DK1102592T3 - Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser - Google Patents

Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser

Info

Publication number: DK1102592T3
Authority: DK; Denmark
Prior art keywords: substituted; zero; moiety; alkyls; polymeric
Prior art date: 1998-07-13

Application number

DK99933882T

Other languages

English (en)

Inventor

Richard B Greenwald

Yun H Choe

Annapurna Pendri

Original Assignee

Enzon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-13

Filing date

1999-07-12

Publication date

2004-08-16

1999-07-12 Application filed by Enzon Inc filed Critical Enzon Inc

2004-08-16 Application granted granted Critical

2004-08-16 Publication of DK1102592T3 publication Critical patent/DK1102592T3/da

Links

ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title 2
150000001491 aromatic compounds Chemical class 0.000 title 1
229960000956 coumarin Drugs 0.000 title 1
235000001671 coumarin Nutrition 0.000 title 1
125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 2
-1 C3-8 Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
JXASPPWQHFOWPL-UHFFFAOYSA-N Tamarixin Natural products C1=C(O)C(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 JXASPPWQHFOWPL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000890 antigenic effect Effects 0.000 abstract 1
150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
239000003574 free electron Substances 0.000 abstract 1
125000004405 heteroalkoxy group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Pyridine Compounds (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK99933882T 1998-07-13 1999-07-12 Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser DK1102592T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/114,860 US6214330B1 (en)	1998-07-13	1998-07-13	Coumarin and related aromatic-based polymeric prodrugs
PCT/US1999/015652 WO2000002568A1 (en)	1998-07-13	1999-07-12	Coumarin and related aromatic-based polymeric prodrugs

Publications (1)

Publication Number	Publication Date
DK1102592T3 true DK1102592T3 (da)	2004-08-16

Family

ID=22357836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99933882T DK1102592T3 (da)	1998-07-13	1999-07-12	Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser

Country Status (9)

Country	Link
US (1)	US6214330B1 (da)
EP (1)	EP1102592B1 (da)
JP (1)	JP4999226B2 (da)
AT (1)	ATE266424T1 (da)
AU (1)	AU4983999A (da)
CA (1)	CA2336663C (da)
DE (1)	DE69917281T2 (da)
DK (1)	DK1102592T3 (da)
WO (1)	WO2000002568A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004264958B2 (en)	2003-08-13	2010-04-15	Biocon, Ltd	Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
WO2005047245A2 (en) *	2003-11-14	2005-05-26	Wisconsin Alumni Research Foundation	Fluorescence assays with improved blocking groups
US20090214472A1 (en) *	2004-03-01	2009-08-27	Enzon Pharmaceuticals Inc.	Interferon-beta polymer conjugates
JP2007533750A (ja) *	2004-04-21	2007-11-22	アルザコーポレイション	緩和なチオール分解条件下で遊離可能なポリマー結合体
WO2005105154A1 (en) *	2004-04-21	2005-11-10	Alza Corporation	Polymer conjugate releasable under mild thiolytic conditions
JP2010503708A (ja) *	2006-09-15	2010-02-04	エンゾンファーマスーティカルズインコーポレイテッド	多官能性リンカーを含む標的化ポリマープロドラッグ
US8367065B2 (en) *	2006-09-15	2013-02-05	Enzon Pharmaceuticals, Inc.	Targeted polymeric prodrugs containing multifunctional linkers
EP2176404A4 (en) *	2007-07-11	2014-11-19	Belrose Pharma Inc	POLYMERIC DRUG DELIVERY SYSTEMS WITH AN AROMATIC ALLYLIC ACID
RU2453332C2 (ru)	2007-10-16	2012-06-20	Байокон Лимитид	Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц
US20100036110A1 (en) *	2008-08-08	2010-02-11	Xiaoliang Sunney Xie	Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
US20100227327A1 (en) *	2008-08-08	2010-09-09	Xiaoliang Sunney Xie	Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
NZ758049A (en)	2013-10-15	2024-03-22	Seagen Inc	Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
KR20180090290A (ko)	2015-12-04	2018-08-10	시애틀 지네틱스, 인크.	사차화 튜불리신 화합물들의 컨쥬게이트들
US11793880B2 (en)	2015-12-04	2023-10-24	Seagen Inc.	Conjugates of quaternized tubulysin compounds
CN109843919A (zh)	2016-03-25	2019-06-04	西雅图基因公司	用于制备聚乙二醇化的药物-接头及其中间体的方法
KR102648564B1 (ko)	2017-03-24	2024-03-19	씨젠 인크.	글루쿠로니드 약물-링커의 제조 공정 및 그 중간물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4179337A (en) *	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
US4399282A (en) *	1979-07-10	1983-08-16	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives
US4943579A (en) *	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
FR2676058B1 (fr)	1991-04-30	1994-02-25	Hoechst Lab	Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
AU8052194A (en) *	1993-10-20	1995-05-08	Enzon, Inc.	2'- and/or 7- substituted taxoids
US5643575A (en)	1993-10-27	1997-07-01	Enzon, Inc.	Non-antigenic branched polymer conjugates
PT751144E (pt)	1995-06-27	2004-12-31	Pharmachemie Bv	Novos pro-farmacos antraciclinicos, metodo para preparacao e tambem a sua utilizacao em quimioterapia selectiva
JPH1087815A (ja) *	1996-08-22	1998-04-07	Enzon Inc	ポリアルキレンオキシドカルボン酸の改良製造方法
WO1998013059A1 (en)	1996-09-27	1998-04-02	Bristol-Myers Squibb Company	Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells

