DK1049788T3 - Proteinekspression i baculovirus-vektorekspressionssystemer - Google Patents

Proteinekspression i baculovirus-vektorekspressionssystemer

Info

Publication number
DK1049788T3
DK1049788T3 DK98962690T DK98962690T DK1049788T3 DK 1049788 T3 DK1049788 T3 DK 1049788T3 DK 98962690 T DK98962690 T DK 98962690T DK 98962690 T DK98962690 T DK 98962690T DK 1049788 T3 DK1049788 T3 DK 1049788T3
Authority
DK
Denmark
Prior art keywords
expression
baculovirus vector
systems
protein expression
protein
Prior art date
Application number
DK98962690T
Other languages
Danish (da)
English (en)
Inventor
Dietmar Kretzdorn
De Wiel Dirk Franciscus Ma Van
Smit Abraham Johannes De
Robertus Jacobus Mari Moormann
Erik Kees Hamann
Original Assignee
Stichting Dienst Landbouwkundi
Pfizer Animal Health S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8229076&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1049788(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stichting Dienst Landbouwkundi, Pfizer Animal Health S A filed Critical Stichting Dienst Landbouwkundi
Application granted granted Critical
Publication of DK1049788T3 publication Critical patent/DK1049788T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK98962690T 1997-12-18 1998-12-17 Proteinekspression i baculovirus-vektorekspressionssystemer DK1049788T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97203989A EP0924298A1 (de) 1997-12-18 1997-12-18 Proteinexpression in Baculovirus-vektor Expressionsystemen

Publications (1)

Publication Number Publication Date
DK1049788T3 true DK1049788T3 (da) 2006-08-28

Family

ID=8229076

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98962690T DK1049788T3 (da) 1997-12-18 1998-12-17 Proteinekspression i baculovirus-vektorekspressionssystemer

Country Status (21)

