DK1051420T3 - Nye cytotoksiske tris(oxazol)-holdige makrolider - Google Patents

Nye cytotoksiske tris(oxazol)-holdige makrolider

Info

Publication number: DK1051420T3
Authority: DK; Denmark
Prior art keywords: represents hydrogen; lower alkyl; macrolides; oxazole; hydrogen
Prior art date: 1998-01-27

Application number

DK99903797T

Other languages

English (en)

Inventor

Tatsuo Instituto Biomar S Higa

Gravalos Dolores Instit Garcia

Jose Luis In Fernandez-Puentes

Original Assignee

Inst Biomar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-27

Filing date

1999-01-27

Publication date

2002-12-30

1999-01-27 Application filed by Inst Biomar Sa filed Critical Inst Biomar Sa

2002-12-30 Application granted granted Critical

2002-12-30 Publication of DK1051420T3 publication Critical patent/DK1051420T3/da

Links

239000003120 macrolide antibiotic agent Substances 0.000 title abstract 4
229940041033 macrolides Drugs 0.000 title abstract 4
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title abstract 2
239000007983 Tris buffer Substances 0.000 title abstract 2
231100000433 cytotoxic Toxicity 0.000 title abstract 2
230000001472 cytotoxic effect Effects 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
150000002431 hydrogen Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK99903797T 1998-01-27 1999-01-27 Nye cytotoksiske tris(oxazol)-holdige makrolider DK1051420T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9801741.1A GB9801741D0 (en)	1998-01-27	1998-01-27	New cytotoxic tris (oxazole)-containing macrolides
PCT/GB1999/000277 WO1999037653A1 (en)	1998-01-27	1999-01-27	New cytotoxic tris(oxazole)-containing macrolides

Publications (1)

Publication Number	Publication Date
DK1051420T3 true DK1051420T3 (da)	2002-12-30

Family

ID=10825984

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99903797T DK1051420T3 (da)	1998-01-27	1999-01-27	Nye cytotoksiske tris(oxazol)-holdige makrolider

Country Status (21)

Country	Link
US (1)	US6391900B1 (da)
EP (1)	EP1051420B1 (da)
JP (1)	JP4511027B2 (da)
KR (1)	KR20010034413A (da)
CN (1)	CN1131869C (da)
AT (1)	ATE229024T1 (da)
AU (1)	AU760184B2 (da)
BR (1)	BR9907748A (da)
CA (1)	CA2319032C (da)
CZ (1)	CZ291931B6 (da)
DE (1)	DE69904294T2 (da)
DK (1)	DK1051420T3 (da)
ES (1)	ES2186324T3 (da)
GB (1)	GB9801741D0 (da)
HU (1)	HUP0101321A3 (da)
IL (1)	IL137545A0 (da)
MX (1)	MXPA00007381A (da)
PL (1)	PL342040A1 (da)
PT (1)	PT1051420E (da)
RU (1)	RU2217433C2 (da)
WO (1)	WO1999037653A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100471727B1 (ko) *	2002-10-14	2005-02-21	학교법인 포항공과대학교	이속사졸린 고리와 불소를 포함하는 거대고리 화합물 및그의 제조방법
CN100360515C (zh) *	2004-04-09	2008-01-09	中国科学院上海药物研究所	抗肿瘤活性成份陵水醇、制备方法和用途
ES2276629B1 (es) *	2005-12-15	2009-04-01	Pharma Mar, S.A.	Compuestos antitumorales.
US20110118343A1 (en) *	2008-07-03	2011-05-19	Pharma Mar, S. A.	Antitumoral Macrolides
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6256493A (ja) *	1985-09-06	1987-03-12	Yamanouchi Pharmaceut Co Ltd	カビラマイド類
FR2664600B1 (fr) *	1990-07-16	1994-09-02	Rhone Poulenc Sante	Nouveau sel derive de la dialcoylaminoalcoyl-sulfonyl-26 pristinamycine iib.
GB9315914D0 (en) *	1993-07-31	1993-09-15	Smithkline Beecham Plc	Novel compound
EP0729950A4 (en)	1994-09-13	2001-02-07	Kyowa Hakko Kogyo Kk	ANTI-HIV MEDICINAL PRODUCTS

