DK1049703T3 - N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2--(4-fluorphenyl)-1,6-dihydro-1-pyrimidinyl)acetoxyl]-L-asparaginsyrealdehyd som en in vivo inhibitor af interleukin-1beta konverterende enzym - Google Patents

N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2--(4-fluorphenyl)-1,6-dihydro-1-pyrimidinyl)acetoxyl]-L-asparaginsyrealdehyd som en in vivo inhibitor af interleukin-1beta konverterende enzym

Info

Publication number: DK1049703T3
Authority: DK; Denmark
Prior art keywords: interleukin; converting enzyme; benzyloxycarbonylamino; acetoxyl; pyrimidinyl
Prior art date: 1998-01-20

Application number

DK98958672T

Other languages

Danish (da)

English (en)

Inventor

Gerald Paul Schielke

Aurash Shahripour

Original Assignee

Abbott Gmbh & Co Kg

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-20

Filing date

1998-11-20

Publication date

2003-06-02

1998-11-20 Application filed by Abbott Gmbh & Co Kg, Warner Lambert Co filed Critical Abbott Gmbh & Co Kg

2003-06-02 Application granted granted Critical

2003-06-02 Publication of DK1049703T3 publication Critical patent/DK1049703T3/da

Links

-1 5-benzyloxycarbonylamino-6-oxo-2- (4-fluorophenyl) -1,6-dihydro-1-pyrimidinyl Chemical group 0.000 title 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 title 1
108090000426 Caspase-1 Proteins 0.000 title 1
229960005261 aspartic acid Drugs 0.000 title 1
229960003328 benzoyl peroxide Drugs 0.000 title 1
238000001727 in vivo Methods 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000004429 Bacillary Dysentery Diseases 0.000 abstract 1
208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
229940082909 Interleukin 1beta converting enzyme inhibitor Drugs 0.000 abstract 1
208000036110 Neuroinflammatory disease Diseases 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
206010040550 Shigella infections Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
108010027775 interleukin-1beta-converting enzyme inhibitor Proteins 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000036303 septic shock Effects 0.000 abstract 1
201000005113 shigellosis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK98958672T 1998-01-20 1998-11-20 N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2--(4-fluorphenyl)-1,6-dihydro-1-pyrimidinyl)acetoxyl]-L-asparaginsyrealdehyd som en in vivo inhibitor af interleukin-1beta konverterende enzym DK1049703T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7191898P	1998-01-20	1998-01-20
PCT/US1998/024848 WO1999036426A1 (fr)	1998-01-20	1998-11-20	ALDEHYDE DE L'ACIDE N-[2-(5-BENZYLOXYCARBONYL-AMINO-6-OXO-2-(4-FLUOROPHENYL)-1,6-DIHYDRO-1-PYRIMIDINYL)ACETOXYL]-L-ASPARTIQUE, INHIBITEUR in vivo DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE-1$g(b)

Publications (1)

Publication Number	Publication Date
DK1049703T3 true DK1049703T3 (da)	2003-06-02

Family

ID=22104428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98958672T DK1049703T3 (da)	1998-01-20	1998-11-20	N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2--(4-fluorphenyl)-1,6-dihydro-1-pyrimidinyl)acetoxyl]-L-asparaginsyrealdehyd som en in vivo inhibitor af interleukin-1beta konverterende enzym

Country Status (11)

Country	Link
EP (1)	EP1049703B1 (fr)
JP (1)	JP2002509153A (fr)
AT (1)	ATE232536T1 (fr)
AU (1)	AU1466399A (fr)
CA (1)	CA2309546A1 (fr)
DE (1)	DE69811404T2 (fr)
DK (1)	DK1049703T3 (fr)
ES (1)	ES2193589T3 (fr)
PT (1)	PT1049703E (fr)
WO (1)	WO1999036426A1 (fr)
ZA (1)	ZA99369B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6664255B1 (en)	1999-05-19	2003-12-16	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6653316B1 (en)	1999-05-19	2003-11-25	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en)	1999-05-19	2005-03-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US7015230B1 (en)	1999-05-19	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6750342B1 (en)	1999-05-19	2004-06-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6458952B1 (en)	1999-05-19	2002-10-01	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6716838B1 (en)	1999-05-19	2004-04-06	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6808902B1 (en)	1999-11-12	2004-10-26	Amgen Inc.	Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US6660885B2 (en)	2000-03-13	2003-12-09	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
WO2001077079A2 (fr)	2000-04-05	2001-10-18	Pharmacia Corporation	Pyridones polycycliques 4-aryl et heteroaryl substituees utiles pour l'inhibition selective de la cascade de coagulation
CA2405561A1 (fr)	2000-04-05	2001-10-18	Pharmacia Corporation	4-pyrones polycycliques a substitution aryle et heteroaryle utiles pour l'inhibition selective de la cascade de coagulation
JP2004501077A (ja)	2000-04-17	2004-01-15	ファルマシア・コーポレーション	凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換１，４−キノン
AU2001222501A1 (en) *	2000-05-18	2001-11-26	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
EP1301490A2 (fr) *	2000-07-18	2003-04-16	Neurogen Corporation	2-aryl-4-pyrimidinones 5-substituees
US7119094B1 (en)	2000-11-20	2006-10-10	Warner-Lambert Company	Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
JP2004517074A (ja)	2000-11-20	2004-06-10	ファルマシア・コーポレーション	凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類
US7015223B1 (en)	2000-11-20	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
CA2451955C (fr)	2001-06-26	2015-09-29	Abgenix, Inc.	Anticorps opgl
CA2462645A1 (fr)	2001-10-03	2003-11-13	Pharmacia Corporation	Composes polycycliques a 5 elements substitues pour l'inhibition selective de la cascade de reactions dans la coagulation sanguine
BR0213092A (pt)	2001-10-03	2004-10-19	Pharmacia Corp	Compostos heterocìclicos de 6 elementos úteis para a inibição seletiva da cascata de coagulação
CN104178491B (zh)	2002-09-06	2018-07-03	安姆根有限公司	治疗性人抗-il-1r1单克隆抗体
AU2005249503B2 (en)	2003-11-10	2011-08-25	Vertex Pharmaceuticals Incorporated	ICE inhibitors for the treatment of autoinflammatory diseases
KR101135765B1 (ko)	2004-03-12	2012-04-23	버텍스 파마슈티칼스 인코포레이티드	아스파르트산 아세탈 카스파아제 억제제의 제조를 위한방법 및 중간체
CA2566362C (fr)	2004-05-15	2013-09-10	Vertex Pharmaceuticals Incorporated	Traitement de crises epileptiques au moyen d'inhibiteurs ice
EP1910379B1 (fr)	2005-07-28	2011-10-19	Vertex Pharmaceuticals Incorporated	Promédicaments d'inhibiteurs de la caspase
JP6006908B2 (ja)	2010-11-05	2016-10-12	ブランダイスユニバーシティＢｒａｎｄｅｉｓＵｎｉｖｅｒｓｉｔｙ	Ｉｃｅ阻害化合物およびその使用
WO2020035482A1 (fr)	2018-08-13	2020-02-20	Iltoo Pharma	Combinaison d'interleukine 2 et d'un inhibiteur de l'interleukine 1, conjugués et utilisations thérapeutiques de celle-ci
EP4526469A1 (fr)	2022-05-16	2025-03-26	Institut National de la Santé et de la Recherche Médicale	Procédés d'évaluation de l'épuisement de cellules souches hématopoïétiques induites par une inflammation chronique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5441960A (en) *	1992-04-16	1995-08-15	Zeneca Limited	1-pyrimidinylacetamide human leukocyte elastate inhibitors
CA2186511C (fr) *	1994-03-31	2009-02-10	Roland E. Dolle	Derives du pyrimidinyle inhibiteurs de l'interleukine

