DK1119370T3 - Omstödelse af virus-fremkaldt systemisk chok og respiratorisk besvær med blokering af lymfotoksin-beta-signalvejen - Google Patents

Omstödelse af virus-fremkaldt systemisk chok og respiratorisk besvær med blokering af lymfotoksin-beta-signalvejen

Info

Publication number: DK1119370T3
Authority: DK; Denmark
Prior art keywords: respiratory distress; blocking; lymphotoxin; reversal; virus
Prior art date: 1998-10-09

Application number

DK99950270T

Other languages

English (en)

Inventor

Jeff Browning

Maryann Puglielli

Rafi Ahmed

Original Assignee

Biogen Idec Inc

Univ Emory

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-09

Filing date

1999-10-08

Publication date

2006-10-02

1999-10-08 Application filed by Biogen Idec Inc, Univ Emory filed Critical Biogen Idec Inc

2006-10-02 Application granted granted Critical

2006-10-02 Publication of DK1119370T3 publication Critical patent/DK1119370T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- C07K16/242—Lymphotoxin [LT]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Cell Biology (AREA)
Mycology (AREA)
Virology (AREA)
Oncology (AREA)
Microbiology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK99950270T 1998-10-09 1999-10-08 Omstödelse af virus-fremkaldt systemisk chok og respiratorisk besvær med blokering af lymfotoksin-beta-signalvejen DK1119370T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10366298P	1998-10-09	1998-10-09

Publications (1)

Publication Number	Publication Date
DK1119370T3 true DK1119370T3 (da)	2006-10-02

Family

ID=22296372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99950270T DK1119370T3 (da)	1998-10-09	1999-10-08	Omstödelse af virus-fremkaldt systemisk chok og respiratorisk besvær med blokering af lymfotoksin-beta-signalvejen

Country Status (27)

Country	Link
US (3)	US20020001585A1 (da)
EP (1)	EP1119370B1 (da)
JP (2)	JP4713738B2 (da)
KR (1)	KR100888832B1 (da)
CN (1)	CN1200733C (da)
AT (1)	ATE329618T1 (da)
AU (1)	AU777492C (da)
BR (1)	BR9915025A (da)
CA (1)	CA2344049C (da)
CY (1)	CY1105059T1 (da)
CZ (1)	CZ20011272A3 (da)
DE (1)	DE69931944T2 (da)
DK (1)	DK1119370T3 (da)
EA (1)	EA006703B1 (da)
EE (1)	EE04661B1 (da)
ES (1)	ES2267294T3 (da)
HU (1)	HUP0103773A3 (da)
IL (2)	IL142284A0 (da)
IS (1)	IS2514B (da)
NO (1)	NO326905B1 (da)
NZ (1)	NZ510560A (da)
PL (1)	PL195264B1 (da)
PT (1)	PT1119370E (da)
SG (1)	SG121778A1 (da)
SK (1)	SK4662001A3 (da)
TR (1)	TR200100974T2 (da)
WO (1)	WO2000021558A1 (da)

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US5925351A (en) *	1995-07-21	1999-07-20	Biogen, Inc.	Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998108B1 (en)	1997-07-07	2006-02-14	La Jolla Institute For Allergy And Immunology	Antibodies to p30 polypeptides and methods making and using same
US7118742B2 (en)	1997-07-07	2006-10-10	La Jolla Institute For Allergy And Immunology	Ligand for herpes simplex virus entry mediator and methods of use
US7060667B1 (en) *	1998-01-30	2006-06-13	Biogen Idec Ma, Inc.	Treatment of follicular lymphomas using inhibitors of the LT pathway
IL142284A0 (en) *	1998-10-09	2002-03-10	Biogen Inc	A pharmaceutical composition containing an agent which blocks the binding of lymphotoxin-b to its receptor
TR200504220T2 (tr)	1998-12-17	2007-04-24	Biogen Idec Ma Inc.	Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
WO2001079496A2 (en) *	2000-03-13	2001-10-25	La Jolla Institute For Allergy And Immunology	Ligand for herpes simplex virus entry mediator and methods of use
DK1674575T3 (da) *	2000-04-12	2010-11-29	Jolla Inst Allergy Immunolog	Ligand for Herpes simplex-indgangsmediator og fremgangsmåder til anvendelse
US7700097B2 (en) *	2003-06-27	2010-04-20	Biogen Idec Ma Inc.	Purification and preferential synthesis of binding molecules
BRPI0509201A (pt) *	2004-03-23	2007-08-28	Biogen Idec Inc	agentes de acoplamento de receptor e usos terapêuticos destes
WO2006074399A2 (en) *	2005-01-05	2006-07-13	Biogen Idec Ma Inc.	Multispecific binding molecules comprising connecting peptides
US8338376B2 (en) *	2006-10-20	2012-12-25	Biogen Idec Ma Inc.	Compositions comprising variant LT-B-R-IG fusion proteins
SG178002A1 (en)	2006-10-20	2012-02-28	Biogen Idec Inc	Treatment of demyelinating disorders
EP3750554A3 (en) *	2007-09-18	2021-07-28	La Jolla Institute for Allergy and Immunology	Light inhibitors for asthma, lung and airway inflammation, respiratory, interstitial, pulmonary and fibrotic disease treatment
CN106591446A (zh) *	2016-12-07	2017-04-26	中国人民解放军军事医学科学院微生物流行病研究所	细胞通路调控分子在作为药物靶点及诊断ebov感染中的应用