Country Link
US (2) US6555346B1 (de)
EP (2) EP0924298A1 (de)
JP (2) JP4220126B2 (de)
KR (3) KR100682171B1 (de)
CN (2) CN101130073A (de)
AR (1) AR015499A1 (de)
AT (1) ATE324456T1 (de)
AU (1) AU750514B2 (de)
BR (1) BR9813692B1 (de)
CA (2) CA2315248C (de)
CO (1) CO4820445A1 (de)
DE (1) DE69834346T2 (de)
DK (1) DK1049788T3 (de)
ES (1) ES2267203T3 (de)
HU (1) HU228122B1 (de)
IL (2) IL136815A0 (de)
NZ (1) NZ505322A (de)
TW (1) TWI225094B (de)
UY (1) UY25315A1 (de)
WO (1) WO1999031257A2 (de)
ZA (1) ZA9811434B (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US6926846B1 (en) 1996-08-08 2005-08-09 Pactiv Corporation Methods of using an oxygen scavenger
EP0924298A1 (de) 1997-12-18 1999-06-23 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Proteinexpression in Baculovirus-vektor Expressionsystemen
EP1035205A1 (de) 1999-03-08 2000-09-13 Stichting Dienst Landbouwkundig Onderzoek Sich nicht verbreitendes Pestivirus
AUPQ233799A0 (en) * 1999-08-19 1999-09-09 Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales Recombinant sub-unit vaccine
CN1338310A (zh) * 2000-08-10 2002-03-06 清华大学 一种猪瘟病毒表位疫苗及其制备方法
WO2002070667A2 (en) * 2001-03-05 2002-09-12 Transtech Pharma, Inc. High level insect expression of rage proteins
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) * 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7795210B2 (en) * 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7179617B2 (en) * 2001-10-10 2007-02-20 Neose Technologies, Inc. Factor IX: remolding and glycoconjugation of Factor IX
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7399613B2 (en) * 2001-10-10 2008-07-15 Neose Technologies, Inc. Sialic acid nucleotide sugars
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US8008252B2 (en) * 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
MXPA04012496A (es) * 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
JP4708027B2 (ja) * 2002-10-01 2011-06-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗癌組成物および抗感染疾患組成物ならびにこれらを使用する方法
KR20060003862A (ko) * 2003-03-14 2006-01-11 네오스 테크놀로지스, 인크. 수용성분기폴리머 및 그 접합체
WO2004091499A2 (en) * 2003-04-09 2004-10-28 Neose Technologies, Inc. Intracellular formation of peptide conjugates
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
EP2055189A1 (de) 2003-04-09 2009-05-06 Neose Technologies, Inc. Glycopegylierungsverfahren und durch die Verfahren hergestellte Proteine/Peptide
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) * 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) * 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
ES2445948T3 (es) * 2003-11-24 2014-03-06 Ratiopharm Gmbh Eritropoyetina glicopegilada
KR101237884B1 (ko) * 2003-12-03 2013-02-27 바이오제너릭스 에이지 글리코 peg화 과립구 콜로니 자극인자
US20080318850A1 (en) * 2003-12-03 2008-12-25 Neose Technologies, Inc. Glycopegylated Factor Ix
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) * 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US7338933B2 (en) * 2004-01-08 2008-03-04 Neose Technologies, Inc. O-linked glycosylation of peptides
EP2327724A3 (de) 2004-02-02 2011-07-27 Ambrx, Inc. Modifizierte humane Wachstumshormon-Polypeptide und deren Verwendungen
KR101699142B1 (ko) 2004-06-18 2017-01-23 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
JP2008507280A (ja) 2004-07-21 2008-03-13 アンブレツクス・インコーポレイテツド 非天然コードアミノ酸を用いた生合成ポリペプチド
WO2006031811A2 (en) * 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
EP1828224B1 (de) 2004-12-22 2016-04-06 Ambrx, Inc. Zusammensetzungen mit, verfahren mit und verwendungen von nichtnatürlichen aminosäuren und polypeptiden
US7816320B2 (en) 2004-12-22 2010-10-19 Ambrx, Inc. Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
JP2008525473A (ja) 2004-12-22 2008-07-17 アンブレツクス・インコーポレイテツド 修飾されたヒト成長ホルモン
CN102732588B (zh) 2004-12-22 2015-01-07 Ambrx公司 氨酰基-tRNA合成酶的组合物及其用途
GB2438760A (en) 2004-12-22 2007-12-05 Ambrx Inc Methods for expression and purification of recombinant human growth hormone
JP2008526864A (ja) * 2005-01-06 2008-07-24 ネオス テクノロジーズ インコーポレイテッド 糖断片を用いる糖結合
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
WO2006078645A2 (en) * 2005-01-19 2006-07-27 Neose Technologies, Inc. Heterologous polypeptide expression using low multiplicity of infection of viruses
EP1866427A4 (de) * 2005-03-30 2010-09-01 Novo Nordisk As Herstellungsverfahren zur produktion von in insektenzelllinien entstandenen peptiden
US20070154992A1 (en) * 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1891231A4 (de) 2005-05-25 2011-06-22 Novo Nordisk As Glykopegylierter faktor ix
EP1888098A2 (de) * 2005-05-25 2008-02-20 Neose Technologies, Inc. Glykopegylierte erythropoetin-formulierungen
WO2006133089A2 (en) 2005-06-03 2006-12-14 Ambrx, Inc. Improved human interferon molecules and their uses
MX2008002149A (es) 2005-08-18 2008-04-22 Ambrx Inc Composiciones de arnt y sus usos.
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
EP1937719A4 (de) * 2005-08-19 2010-11-24 Novo Nordisk As Glycopegylierter faktor vii und faktor viia
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
EP1951890A4 (de) 2005-11-16 2009-06-24 Ambrx Inc Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren
CN100497612C (zh) * 2006-01-25 2009-06-10 中国农业科学院生物技术研究所 一种耐高温乳糖酶的制备方法
CU23544A1 (es) 2006-02-28 2010-06-17 Ct Ingenieria Genetica Biotech Antígenos vacunales quiméricos contra el virus de la peste porcina clásica
ES2516694T3 (es) * 2006-07-21 2014-10-31 Ratiopharm Gmbh Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
