DK1071402T3 - Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer - Google Patents
Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stofferInfo
- Publication number
- DK1071402T3 DK1071402T3 DK99919195T DK99919195T DK1071402T3 DK 1071402 T3 DK1071402 T3 DK 1071402T3 DK 99919195 T DK99919195 T DK 99919195T DK 99919195 T DK99919195 T DK 99919195T DK 1071402 T3 DK1071402 T3 DK 1071402T3
- Authority
- DK
- Denmark
- Prior art keywords
- dissolution
- surfactants
- sub
- particles
- compressed gas
- Prior art date
Links
- 238000004090 dissolution Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 239000004094 surface-active agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/51—Methods thereof
- B01F23/511—Methods thereof characterised by the composition of the liquids or solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/59—Mixing systems, i.e. flow charts or diagrams
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B01F25/28—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector
- B01F25/281—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector the jet injector being of the explosive rapid expansion of supercritical solutions [RESS] or fluid injection of molecular spray [FIMS] type, i.e. the liquid is jetted in an environment (gas or liquid) by nozzles, in conditions of significant pressure drop, with the possible generation of shock waves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/008—Processes carried out under supercritical conditions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/04—Specific aggregation state of one or more of the phases to be mixed
- B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Glanulating (AREA)
- Colloid Chemistry (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98106534 | 1998-04-09 | ||
| PCT/EP1999/002316 WO1999052504A1 (fr) | 1998-04-09 | 1999-04-06 | Procede de production de particules submicroniques par dissolution dans du gaz comprime et des tensioactifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1071402T3 true DK1071402T3 (da) | 2007-02-19 |
Family
ID=8231746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99919195T DK1071402T3 (da) | 1998-04-09 | 1999-04-06 | Fremgangsmåde til af partikler med (sub)mikronstörrelse ved oplösning i komprimeret gas og overfladeaktive stoffer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6299906B1 (fr) |
| EP (1) | EP1071402B1 (fr) |
| JP (1) | JP2002511398A (fr) |
| KR (1) | KR20010042566A (fr) |
| CN (1) | CN1148169C (fr) |
| AU (1) | AU3705799A (fr) |
| CA (1) | CA2326349A1 (fr) |
| DK (1) | DK1071402T3 (fr) |
| ES (1) | ES2272066T3 (fr) |
| WO (1) | WO1999052504A1 (fr) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE386506T1 (de) | 1995-10-17 | 2008-03-15 | Jagotec Ag | Verabreichung unlöslicher arzneistoffe |
| EP1319400A3 (fr) * | 1998-06-19 | 2003-11-19 | Skyepharma Canada Inc. | Procédés de production de particules submicrones de composés insolubles dans l'eau |
| CA2335472C (fr) * | 1998-06-19 | 2008-10-28 | Rtp Pharma Inc. | Procedes de production de particules submicroniques de composes insolubles dans l'eau |
| AU5745599A (en) * | 1998-09-15 | 2000-04-03 | Henkel Kommanditgesellschaft Auf Aktien | Method for producing nanoparticles |
| ATE281829T1 (de) * | 1999-07-13 | 2004-11-15 | Degussa | Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase |
| PT1263413E (pt) * | 2000-03-09 | 2006-08-31 | Univ Ohio State Res Found | Metodo de preparacao de dispersoes solidas |
| AU2001281846B2 (en) * | 2000-06-27 | 2006-04-27 | Cheplapharm Arzneimittel Gmbh | Method for preparing a composition |
| AUPR197000A0 (en) * | 2000-12-08 | 2001-01-11 | Unisearch Limited | Synthesis of small particles |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| US7193084B2 (en) * | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US20030096013A1 (en) * | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| GB0102075D0 (en) * | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
