DK1119635T3 - Ikke-homogene systemer til spaltning af enantiomerblandinger - Google Patents

Ikke-homogene systemer til spaltning af enantiomerblandinger

Info

Publication number
DK1119635T3
DK1119635T3 DK99954779.7T DK99954779T DK1119635T3 DK 1119635 T3 DK1119635 T3 DK 1119635T3 DK 99954779 T DK99954779 T DK 99954779T DK 1119635 T3 DK1119635 T3 DK 1119635T3
Authority
DK
Denmark
Prior art keywords
cleavage
enantiomeric mixtures
homogeneous systems
homogeneous
systems
Prior art date
Application number
DK99954779.7T
Other languages
English (en)
Inventor
Yiming Yao
Yi Fong Wang
Merrick R Almond
Original Assignee
Althea Technologies Inc
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Althea Technologies Inc, Gilead Sciences Inc filed Critical Althea Technologies Inc
Application granted granted Critical
Publication of DK1119635T3 publication Critical patent/DK1119635T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK99954779.7T 1998-10-09 1999-10-08 Ikke-homogene systemer til spaltning af enantiomerblandinger DK1119635T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10380498P 1998-10-09 1998-10-09
PCT/US1999/023405 WO2000022157A1 (en) 1998-10-09 1999-10-08 Non-homogeneous systems for the resolution of enantiomeric mixtures

Publications (1)

Publication Number Publication Date
DK1119635T3 true DK1119635T3 (da) 2012-08-20

Family

ID=22297117

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99954779.7T DK1119635T3 (da) 1998-10-09 1999-10-08 Ikke-homogene systemer til spaltning af enantiomerblandinger

Country Status (16)

Country Link
EP (1) EP1119635B1 (da)
JP (1) JP4532740B2 (da)
KR (3) KR101072439B1 (da)
CN (2) CN100351389C (da)
AU (1) AU773127B2 (da)
BR (2) BRPI9914375B1 (da)
CA (1) CA2346702C (da)
CY (1) CY1113592T1 (da)
DK (1) DK1119635T3 (da)
ES (1) ES2386535T3 (da)
IL (2) IL142393A0 (da)
MX (1) MXPA01003619A (da)
PT (1) PT1119635E (da)
RU (1) RU2247779C2 (da)
SG (1) SG141217A1 (da)
WO (1) WO2000022157A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827727A (en) 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en) 2000-05-16 2005-07-26 Brantford Chemicals Inc. 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
JP2005502310A (ja) * 2000-12-01 2005-01-27 ディヴァーサ コーポレイション ハイドロラーゼ酵素および速度論的分割における用途
DE10104231A1 (de) 2001-01-31 2002-08-08 Consortium Elektrochem Ind Verfahren zur enzymatischen Herstellung von enantiomerenreinen 1,3-Dioxolan-4-on-Derivaten
PT1574512E (pt) * 2001-03-01 2008-03-05 Abbott Lab Formas polimórficas e outras formas cristalinas de cis-ftc
KR100433633B1 (ko) * 2002-04-18 2004-05-31 학교법인 포항공과대학교 무용매 이상계 시스템을 이용한 효소적 광학분할 방법
AU2011272825A1 (en) 2010-06-30 2013-01-10 Codexis, Inc. Chemically modified carbonic anhydrases useful in carbon capture systems
CN109439707A (zh) * 2018-12-07 2019-03-08 武汉工程大学 恩曲他滨的酶催化制备方法
CN109355328A (zh) * 2018-12-07 2019-02-19 武汉工程大学 拉米夫定的酶催化制备方法
CN109628508B (zh) * 2018-12-10 2021-08-10 华南理工大学 一种酶法拆分手性物质的方法
CN117567460A (zh) * 2022-08-08 2024-02-20 明慧医药(杭州)有限公司 一种前药化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
IL89848A (en) * 1988-04-07 1997-08-14 Sepracor Chiral ester derivatives
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
GB9307924D0 (en) * 1993-04-16 1993-06-02 Zeneca Ltd Chrial synthesis
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents

Also Published As

Publication number Publication date
CA2346702A1 (en) 2000-04-20
JP2002527073A (ja) 2002-08-27
IL142393A0 (en) 2002-03-10
ES2386535T3 (es) 2012-08-22
WO2000022157A1 (en) 2000-04-20
MXPA01003619A (es) 2002-09-18
KR100686552B1 (ko) 2007-02-27
KR20060094539A (ko) 2006-08-29
JP4532740B2 (ja) 2010-08-25
CN100351389C (zh) 2007-11-28
SG141217A1 (en) 2008-04-28
CN1329671A (zh) 2002-01-02
EP1119635A1 (en) 2001-08-01
EP1119635B1 (en) 2012-05-23
KR20090127196A (ko) 2009-12-09
CA2346702C (en) 2012-05-29
IL211829A (en) 2013-08-29
PT1119635E (pt) 2012-07-24
BRPI9914375B1 (pt) 2018-03-13
CN101186937A (zh) 2008-05-28
RU2247779C2 (ru) 2005-03-10
AU1104400A (en) 2000-05-01
BR9914375A (pt) 2001-11-20
IL211829A0 (en) 2011-05-31
CY1113592T1 (el) 2016-06-22
KR101072439B1 (ko) 2011-10-11
AU773127B2 (en) 2004-05-20
KR20010099679A (ko) 2001-11-09

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