CN106008699A (zh) 2006-09-08 2016-10-12 Ambrx公司 经修饰的人类血浆多肽或Fc骨架和其用途
MX2009002460A (es) 2006-09-08 2009-03-20 Ambrx Inc Arnt supresor hibrido para celulas de vertebrados.
US8969532B2 (en) * 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
US20100041872A1 (en) * 2006-10-04 2010-02-18 Defrees Shawn Glycerol linked pegylated sugars and glycopeptides
WO2008073620A2 (en) * 2006-11-02 2008-06-19 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
CA2682147C (en) 2007-03-30 2017-08-08 Ambrx, Inc. Modified fgf-21 polypeptides and their uses
KR20100016160A (ko) 2007-04-03 2010-02-12 바이오제너릭스 에이지 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법
MX2009011870A (es) 2007-05-02 2009-11-12 Ambrx Inc Polipeptidos de interferon beta modificados y usos de los mismos.
US20090053167A1 (en) * 2007-05-14 2009-02-26 Neose Technologies, Inc. C-, S- and N-glycosylation of peptides
EP2162535A4 (de) * 2007-06-04 2011-02-23 Novo Nordisk As O-verknüpfte glykosylierung unter verwendung von n-acetylglucosaminyl-transferasen
WO2008154639A2 (en) * 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) * 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
CN101152570B (zh) * 2007-10-19 2010-11-24 清华大学 一种猪瘟病毒表位疫苗及其制备方法
MX2010005317A (es) 2007-11-20 2010-06-02 Ambrx Inc Polipeptidos de insulina modificados y sus usos.
NZ586947A (en) 2008-02-08 2012-11-30 Ambrx Inc Modified leptin polypeptides and their uses
KR101582841B1 (ko) 2008-02-27 2016-01-11 노보 노르디스크 에이/에스 콘쥬게이트된 인자 ｖｉｉｉ 분자
PT2318029T (pt) 2008-07-23 2018-01-10 Ambrx Inc Polipéptidos de g-csf bovino modificados e suas utilizações
TWI362416B (en) * 2008-07-31 2012-04-21 Mao Xing Biolog Technology Co Ltd Yeast expressed classical swine fever virus glycoprotein e2 and use thereof
PE20110480A1 (es) 2008-09-26 2011-07-01 Ambrx Inc Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales
MX2011003272A (es) 2008-09-26 2011-04-28 Ambrx Inc Polipeptidos de eritropoyetina animal modificados y sus usos.
EP2202298A1 (de) 2008-12-23 2010-06-30 Stichting Dienst Landbouwkundig Onderzoek Rekombinantes Virus der klassischen Schweinepest (KSP) mit einem modifizierten E2-Protein und Verfahren zur Erzeugung des besagten Klassiche-Schweinepest-Virus
JP2013515081A (ja) 2009-12-21 2013-05-02 アンブルックス，インコーポレイテッド 修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用
NZ600361A (en) 2009-12-21 2014-06-27 Ambrx Inc Modified bovine somatotropin polypeptides and their uses
MA34521B1 (fr) 2010-08-17 2013-09-02 Ambrx Inc Polypeptides de relaxine modifiés et leurs utilisations
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
TWI480288B (zh) 2010-09-23 2015-04-11 Lilly Co Eli 牛顆粒細胞群落刺激因子及其變體之調配物
RS56579B1 (sr) * 2011-08-24 2018-02-28 Zoetis Services Llc Poboljšano dijagnostikovanje vakcina
CN105392362B (zh) * 2012-06-12 2018-11-09 替代基因表达公司 用于在宿主昆虫中表达重组蛋白的杆状病毒dna元件
CN104735977B (zh) * 2012-06-12 2016-09-21 替代基因表达公司 用于在宿主细胞中表达重组蛋白的杆状病毒dna元件
CA2903811A1 (en) 2013-03-15 2014-09-25 Spectrum Brands, Inc. Electro-mechanical locks with bezel turning function
DE102013103336A1 (de) * 2013-04-03 2014-10-09 B. Braun Avitum Ag Vorrichtung zur Identifizierung einer Dialysatorvorrichtung oder einer Komponente derselben, und hierfür verwendbare Sensorvorrichtung
JP2015015931A (ja) * 2013-07-12 2015-01-29 株式会社Ｕｍｎファーマ ウイルス様粒子を含む培養物の製造方法
US10392603B2 (en) * 2013-08-30 2019-08-27 The Chemo-Sero-Therapeutic Research Institute Method of viral purification
CN103882051B (zh) * 2014-03-20 2016-04-06 北京市农林科学院 一种检测猪瘟病毒抗体的elisa方法及检测试剂盒
SMT202100388T1 (it) 2014-10-24 2021-09-14 Bristol Myers Squibb Co Polipeptidi fgf-21 modificati e loro usi
KR20170083249A (ko) * 2016-01-08 2017-07-18 경상대학교산학협력단 곤충세포를 이용한 식물 유래 오스모틴 단백질의 대량 생산 방법
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
EP3810782A2 (de) 2018-06-22 2021-04-28 Asklepios Biopharmaceutical, Inc. Vektoren zur genfreisetzung, die in zellen persistieren
CN109182380B (zh) * 2018-08-14 2022-06-03 浙江大学 杆状病毒表达的猪瘟e2亚单位疫苗的制备方法及应用
GB202013940D0 (en) 2020-09-04 2020-10-21 Synpromics Ltd Regulatory nucleic acid sequences
AU2021358957A1 (en) 2020-10-07 2023-06-08 AskBio Inc. Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy. disorders including limb girdle 21
CN112646840B (zh) * 2020-12-25 2022-11-18 石河子大学 一种杆状病毒表达系统制备牛病毒性腹泻病毒e2蛋白的方法及应用
CA3227296A1 (en) * 2021-07-28 2023-02-02 Tomas Cinek Large scale adeno-associated virus production systems
US20250051820A1 (en) 2021-12-27 2025-02-13 Denka Company Limited Method for producing protein in baculovirus expression system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA901719B (en) * 1989-03-19 1991-01-30 Akzo Nv Hog cholera virus vaccine and diagnostics
US5514634A (en) 1991-11-06 1996-05-07 Mobil Oil Corporation High activity polyethylene catalysts
JP3846808B2 (ja) * 1994-06-17 2006-11-15 インステイテユート・ボール・デイールホウデリイ・エン・デイールゲゾンドハイド ペスチウイルス株のヌクレオチド配列、それらの配列によりコードされるポリペプチド、ならびにペスチウイルス感染の診断および予防のためのそれらの使用
PT772632E (pt) * 1994-12-20 2002-02-28 Akzo Nobel Nv Proteina estimuladora de celulas t de pestivirus
WO1996025496A1 (en) * 1995-02-17 1996-08-22 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) PRODUCTION OF BIOLOGICALLY ACTIVE RECOMBINANT BOVINE FOLLICLE STIMULATING HORMONE (REC bFSH) IN THE BACULOVIRUS EXPRESSION SYSTEM
EP0924298A1 (de) 1997-12-18 1999-06-23 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Proteinexpression in Baculovirus-vektor Expressionsystemen