1998
- 1998-01-27 GB GBGB9801741.1A patent/GB9801741D0/en not_active Ceased
1999
- 1999-01-27 EP EP99903797A patent/EP1051420B1/en not_active Expired - Lifetime
- 1999-01-27 JP JP2000528574A patent/JP4511027B2/ja not_active Expired - Fee Related
- 1999-01-27 CN CN998045632A patent/CN1131869C/zh not_active Expired - Fee Related
- 1999-01-27 PT PT99903797T patent/PT1051420E/pt unknown
- 1999-01-27 MX MXPA00007381A patent/MXPA00007381A/es unknown
- 1999-01-27 WO PCT/GB1999/000277 patent/WO1999037653A1/en not_active Ceased
- 1999-01-27 RU RU2000122441/04A patent/RU2217433C2/ru not_active IP Right Cessation
- 1999-01-27 AU AU24319/99A patent/AU760184B2/en not_active Ceased
- 1999-01-27 KR KR1020007008182A patent/KR20010034413A/ko not_active Ceased
- 1999-01-27 BR BR9907748-5A patent/BR9907748A/pt not_active IP Right Cessation
- 1999-01-27 IL IL13754599A patent/IL137545A0/xx unknown
- 1999-01-27 US US09/601,146 patent/US6391900B1/en not_active Expired - Fee Related
- 1999-01-27 ES ES99903797T patent/ES2186324T3/es not_active Expired - Lifetime
- 1999-01-27 DK DK99903797T patent/DK1051420T3/da active
- 1999-01-27 DE DE69904294T patent/DE69904294T2/de not_active Expired - Lifetime
- 1999-01-27 HU HU0101321A patent/HUP0101321A3/hu unknown
- 1999-01-27 PL PL99342040A patent/PL342040A1/xx unknown
- 1999-01-27 CA CA002319032A patent/CA2319032C/en not_active Expired - Fee Related
- 1999-01-27 AT AT99903797T patent/ATE229024T1/de not_active IP Right Cessation
- 1999-01-27 CZ CZ20002754A patent/CZ291931B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1131869C (zh)	2003-12-24
KR20010034413A (ko)	2001-04-25
IL137545A0 (en)	2001-07-24
PL342040A1 (en)	2001-05-21
DE69904294D1 (de)	2003-01-16
CN1320127A (zh)	2001-10-31
JP4511027B2 (ja)	2010-07-28
GB9801741D0 (en)	1998-03-25
RU2217433C2 (ru)	2003-11-27
HUP0101321A3 (en)	2002-06-28
AU760184B2 (en)	2003-05-08
CA2319032A1 (en)	1999-07-29
CZ291931B6 (cs)	2003-06-18
MXPA00007381A (es)	2002-06-04
US6391900B1 (en)	2002-05-21
ES2186324T3 (es)	2003-05-01
WO1999037653A1 (en)	1999-07-29
BR9907748A (pt)	2000-10-17
ATE229024T1 (de)	2002-12-15
JP2002501074A (ja)	2002-01-15
CZ20002754A3 (cs)	2002-02-13
AU2431999A (en)	1999-08-09
EP1051420A1 (en)	2000-11-15
EP1051420B1 (en)	2002-12-04
PT1051420E (pt)	2003-02-28
CA2319032C (en)	2009-09-08
HUP0101321A2 (hu)	2001-09-28
DE69904294T2 (de)	2003-08-21

Publication	Publication Date	Title
NO20016401L (no)	2002-01-23	Th2 differensieringsinhibitorer
DK1037607T3 (da)	2004-06-21	Hidtil ukendt suppositoriumsform, der omfatter en syrelabil aktiv forbindelse
TR199800011T1 (xx)	1998-04-21	Benzo$g] kuinolin t�revleri
MY138525A (en)	2009-06-30	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
MX9603050A (es)	1997-03-29	Derivados de la 1-h-3-aril-pirrolidin-2,4-diona como agentes pesticidas.
NO995846L (no)	2000-01-28	Oksazolidinon-antibakterielle midler med en tiokarbonylfunksjonalitet
DK0949268T3 (da)	2004-03-29	Nye derivater af 2-fluor-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribohexopyranosyl)-oxy)-6-O-methyl-3-oxo-erythromycin, fremgangsmåde til deres fremstilling af deres anvendelse til syntese af aktive stoffer i medikamenter
ATE413175T1 (de)	2008-11-15	Spiroinden- und spiroindan-verbindungen
SI1385518T1 (sl)	2009-02-28	Benzimidazolonske spojine
MXPA03002911A (es)	2003-09-10	Compuestos quimicos.
NO951443L (da)	1995-10-19
AU2001266575A1 (en)	2002-01-08	Chemical compounds
DK1311499T3 (da)	2006-08-07	Bicycliske forbindelser som H3-receptorligander
WO2002000638A8 (en)	2003-08-28	Substituted phthalides as anti-convulsive drugs
ES2193539T3 (es)	2003-11-01	Benzonaftiridinas.
ATE229024T1 (de)	2002-12-15	Cytotoxische tris oxazole makrolide
TR200302288T2 (tr)	2004-12-21	Terapi için yeni bileşikler ve metotlar.
TW200505446A (en)	2005-02-16	Inhibitor of cox
DK1347984T3 (da)	2005-01-10	Fremgangsmåde til fremstilling af taxanderivater
MXPA02012472A (es)	2004-01-26	Compuestos quimicos.
IL158641A0 (en)	2004-05-12	Process for preparing a thiazole ppar-ligand and polymorphs thereof
NO994902L (no)	1999-12-07	Forebygging av brystkreft ved selektive östrogenreseptormodulatorer
MXPA04003086A (es)	2004-09-06	Proceso para sintesis estereoselectiva de 2-hidroximetil-cromanos.
SG155066A1 (en)	2009-09-30	Oxetane compounds containing styrenic functionality
IT1314486B1 (it)	2002-12-18	Torcia per attivita' subacquea.