| US6749845B2 (en) * | 2001-02-15 | 2004-06-15 | Aeropharm Technology, Inc. | Modulated release particles for lung delivery |
| FR2824754B1 (fr) * | 2001-05-15 | 2004-05-28 | Separex Sa | Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble |
| CA2448993A1 (fr) | 2001-06-19 | 2002-12-27 | Roche Vitamins Ag | Procede pour la preparation de dispersions |
| EP1404438A2 (fr) * | 2001-07-12 | 2004-04-07 | Eastman Kodak Company | Processus de production de nanomatiere assiste par tensioactif |
| JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| US7329789B1 (en) * | 2001-10-25 | 2008-02-12 | Phasex Corporation | Method for extraction and concentration of carotenoids using supercritical fluids |
| CA2484052C (fr) * | 2002-04-11 | 2011-06-14 | Medimmune Vaccines, Inc. | Conservation de matieres bioactives par sechage par pulverisation |
| FR2838356B1 (fr) * | 2002-04-15 | 2004-05-28 | Separex Sa | Procede d'obtention d'une suspension stable de particules dans un liquide |
| WO2003088951A1 (fr) * | 2002-04-15 | 2003-10-30 | Eiffel Technologies Limited | Formulation de fines particules au moyen de gaz liquefies ou denses |
| US6998051B2 (en) * | 2002-07-03 | 2006-02-14 | Ferro Corporation | Particles from supercritical fluid extraction of emulsion |
| US6966990B2 (en) | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
| KR20050088175A (ko) * | 2002-12-17 | 2005-09-02 | 메드이뮨 백신즈 인코포레이티드 | 생물활성 물질의 고압 분무 건조 |
| JP4017996B2 (ja) * | 2003-02-05 | 2007-12-05 | シャープ株式会社 | 現像剤製造方法、現像剤製造装置、及び現像剤 |
| US6931888B2 (en) | 2003-02-07 | 2005-08-23 | Ferro Corporation | Lyophilization method and apparatus for producing particles |
| US7083748B2 (en) * | 2003-02-07 | 2006-08-01 | Ferro Corporation | Method and apparatus for continuous particle production using supercritical fluid |
| BRPI0409860A (pt) * | 2003-04-29 | 2006-05-16 | Akzo Nobel Nv | processo de solidificação anti-solvente |
| US20060008531A1 (en) * | 2003-05-08 | 2006-01-12 | Ferro Corporation | Method for producing solid-lipid composite drug particles |
| EA015349B1 (ru) * | 2003-07-11 | 2011-06-30 | Ф. Хоффманн-Ля Рош Аг | Твёрдая разовая пероральная фармацевтическая дозированная форма саквинавирмезилата и способ её изготовления |
| BR0302424A (pt) * | 2003-07-23 | 2005-03-29 | Cristalia Prod Quimicos Farm | Composição farmacêutica com biodisponibilidade ampliada adequada à adiministração oral de inibidores da protease retroviral. processo de preparação de composição farmacêutica concentrada contendo inibidor da protease retroviral |
| JP2007520555A (ja) * | 2004-02-05 | 2007-07-26 | バクスター・インターナショナル・インコーポレイテッド | 自己安定化剤の使用により調製された分散剤 |
| KR101179393B1 (ko) * | 2004-03-23 | 2012-09-07 | 노파르티스 아게 | 제약 조성물 |
| US7220456B2 (en) * | 2004-03-31 | 2007-05-22 | Eastman Kodak Company | Process for the selective deposition of particulate material |
| US7754243B2 (en) * | 2004-08-03 | 2010-07-13 | Clemson University Research Foundation | Aqueous suspension of nanoscale drug particles from supercritical fluid processing |
| US20060246141A1 (en) * | 2005-04-12 | 2006-11-02 | Elan Pharma International, Limited | Nanoparticulate lipase inhibitor formulations |
| EP2077823B1 (fr) * | 2006-10-11 | 2012-06-27 | Crititech, Inc. | Procédé pour précipiter de petites particules de médicament dans des contenants d'utilisation |
| TWI405590B (zh) | 2007-04-06 | 2013-08-21 | 活效製藥股份有限公司 | 微粉碎化有機化合物粒子之製法 |
| US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| WO2009039458A2 (fr) * | 2007-09-19 | 2009-03-26 | Massachusetts Institute Of Technology | Encapsulation de virus/nanofil dans des microgels de polymère pour des dispositifs 2d et 3d destinés à l'énergie et à l'électronique |
| WO2010117976A1 (fr) | 2009-04-09 | 2010-10-14 | Entegrion, Inc | Produits sanguins séchés par pulvérisation et procédés de fabrication de ceux-ci |
