DK1135403T3 - 17beta-acyl-17alfa-propynyl-11beta-arylsteroider og deres derivater med agonistiske eller antagonistiske hormonale egenskaber - Google Patents

17beta-acyl-17alfa-propynyl-11beta-arylsteroider og deres derivater med agonistiske eller antagonistiske hormonale egenskaber

Info

Publication number
DK1135403T3
DK1135403T3 DK99964047T DK99964047T DK1135403T3 DK 1135403 T3 DK1135403 T3 DK 1135403T3 DK 99964047 T DK99964047 T DK 99964047T DK 99964047 T DK99964047 T DK 99964047T DK 1135403 T3 DK1135403 T3 DK 1135403T3
Authority
DK
Denmark
Prior art keywords
17beta
acyl
propynyl
11beta
17alpha
Prior art date
Application number
DK99964047T
Other languages
English (en)
Inventor
C Edgar Cook
John A Kepler
Jill M O'reilly
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Application granted granted Critical
Publication of DK1135403T3 publication Critical patent/DK1135403T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99964047T 1998-12-04 1999-12-03 17beta-acyl-17alfa-propynyl-11beta-arylsteroider og deres derivater med agonistiske eller antagonistiske hormonale egenskaber DK1135403T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/205,395 US6172052B1 (en) 1998-12-04 1998-12-04 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
PCT/US1999/028535 WO2000034306A1 (en) 1998-12-04 1999-12-03 17β-ACYL-17α-PROPYNYL-11β-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES

Publications (1)

Publication Number Publication Date
DK1135403T3 true DK1135403T3 (da) 2003-11-24

Family

ID=22762018

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99964047T DK1135403T3 (da) 1998-12-04 1999-12-03 17beta-acyl-17alfa-propynyl-11beta-arylsteroider og deres derivater med agonistiske eller antagonistiske hormonale egenskaber

Country Status (14)

Country Link
US (1) US6172052B1 (da)
EP (1) EP1135403B1 (da)
CN (1) CN1348461A (da)
AT (1) ATE246201T1 (da)
AU (1) AU777048B2 (da)
CA (1) CA2358466C (da)
DE (1) DE69910068T2 (da)
DK (1) DK1135403T3 (da)
ES (1) ES2203233T3 (da)
NZ (1) NZ512697A (da)
PT (1) PT1135403E (da)
RU (1) RU2230071C2 (da)
SI (1) SI1135403T1 (da)
WO (1) WO2000034306A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2152671T3 (es) 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6262042B1 (en) * 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
ATE396197T1 (de) * 2000-03-17 2008-06-15 Us Gov Health & Human Serv 17-alpha-substituierte-11-beta-substituierte-4- aryl und 21-substituierte 19-norpregnadienedione mit antigestagener aktivität
CA2771944A1 (en) * 2003-07-16 2005-01-27 Teva Women's Health, Inc. Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration
TW200531977A (en) * 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
MX2012010327A (es) * 2010-03-22 2012-11-16 Repros Therapeutics Inc Composiciones y metodos para la administracion no toxica de antiprogestinas.
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
EP2881638A1 (de) 2013-12-09 2015-06-10 HILTI Aktiengesellschaft Vorrichtung zur Durchführung von Rohren oder Kabeln durch eine Gebäudeföffnung
EP3088783A1 (de) 2015-04-27 2016-11-02 Hilti Aktiengesellschaft Brandschutzmanschette
EP3088784A1 (de) 2015-04-27 2016-11-02 Hilti Aktiengesellschaft Brandschutzmanschette
US20170030490A1 (en) 2015-07-28 2017-02-02 Hilti Aktiengesellschaft Air, acoustic and/or fire sealing sleeve insert and air, acoustic and/or fire sealing device
EP3306158A1 (de) 2016-10-05 2018-04-11 HILTI Aktiengesellschaft Durchführung einer leitung durch ein gebäudebauteil
WO2023185673A1 (zh) * 2022-03-31 2023-10-05 成都赛璟生物医药科技有限公司 一种cdk8抑制剂及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047928A (en) * 1986-10-24 1991-09-10 Wiedemer John D Billing system for computer software
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DK0411733T3 (da) 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-oner
DE4000686A1 (de) * 1990-01-12 1991-07-18 Dornier Gmbh Lindauer Steg-ladensohle fuer eine greifer-webmaschine
FR2659233B1 (fr) 1990-03-06 1994-01-21 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques chez les animaux d'elevage.
US5407928A (en) 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
RU2127112C1 (ru) * 1992-03-02 1999-03-10 Шеринг Аг Эстроген (прогестин)антипрогестиновый способ пероральной контрацепции и регулирования менструации, фармацевтическая композиция и набор лекарственных средств
FR2757399B1 (fr) 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
RU2165938C1 (ru) * 2000-06-23 2001-04-27 Насыбуллин Радик Равильевич СПОСОБ ПОЛУЧЕНИЯ 17β-ГИДРОКСИ-11β-[4-(ДИМЕТИЛАМИНО)ФЕНИЛ]-17α-(ПРОП-1-ИНИЛ)-ЭСТРА-4,9 -ДИЕН-3-ОНА

