DK1071402T3 - Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer - Google Patents

Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer

Info

Publication number
DK1071402T3
DK1071402T3 DK99919195T DK99919195T DK1071402T3 DK 1071402 T3 DK1071402 T3 DK 1071402T3 DK 99919195 T DK99919195 T DK 99919195T DK 99919195 T DK99919195 T DK 99919195T DK 1071402 T3 DK1071402 T3 DK 1071402T3
Authority
DK
Denmark
Prior art keywords
dissolution
surfactants
sub
particles
compressed gas
Prior art date
Application number
DK99919195T
Other languages
Danish (da)
English (en)
Inventor
Alexander Bausch
Pirmin Hidber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1071402T3 publication Critical patent/DK1071402T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50Mixing liquids with solids
    • B01F23/51Methods thereof
    • B01F23/511Methods thereof characterised by the composition of the liquids or solids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50Mixing liquids with solids
    • B01F23/59Mixing systems, i.e. flow charts or diagrams
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/28Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector
    • B01F25/281Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector the jet injector being of the explosive rapid expansion of supercritical solutions [RESS] or fluid injection of molecular spray [FIMS] type, i.e. the liquid is jetted in an environment (gas or liquid) by nozzles, in conditions of significant pressure drop, with the possible generation of shock waves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008Processes carried out under supercritical conditions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22Mixing of ingredients for pharmaceutical or medical compositions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50Mixing liquids with solids
    • B01F23/56Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Glanulating (AREA)
  • Colloid Chemistry (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
DK99919195T 1998-04-09 1999-04-06 Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer DK1071402T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98106534 1998-04-09
PCT/EP1999/002316 WO1999052504A1 (fr) 1998-04-09 1999-04-06 Procede de production de particules submicroniques par dissolution dans du gaz comprime et des tensioactifs

Publications (1)

Publication Number Publication Date
DK1071402T3 true DK1071402T3 (da) 2007-02-19

Family

ID=8231746

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99919195T DK1071402T3 (da) 1998-04-09 1999-04-06 Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer

Country Status (10)

