-08 Forschungszentrum Karlsruhe Gmbh Bandscheibenimplantat sowie Verfahren zur Herstellung eines solchen
US20110076396A1 (en) * 2009-09-28 2011-03-31 Limin Guan Method of forming a calcium phosphate coating within a porous material
CA2800731A1 (en) * 2010-05-28 2011-12-01 Garnet Biotherapeutics, Inc. Compositions and methods of using living and non-living bioactive devices with components derived from self-renewing colony forming cells cultured and expanded in vitro
ES2662331T3 (es) * 2010-08-10 2018-04-06 Lifecell Corporation Matrices tisulares regenerativas
EP2757964B1 (en) 2011-05-26 2016-05-04 Cartiva, Inc. Tapered joint implant and related tools
US9415562B1 (en) * 2011-08-17 2016-08-16 Hrl Laboratories, Llc Ultra-light micro-lattices and a method for forming the same
KR102120629B1 (ko) 2011-11-29 2020-06-09 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 3차원 조직 배양 및 조직 공학을 위한 글루코만난 스캐폴딩
US9539773B2 (en) 2011-12-06 2017-01-10 Hrl Laboratories, Llc Net-shape structure with micro-truss core
US8485820B1 (en) 2011-12-22 2013-07-16 Mohamed Ikbal Ali Devices and methods for enhancing bone growth
DK2793962T3 (da) * 2011-12-23 2016-08-15 Dang Quang Svend Le Fremgangsmåde til modificering af overflademorfologien af en medicinsk indretning
US9017806B2 (en) 2012-03-23 2015-04-28 Hrl Laboratories, Llc High airflow micro-truss structural apparatus
KR101304015B1 (ko) * 2012-06-15 2013-09-04 단국대학교 산학협력단 조직 공학용 하이드로겔-다공성 생체세라믹 융합형 스캐폴드 및 이의 제조방법
CN102961781B (zh) * 2012-12-18 2015-08-05 中国科学院长春应用化学研究所 一种组织工程支架材料的制备方法
MX2015017235A (es) 2013-06-13 2017-05-04 Orgenesis Ltd Poblaciones celulares, metodos de transdiferenciacion y metodos de uso de los mismos.
WO2016072017A1 (ja) * 2014-11-07 2016-05-12 オリンパス株式会社 生体組織接合材および生体組織接合方法
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
ES2578705B1 (es) * 2015-01-28 2017-08-04 Universitat Politècnica De Catalunya Andamio macroporoso para ingeniería de tejidos óseos, método de diseño tridimensional y aplicaciones
EP3277228B1 (en) 2015-03-31 2020-01-15 Cartiva, Inc. Carpometacarpal (cmc) implants
WO2016161025A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
WO2016168363A1 (en) 2015-04-14 2016-10-20 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US11331191B2 (en) 2015-08-12 2022-05-17 Howmedica Osteonics Corp. Bioactive soft tissue implant and methods of manufacture and use thereof
CA2938576A1 (en) 2015-08-12 2017-02-12 Howmedica Osteonics Corp. Methods for forming scaffolds
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
EP3241571B1 (en) 2016-05-02 2020-07-22 Howmedica Osteonics Corporation Bioactive soft tissue implant and methods of manufacture and use thereof
CN109790515B (zh) 2016-09-27 2023-05-05 富士胶片株式会社 细胞组织的制造方法及多孔膜
CA3056923A1 (en) 2017-03-23 2018-09-27 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
US11160870B2 (en) 2017-05-10 2021-11-02 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
KR102198398B1 (ko) * 2017-09-22 2021-01-05 고려대학교 산학협력단 비용매상분리법을 이용한 다공성 코어-치밀성 쉘 구조형 스캐폴드 제조 기술
US20250101627A1 (en) * 2022-01-27 2025-03-27 East China University Of Science And Technology Preparation method of collagen material stripped from electrode and use of collagen material

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
DE4120325A1 (de) 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
US5277811A (en) * 1992-04-14 1994-01-11 Millipore Corporation Process for forming porous polymeric product from a nonporous polymeric composition and product
US5228994A (en) * 1992-10-13 1993-07-20 Millipore Corporation Composite microporous membranes
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
GB2301362B (en) 1995-05-30 1999-01-06 Johnson & Johnson Medical Absorbable implant materials having controlled porosity

Also Published As

Publication number Publication date
ES2207861T3 (es) 2004-06-01
JP2001523483A (ja) 2001-11-27
CN1285757A (zh) 2001-02-28
JP4636684B2 (ja) 2011-02-23
ATE247994T1 (de) 2003-09-15
EP1030697A2 (en) 2000-08-30
DE69817600T2 (de) 2004-06-24
CA2221195A1 (en) 1999-05-14
US6379962B1 (en) 2002-04-30
IL136093A0 (en) 2001-05-20
AU1138099A (en) 1999-06-07
KR20010015819A (ko) 2001-02-26
CA2310070C (en) 2008-01-08
NZ504973A (en) 2003-07-25
WO1999025391A2 (en) 1999-05-27
BR9814036B1 (pt) 2011-07-26
AU749041B2 (en) 2002-06-20
CA2310070A1 (en) 1999-05-27
BR9814036A (pt) 2000-11-21
DE69817600D1 (de) 2003-10-02
AU2002300496B2 (en) 2005-04-21
KR100664772B1 (ko) 2007-01-04
EP1030697B1 (en) 2003-08-27
WO1999025391A3 (en) 1999-08-26
CN1212866C (zh) 2005-08-03

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