DK1126881T3 - Mucoadhæsive polymerer, anvendelse deraf samt fremstillingsmåde deraf - Google Patents

Mucoadhæsive polymerer, anvendelse deraf samt fremstillingsmåde deraf

Info

Publication number
DK1126881T3
DK1126881T3 DK99953421T DK99953421T DK1126881T3 DK 1126881 T3 DK1126881 T3 DK 1126881T3 DK 99953421 T DK99953421 T DK 99953421T DK 99953421 T DK99953421 T DK 99953421T DK 1126881 T3 DK1126881 T3 DK 1126881T3
Authority
DK
Denmark
Prior art keywords
mucoadhesive polymers
preparation
polymers
mucoadhesive
production method
Prior art date
Application number
DK99953421T
Other languages
English (en)
Inventor
Andreas Bernkop-Schnuerch
Original Assignee
Andreas Bernkop-Schnuerch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andreas Bernkop-Schnuerch filed Critical Andreas Bernkop-Schnuerch
Application granted granted Critical
Publication of DK1126881T3 publication Critical patent/DK1126881T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Paper (AREA)
DK99953421T 1998-11-04 1999-11-04 Mucoadhæsive polymerer, anvendelse deraf samt fremstillingsmåde deraf DK1126881T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0182898A AT406054B (de) 1998-11-04 1998-11-04 Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung
EP99953421A EP1126881B1 (de) 1998-11-04 1999-11-04 Mucoadhäsive polymere, deren verwendung sowie deren herstellungsverfahren

Publications (1)

Publication Number Publication Date
DK1126881T3 true DK1126881T3 (da) 2004-10-18

Family

ID=3521872

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99953421T DK1126881T3 (da) 1998-11-04 1999-11-04 Mucoadhæsive polymerer, anvendelse deraf samt fremstillingsmåde deraf

Country Status (11)