1998
- 1998-11-20 DK DK98958672T patent/DK1049703T3/da active
- 1998-11-20 EP EP98958672A patent/EP1049703B1/fr not_active Expired - Lifetime
- 1998-11-20 ES ES98958672T patent/ES2193589T3/es not_active Expired - Lifetime
- 1998-11-20 DE DE69811404T patent/DE69811404T2/de not_active Expired - Fee Related
- 1998-11-20 PT PT98958672T patent/PT1049703E/pt unknown
- 1998-11-20 CA CA002309546A patent/CA2309546A1/fr not_active Abandoned
- 1998-11-20 JP JP2000540142A patent/JP2002509153A/ja not_active Abandoned
- 1998-11-20 AU AU14663/99A patent/AU1466399A/en not_active Abandoned
- 1998-11-20 WO PCT/US1998/024848 patent/WO1999036426A1/fr not_active Ceased
- 1998-11-20 AT AT98958672T patent/ATE232536T1/de not_active IP Right Cessation
1999
- 1999-01-19 ZA ZA9900369A patent/ZA99369B/xx unknown

Also Published As

Publication number	Publication date
PT1049703E (pt)	2003-06-30
ES2193589T3 (es)	2003-11-01
AU1466399A (en)	1999-08-02
DE69811404T2 (de)	2003-12-04
JP2002509153A (ja)	2002-03-26
EP1049703B1 (fr)	2003-02-12
ATE232536T1 (de)	2003-02-15
EP1049703A1 (fr)	2000-11-08
CA2309546A1 (fr)	1999-07-22
WO1999036426A1 (fr)	1999-07-22
ZA99369B (en)	1999-07-20
DE69811404D1 (de)	2003-03-20

Publication	Publication Date	Title
ATE232536T1 (de)	2003-02-15	N-(2-(5-benzyloxycarbonyl-amino-6-oxo-2-(4-
NO991674D0 (no)	1999-04-09	Interleukin-1<Beta>omdannelsesenzym-inhibitor-sulfonamider
DK1240165T3 (da)	2005-08-08	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamid-inhibitorer af cyclinafhængige kinaser
DE69532113D1 (de)	2003-12-18	Pyrimidin-derivate als interleukin inhibitoren
BR9712085A (pt)	2000-10-24	Inibidores de metaloprotease heterocìclicos
EA200500472A1 (ru)	2005-10-27	Ацетил 2-гидрокси-1,3-диаминоалканы
EA200200520A1 (ru)	2002-10-31	Производные гетероциклоалкилсульфонилпиразола в качестве противовоспалительных/анальгетических агентов
TR200003252T2 (tr)	2001-04-20	Interleukın-1ß dönüştürme enzimi succınamıde inhibitörleri.
BR9713314A (pt)	2000-01-25	Inibidores da enzima de conversão interleucina-1beta de ácido aspártico substituìdo com sulfonamida
BR9503572A (pt)	1996-04-30	Composto composiçao farmaceutica e método de tratamento ou prevençao de uma doença
LT2003001A (en)	2003-11-25	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
DE60133385D1 (de)	2008-05-08	(+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol oder prodrug davon zur behandlung von demenzsymptomen oder kognitiven störungen
DE69925160D1 (de)	2005-06-09	Arylpiperidin- und aryl-1,2,5,6-tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
SE9902596D0 (sv)	1999-07-06	Pharmaceutically active compounds