| KR100924236B1 (ko) | 2009-06-23 | 2009-10-29 | 충남대학교산학협력단 | 균일한 입도분포를 가지는 초미세입자의 신규한 제조방법 및 장치 |
| US20110142885A1 (en) | 2009-09-16 | 2011-06-16 | Velico Medical, Inc. | Spray-dried human plasma |
| US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
| CN103222964B (zh) * | 2013-01-29 | 2014-10-08 | 青岛大学 | 一种奥利司他口服制剂及其制备方法 |
| US9561184B2 (en) * | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
| EP3275433A1 (fr) | 2016-07-29 | 2018-01-31 | Som Innovation Biotech S.L. | Composition à libération prolongée comprenant du tolcapone micronisé |
| CN110115952B (zh) * | 2018-02-05 | 2021-10-15 | 绍兴吉能纳米科技有限公司 | 一种可使用低温液化气体的高压均质方法 |
| US12246266B2 (en) | 2022-09-15 | 2025-03-11 | Velico Medical, Inc. | Disposable for a spray drying system |
| US12539355B2 (en) | 2022-09-15 | 2026-02-03 | Velico Medical, Inc. | Dryer for a spray drying system |
| WO2024059770A1 (fr) | 2022-09-15 | 2024-03-21 | Velico Medical, Inc. | Système de séchage par pulvérisation rapide |
| US12246093B2 (en) | 2022-09-15 | 2025-03-11 | Velico Medical, Inc. | Methods for making spray dried plasma |
| US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
| US12571587B2 (en) | 2022-09-15 | 2026-03-10 | Velico Medical, Inc. | Finishing apparatus for a spray drying system |
| US12083447B2 (en) | 2022-09-15 | 2024-09-10 | Velico Medical, Inc. | Alignment of a disposable for a spray drying plasma system |
| US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
| US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
| CN120361800B (zh) * | 2025-06-24 | 2025-09-23 | 苏州大学 | 一种基于反溶剂蒸气干燥设备制备亚微米及微米级均一颗粒的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998753A (en) * | 1974-08-13 | 1976-12-21 | Hoffmann-La Roche Inc. | Water dispersible carotenoid preparations and processes thereof |
| US4734227A (en) * | 1983-09-01 | 1988-03-29 | Battelle Memorial Institute | Method of making supercritical fluid molecular spray films, powder and fibers |
| US5169433A (en) * | 1990-07-18 | 1992-12-08 | Formulogics, Inc. | Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide |
| US5170727A (en) * | 1991-03-29 | 1992-12-15 | Union Carbide Chemicals & Plastics Technology Corporation | Supercritical fluids as diluents in combustion of liquid fuels and waste materials |
| SI9400079B (sl) * | 1994-02-15 | 2003-02-28 | Dr. Weidner Eckhard, Dipl. Ing. | Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom |
| ATE386506T1 (de) * | 1995-10-17 | 2008-03-15 | Jagotec Ag | Verabreichung unlöslicher arzneistoffe |
| CN1233169A (zh) | 1996-10-14 | 1999-10-27 | 弗·哈夫曼-拉罗切有限公司 | 一种粉末状制剂的制备工艺 |
-
1999
- 1999-04-06 KR KR1020007011231A patent/KR20010042566A/ko not_active Abandoned
- 1999-04-06 DK DK99919195T patent/DK1071402T3/da active
- 1999-04-06 AU AU37057/99A patent/AU3705799A/en not_active Abandoned
- 1999-04-06 US US09/287,409 patent/US6299906B1/en not_active Expired - Fee Related
- 1999-04-06 CN CNB998046868A patent/CN1148169C/zh not_active Expired - Fee Related
- 1999-04-06 ES ES99919195T patent/ES2272066T3/es not_active Expired - Lifetime
- 1999-04-06 WO PCT/EP1999/002316 patent/WO1999052504A1/fr not_active Ceased
- 1999-04-06 CA CA002326349A patent/CA2326349A1/fr not_active Abandoned
- 1999-04-06 JP JP2000543114A patent/JP2002511398A/ja active Pending
- 1999-04-06 EP EP99919195A patent/EP1071402B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1071402B1 (fr) | 2006-09-13 |
| US6299906B1 (en) | 2001-10-09 |
| CN1148169C (zh) | 2004-05-05 |
| CA2326349A1 (fr) | 1999-10-21 |
| ES2272066T3 (es) | 2007-04-16 |
| CN1295466A (zh) | 2001-05-16 |
| AU3705799A (en) | 1999-11-01 |
| JP2002511398A (ja) | 2002-04-16 |
| WO1999052504A1 (fr) | 1999-10-21 |
| EP1071402A1 (fr) | 2001-01-31 |
| KR20010042566A (ko) | 2001-05-25 |
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| Publication | Publication Date | Title |
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