1998
- 1998-07-13 US US09/114,860 patent/US6214330B1/en not_active Expired - Lifetime
1999
- 1999-07-12 CA CA002336663A patent/CA2336663C/en not_active Expired - Fee Related
- 1999-07-12 WO PCT/US1999/015652 patent/WO2000002568A1/en not_active Ceased
- 1999-07-12 DK DK99933882T patent/DK1102592T3/da active
- 1999-07-12 EP EP99933882A patent/EP1102592B1/en not_active Expired - Lifetime
- 1999-07-12 AT AT99933882T patent/ATE266424T1/de not_active IP Right Cessation
- 1999-07-12 JP JP2000558827A patent/JP4999226B2/ja not_active Expired - Fee Related
- 1999-07-12 AU AU49839/99A patent/AU4983999A/en not_active Abandoned
- 1999-07-12 DE DE69917281T patent/DE69917281T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2000002568A1 (en)	2000-01-20
JP4999226B2 (ja)	2012-08-15
EP1102592A1 (en)	2001-05-30
CA2336663A1 (en)	2000-01-20
EP1102592A4 (en)	2001-12-19
AU4983999A (en)	2000-02-01
ATE266424T1 (de)	2004-05-15
CA2336663C (en)	2009-10-20
DE69917281D1 (de)	2004-06-17
US6214330B1 (en)	2001-04-10
JP2002520288A (ja)	2002-07-09
EP1102592B1 (en)	2004-05-12
DE69917281T2 (de)	2005-06-30

Publication	Publication Date	Title
DK1102592T3 (da)	2004-08-16	Polymere promedikamenter der er baseret på coumarin og beslægtede aromatiske forbindelser
DK1041995T3 (da)	2006-07-10	Trialkyl-blokeringsfaciliterede polymere prolægemidler af amino-indeholdende bioaktive midler
YU64092A (sh)	1995-03-27	Fluoralkoksibenzamino derivati heterocikličnih jedinjenja koja sadrže azot
SE7600047L (sv)	1976-07-07	Stabiliserade nitrilpolymerer
BR9813480A (pt)	2000-10-10	Compostos inibidores de neuraminidase de ciclopentano substituìdo, composição e métodos de inibição da neuraminidase do vìrus da influenza- e de tratamento de infecção por vìrus da influenza-
NO940610L (no)	1994-08-29	Oksazolidinedionderivater, deres fremstilling og anvendelse
ES2062395T3 (es)	1994-12-16	Nuevos compuestos de bencimidazol y su uso.
DE60015606D1 (de)	2004-12-09	Zusammensetzungen, enthaltend aminische antioxidantien auf basis von n-(4-anilinophenyl)amiden
DE60031577D1 (de)	2006-12-07	Hemmer der zelladhäsion
ES445075A1 (es)	1977-08-01	Un procedimiento para la preparacion de nuevos acidos fenoxi-alquil-carboxilicos.
NO20005714D0 (no)	2000-11-13	Nye substituerte cykliske forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
EP0709373A4 (en)	1996-09-25	NEW PYRROLIDINE DERIVATIVE
GB2303851A (en)	1997-03-05	Pharmaceutical diketopiperazine compounds
ATE422163T1 (de)	2009-02-15	Absorbierbare alpha-cyanacrylat-zusammensetzungen
ATE439147T1 (de)	2009-08-15	Prodrugs von krebsmitteln mit substituierten aromatischen säuren
DK340081A (da)	1982-03-04	Polyesteramider og deres anvendelse til kloebning af organiske og uorganiske substrater
AR037342A1 (es)	2004-11-03	Sulfonamidas ciclicas, inhibidores del factor xa de la coagulacion
DK623486D0 (da)	1986-12-22	Guanidinobenzoesyreesterderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
CO5060509A1 (es)	2001-07-30	2-aminopiridinas que contienen sustituyentes de anillos condensados
ES2053018T3 (es)	1994-07-16	Tetrapeptido ciclico y procedimiento para su preparacion.
NO20052598L (no)	2005-05-30	Nye 2,3-dihydro-4(1H)-pyridonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem.
DK0420803T3 (da)	1994-04-05	Benzo-1,2,3-thiadiazol-derivater og deres anvendelse til beskyttelse af planter mod sygdomme
DK209575A (da)	1975-11-15	Pyroglutamylforbindelser med antidepressiv virkning og fremgangsmade til deres fremstilling
DE60008362D1 (en)	2004-03-25	3-bicycloaryl-2-aminomethyl bicycloalkane als serotoniner reuptake inhibitor
ATE367377T1 (de)	2007-08-15	Bis(5-aryl-2-pyridyl)derivate