DK1178047T3 - Diazabicyclooctanderivater og terapeutiske anvendelser deraf - Google Patents

Diazabicyclooctanderivater og terapeutiske anvendelser deraf

Info

Publication number: DK1178047T3
Authority: DK; Denmark
Prior art keywords: alkyl; chem; formula; aryl; heteroaryl
Prior art date: 2000-08-03

Application number

DK01306313T

Other languages

Danish (da)

English (en)

Inventor

Anton Franz Josef Fliri

Randall James Gallaschun

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-03

Filing date

2001-07-23

Publication date

2004-05-24

2001-07-23 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-05-24 Application granted granted Critical

2004-05-24 Publication of DK1178047T3 publication Critical patent/DK1178047T3/da

Links

NFDXQGNDWIPXQL-UHFFFAOYSA-N 1-cyclooctyldiazocane Chemical class C1CCCCCCC1N1NCCCCCC1 NFDXQGNDWIPXQL-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
125000003118 aryl group Chemical group 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Psychology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK01306313T 2000-08-03 2001-07-23 Diazabicyclooctanderivater og terapeutiske anvendelser deraf DK1178047T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22270600P	2000-08-03	2000-08-03

Publications (1)

Publication Number	Publication Date
DK1178047T3 true DK1178047T3 (da)	2004-05-24

Family

ID=22833344

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01306313T DK1178047T3 (da)	2000-08-03	2001-07-23	Diazabicyclooctanderivater og terapeutiske anvendelser deraf

Country Status (12)

Country	Link
US (1)	US6531468B2 (de)
EP (1)	EP1178047B1 (de)
JP (1)	JP3825657B2 (de)
AT (1)	ATE260281T1 (de)
BR (1)	BR0103180A (de)
CA (1)	CA2354605C (de)
DE (1)	DE60102106T2 (de)
DK (1)	DK1178047T3 (de)
ES (1)	ES2211738T3 (de)
MX (1)	MXPA01007955A (de)
PT (1)	PT1178047E (de)
TR (1)	TR200400510T4 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1640364A1 (de) *	2003-06-27	2006-03-29	Toray Fine Chemicals Co., Ltd.	Verfahren zur herstellung einer stickstoffhaltigen heterocyclischen verbindung
EP1869050A1 (de)	2005-04-04	2007-12-26	Neurosearch A/S	Neue substituierte diazabicycloderivate und ihre verwendung als inhibitoren der monoaminneurotransmitterwiederaufnahme
MX2010008778A (es)	2008-02-15	2010-08-30	Hoffmann La Roche	Derivados de 3-alquil-piperazina y usos de la misma.
CA2730599C (en)	2008-07-23	2016-09-13	Toray Industries, Inc.	Therapeutic agent for chronic renal failure
MX346318B (es)	2009-06-26	2017-03-15	Nippon Shinyaku Co Ltd	Cristales.
IN2015MN00002A (de)	2012-07-09	2015-10-16	Lupin Ltd
US10231970B2 (en)	2014-09-30	2019-03-19	NV Heterocycles	Methods of producing heteropolycycles via bis-epoxidation
DK4331607T3 (da)	2015-12-02	2025-05-19	Nippon Shinyaku Co Ltd	Fast farmaceutisk sammensætning indeholdende 2-{4-[n-(5,6-diphenylpyrazin-2-yl)-n-isopropylamino]butyloxy}-n-(methylsulfonyl)acetamid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3951980A (en) *	1974-05-09	1976-04-20	Stanford Research Institute	3-Substituted-8-methyl-3,8-diazabicyclo[3.2.1]octanes
FR2531709A1 (fr) *	1982-08-13	1984-02-17	Sanofi Sa	Diazabicyclooctanes, procede pour leur preparation et compositions pharmaceutiques les renfermant