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US4485045A (en) *	1981-07-06	1984-11-27	Research Corporation	Synthetic phosphatidyl cholines useful in forming liposomes
DE3218121A1 (de)	1982-05-14	1983-11-17	Leskovar, Peter, Dr.-Ing., 8000 München	Arzneimittel zur tumorbehandlung
US4816567A (en) *	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
US4544545A (en) *	1983-06-20	1985-10-01	Trustees University Of Massachusetts	Liposomes containing modified cholesterol for organ targeting
US5225538A (en) *	1989-02-23	1993-07-06	Genentech, Inc.	Lymphocyte homing receptor/immunoglobulin fusion proteins
US7030080B2 (en) *	1990-06-27	2006-04-18	Biogen, Inc.	Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof
US5795964A (en) *	1990-06-27	1998-08-18	Biogen, Inc.	Lymphotoxin-beta and lymphotoxin-beta complexes
ES2157889T3 (es) *	1990-06-27	2001-09-01	Biogen Inc	Linfotoxina complejada de superficie.
AU692146B2 (en)	1990-06-27	1998-06-04	Biogen Idec Ma Inc.	Lymphotoxin-beta, lymphotoxin-beta complexes, pharmaceutical preparations and therapeutic uses thereof
WO1994004679A1 (en)	1991-06-14	1994-03-03	Genentech, Inc.	Method for making humanized antibodies
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US6312691B1 (en) *	1996-01-26	2001-11-06	Jeffrey L. Browning	Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents
US5925351A (en) *	1995-07-21	1999-07-20	Biogen, Inc.	Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6291207B1 (en) *	1995-07-28	2001-09-18	Northwestern University	Herpes virus entry receptor protein
WO1998017313A2 (en) *	1996-10-25	1998-04-30	Biogen, Inc.	Soluble lymphotoxin-beta receptors, anti-lymphotoxin receptor antibodies, and anti-lymphotoxin ligand antibodies as therapeutic agents for the treatment of immunological diseases
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IL142284A0 (en) *	1998-10-09	2002-03-10	Biogen Inc	A pharmaceutical composition containing an agent which blocks the binding of lymphotoxin-b to its receptor
TR200504220T2 (tr) *	1998-12-17	2007-04-24	Biogen Idec Ma Inc.	Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
EP1539793A4 (en) *	2002-07-01	2006-02-01		HUMANIZED ANTIBODIES AGAINST THE RECEPTOR OF LYMPHOTOXIN BETA