Country Link
US (1) US7354600B1 (da)
EP (1) EP1126881B1 (da)
JP (2) JP4744693B2 (da)
CN (1) CN1230203C (da)
AT (2) AT406054B (da)
AU (1) AU760929B2 (da)
CA (1) CA2348842C (da)
DE (1) DE59909764D1 (da)
DK (1) DK1126881T3 (da)
ES (1) ES2222740T3 (da)
WO (1) WO2000025823A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406054B (de) * 1998-11-04 2000-02-25 Andreas Bernkop-Schnuerch Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung
ATE312076T1 (de) † 2001-02-22 2005-12-15 Anika Therapeutics Inc Thiol-modifizierte hyaluronan-derivate
WO2004067582A1 (en) * 2003-01-28 2004-08-12 Akzo Nobel Coatings International B.V. Curable composition comprising a compound having radically polymerizable olefinically unsaturated groups, an oxidation-reduction enzyme, and a thiol-functional compound
US8932983B1 (en) 2005-12-07 2015-01-13 Crystal Clear Technologies, Inc. Chitosan based adsorbent
WO2007071375A1 (en) * 2005-12-22 2007-06-28 Unilever Plc Antiperspirant compositions
GB0526136D0 (en) * 2005-12-22 2006-02-01 Unilever Plc Antiperspirant compositions
WO2009132224A2 (en) 2008-04-24 2009-10-29 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
EP2310002B1 (en) 2008-04-24 2016-11-02 Medtronic, Inc Protective gel based on chitosan and oxidized polysaccharide
EP2296637B1 (en) 2008-04-24 2014-04-02 Medtronic, Inc Chitosan-containing protective composition
CN102216381B (zh) 2008-04-24 2016-06-15 麦德托尼克公司 可再水化的多糖颗粒和海绵体
US8257720B2 (en) 2009-04-20 2012-09-04 Conopco, Inc. Stabilized cationic ammonium compounds and compositions comprising the same
US8324255B2 (en) 2009-09-15 2012-12-04 Conopco, Inc. Chelator stabilized cationic ammonium compounds and compositions comprising the same
ES2659442T3 (es) * 2009-09-30 2018-03-15 Thiomatrix Forschungs- Und Beratungs Gmbh Polímeros mucoadhesivos con estructuras parciales de vitamina B
CN102399295B (zh) 2010-09-09 2013-11-06 常州百瑞吉生物医药有限公司 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途
EP2597110A1 (en) 2011-11-28 2013-05-29 Fundación Cidetec Self-healing material and method for the preparation thereof
CN106456536B (zh) * 2014-05-07 2020-05-12 克罗马药品股份有限公司 水性眼用溶液和治疗干眼综合征的方法
WO2017072236A1 (en) 2015-10-30 2017-05-04 Croma-Pharma Gesellschaft M.B.H. Therapeutic use of a sterile aqueous ophthalmic solution
JP2018532753A (ja) 2015-10-30 2018-11-08 クロマ−ファーマ ゲゼルシャフト エム．ベー．ハー． 滅菌水性点眼液の治療的使用
EP3618803A1 (en) 2017-05-03 2020-03-11 Croma-Pharma GmbH Sterile aqueous ophthalmic solution containing n-(n-acetylcysteinyl)-chitosan for treating non-infectious corneal disorders
WO2019238954A1 (en) 2018-06-15 2019-12-19 Croma-Pharma Gmbh Hydrogel composition comprising a crosslinked polymer
BR112020024654B1 (pt) 2018-06-15 2024-02-27 Croma-Pharma Gmbh Composição de hidrogel estéril, unidade de aplicação para injeção,seus usos, método cosmético, enchimento de tecido mole, e implante ou depósito
PL4077402T3 (pl) 2019-12-19 2024-07-29 Croma-Pharma Gmbh Kwas hialuronowy modyfikowany tiolem i hydrożel zawierający usieciowany kwas hialuronowy
WO2021156435A1 (en) 2020-02-07 2021-08-12 Bioadhesive Ophthalmics Mucoadhesive solid or semisolid ocular delivery systems based on preactivated thiomers
US20230263901A1 (en) * 2021-01-29 2023-08-24 Yimin Sun Mucus adhesion drug delivery
CA3227607A1 (en) 2021-08-03 2023-02-09 Jean CUINE Mucoadhesive ocular delivery system for the treatment of glaucoma
CN116333197A (zh) * 2023-04-12 2023-06-27 厦门君德医药科技有限公司 胃肠道粘膜性聚合物、组合物及制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277413B1 (en) * 1986-10-06 1992-04-22 Kuraray Co., Ltd. Adhesive particularly for dental use
FR2687071B1 (fr) * 1992-02-10 1995-06-23 Exsymol Sa Vecteur pour principe(s) actif(s) therapeutique(s) ou cosmetique(s) a usage externe et composition therapeutique ou cosmetique comprenant un tel vecteur.
FR2692582B1 (fr) * 1992-06-18 1998-09-18 Flamel Tech Sa Nouveaux derives reticulables de collagene, leur procede d'obtention et leur application a la preparation de biomateriaux.
FR2699184B1 (fr) * 1992-12-16 1995-03-10 Flamel Tech Sa Nouveaux dérivés de collagène, leur procédé d'obtention et leur application à la préparation de biomatériaux.
US5665383A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5670468A (en) * 1993-04-09 1997-09-23 The Procter & Gamble Company Machine dishwashing method employing a metallo catalyst and enzymatic source of hydrogen peroxide
FR2707992B1 (fr) * 1993-07-21 1995-10-13 Flamel Tech Sa Nouveaux produits organiques contenant des fonctions thiols réactives, l'un de leurs procédés de préparation et les biomatériaux les contenant.
FR2707878A1 (fr) * 1993-07-21 1995-01-27 Imedex Nouvelles compositions adhésives à usage chirurgical.
FR2723957A1 (fr) * 1994-08-29 1996-03-01 Flamel Tech Sa Biopolymere modifie par incorporation de groupements soufres de reticulation, l'un de ses procedes d'obtention et ses applications dans la fabrication de biomateriaux
CA2244664C (en) * 1996-02-09 2008-06-03 Amgen Inc. Composition comprising interleukin-1 inhibitor and controlled release polymer
AT406054B (de) * 1998-11-04 2000-02-25 Andreas Bernkop-Schnuerch Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung
US6514535B2 (en) * 1999-05-21 2003-02-04 Noveon Ip Holdings Corp. Bioadhesive hydrogels with functionalized degradable crosslinks

Also Published As

Publication number Publication date
CA2348842A1 (en) 2000-05-11
EP1126881A1 (de) 2001-08-29
CA2348842C (en) 2009-05-12
CN1325312A (zh) 2001-12-05
JP4744693B2 (ja) 2011-08-10
JP2011140655A (ja) 2011-07-21
ES2222740T3 (es) 2005-02-01
AU760929B2 (en) 2003-05-22
AU1018200A (en) 2000-05-22
CN1230203C (zh) 2005-12-07
ATE269105T1 (de) 2004-07-15
JP2002528518A (ja) 2002-09-03
ATA182898A (de) 1999-06-15
AT406054B (de) 2000-02-25
WO2000025823A1 (de) 2000-05-11
DE59909764D1 (de) 2004-07-22
US7354600B1 (en) 2008-04-08
EP1126881B1 (de) 2004-06-16

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