2001
- 2001-07-23 AT AT01306313T patent/ATE260281T1/de not_active IP Right Cessation
- 2001-07-23 PT PT01306313T patent/PT1178047E/pt unknown
- 2001-07-23 TR TR2004/00510T patent/TR200400510T4/xx unknown
- 2001-07-23 EP EP01306313A patent/EP1178047B1/de not_active Expired - Lifetime
- 2001-07-23 DE DE60102106T patent/DE60102106T2/de not_active Expired - Fee Related
- 2001-07-23 DK DK01306313T patent/DK1178047T3/da active
- 2001-07-23 ES ES01306313T patent/ES2211738T3/es not_active Expired - Lifetime
- 2001-08-01 BR BR0103180-5A patent/BR0103180A/pt not_active IP Right Cessation
- 2001-08-01 US US09/920,587 patent/US6531468B2/en not_active Expired - Fee Related
- 2001-08-01 CA CA002354605A patent/CA2354605C/en not_active Expired - Fee Related
- 2001-08-02 JP JP2001235227A patent/JP3825657B2/ja not_active Expired - Fee Related
- 2001-08-03 MX MXPA01007955A patent/MXPA01007955A/es unknown

Also Published As

Publication number	Publication date
JP3825657B2 (ja)	2006-09-27
EP1178047B1 (de)	2004-02-25
US20020068748A1 (en)	2002-06-06
US6531468B2 (en)	2003-03-11
TR200400510T4 (tr)	2004-08-23
ATE260281T1 (de)	2004-03-15
MXPA01007955A (es)	2002-08-06
EP1178047A1 (de)	2002-02-06
DE60102106T2 (de)	2004-07-15
CA2354605C (en)	2006-05-30
BR0103180A (pt)	2002-03-26
DE60102106D1 (de)	2004-04-01
JP2002088084A (ja)	2002-03-27
CA2354605A1 (en)	2002-02-03
PT1178047E (pt)	2004-05-31
ES2211738T3 (es)	2004-07-16

Publication	Publication Date	Title
JO2294B1 (en)	2005-09-12	4 - Phenylpyridine derivatives
IS6459A (is)	2002-07-05	Arýl sambrædd azapólýsýklísk efnasambönd
ATE131479T1 (de)	1995-12-15	1,3-dihydro-2h-imidano 4,5-b-quinolin-2-ein derivate als phosphodiestenase hemmer
DK1104759T3 (da)	2004-01-26	Heteroarylphenylpyrazolforbindelser som antiinflammatoriske/analgetiske midler
MXPA01007940A (es)	2003-08-20	Derivados de azabicicloalcano y usos terapeuticos de los mismos.
AU626740B2 (en)	1992-08-06	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
FI942976A0 (fi)	1994-06-21	5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaiset
TR200400510T4 (tr)	2004-08-23	Diazabisiklooktan türevleri ve bunların terapötik kullanımları
BR0011127A (pt)	2002-02-19	Derivados de 4-fenil-pirimidina
HUT63159A (en)	1993-07-28	Process for producing tokoferol derivatives and pharmaceutical compositions comprising same as active ingredient
DK1083178T3 (da)	2005-01-24	Tetrahydroquinazolin-2,4-dioner og terapeutiske anvendelser deraf
NO20033049D0 (no)	2003-07-03	Fremgangsmåte for fremstilling av (+/-) trans-4-p-fluorfenyl- 3-hydroksymetyl-1
FI914219A0 (fi)	1991-09-06	3-(1h-indazol-3-yl)-4-pyridinaminer, foerfarande och mellanprodukter foer deras framstaellning och deras anvaendning som laekemedel.
NO20020475L (no)	2002-03-13	2-aminotetralinderivater for terapi av glaukom
SE8802428D0 (sv)	1988-06-28	New compounds
ATE258934T1 (de)	2004-02-15	Azaindol derivate und ihre verwendung als antithrombotische wirkstoffe
ATE186912T1 (de)	1999-12-15	Carbamoylpyrrolidon-derivate zur behandlung von depressionen und cerebrovasculären störungen
DE69722630D1 (de)	2003-07-10	Therapeutisches mittel zur behandlung von nierenerkrankungen
HU9302081D0 (en)	1993-10-28	Procedure for producing preparations for preventing and/or curing ulceral diseases