DK1034174T3 - Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer - Google Patents

Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer

Info

Publication number: DK1034174T3
Authority: DK; Denmark
Prior art keywords: azaring; heterocyclic group; ach receptor; receptor modulators; ether derivatives
Prior art date: 1997-11-05

Application number

DK98952578T

Other languages

Danish (da)

English (en)

Inventor

Dan Peters

Gunnar M Olsen

Simon Feldbaek Nielsen

Elsebet Ostergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-05

Filing date

1998-11-05

Publication date

2003-09-22

1998-11-05 Application filed by Neurosearch As filed Critical Neurosearch As

2003-09-22 Application granted granted Critical

2003-09-22 Publication of DK1034174T3 publication Critical patent/DK1034174T3/da

Links

108010009685 Cholinergic Receptors Proteins 0.000 title abstract 2
102000034337 acetylcholine receptors Human genes 0.000 title abstract 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title 1
150000002170 ethers Chemical class 0.000 title 1
229960002715 nicotine Drugs 0.000 title 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK98952578T 1997-11-05 1998-11-05 Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer DK1034174T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK125997		1997-11-05
DKPA199800850		1998-06-26
PCT/DK1998/000478 WO1999024422A1 (fr)	1997-11-05	1998-11-05	Derives d'azacyclo-ether et leur utilisation en tant que modulateurs des recepteurs ach nicotiniques

Publications (1)

Publication Number	Publication Date
DK1034174T3 true DK1034174T3 (da)	2003-09-22

Family

ID=26064766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98952578T DK1034174T3 (da)	1997-11-05	1998-11-05	Azaringetherderivater og disses anvendelse som nikotin-ACh-receptormodulatorer

Country Status (11)

Country	Link
US (3)	US6756386B1 (fr)
EP (2)	EP1034174B1 (fr)
JP (1)	JP2001522846A (fr)
CN (1)	CN1173972C (fr)
AT (1)	ATE247104T1 (fr)
AU (1)	AU747419B2 (fr)
CA (1)	CA2306477A1 (fr)
DE (1)	DE69817214T2 (fr)
DK (1)	DK1034174T3 (fr)
NZ (1)	NZ503626A (fr)
WO (1)	WO1999024422A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2341989A1 (fr) *	1998-08-25	2000-03-02	Ortho-Mcneil Pharmaceutical, Inc.	Pyridyl ethers et thioethers tenant lieu de ligands pour le recepteur de l'acetycholine nicotinique, et application therapeutique
US6303638B1 (en)	1999-08-06	2001-10-16	The Regents Of The University Of California	Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor
CA2381252A1 (fr) *	1999-09-14	2001-03-22	Abbott Laboratories	Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique
DE10117686A1 (de) *	2001-04-09	2002-10-24	Celanese Ventures Gmbh	Protonenleitende Membran und deren Verwendung
JP2005514362A (ja) *	2001-11-19	2005-05-19	イーランファーマスーティカルズ、インコーポレイテッド	３，４二置換、３，５二置換、及び３，４，５置換ピペリジン及びピペラジン
EP1638939A2 (fr) *	2003-06-24	2006-03-29	Neurosearch A/S	Derives de noyaux aza et utilisation de ceux-ci comme inhibiteurs de la recapture des neurotransmetteurs monoaminergiques
CA2529790A1 (fr) *	2003-06-27	2005-01-27	Banyu Pharmaceutical Co., Ltd.	Derive heterocyclique sature azote d'heteroaryloxy
US20070191815A1 (en)	2004-09-13	2007-08-16	Chrono Therapeutics, Inc.	Biosynchronous transdermal drug delivery
US20070232659A1 (en) *	2004-06-18	2007-10-04	Dan Peters	Novel Alkyl Substituted Piperidine Derivatives as Monoamine Neurotransmitter Re-Uptake Inhibitors
US20070134169A1 (en) *	2005-12-11	2007-06-14	Rabinoff Michael D	Methods for smoking cessation or alcohol cessation or other addiction cessation
ES2521494T3 (es)	2007-04-02	2014-11-12	Parkinson's Institute	Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos
WO2016123406A1 (fr)	2015-01-28	2016-08-04	Chrono Therapeutics Inc.	Procédés et systèmes d'administration de médicament
JP6654960B2 (ja) *	2016-01-15	2020-02-26	日本曹達株式会社	ルテニウム錯体の製造方法
WO2018129304A1 (fr)	2017-01-06	2018-07-12	Chrono Therapeutics Inc.	Dispositifs et methodes d'administration transdermique de medicament
CA3101966A1 (fr)	2018-05-29	2019-12-05	Morningside Venture Investments Limited	Procedes et systemes d'administration de medicament
US12397141B2 (en)	2018-11-16	2025-08-26	Morningside Venture Investments Limited	Thermally regulated transdermal drug delivery system

