DK1140826T3 - Fremgangsmåde til fremstilling af (2S,4R,9S)-octahydro-1H-indol-2-carbonsyre og mellemprodukter dertil - Google Patents

Fremgangsmåde til fremstilling af (2S,4R,9S)-octahydro-1H-indol-2-carbonsyre og mellemprodukter dertil

Info

Publication number: DK1140826T3
Authority: DK; Denmark
Prior art keywords: octahydro; indole; carboxylic acid; dialkoxyethyl; subjecting
Prior art date: 1999-01-07

Application number

DK99966978T

Other languages

English (en)

Inventor

Klaus Ebel

Frank Ohlbach

Christoph Nuebling

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-07

Filing date

1999-12-21

Publication date

2004-09-06

1999-12-21 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2004-09-06 Application granted granted Critical

2004-09-06 Publication of DK1140826T3 publication Critical patent/DK1140826T3/da

Links

238000000034 method Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
238000005698 Diels-Alder reaction Methods 0.000 abstract 1
238000006842 Henry reaction Methods 0.000 abstract 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
150000002825 nitriles Chemical class 0.000 abstract 1
LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK99966978T 1999-01-07 1999-12-21 Fremgangsmåde til fremstilling af (2S,4R,9S)-octahydro-1H-indol-2-carbonsyre og mellemprodukter dertil DK1140826T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19900205A DE19900205A1 (de)	1999-01-07	1999-01-07	Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür
PCT/EP1999/010159 WO2000040555A1 (de)	1999-01-07	1999-12-21	Verfahren zur herstellung von (2s,4r,9s)-octahydro-1h-indol-2-carbonsäure und zwischenprodukte dafür

Publications (1)

Publication Number	Publication Date
DK1140826T3 true DK1140826T3 (da)	2004-09-06

Family

ID=7893634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99966978T DK1140826T3 (da)	1999-01-07	1999-12-21	Fremgangsmåde til fremstilling af (2S,4R,9S)-octahydro-1H-indol-2-carbonsyre og mellemprodukter dertil

Country Status (10)

Country	Link
US (1)	US6559318B1 (da)
EP (1)	EP1140826B1 (da)
JP (1)	JP4800482B2 (da)
CN (1)	CN1334803A (da)
AT (1)	ATE266003T1 (da)
DE (2)	DE19900205A1 (da)
DK (1)	DK1140826T3 (da)
ES (1)	ES2221474T3 (da)
PT (1)	PT1140826E (da)
WO (1)	WO2000040555A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2477391A1 (en) *	2002-03-01	2003-09-12	Denis Schrier	Method of treating osteoarthritis
EP1687271A1 (en) *	2003-11-25	2006-08-09	Texcontor Etablissement	A method for the preparation of (2s, 3ar, 7as)-octahydro-1h-indole-2-carboxylic acid as key intermediate in the preparation of trandolapril by reacting a cyclohexyl aziridine with a dialkyl malonate
WO2007003947A2 (en)	2005-07-05	2007-01-11	Cipla Limited	Process for the synthesis of the ace inhibitor trandolapril
KR101329457B1 (ko)	2006-12-19	2013-11-15	에스케이바이오팜 주식회사	옥타하이드로인돌-2-카르복시산의 제조방법
CA2768239A1 (en) *	2009-07-16	2011-01-20	Abbott Laboratories	Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril
CN110452950A (zh) *	2019-07-15	2019-11-15	江苏永达药业有限公司	一种群多普利中间体的消旋体的拆分方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ202903A (en)	1981-12-29	1988-01-08	Hoechst Ag	1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
DE3322530A1 (de)	1983-06-23	1985-01-10	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
FR2605630B1 (fr) *	1986-10-22	1989-06-30	Roussel Uclaf	Procede de preparation de derives de l'octahydroindole et intermediaires de preparation

1999
- 1999-01-07 DE DE19900205A patent/DE19900205A1/de not_active Withdrawn
- 1999-12-21 DK DK99966978T patent/DK1140826T3/da active
- 1999-12-21 PT PT99966978T patent/PT1140826E/pt unknown
- 1999-12-21 AT AT99966978T patent/ATE266003T1/de active
- 1999-12-21 WO PCT/EP1999/010159 patent/WO2000040555A1/de not_active Ceased
- 1999-12-21 CN CN99816050A patent/CN1334803A/zh active Pending
- 1999-12-21 EP EP99966978A patent/EP1140826B1/de not_active Expired - Lifetime
- 1999-12-21 US US09/869,651 patent/US6559318B1/en not_active Expired - Lifetime
- 1999-12-21 DE DE59909425T patent/DE59909425D1/de not_active Expired - Lifetime
- 1999-12-21 JP JP2000592264A patent/JP4800482B2/ja not_active Expired - Fee Related
- 1999-12-21 ES ES99966978T patent/ES2221474T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP4800482B2 (ja)	2011-10-26
JP2002534412A (ja)	2002-10-15
WO2000040555A1 (de)	2000-07-13
DE19900205A1 (de)	2000-07-13
US6559318B1 (en)	2003-05-06
EP1140826B1 (de)	2004-05-06
CN1334803A (zh)	2002-02-06
PT1140826E (pt)	2004-09-30
ATE266003T1 (de)	2004-05-15
EP1140826A1 (de)	2001-10-10
ES2221474T3 (es)	2004-12-16
DE59909425D1 (de)	2004-06-09

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