DK1108041T3 - Transgen syntese af amorpha-4,11-dien - Google Patents
Transgen syntese af amorpha-4,11-dienInfo
- Publication number
- DK1108041T3 DK1108041T3 DK99944535T DK99944535T DK1108041T3 DK 1108041 T3 DK1108041 T3 DK 1108041T3 DK 99944535 T DK99944535 T DK 99944535T DK 99944535 T DK99944535 T DK 99944535T DK 1108041 T3 DK1108041 T3 DK 1108041T3
- Authority
- DK
- Denmark
- Prior art keywords
- amorpha
- diene
- synthase
- diene synthase
- production
- Prior art date
Links
- HMTAHNDPLDKYJT-CBBWQLFWSA-N amorpha-4,11-diene Chemical compound C1=C(C)CC[C@H]2[C@H](C)CC[C@@H](C(C)=C)[C@H]21 HMTAHNDPLDKYJT-CBBWQLFWSA-N 0.000 title abstract 3
- HMTAHNDPLDKYJT-UHFFFAOYSA-N amorphadiene Natural products C1=C(C)CCC2C(C)CCC(C(C)=C)C21 HMTAHNDPLDKYJT-UHFFFAOYSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 108010022380 Amorpha-4,11-diene synthase Proteins 0.000 abstract 7
- 240000000011 Artemisia annua Species 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 239000003430 antimalarial agent Substances 0.000 abstract 2
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 abstract 2
- 229960004191 artemisinin Drugs 0.000 abstract 2
- 229930101531 artemisinin Natural products 0.000 abstract 2
- 238000010367 cloning Methods 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
- Holo Graphy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202854A EP0982404A1 (en) | 1998-08-27 | 1998-08-27 | DNA encoding amorpha-4,11-diene synthase |
| PCT/EP1999/006302 WO2000012725A2 (en) | 1998-08-27 | 1999-08-27 | Transgenic amorpha-4,11-diene synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1108041T3 true DK1108041T3 (da) | 2007-04-10 |
Family
ID=8234064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99944535T DK1108041T3 (da) | 1998-08-27 | 1999-08-27 | Transgen syntese af amorpha-4,11-dien |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7091027B1 (da) |
| EP (2) | EP0982404A1 (da) |
| JP (1) | JP4638036B2 (da) |
| CN (1) | CN1253573C (da) |
| AT (1) | ATE348174T1 (da) |
| AU (1) | AU766764B2 (da) |
| BR (1) | BR9913196A (da) |
| CA (1) | CA2340925C (da) |
| CY (1) | CY1105926T1 (da) |
| DE (1) | DE69934413T2 (da) |
| DK (1) | DK1108041T3 (da) |
| ES (1) | ES2274636T3 (da) |
| HK (1) | HK1042516B (da) |
| ID (1) | ID28532A (da) |
| MX (1) | MXPA01002040A (da) |
| OA (1) | OA11642A (da) |
| PT (1) | PT1108041E (da) |
| WO (1) | WO2000012725A2 (da) |
| ZA (1) | ZA200101455B (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0982404A1 (en) * | 1998-08-27 | 2000-03-01 | Wallaart, Thorvald Eelco | DNA encoding amorpha-4,11-diene synthase |
| EP1231273A1 (en) | 2001-02-12 | 2002-08-14 | Plant Research International B.V. | Terpene synthase/cyclase and olefin synthase and uses thereof |
| CN1589327A (zh) * | 2001-09-17 | 2005-03-02 | 植物研究国际公司 | 用于生物转化的植物酶 |
| EP2298859A3 (en) | 2004-07-27 | 2011-05-25 | The Regents of the University of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| EP1866428A2 (en) | 2005-03-18 | 2007-12-19 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| WO2006111924A2 (en) * | 2005-04-19 | 2006-10-26 | University Of Kentucky Research Foundation | Transformed plants accumulating terpenes |
| JP5135215B2 (ja) * | 2005-07-01 | 2013-02-06 | ユニバーシティー オブ ケンタッキー リサーチ ファンデーション | モノテルペン及び／又はセスキテルペンを蓄積する形質転換植物 |
| CN101495499B (zh) * | 2005-07-05 | 2013-09-04 | 加利福尼亚大学董事会 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| WO2008100251A1 (en) * | 2007-02-13 | 2008-08-21 | Ls9, Inc. | Modified microorganism uses therefor |
| CN101454453B (zh) | 2006-04-05 | 2012-12-19 | 加拿大国家研究委员会 | 编码二氢青蒿酸生物合成中的酶的核苷酸序列 |
| US20100242345A1 (en) | 2006-05-19 | 2010-09-30 | LS9, Inc | Production of fatty acids & derivatives thereof |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| EP2078092A2 (en) | 2006-09-28 | 2009-07-15 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| CN101074443B (zh) * | 2006-11-14 | 2011-08-03 | 西南大学 | 携带质体转运肽的紫槐二烯合成酶融合基因及应用 |
| CA2725175A1 (en) * | 2008-05-23 | 2009-11-26 | Cibus Oils, Llc | Production of squalene using yeast |
