DK1102770T3 - Parmamagnetiske 3-,8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse, fremgangsmåde til deres fremstilling og deres anvendelse til nekrose- og infarkt-MR-imaging - Google Patents
Parmamagnetiske 3-,8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse, fremgangsmåde til deres fremstilling og deres anvendelse til nekrose- og infarkt-MR-imagingInfo
- Publication number
- DK1102770T3 DK1102770T3 DK99936616T DK99936616T DK1102770T3 DK 1102770 T3 DK1102770 T3 DK 1102770T3 DK 99936616 T DK99936616 T DK 99936616T DK 99936616 T DK99936616 T DK 99936616T DK 1102770 T3 DK1102770 T3 DK 1102770T3
- Authority
- DK
- Denmark
- Prior art keywords
- necrosis
- methods
- parmamagnetic
- infarct
- preparation
- Prior art date
Links
- 206010061216 Infarction Diseases 0.000 title abstract 2
- 206010028851 Necrosis Diseases 0.000 title abstract 2
- 230000007574 infarction Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000017074 necrotic cell death Effects 0.000 title abstract 2
- -1 8-substituted deuteroporphyrin Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- VAJVGAQAYOAJQI-UHFFFAOYSA-N 3-[18-(2-carboxylatoethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-21,24-diium-2-yl]propanoate Chemical class N1C(C=C2C(C)=CC(N2)=CC=2C(=C(CCC(O)=O)C(=C3)N=2)C)=CC(C)=C1C=C1C(C)=C(CCC(O)=O)C3=N1 VAJVGAQAYOAJQI-UHFFFAOYSA-N 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
- 150000004032 porphyrins Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19835082A DE19835082A1 (de) | 1998-07-24 | 1998-07-24 | Paramagnetische 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung für das Nekrose- und Infarkt-MR-Imaging |
| PCT/EP1999/005522 WO2000005235A1 (de) | 1998-07-24 | 1999-07-15 | Paramagnetische 3-,8-substituierte deuteroporphyrinderivate, diese enthaltende pharmazeutische mittel, verfahren zu ihrer herstellung und ihre verwendung für das nekrose- und infarkt-mr-imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1102770T3 true DK1102770T3 (da) | 2003-12-01 |
Family
ID=7876347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99936616T DK1102770T3 (da) | 1998-07-24 | 1999-07-15 | Parmamagnetiske 3-,8-substituerede deuteroporphyrinderivater, farmaceutiske midler indeholdende disse, fremgangsmåde til deres fremstilling og deres anvendelse til nekrose- og infarkt-MR-imaging |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1102770B1 (da) |
| JP (1) | JP2002521384A (da) |
| AT (1) | ATE247659T1 (da) |
| AU (1) | AU5164699A (da) |
| DE (2) | DE19835082A1 (da) |
| DK (1) | DK1102770T3 (da) |
| ES (1) | ES2205863T3 (da) |
| NO (1) | NO317788B1 (da) |
| PT (1) | PT1102770E (da) |
| TW (1) | TW553941B (da) |
| WO (1) | WO2000005235A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312244B2 (en) | 1999-04-30 | 2007-12-25 | Cellgate, Inc. | Polyamine analog-amino acid conjugates useful as anticancer agents |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| WO2000066175A2 (en) | 1999-04-30 | 2000-11-09 | Slil Biomedical Corporation | Conjugates as therapies for cancer and prostate diseases |
| US6906050B2 (en) | 2001-05-31 | 2005-06-14 | Miravant Pharmaceuticals, Inc. | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis |
| EP1525003A1 (en) * | 2002-06-28 | 2005-04-27 | Pharmacia Corporation | Methods and contrast agents useful in quantifying nitric oxide |
| DE10240343A1 (de) * | 2002-08-27 | 2004-03-11 | Schering Ag | Peroxynitrit-Umlagerungskatalysatoren |
| WO2012105483A1 (ja) * | 2011-01-31 | 2012-08-09 | 国立大学法人宇都宮大学 | ポルフィリン型骨格を有する化合物の金属錯体の製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284647A (en) * | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
| US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
| DE3827940A1 (de) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4232925A1 (de) * | 1992-09-28 | 1994-03-31 | Diagnostikforschung Inst | 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung |
| EP0758907A1 (en) * | 1994-05-11 | 1997-02-26 | Schering Aktiengesellschaft | The use of porphyrin-complex or expanded porphyrin-complex compounds as localization diagnosticum for infarction or necrosis |
| DE19824653A1 (de) * | 1998-02-25 | 1999-08-26 | Schering Ag | Nekrose-affine Verbindungen und ihre Verwendung zur Herstellung von Präparaten zur Pharmakotherapie |
-
1998
- 1998-07-24 DE DE19835082A patent/DE19835082A1/de not_active Withdrawn
-
1999
- 1999-07-02 TW TW088111288A patent/TW553941B/zh not_active IP Right Cessation
- 1999-07-15 ES ES99936616T patent/ES2205863T3/es not_active Expired - Lifetime
- 1999-07-15 JP JP2000561191A patent/JP2002521384A/ja active Pending
- 1999-07-15 PT PT99936616T patent/PT1102770E/pt unknown
- 1999-07-15 WO PCT/EP1999/005522 patent/WO2000005235A1/de not_active Ceased
- 1999-07-15 DK DK99936616T patent/DK1102770T3/da active
- 1999-07-15 DE DE59906695T patent/DE59906695D1/de not_active Expired - Fee Related
- 1999-07-15 EP EP99936616A patent/EP1102770B1/de not_active Expired - Lifetime
- 1999-07-15 AT AT99936616T patent/ATE247659T1/de not_active IP Right Cessation
- 1999-07-15 AU AU51646/99A patent/AU5164699A/en not_active Abandoned
-
2001
- 2001-01-23 NO NO20010392A patent/NO317788B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE19835082A1 (de) | 2000-02-03 |
| ATE247659T1 (de) | 2003-09-15 |
| AU5164699A (en) | 2000-02-14 |
| TW553941B (en) | 2003-09-21 |
| NO317788B1 (no) | 2004-12-13 |
| NO20010392L (no) | 2001-03-23 |
| NO20010392D0 (no) | 2001-01-23 |
| JP2002521384A (ja) | 2002-07-16 |
| DE59906695D1 (de) | 2003-09-25 |
| PT1102770E (pt) | 2004-01-30 |
| EP1102770B1 (de) | 2003-08-20 |
| ES2205863T3 (es) | 2004-05-01 |
| WO2000005235A1 (de) | 2000-02-03 |
| EP1102770A1 (de) | 2001-05-30 |
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