Also Published As

Publication number Publication date
RU2230071C2 (ru) 2004-06-10
NZ512697A (en) 2003-01-31
ATE246201T1 (de) 2003-08-15
DE69910068T2 (de) 2004-04-15
AU2036600A (en) 2000-06-26
CA2358466C (en) 2008-04-15
PT1135403E (pt) 2003-12-31
DE69910068D1 (de) 2003-09-04
EP1135403A4 (en) 2002-03-27
CA2358466A1 (en) 2000-06-15
US6172052B1 (en) 2001-01-09
CN1348461A (zh) 2002-05-08
WO2000034306A1 (en) 2000-06-15
SI1135403T1 (en) 2004-02-29
EP1135403A1 (en) 2001-09-26
AU777048B2 (en) 2004-09-30
RU2001118273A (ru) 2004-03-10
ES2203233T3 (es) 2004-04-01
EP1135403B1 (en) 2003-07-30

Similar Documents

Publication Publication Date Title
MXPA00008738A (es) 20-ceto-1 1b-arilesteroides y sus derivados teniendo propiedades agonistas o antagonistas hormonales.
DK1082337T3 (da) 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber
ATE246201T1 (de) 17beta-acyl-17alpha-propynyl-11beta-arylsteroid und ihre derivate mit agonistischen oder antagonistischen hormonalen aktivitäten
BR0104654A (pt) Artigo absorvente
AR032471A1 (es) Derivado de androstano y solvatos del mismo, su uso para la fabricacion de medicamentos, composiciones farmaceuticas que los comprenden, procesos para preparar tales derivados, intermediarios utiles en la preparacion de tales derivados, procesos para preparar tales intermediarios, y compuestos inter
MX9709874A (es) N-(INDOL-2-CARBONIL) beta-ALANILAMIDAS SUSTITUIDAS Y DERIVADOS COMO INHIBIDORES DE GLUCOGENO FOSFORILASA, USO DE LOS MISMOS Y COMPOSICIONES QUE LOS CONTIENEN.
DE50007731D1 (de) Zusatzflügel für Hauptflügel von Flugzeugen
NO20005265D0 (no) Substituerte benzamider, deres fremstilling og anvendelse som inhibitorer av cystin-proteaser
CY1109451T1 (el) 17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη
DE69840603D1 (de) Alpha-ketoamidhaltige multikatalytische protease inhibitoren
CA2333668A1 (en) 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
DE60121461D1 (de) Kondensierte pyridoindolderivate
DK279790A (da) Aromatiske steroid-5-alfa-reduktaseinhibitorer
AU4179399A (en) Use of nmda antagonists and/or sodium channel antagonists for the treatment of inflammatory disorders
DE59903146D1 (de) Herstellung vernetzbarer wasserlöslicher oder wasserdispergierbarer Zusammensetzungen und daraus erhältlicher strahlungsempfindlicher Gemische
PT1007516E (pt) Polimorfos e hidratos de diciclanilo e sua preparacao
DK1196428T3 (da) 11-beta-aryl-17,17-spirothiolan-substituerede steroider
NO20023841L (no) Anvendelse av glukokortikoidreseptorantagonister for forebygging og behandling av sykdommer av reproduksjonssystemet hos menn
DK1051404T3 (da) Substituerede phenyluraciler med herbicid virkning
DK1444247T3 (da) Tibolonformuleringer
DK0434020T3 (da) 2,19-Methylenoxy- og 2,19-methylenthiobroforbundne steroider og deres anvendelse som inhibitorer af aromatase og 19-hydroxylase
SE9901273D0 (sv) Novel compounds
SE9802754D0 (sv) Belysning av strömställare, reglerdon eller annat instrument
ECSP003563A (es) Trifluorbutenos nematicidas