DK1133283T3 - Fremgangsmåde til fremstilling af lægemiddelpartikler - Google Patents

Fremgangsmåde til fremstilling af lægemiddelpartikler

Info

Publication number
DK1133283T3
DK1133283T3 DK99963729T DK99963729T DK1133283T3 DK 1133283 T3 DK1133283 T3 DK 1133283T3 DK 99963729 T DK99963729 T DK 99963729T DK 99963729 T DK99963729 T DK 99963729T DK 1133283 T3 DK1133283 T3 DK 1133283T3
Authority
DK
Denmark
Prior art keywords
drug particles
preparation
susceptible
degradation
substance
Prior art date
Application number
DK99963729T
Other languages
English (en)
Inventor
Catherine Boissier
Anne Mari Juppo
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1133283T3 publication Critical patent/DK1133283T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0403Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99963729T 1998-11-23 1999-11-22 Fremgangsmåde til fremstilling af lægemiddelpartikler DK1133283T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9804003A SE9804003D0 (sv) 1998-11-23 1998-11-23 A method of producing drug particles
PCT/SE1999/002152 WO2000030612A1 (en) 1998-11-23 1999-11-22 A method of producing drug particles

Publications (1)

Publication Number Publication Date
DK1133283T3 true DK1133283T3 (da) 2005-01-24

Family

ID=20413380

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99963729T DK1133283T3 (da) 1998-11-23 1999-11-22 Fremgangsmåde til fremstilling af lægemiddelpartikler

Country Status (12)

Country Link
US (1) US6596315B1 (da)
EP (1) EP1133283B1 (da)
JP (1) JP4612191B2 (da)
AT (1) ATE278390T1 (da)
AU (1) AU754385B2 (da)
CA (1) CA2349711C (da)
DE (1) DE69920945T2 (da)
DK (1) DK1133283T3 (da)
ES (1) ES2228148T3 (da)
PT (1) PT1133283E (da)
SE (1) SE9804003D0 (da)
WO (1) WO2000030612A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
CA2290893C (en) 1999-11-16 2007-05-01 Bernard Charles Sherman Magnesium omeprazole
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
AUPR197000A0 (en) * 2000-12-08 2001-01-11 Unisearch Limited Synthesis of small particles
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
EP1478386A4 (en) 2002-02-25 2005-12-28 Phasex Corp METHOD OF DRYING WATER-BASED MATERIALS
WO2003088951A1 (en) * 2002-04-15 2003-10-30 Eiffel Technologies Limited Formulation of fine particles using liquefied or dense gases
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
EP1546131A1 (en) 2002-08-30 2005-06-29 Dr. Reddy's Laboratories Ltd. Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof
WO2004046134A2 (en) * 2002-11-18 2004-06-03 Dr. Reddy's Laboratories Limited Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation
MXPA05011343A (es) 2003-05-08 2005-12-12 Nektar Therapeutics Uk Ltd Materiales particulados.
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2006272438B2 (en) 2005-07-15 2011-08-04 Map Pharmaceuticals, Inc. Method of particle formation
AU2007266574A1 (en) * 2006-06-01 2007-12-06 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
DK2425820T3 (da) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc Fremgangsmåde til terapeutisk administration af dhe for at muliggøre hurtig lindring af migræne, mens bivirkningsprofilen minimeres
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
WO2017145146A1 (en) 2016-02-25 2017-08-31 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3744329A1 (de) 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
HU209603B (en) * 1988-10-05 1994-09-28 Upjohn Co Process for production of solid powders in finalydivided microcristallin form
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
GB9413202D0 (en) 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0806940B1 (en) * 1994-12-22 2003-04-09 AstraZeneca AB Aerosol drug formulations
ATE386506T1 (de) * 1995-10-17 2008-03-15 Jagotec Ag Verabreichung unlöslicher arzneistoffe
SE510666C2 (sv) 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer

Also Published As

Publication number Publication date
US6596315B1 (en) 2003-07-22
ES2228148T3 (es) 2005-04-01
ATE278390T1 (de) 2004-10-15
CA2349711C (en) 2008-07-15
AU754385B2 (en) 2002-11-14
DE69920945T2 (de) 2005-08-25
AU2010200A (en) 2000-06-13
DE69920945D1 (de) 2004-11-11
EP1133283A1 (en) 2001-09-19
JP4612191B2 (ja) 2011-01-12
EP1133283B1 (en) 2004-10-06
CA2349711A1 (en) 2000-06-02
SE9804003D0 (sv) 1998-11-23
JP2002530317A (ja) 2002-09-17
PT1133283E (pt) 2005-01-31
WO2000030612A1 (en) 2000-06-02

Similar Documents

Publication Publication Date Title
DK1133283T3 (da) Fremgangsmåde til fremstilling af lægemiddelpartikler
DK0820276T3 (da) Fremgangsmåde til fremstilling af respirerbare partikler
EE200200183A (et) Meetod polüisobuteenfenooli sisaldavate Mannichi aduktide saamiseks
DK1226188T3 (da) Fremgangsmåde til fremstilling af mannichaddukter, som indeholder polyisobutenphenol
DK1242361T3 (da) Fremgangsmåde til fremstilling af tolterodin og analoger deraf såvel som mellemprodukter fremstillet i fremgangsmåden
EA200001129A3 (ru) Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина
IS5982A (is) Aðferð til framleiðslu á 5-sýanóþalíði
IS5952A (is) Aðferð til framleiðslu á 5-sýanóþalíði
DK199801526A (da) Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
DK1277724T3 (da) Fremgangsmåde til fremstilling af monofluormethylethere
AU2002246702A1 (en) Method of screening for gpr40 ligands
DK1519944T3 (da) Fremgangsmåder til fremstilling af fibrinogen
DK0975790T3 (da) Ny fremgangsmåde til isolering af polysaccharider
DK1017684T3 (da) Kontrastmiddel til afbildning af infarkter og nekroser
ATE202483T1 (de) Immuntolerante prothrombinkomplex-präparation
DE69927602D1 (de) Verfahren zur herstellung von vitaminpulvern
DK1325022T3 (da) Fremgangsmåde til fremstilling af 21-hydroxy-6,19-oxidoprogesteron (21OH-6OP)
DK1456229T3 (da) Fremgangsmåe til fremstilling af echinocandin-derivater
ATE275149T1 (de) Verfahren zur herstellung von taxanderivaten
DK1206452T3 (da) Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
DK1037613T3 (da) Fremgangsmåde til fremstilling af farmaceutiske formuleringer, der indeholder en ekstrakt
DK1203000T3 (da) Fremgangsmåde til fremstilling af phosphonomethylglycin
ATE246250T1 (de) Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine
DK0735043T3 (da) Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran
DK1511724T3 (da) Fremgangsmåde til fremstilling af thioalkylaminderivater