DK1174418T3 - Fremgangsmåde til fremstilling af vandfrit gabapentin af farmaceutisk kvalitet - Google Patents

Fremgangsmåde til fremstilling af vandfrit gabapentin af farmaceutisk kvalitet

Info

Publication number: DK1174418T3
Authority: DK; Denmark
Prior art keywords: pharmaceutical grade; preparation; gabapentin; grade anhydrous; anhydrous gabapentin
Prior art date: 1999-04-26

Application number

DK00914185T

Other languages

English (en)

Inventor

Lista Eugenia Pagans

Llado Jordi Bosch

Miguel M Del Carmen Onrubia

Original Assignee

Medichem Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-26

Filing date

2000-04-04

Publication date

2004-05-10

2000-04-04 Application filed by Medichem Sa filed Critical Medichem Sa

2004-05-10 Application granted granted Critical

2004-05-10 Publication of DK1174418T3 publication Critical patent/DK1174418T3/da

Links

UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 6
229960002870 gabapentin Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
XBUDZAQEMFGLEU-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]acetic acid;hydron;chloride Chemical compound Cl.OC(=O)CC1(CN)CCCCC1 XBUDZAQEMFGLEU-UHFFFAOYSA-N 0.000 abstract 1
230000001476 alcoholic effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003456 ion exchange resin Substances 0.000 abstract 1
229920003303 ion-exchange polymer Polymers 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
230000003472 neutralizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK00914185T 1999-04-26 2000-04-04 Fremgangsmåde til fremstilling af vandfrit gabapentin af farmaceutisk kvalitet DK1174418T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES009900858A ES2164527B1 (es)	1999-04-26	1999-04-26	Procedimiento de obtencion de gabapentina de calidad farmaceutica.

Publications (1)

Publication Number	Publication Date
DK1174418T3 true DK1174418T3 (da)	2004-05-10

Family

ID=8308147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00914185T DK1174418T3 (da)	1999-04-26	2000-04-04	Fremgangsmåde til fremstilling af vandfrit gabapentin af farmaceutisk kvalitet

Country Status (13)

Country	Link
US (1)	US6528682B1 (da)
EP (1)	EP1174418B1 (da)
AT (1)	ATE257818T1 (da)
AU (1)	AU3559200A (da)
CA (1)	CA2371210A1 (da)
DE (1)	DE60007734T2 (da)
DK (1)	DK1174418T3 (da)
ES (2)	ES2164527B1 (da)
HU (1)	HUP0200741A3 (da)
IL (1)	IL145920A (da)
PT (1)	PT1174418E (da)
SI (1)	SI1174418T1 (da)
WO (1)	WO2000064857A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001266992B8 (en) *	2000-06-16	2005-12-01	Teva Pharmaceutical Industries Ltd.	Stable gabapentin having pH within a controlled range
IT1319234B1 (it)	2000-10-23	2003-09-26	Zambon Spa	Processo di preparazione di gabapentina.
EP1494996A1 (en) *	2002-04-16	2005-01-12	Taro Pharmaceutical Industries Limited	Process for preparing gabapentin
EP1615875A2 (en)	2003-04-21	2006-01-18	Matrix Laboratories Limited	Process for the preparation of gabapentin form-ii
US20070043236A1 (en) *	2003-05-19	2007-02-22	Chandiran Thakashina M	Process for preparation of gabapentin
US7169812B2 (en) *	2003-07-01	2007-01-30	Medtronic, Inc.	Process for producing injectable gabapentin compositions
US20050187295A1 (en) *	2004-02-19	2005-08-25	Surendra Kalyan	Processes for the preparation of gabapentin
WO2005117526A2 (en) *	2004-06-03	2005-12-15	Matrix Laboratories Ltd	An improved process for the purification of gabapentin
GB0416228D0 (en)	2004-07-20	2004-08-25	Sandoz Ind Products S A	Process for the preparation of gabapentin
US20080103334A1 (en) *	2006-10-26	2008-05-01	Ipca Laboratories Ltd	Process For Synthesis Of Gabapentin
IN2015DN02697A (da) *	2012-11-16	2015-09-04	Lonza Ag

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4894476A (en) *	1988-05-02	1990-01-16	Warner-Lambert Company	Gabapentin monohydrate and a process for producing the same
IL119890A (en) *	1996-12-24	2002-03-10	Teva Pharma	Gabapentin form iii and preparation of gabapentin form ii
ES2137137B1 (es) *	1998-05-25	2000-08-16	Medichem Sa	Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
ITMI981535A1 (it) *	1998-07-03	2000-01-03	Zambon Spa	Processo per la preparazione di gabapentina

1999
- 1999-04-26 ES ES009900858A patent/ES2164527B1/es not_active Expired - Fee Related
2000
- 2000-04-04 AT AT00914185T patent/ATE257818T1/de not_active IP Right Cessation
- 2000-04-04 DE DE60007734T patent/DE60007734T2/de not_active Expired - Fee Related
- 2000-04-04 IL IL14592000A patent/IL145920A/xx unknown
- 2000-04-04 EP EP00914185A patent/EP1174418B1/en not_active Expired - Lifetime
- 2000-04-04 HU HU0200741A patent/HUP0200741A3/hu unknown
- 2000-04-04 WO PCT/ES2000/000121 patent/WO2000064857A1/es not_active Ceased
- 2000-04-04 PT PT00914185T patent/PT1174418E/pt unknown
- 2000-04-04 CA CA002371210A patent/CA2371210A1/en not_active Abandoned
- 2000-04-04 SI SI200030345T patent/SI1174418T1/xx unknown
- 2000-04-04 DK DK00914185T patent/DK1174418T3/da active
- 2000-04-04 ES ES00914185T patent/ES2213571T3/es not_active Expired - Lifetime
- 2000-04-04 AU AU35592/00A patent/AU3559200A/en not_active Abandoned
- 2000-04-04 US US09/959,183 patent/US6528682B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60007734T2 (de)	2004-12-02
SI1174418T1 (en)	2004-06-30
AU3559200A (en)	2000-11-10
US6528682B1 (en)	2003-03-04
ES2213571T3 (es)	2004-09-01
HUP0200741A3 (en)	2002-11-28
HUP0200741A2 (hu)	2002-07-29
EP1174418A1 (en)	2002-01-23
ATE257818T1 (de)	2004-01-15
WO2000064857A1 (es)	2000-11-02
PT1174418E (pt)	2004-05-31
IL145920A (en)	2005-09-25
ES2164527A1 (es)	2002-02-16
IL145920A0 (en)	2002-07-25
CA2371210A1 (en)	2000-11-02
DE60007734D1 (de)	2004-02-19
ES2164527B1 (es)	2003-04-01
EP1174418B1 (en)	2004-01-14

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