1999
- 1999-10-08 IL IL14228499A patent/IL142284A0/xx unknown
- 1999-10-08 CA CA002344049A patent/CA2344049C/en not_active Expired - Fee Related
- 1999-10-08 AU AU62964/99A patent/AU777492C/en not_active Ceased
- 1999-10-08 CZ CZ20011272A patent/CZ20011272A3/cs unknown
- 1999-10-08 AT AT99950270T patent/ATE329618T1/de active
- 1999-10-08 TR TR2001/00974T patent/TR200100974T2/xx unknown
- 1999-10-08 ES ES99950270T patent/ES2267294T3/es not_active Expired - Lifetime
- 1999-10-08 CN CNB998119555A patent/CN1200733C/zh not_active Expired - Fee Related
- 1999-10-08 EE EEP200100211A patent/EE04661B1/xx not_active IP Right Cessation
- 1999-10-08 SG SG200303599A patent/SG121778A1/en unknown
- 1999-10-08 EP EP99950270A patent/EP1119370B1/en not_active Expired - Lifetime
- 1999-10-08 PT PT99950270T patent/PT1119370E/pt unknown
- 1999-10-08 JP JP2000575531A patent/JP4713738B2/ja not_active Expired - Fee Related
- 1999-10-08 DE DE69931944T patent/DE69931944T2/de not_active Expired - Lifetime
- 1999-10-08 BR BR9915025-5A patent/BR9915025A/pt not_active Application Discontinuation
- 1999-10-08 EA EA200100430A patent/EA006703B1/ru not_active IP Right Cessation
- 1999-10-08 PL PL99347177A patent/PL195264B1/pl unknown
- 1999-10-08 DK DK99950270T patent/DK1119370T3/da active
- 1999-10-08 KR KR1020017004493A patent/KR100888832B1/ko not_active Expired - Fee Related
- 1999-10-08 WO PCT/US1999/023477 patent/WO2000021558A1/en not_active Ceased
- 1999-10-08 NZ NZ510560A patent/NZ510560A/en not_active IP Right Cessation
- 1999-10-08 SK SK466-2001A patent/SK4662001A3/sk unknown
- 1999-10-08 HU HU0103773A patent/HUP0103773A3/hu unknown
2001
- 2001-03-09 IS IS5882A patent/IS2514B/is unknown
- 2001-03-27 IL IL142284A patent/IL142284A/en not_active IP Right Cessation
- 2001-04-06 NO NO20011757A patent/NO326905B1/no not_active IP Right Cessation
- 2001-04-09 US US09/829,031 patent/US20020001585A1/en not_active Abandoned
2004
- 2004-04-21 US US10/829,720 patent/US7452530B2/en not_active Expired - Fee Related
2006
- 2006-06-26 CY CY20061100872T patent/CY1105059T1/el unknown
2008
- 2008-10-08 US US12/247,374 patent/US20090087403A1/en not_active Abandoned
2010
- 2010-02-19 JP JP2010035451A patent/JP2010155852A/ja active Pending

Also Published As

Publication number	Publication date
EA006703B1 (ru)	2006-02-24
PT1119370E (pt)	2006-09-29
AU777492C (en)	2005-05-26
TR200100974T2 (tr)	2001-11-21
US20020001585A1 (en)	2002-01-03
JP2010155852A (ja)	2010-07-15
PL195264B1 (pl)	2007-08-31
CA2344049C (en)	2009-12-15
HUP0103773A3 (en)	2003-10-28
NO20011757D0 (no)	2001-04-06
EE200100211A (et)	2002-08-15
CN1323223A (zh)	2001-11-21
NO20011757L (no)	2001-06-08
IL142284A0 (en)	2002-03-10
IL142284A (en)	2009-11-18
AU777492B2 (en)	2004-10-21
US7452530B2 (en)	2008-11-18
JP4713738B2 (ja)	2011-06-29
US20040198635A1 (en)	2004-10-07
CZ20011272A3 (cs)	2001-09-12
AU6296499A (en)	2000-05-01
KR100888832B1 (ko)	2009-03-17
ATE329618T1 (de)	2006-07-15
WO2000021558A9 (en)	2001-05-25
BR9915025A (pt)	2001-08-14
NZ510560A (en)	2003-09-26
WO2000021558A1 (en)	2000-04-20
IS2514B (is)	2009-06-15
CN1200733C (zh)	2005-05-11
DE69931944T2 (de)	2007-02-08
CA2344049A1 (en)	2000-04-20
PL347177A1 (en)	2002-03-25
CY1105059T1 (el)	2010-03-03
ES2267294T3 (es)	2007-03-01
DE69931944D1 (de)	2006-07-27
IS5882A (is)	2001-03-09
KR20010080073A (ko)	2001-08-22
SG121778A1 (en)	2006-05-26
SK4662001A3 (en)	2001-11-06
EP1119370A1 (en)	2001-08-01
US20090087403A1 (en)	2009-04-02
EE04661B1 (et)	2006-08-15
HUP0103773A2 (hu)	2002-01-28
EA200100430A1 (ru)	2001-10-22
EP1119370B1 (en)	2006-06-14
NO326905B1 (no)	2009-03-16
JP2002527403A (ja)	2002-08-27

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