Country Link
US (1) US6299906B1 (fr)
EP (1) EP1071402B1 (fr)
JP (1) JP2002511398A (fr)
KR (1) KR20010042566A (fr)
CN (1) CN1148169C (fr)
AU (1) AU3705799A (fr)
CA (1) CA2326349A1 (fr)
DK (1) DK1071402T3 (fr)
ES (1) ES2272066T3 (fr)
WO (1) WO1999052504A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE386506T1 (de) 1995-10-17 2008-03-15 Jagotec Ag Verabreichung unlöslicher arzneistoffe
EP1319400A3 (fr) * 1998-06-19 2003-11-19 Skyepharma Canada Inc. Procédés de production de particules submicrones de composés insolubles dans l'eau
CA2335472C (fr) * 1998-06-19 2008-10-28 Rtp Pharma Inc. Procedes de production de particules submicroniques de composes insolubles dans l'eau
AU5745599A (en) * 1998-09-15 2000-04-03 Henkel Kommanditgesellschaft Auf Aktien Method for producing nanoparticles
ATE281829T1 (de) * 1999-07-13 2004-11-15 Degussa Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase
PT1263413E (pt) * 2000-03-09 2006-08-31 Univ Ohio State Res Found Metodo de preparacao de dispersoes solidas
AU2001281846B2 (en) * 2000-06-27 2006-04-27 Cheplapharm Arzneimittel Gmbh Method for preparing a composition
AUPR197000A0 (en) * 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6869617B2 (en) 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
GB0102075D0 (en) * 2001-01-26 2001-03-14 Astrazeneca Ab Process
US6749845B2 (en) * 2001-02-15 2004-06-15 Aeropharm Technology, Inc. Modulated release particles for lung delivery
FR2824754B1 (fr) * 2001-05-15 2004-05-28 Separex Sa Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble
CA2448993A1 (fr) 2001-06-19 2002-12-27 Roche Vitamins Ag Procede pour la preparation de dispersions
EP1404438A2 (fr) * 2001-07-12 2004-04-07 Eastman Kodak Company Processus de production de nanomatiere assiste par tensioactif
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US7329789B1 (en) * 2001-10-25 2008-02-12 Phasex Corporation Method for extraction and concentration of carotenoids using supercritical fluids
CA2484052C (fr) * 2002-04-11 2011-06-14 Medimmune Vaccines, Inc. Conservation de matieres bioactives par sechage par pulverisation
FR2838356B1 (fr) * 2002-04-15 2004-05-28 Separex Sa Procede d'obtention d'une suspension stable de particules dans un liquide
WO2003088951A1 (fr) * 2002-04-15 2003-10-30 Eiffel Technologies Limited Formulation de fines particules au moyen de gaz liquefies ou denses
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
KR20050088175A (ko) * 2002-12-17 2005-09-02 메드이뮨 백신즈 인코포레이티드 생물활성 물질의 고압 분무 건조
JP4017996B2 (ja) * 2003-02-05 2007-12-05 シャープ株式会社 現像剤製造方法、現像剤製造装置、及び現像剤
US6931888B2 (en) 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
BRPI0409860A (pt) * 2003-04-29 2006-05-16 Akzo Nobel Nv processo de solidificação anti-solvente
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
EA015349B1 (ru) * 2003-07-11 2011-06-30 Ф. Хоффманн-Ля Рош Аг Твёрдая разовая пероральная фармацевтическая дозированная форма саквинавирмезилата и способ её изготовления
BR0302424A (pt) * 2003-07-23 2005-03-29 Cristalia Prod Quimicos Farm Composição farmacêutica com biodisponibilidade ampliada adequada à adiministração oral de inibidores da protease retroviral. processo de preparação de composição farmacêutica concentrada contendo inibidor da protease retroviral
JP2007520555A (ja) * 2004-02-05 2007-07-26 バクスター・インターナショナル・インコーポレイテッド 自己安定化剤の使用により調製された分散剤
KR101179393B1 (ko) * 2004-03-23 2012-09-07 노파르티스 아게 제약 조성물
US7220456B2 (en) * 2004-03-31 2007-05-22 Eastman Kodak Company Process for the selective deposition of particulate material
US7754243B2 (en) * 2004-08-03 2010-07-13 Clemson University Research Foundation Aqueous suspension of nanoscale drug particles from supercritical fluid processing
US20060246141A1 (en) * 2005-04-12 2006-11-02 Elan Pharma International, Limited Nanoparticulate lipase inhibitor formulations
EP2077823B1 (fr) * 2006-10-11 2012-06-27 Crititech, Inc. Procédé pour précipiter de petites particules de médicament dans des contenants d'utilisation
TWI405590B (zh) 2007-04-06 2013-08-21 活效製藥股份有限公司 微粉碎化有機化合物粒子之製法
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
WO2009039458A2 (fr) * 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Encapsulation de virus/nanofil dans des microgels de polymère pour des dispositifs 2d et 3d destinés à l'énergie et à l'électronique
WO2010117976A1 (fr) 2009-04-09 2010-10-14 Entegrion, Inc Produits sanguins séchés par pulvérisation et procédés de fabrication de ceux-ci
KR100924236B1 (ko) 2009-06-23 2009-10-29 충남대학교산학협력단 균일한 입도분포를 가지는 초미세입자의 신규한 제조방법 및 장치
US20110142885A1 (en) 2009-09-16 2011-06-16 Velico Medical, Inc. Spray-dried human plasma
US20140083628A1 (en) 2012-09-27 2014-03-27 Velico Medical, Inc. Spray drier assembly for automated spray drying
CN103222964B (zh) * 2013-01-29 2014-10-08 青岛大学 一种奥利司他口服制剂及其制备方法
US9561184B2 (en) * 2014-09-19 2017-02-07 Velico Medical, Inc. Methods and systems for multi-stage drying of plasma
EP3275433A1 (fr) 2016-07-29 2018-01-31 Som Innovation Biotech S.L. Composition à libération prolongée comprenant du tolcapone micronisé
CN110115952B (zh) * 2018-02-05 2021-10-15 绍兴吉能纳米科技有限公司 一种可使用低温液化气体的高压均质方法
US12246266B2 (en) 2022-09-15 2025-03-11 Velico Medical, Inc. Disposable for a spray drying system
US12539355B2 (en) 2022-09-15 2026-02-03 Velico Medical, Inc. Dryer for a spray drying system
WO2024059770A1 (fr) 2022-09-15 2024-03-21 Velico Medical, Inc. Système de séchage par pulvérisation rapide
US12246093B2 (en) 2022-09-15 2025-03-11 Velico Medical, Inc. Methods for making spray dried plasma
US11998861B2 (en) 2022-09-15 2024-06-04 Velico Medical, Inc. Usability of a disposable for a spray drying plasma system
US12571587B2 (en) 2022-09-15 2026-03-10 Velico Medical, Inc. Finishing apparatus for a spray drying system
US12083447B2 (en) 2022-09-15 2024-09-10 Velico Medical, Inc. Alignment of a disposable for a spray drying plasma system
US11841189B1 (en) 2022-09-15 2023-12-12 Velico Medical, Inc. Disposable for a spray drying system
US11975274B2 (en) 2022-09-15 2024-05-07 Velico Medical, Inc. Blood plasma product
CN120361800B (zh) * 2025-06-24 2025-09-23 苏州大学 一种基于反溶剂蒸气干燥设备制备亚微米及微米级均一颗粒的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998753A (en) * 1974-08-13 1976-12-21 Hoffmann-La Roche Inc. Water dispersible carotenoid preparations and processes thereof
US4734227A (en) * 1983-09-01 1988-03-29 Battelle Memorial Institute Method of making supercritical fluid molecular spray films, powder and fibers
US5169433A (en) * 1990-07-18 1992-12-08 Formulogics, Inc. Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide
US5170727A (en) * 1991-03-29 1992-12-15 Union Carbide Chemicals & Plastics Technology Corporation Supercritical fluids as diluents in combustion of liquid fuels and waste materials
SI9400079B (sl) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
ATE386506T1 (de) * 1995-10-17 2008-03-15 Jagotec Ag Verabreichung unlöslicher arzneistoffe
CN1233169A (zh) 1996-10-14 1999-10-27 弗·哈夫曼-拉罗切有限公司 一种粉末状制剂的制备工艺