| WO2010019696A2 (en) | 2008-08-12 | 2010-02-18 | Allylix, Inc. | Method for production of isoprenoids |
| EP2350264A4 (en) | 2008-11-06 | 2012-08-29 | Univ Johns Hopkins | TREATMENT OF CHRONIC INFLAMMATION OF THE RESPIRATORY TRACT |
| CN111808892A (zh) | 2009-04-27 | 2020-10-23 | 基因组股份公司 | 脂肪酸酯的产生 |
| WO2011036232A1 (en) * | 2009-09-25 | 2011-03-31 | Basf Plant Science Company Gmbh | Plants having enhanced yield-related traits and a method for making the same |
| CN102242145A (zh) * | 2011-04-20 | 2011-11-16 | 上海交通大学 | 转aoc基因提高青蒿中青蒿素含量的方法 |
| CN103276000B (zh) * | 2013-05-31 | 2015-02-04 | 天津大学 | 一种生产青蒿二烯的酵母菌及构建方法 |
| JP6436417B2 (ja) * | 2014-12-01 | 2018-12-12 | 住友ゴム工業株式会社 | アモルファ−４，１１−ジエン増産方法及び天然ゴム増産方法 |
| CN112877355A (zh) * | 2021-01-22 | 2021-06-01 | 杜云龙 | 一种利用烟草表达三七皂苷的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994000584A2 (en) * | 1992-06-23 | 1994-01-06 | Worcester Polytechnic Institute | Artemisia annua transformed with agrobacterium rhizogenes |
| WO1999038957A1 (en) * | 1998-02-02 | 1999-08-05 | Washington State University Research Foundation | GERMACRENE C SYNTHASE GENE OF $i(LYCOPERSICON ESCULENTUM) |
| EP0982404A1 (en) * | 1998-08-27 | 2000-03-01 | Wallaart, Thorvald Eelco | DNA encoding amorpha-4,11-diene synthase |
| AR022383A1 (es) | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
-
1998
- 1998-08-27 EP EP98202854A patent/EP0982404A1/en not_active Withdrawn
-
1999
- 1999-08-27 DE DE69934413T patent/DE69934413T2/de not_active Expired - Lifetime
- 1999-08-27 US US09/763,822 patent/US7091027B1/en not_active Expired - Fee Related
- 1999-08-27 EP EP99944535A patent/EP1108041B1/en not_active Expired - Lifetime
- 1999-08-27 HK HK02103166.0A patent/HK1042516B/zh not_active IP Right Cessation
- 1999-08-27 ID IDW20010707A patent/ID28532A/id unknown
- 1999-08-27 JP JP2000567711A patent/JP4638036B2/ja not_active Expired - Fee Related
- 1999-08-27 MX MXPA01002040A patent/MXPA01002040A/es active IP Right Grant
- 1999-08-27 PT PT99944535T patent/PT1108041E/pt unknown
- 1999-08-27 BR BR9913196-0A patent/BR9913196A/pt active Search and Examination
- 1999-08-27 AU AU57423/99A patent/AU766764B2/en not_active Ceased
- 1999-08-27 AT AT99944535T patent/ATE348174T1/de active
- 1999-08-27 CN CNB998117145A patent/CN1253573C/zh not_active Expired - Fee Related
- 1999-08-27 DK DK99944535T patent/DK1108041T3/da active
- 1999-08-27 CA CA2340925A patent/CA2340925C/en not_active Expired - Fee Related
- 1999-08-27 OA OA1200100047A patent/OA11642A/en unknown
- 1999-08-27 WO PCT/EP1999/006302 patent/WO2000012725A2/en not_active Ceased
- 1999-08-27 ES ES99944535T patent/ES2274636T3/es not_active Expired - Lifetime
-
2001
- 2001-02-21 ZA ZA200101455A patent/ZA200101455B/en unknown
-
2006
- 2006-07-18 US US11/488,906 patent/US7541172B2/en not_active Expired - Fee Related
-
2007
- 2007-01-15 CY CY20071100053T patent/CY1105926T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2340925A1 (en) | 2000-03-09 |
| ID28532A (id) | 2001-05-31 |
| CA2340925C (en) | 2011-07-12 |
| CN1253573C (zh) | 2006-04-26 |
| CN1321194A (zh) | 2001-11-07 |
| WO2000012725A3 (en) | 2000-06-02 |
| DE69934413T2 (de) | 2007-09-27 |
| BR9913196A (pt) | 2001-09-25 |
| EP1108041B1 (en) | 2006-12-13 |
| EP1108041A2 (en) | 2001-06-20 |
| OA11642A (en) | 2004-11-22 |
| US7541172B2 (en) | 2009-06-02 |
| WO2000012725A2 (en) | 2000-03-09 |
| US20070031947A1 (en) | 2007-02-08 |
| ES2274636T3 (es) | 2007-05-16 |
| AU766764B2 (en) | 2003-10-23 |
| HK1042516B (zh) | 2006-09-29 |
| CY1105926T1 (el) | 2011-04-06 |
| ATE348174T1 (de) | 2007-01-15 |
| JP2002523101A (ja) | 2002-07-30 |
| ZA200101455B (en) | 2001-08-28 |
| US7091027B1 (en) | 2006-08-15 |
| PT1108041E (pt) | 2007-03-30 |
| HK1042516A1 (en) | 2002-08-16 |
| JP4638036B2 (ja) | 2011-02-23 |
| AU5742399A (en) | 2000-03-21 |
| MXPA01002040A (es) | 2002-04-24 |
| EP0982404A1 (en) | 2000-03-01 |
| DE69934413D1 (de) | 2007-01-25 |
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