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR829845A (fr)	1936-12-04	1938-07-07	Delle Atel Const Electr	Coupe-circuit à basse tension à élément fusible rechargeable
FR2306697A1 (fr) *	1975-04-10	1976-11-05	Sogeras	Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants
US4379161A (en) *	1979-06-07	1983-04-05	Michel Thominet	Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
DE3227741A1 (de) *	1982-07-24	1984-01-26	Hoechst Ag, 6230 Frankfurt	1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung
US4592866A (en) *	1982-09-30	1986-06-03	A. H. Robins Company, Inc.	Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
ZA848275B (en) *	1983-12-28	1985-08-28	Degussa	New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4667031A (en) *	1985-10-15	1987-05-19	Ethyl Corporation	Process for preparing oxazepinones
DE3835291A1 (de) *	1988-04-19	1989-11-02	Bayer Ag	1,3-disubstituierte pyrrolidine
FR2640266B2 (fr)	1988-07-12	1992-07-10	Synthelabo	Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
DE4208254A1 (de)	1992-03-14	1993-09-16	Hoechst Ag	Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
IL107184A (en) *	1992-10-09	1997-08-14	Abbott Lab	Heterocyclic ether compounds that enhance cognitive function
AU3162695A (en) *	1994-08-03	1996-03-04	Asta Medica Aktiengesellschaft	Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
GB2295387A (en) *	1994-11-23	1996-05-29	Glaxo Inc	Quinazoline antagonists of alpha 1c adrenergic receptors
IL118279A (en) *	1995-06-07	2006-10-05	Abbott Lab	Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
EP0880501A1 (fr) *	1996-02-02	1998-12-02	Zeneca Limited	Composes heterocycliques utiles en tant qu'agents pharmaceutiques
US5629325A (en) *	1996-06-06	1997-05-13	Abbott Laboratories	3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
EP0863136B1 (fr)	1997-02-25	2003-09-24	Akzo Nobel N.V.	Dérivés d'azétidine et de pyrrolidine
CA2341989A1 (fr)	1998-08-25	2000-03-02	Ortho-Mcneil Pharmaceutical, Inc.	Pyridyl ethers et thioethers tenant lieu de ligands pour le recepteur de l'acetycholine nicotinique, et application therapeutique
DE19904261A1 (de)	1999-02-03	2000-08-10	Basf Ag	Verfahren zur Herstellung von Dimethylsulfit
RU2145680C1 (ru)	1999-06-28	2000-02-20	Открытое акционерное общество "Магистральные нефтепроводы Центральной Сибири"	Пеногенератор (варианты)
GB0203968D0 (en)	2002-02-19	2002-04-03	Gavon Res & Dev Ltd	Mixer
JP2003297848A (ja)	2002-04-01	2003-10-17	Matsushita Electric Ind Co Ltd	半導体装置の製造方法