Also Published As

Publication number Publication date
EP1071402B1 (fr) 2006-09-13
US6299906B1 (en) 2001-10-09
CN1148169C (zh) 2004-05-05
CA2326349A1 (fr) 1999-10-21
ES2272066T3 (es) 2007-04-16
CN1295466A (zh) 2001-05-16
AU3705799A (en) 1999-11-01
JP2002511398A (ja) 2002-04-16
WO1999052504A1 (fr) 1999-10-21
EP1071402A1 (fr) 2001-01-31
KR20010042566A (ko) 2001-05-25

Similar Documents

Publication Publication Date Title
DK1071402T3 (da) Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer
PT1404899E (pt) Método e elétrodo para definir e replicar estruturas em materiais condutores
GB2384309B8 (en) High throughput processing system and method of using
EP1331984A4 (fr) Appareil et procede de dissolution de gaz
DK9700059U1 (da) Apparat til brug ved by-pass operationer og anvendelse af sådant apparat
GB2361883B (en) Method and apparatus for analysing low concentrations of particles
GB0129251D0 (en) Method and apparatus for achieving power augmentation in gas
EP1119014A4 (fr) Afficheur, et technique de demontage et de recuperation de pieces associee
AU2001281346A1 (en) Apparatus and method of improved consumable alignment in material processing apparatus
AU2001285019A1 (en) Phase-shift masks and methods of fabrication
AU4896801A (en) Apparatus and method for electrochemical processing of substrates
PL357710A1 (en) Method of and apparatus for assisting in designing work
AU4896601A (en) Apparatus and method for electrochemical processing of substrates
AU4095201A (en) Transaction processing system and method of operation thereof
SG92672A1 (en) Method of removing particles from stage and cleaning plate
AU2001265164A1 (en) Agent and method for treating metal surfaces
AU2001282300A1 (en) System and method for removing particles entrained in an ion beam
AU9309201A (en) Particulate and process gas stream sampler
WO2005029553A3 (fr) Procedes de nettoyage d'un ensemble de structures comprenant de l'oxyde d'yttrium dans un systeme de traitement au plasma
IL157608A0 (en) New crystal forms of lamotrigine and processes for their preparations
GB0128625D0 (en) Method and apparatus for verifying integrity of cascade impactors
DK0904153T3 (da) Fremgangsmåde ved vådformaling og knusemaskine til udøvelse af fremgangsmåden
FI20001945L (fi) Jäähdytysmenetelmä ja- laitteisto ylöspäin tapahtuvan metallien jatkuvavalun yhteydessä
EP1316352A4 (fr) Procede de traitement du mercure dans un gaz d'echappement et systeme de traitement de gaz d'echappement
PL346518A1 (en) Method of and system for analysing for use in integrated engineering