Also Published As

Publication number Publication date
HK1037670A1 (en) 2002-02-15
CA2315248C (en) 2008-10-14
EP1049788A2 (de) 2000-11-08
CN1283801C (zh) 2006-11-08
IL181468A0 (en) 2007-07-04
JP4220126B2 (ja) 2009-02-04
CN101130073A (zh) 2008-02-27
EP0924298A1 (de) 1999-06-23
WO1999031257A3 (en) 1999-08-26
ES2267203T3 (es) 2007-03-01
HUP0101136A2 (hu) 2001-08-28
DE69834346T2 (de) 2007-04-19
AR015499A1 (es) 2001-05-02
BR9813692B1 (pt) 2011-03-09
CA2635158A1 (en) 1999-06-24
US6919085B2 (en) 2005-07-19
HUP0101136A3 (en) 2010-01-28
JP2007254482A (ja) 2007-10-04
AU750514B2 (en) 2002-07-18
ATE324456T1 (de) 2006-05-15
WO1999031257A2 (en) 1999-06-24
ZA9811434B (en) 1999-06-16
KR100682171B1 (ko) 2007-02-12
CO4820445A1 (es) 1999-07-28
CA2315248A1 (en) 1999-06-24
KR100699609B1 (ko) 2007-03-27
AU1786599A (en) 1999-07-05
JP2003533964A (ja) 2003-11-18
US20040028701A1 (en) 2004-02-12
IL136815A0 (en) 2001-06-14
HU228122B1 (en) 2012-11-28
JP4336723B2 (ja) 2009-09-30
IL181468A (en) 2010-12-30
US6555346B1 (en) 2003-04-29
KR100796871B1 (ko) 2008-01-22
NZ505322A (en) 2003-02-28
KR20010033304A (ko) 2001-04-25
UY25315A1 (es) 1999-09-27
DE69834346D1 (en) 2006-06-01
EP1049788B1 (de) 2006-04-26
KR20050115341A (ko) 2005-12-07
BR9813692A (pt) 2001-11-13
KR20050115340A (ko) 2005-12-07
CN1295620A (zh) 2001-05-16
TWI225094B (en) 2004-12-11

Similar Documents

Publication Publication Date Title
DK1049788T3 (da) Proteinekspression i baculovirus-vektorekspressionssystemer
EE200000148A (et) Kay - uus immuunsüsteemi valk
NO20002677D0 (no) Polyeteresteramider
NO983364L (no) Konsensusproteiner
ID24289A (id) Benzotiazol inhibitor-inhibitor protein terosin kinase
NO20002990L (no) Nytt overflateprotein
DE69839603D1 (de) Zierenden proteins
EP1040117A4 (de) 110 menschliche sekretierte proteines
DE69817671D1 (de) Antragsrolle
EP1018551A4 (de) Megsin-protein
EP1012262A4 (de) Menschliches frezzeled-ähnliches protein
DE69925271D1 (de) Angiostatin-bindendes protein
TR199701666A3 (tr) Sismanliga karsi proteinler
ATE301713T1 (de) Plazentaprotein 13
DE69830081D1 (de) Zwischenstück
ATE235511T1 (de) Vielfältig verzweigte peptidkonstruktionen
FI972138A0 (fi) Returtraog i bestrykningsanordning
BR9700300A (pt) Aperfeiçoamentos em termostatos
KR980000586U (ko) 수저통
BR9705695A (pt) Aperfeiçoamento em polvilhadeira
ITMI972543A1 (it) Proteina p27bbp
DK1017798T3 (da) Lunasinpeptider
NO20000976D0 (no) Peptider
BR9704073A (pt) Disposição em publicação tecnico-informativa
BR7701968U (pt) Disposição em secador de talheres