1998
- 1998-11-05 CA CA002306477A patent/CA2306477A1/fr not_active Abandoned
- 1998-11-05 EP EP98952578A patent/EP1034174B1/fr not_active Expired - Lifetime
- 1998-11-05 JP JP2000520436A patent/JP2001522846A/ja not_active Withdrawn
- 1998-11-05 EP EP03011485A patent/EP1357121A1/fr not_active Withdrawn
- 1998-11-05 DE DE69817214T patent/DE69817214T2/de not_active Expired - Lifetime
- 1998-11-05 WO PCT/DK1998/000478 patent/WO1999024422A1/fr not_active Ceased
- 1998-11-05 AT AT98952578T patent/ATE247104T1/de not_active IP Right Cessation
- 1998-11-05 DK DK98952578T patent/DK1034174T3/da active
- 1998-11-05 AU AU10224/99A patent/AU747419B2/en not_active Ceased
- 1998-11-05 CN CNB988106507A patent/CN1173972C/zh not_active Expired - Fee Related
- 1998-11-05 NZ NZ503626A patent/NZ503626A/en unknown
2000
- 2000-04-14 US US09/550,379 patent/US6756386B1/en not_active Expired - Fee Related
2004
- 2004-05-19 US US10/848,132 patent/US7202237B2/en not_active Expired - Fee Related
2007
- 2007-03-09 US US11/715,872 patent/US20070161614A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1034174B1 (fr)	2003-08-13
US20040242558A1 (en)	2004-12-02
AU1022499A (en)	1999-05-31
CA2306477A1 (fr)	1999-05-20
DE69817214T2 (de)	2004-06-09
CN1173972C (zh)	2004-11-03
US20070161614A1 (en)	2007-07-12
HK1032234A1 (en)	2001-07-13
EP1357121A1 (fr)	2003-10-29
ATE247104T1 (de)	2003-08-15
EP1034174A1 (fr)	2000-09-13
US6756386B1 (en)	2004-06-29
DE69817214D1 (de)	2003-09-18
JP2001522846A (ja)	2001-11-20
WO1999024422A1 (fr)	1999-05-20
AU747419B2 (en)	2002-05-16
US7202237B2 (en)	2007-04-10
CN1278258A (zh)	2000-12-27
NZ503626A (en)	2002-05-31

Publication	Publication Date	Title
DK0984966T3 (da)	2003-05-05	9-azabicyclo[3.3.1]non-2-en derivater, som er cholinerge ligander på nikotin-ACh receptorer
DE69817214D1 (de)	2003-09-18	Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren
CA2289574A1 (fr)	1998-12-03	Derives de 8-azabicyclo[3.2.1]oct-2-ene et -octane utilises comme ligands cholinergiques de recepteurs nicotiniques de l'ach
NO20060219L (no)	2006-04-28	Forbindelser
ATE254618T1 (de)	2003-12-15	Spiro chinuclidin-derivate, ihre herstellung und verwendung
ES2195933T3 (es)	2003-12-16	Nuevos derivados de flavonas, xantonas y cumarinas.
DE68906183D1 (de)	1993-06-03	2'-desoxy-5-fluoruridinderivate.
FI844333L (fi)	1985-05-08	11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
DE69839753D1 (de)	2008-09-04	2-(Arylphenyl)amino-imidazolin-Derivate
ES2073258T3 (es)	1995-08-01	Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
LV12824B (lv)	2002-09-20	Fibrinogēnu receptoru antagonistu iegūšanas paņēmiens
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
ES2090948T3 (es)	1996-10-16	Derivados de carbinol terciario 2-sustituidos de 1,5-iminoazucares como compuestos antivirales.
ATE204868T1 (de)	2001-09-15	2-aryl-3-aminoaryloxynaphthylverbindungen, zwischenverbindungen, zusammensetzungen und verfahren
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
DE69911176D1 (de)	2003-10-16	Spiropiperidin-derivate
DE69810107D1 (de)	2003-01-23	Azacyclooktan- und heptan-derivate, ihre herstellung und ihre therapeutische verwendung
EP0407594A4 (en)	1991-09-25	Novel tetrahydropyrimidine derivatives, process for their preparation and insecticides containing same as active ingredients
ES8301480A1 (es)	1982-12-01	Un procedimiento para la produccion de derivados de 11-piperazinil-5h--pirrolo 1,2-b, 1,2,5 benzotriazepina.
DE69000806D1 (de)	1993-03-11	Indol-derivate.
ATE71367T1 (de)	1992-01-15	Verfahren zur herstellung von indolinen.
MX9202183A (es)	1993-11-01	Ftalidas substituidas, ftalidas heterociclicas y sus derivados, proceso para su preparacion y composiciones que contienen las mismas.
YU38498A (sh)	2001-09-28	Derivati 2-(arilfenil)amino-imidazolina