DK1070078T3 - Form VI 5,6-dichlor-2-(isopropylamino-)-1-beta-L-ribofuranosyl)-1H-benzimidazol - Google Patents

Form VI 5,6-dichlor-2-(isopropylamino-)-1-beta-L-ribofuranosyl)-1H-benzimidazol

Info

Publication number
DK1070078T3
DK1070078T3 DK99919169T DK99919169T DK1070078T3 DK 1070078 T3 DK1070078 T3 DK 1070078T3 DK 99919169 T DK99919169 T DK 99919169T DK 99919169 T DK99919169 T DK 99919169T DK 1070078 T3 DK1070078 T3 DK 1070078T3
Authority
DK
Denmark
Prior art keywords
ribofuranosyl
isopropylamino
benzimidazole
dichloro
beta
Prior art date
Application number
DK99919169T
Other languages
Danish (da)
English (en)
Inventor
Barry Howard Carter
Anne Hodgson
Lian-Feng Huang
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DK1070078T3 publication Critical patent/DK1070078T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK99919169T 1998-04-07 1999-04-01 Form VI 5,6-dichlor-2-(isopropylamino-)-1-beta-L-ribofuranosyl)-1H-benzimidazol DK1070078T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807355.4A GB9807355D0 (en) 1998-04-07 1998-04-07 Antiviral compound
PCT/EP1999/002213 WO1999051617A2 (en) 1998-04-07 1999-04-01 FORM VI 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(β-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE

Publications (1)

Publication Number Publication Date
DK1070078T3 true DK1070078T3 (da) 2003-05-19

Family

ID=10829933

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99919169T DK1070078T3 (da) 1998-04-07 1999-04-01 Form VI 5,6-dichlor-2-(isopropylamino-)-1-beta-L-ribofuranosyl)-1H-benzimidazol

Country Status (39)

Country Link
US (1) US6482939B1 (id)
EP (1) EP1070078B1 (id)
JP (1) JP2002510702A (id)
KR (1) KR100573635B1 (id)
CN (1) CN1222534C (id)
AP (1) AP2000001946A0 (id)
AR (1) AR014973A1 (id)
AT (1) ATE231517T1 (id)
AU (1) AU753527B2 (id)
BG (1) BG104909A (id)
BR (2) BRPI9909471B8 (id)
CA (1) CA2327495C (id)
CO (1) CO5011057A1 (id)
DE (1) DE69905025T2 (id)
DK (1) DK1070078T3 (id)
EA (1) EA002953B1 (id)
EE (1) EE04121B1 (id)
EG (1) EG24597A (id)
ES (1) ES2191429T3 (id)
GB (1) GB9807355D0 (id)
GE (1) GEP20022840B (id)
HR (1) HRP20000670B1 (id)
HU (1) HUP0101549A3 (id)
ID (1) ID26573A (id)
IL (2) IL138559A0 (id)
IS (1) IS5634A (id)
MA (1) MA26617A1 (id)
NO (1) NO316896B1 (id)
NZ (1) NZ507012A (id)
OA (1) OA11534A (id)
PE (1) PE20000356A1 (id)
PL (1) PL194752B1 (id)
PT (1) PT1070078E (id)
SI (1) SI1070078T1 (id)
SK (1) SK283735B6 (id)
TR (1) TR200002847T2 (id)
WO (1) WO1999051617A2 (id)
YU (1) YU58600A (id)
ZA (1) ZA200005197B (id)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
US20110008463A1 (en) * 2008-03-12 2011-01-13 Jan Pieter Hendrik Bosselaers Combinations of hydroxypyrion compounds and silver compounds
US8541391B2 (en) * 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
WO2023105483A1 (en) * 2021-12-10 2023-06-15 Assembly Biosciences, Inc. Crystalline forms of a 5-aminopyrazole compound useful for treating hbv
PL4475844T3 (pl) 2022-10-12 2025-11-12 Takeda Pharmaceutical Company Limited Sposób otrzymywania maribawiru
EP4719351A2 (en) 2023-05-31 2026-04-08 Takeda Pharmaceutical Company Limited Maribavir compositions and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1994008456A1 (en) 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB2319961A (en) 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound

Also Published As

Publication number Publication date
BG104909A (bg) 2001-06-29
CN1222534C (zh) 2005-10-12
AU753527B2 (en) 2002-10-17
US6482939B1 (en) 2002-11-19
KR100573635B1 (ko) 2006-04-26
BRPI9909471B1 (pt) 2018-11-21
YU58600A (sh) 2003-04-30
HUP0101549A3 (en) 2003-07-28
WO1999051617A3 (en) 1999-12-09
CA2327495C (en) 2009-01-20
TR200002847T2 (tr) 2001-01-22
CA2327495A1 (en) 1999-10-14
ID26573A (id) 2001-01-18
HRP20000670A2 (en) 2000-12-31
GEP20022840B (en) 2002-11-25
PT1070078E (pt) 2003-06-30
EP1070078A2 (en) 2001-01-24
MA26617A1 (fr) 2004-12-20
PL343712A1 (en) 2001-08-27
EP1070078B1 (en) 2003-01-22
KR20010074473A (ko) 2001-08-04
SK14822000A3 (sk) 2001-07-10
DE69905025T2 (de) 2003-10-16
JP2002510702A (ja) 2002-04-09
WO1999051617A2 (en) 1999-10-14
NO20005003D0 (no) 2000-10-04
HUP0101549A2 (hu) 2001-10-28
DE69905025D1 (de) 2003-02-27
ATE231517T1 (de) 2003-02-15
CO5011057A1 (es) 2001-02-28
BRPI9909471B8 (pt) 2021-05-25
CN1304413A (zh) 2001-07-18
GB9807355D0 (en) 1998-06-03
ES2191429T3 (es) 2003-09-01
EA002953B1 (ru) 2002-12-26
PE20000356A1 (es) 2000-04-26
IL138559A (en) 2006-12-31
BR9909471A (pt) 2000-12-19
HK1032060A1 (en) 2001-07-06
IL138559A0 (en) 2001-10-31
AR014973A1 (es) 2001-04-11
AP2000001946A0 (en) 2000-12-31
NO316896B1 (no) 2004-06-14
HRP20000670B1 (en) 2004-04-30
ZA200005197B (en) 2001-09-27
OA11534A (en) 2004-05-06
NO20005003L (no) 2000-12-06
EE04121B1 (et) 2003-08-15
SI1070078T1 (en) 2003-08-31
SK283735B6 (sk) 2003-12-02
PL194752B1 (pl) 2007-07-31
EG24597A (en) 2009-12-14
EE200000585A (et) 2002-04-15
AU3703899A (en) 1999-10-25
EA200000909A1 (ru) 2001-06-25
IS5634A (is) 2000-09-22
NZ507012A (en) 2003-06-30

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