DK1200385T3 - Krystaller af natriumsalt af pravastatin - Google Patents

Krystaller af natriumsalt af pravastatin

Info

Publication number: DK1200385T3
Authority: DK; Denmark
Prior art keywords: pravastatin; sodium salt; crystalline form; cervastatin; fluvastatin
Prior art date: 1999-08-06

Application number

DK00946239T

Other languages

English (en)

Inventor

Zlatko Pflaum

Original Assignee

Lek Tovarna Farmacevtskih

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2000-08-04

Publication date

2005-05-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432515&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1200385(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-08-04 Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih

2005-05-23 Application granted granted Critical

2005-05-23 Publication of DK1200385T3 publication Critical patent/DK1200385T3/da

Links

TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 5
229960002965 pravastatin Drugs 0.000 title abstract 5
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title abstract 5
159000000000 sodium salts Chemical class 0.000 title abstract 4
239000013078 crystal Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 3
ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 abstract 2
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 2
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 2
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 2
229960005370 atorvastatin Drugs 0.000 abstract 2
SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 abstract 2
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
229960003765 fluvastatin Drugs 0.000 abstract 2
229960002855 simvastatin Drugs 0.000 abstract 2
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 2
241000894007 species Species 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
OTYCUXCZGNDFQD-UHFFFAOYSA-N 7-naphthalen-1-ylheptanoic acid Chemical compound C1=CC=C2C(CCCCCCC(=O)O)=CC=CC2=C1 OTYCUXCZGNDFQD-UHFFFAOYSA-N 0.000 abstract 1
241000187643 Amycolatopsis Species 0.000 abstract 1
241000228212 Aspergillus Species 0.000 abstract 1
229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
241000235395 Mucor Species 0.000 abstract 1
241000187654 Nocardia Species 0.000 abstract 1
241000228143 Penicillium Species 0.000 abstract 1
AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 abstract 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
239000003529 anticholesteremic agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
229960004844 lovastatin Drugs 0.000 abstract 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
229950009116 mevastatin Drugs 0.000 abstract 1
AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 1
BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK00946239T 1999-08-06 2000-08-04 Krystaller af natriumsalt af pravastatin DK1200385T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9900191A SI20305A (sl)	1999-08-06	1999-08-06	Kristali natrijeve soli pravastatina
PCT/IB2000/001103 WO2001010813A1 (en)	1999-08-06	2000-08-04	Crystals of the sodium salt of pravastatin

Publications (1)

Publication Number	Publication Date
DK1200385T3 true DK1200385T3 (da)	2005-05-23

Family

ID=20432515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00946239T DK1200385T3 (da)	1999-08-06	2000-08-04	Krystaller af natriumsalt af pravastatin

Country Status (24)

Country	Link
US (3)	US7078558B1 (da)
EP (1)	EP1200385B2 (da)
JP (1)	JP2003506424A (da)
KR (2)	KR20070086847A (da)
CN (1)	CN1205172C (da)
AT (1)	ATE287389T1 (da)
BG (1)	BG65368B1 (da)
CA (1)	CA2379335A1 (da)
CZ (1)	CZ2002414A3 (da)
DE (1)	DE60017568T2 (da)
DK (1)	DK1200385T3 (da)
ES (1)	ES2235911T5 (da)
HR (1)	HRP20020106A2 (da)
HU (1)	HUP0202536A3 (da)
IL (3)	IL148050A0 (da)
NZ (1)	NZ516685A (da)
PL (1)	PL365850A1 (da)
PT (1)	PT1200385E (da)
RU (1)	RU2247711C2 (da)
SI (2)	SI20305A (da)
SK (1)	SK1742002A3 (da)
WO (1)	WO2001010813A1 (da)
YU (1)	YU5402A (da)
ZA (1)	ZA200200437B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI20305A (sl) *	1999-08-06	2001-02-28	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Kristali natrijeve soli pravastatina
SI20070A (sl) *	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Nove soli inhibitorjev HMG-CoA reduktaze
CZ20021998A3 (cs)	1999-12-14	2003-02-12	Biogal Gyogyszergyar Rt.	Nové formy sodné soli pravastatinu
JP3236282B1 (ja) *	2000-10-16	2001-12-10	三共株式会社	プラバスタチンを精製する方法
JP2002121172A (ja) *	2000-10-16	2002-04-23	Sankyo Co Ltd	プラバスタチン又はその薬理上許容される塩の精製方法
WO2002057229A1 (en)	2001-01-19	2002-07-25	Biocon India Limited	FORM V CRYSTALLINE [R-(R,R)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
US6716615B2 (en)	2002-02-27	2004-04-06	Yung Shin Pharmaceutical Ind. Co., Ltd.	Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP4308021B2 (ja)	2002-03-18	2009-08-05	バイオコン・リミテッド	望ましい粒子サイズのアモルファスＨＭＧ−ＣｏＡレダクターゼ阻害剤
CN1819863A (zh) *	2003-06-10	2006-08-16	大正制药株式会社	放射形球状晶析物及其制造方法以及使用它的干粉制剂
CN1293874C (zh) *	2003-08-18	2007-01-10	李朝晖	以洛伐他汀盐为主要活性成分的中药红曲及其制剂
PL1641447T3 (pl)	2003-11-24	2009-04-30	Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag	Sposób oczyszczania prawastatyny
US20080242725A1 (en) *	2004-03-01	2008-10-02	Janez Kerc	Pharmaceutical Composition
NZ552390A (en) *	2004-08-06	2010-01-29	Transform Pharmaceuticals Inc	Novel fenofibrate formulations and related methods of treatment
EP1786414A4 (en)	2004-08-06	2008-04-09	Transform Pharmaceuticals Inc	NEW PHARMACEUTICAL STATIN COMPOSITIONS AND RELEVANT TREATMENT PROCEDURES
US20090042979A1 (en) *	2004-08-06	2009-02-12	Transform Pharmaceuticals Inc.	Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
CN101115706A (zh) *	2005-02-09	2008-01-30	特瓦药厂私人有限公司	制备普伐他汀钠的方法
JP4895510B2 (ja) *	2005-02-23	2012-03-14	株式会社トクヤマ	バリオールアミンの製造方法
JP4813841B2 (ja) *	2005-07-25	2011-11-09	キユーピー株式会社	プラバスタチンナトリウムの製造方法
WO2009148709A1 (en) *	2008-04-16	2009-12-10	University Of Utah Research Foundation	Pharmacological targeting of vascular malformations
CN101348476B (zh) *	2008-09-05	2011-05-11	丽珠集团新北江制药股份有限公司	一种制备4,5,6,7-四氢普伐他汀及其钠盐的方法和固体结晶形式
CN101648867B (zh) *	2009-09-04	2012-07-11	天津大学	一种普伐他汀钠晶型及其制备方法和应用
EP2343054A1 (en)	2010-01-04	2011-07-13	LEK Pharmaceuticals d.d.	Pellets and microparticles of pravastatin sodium and a process of making them
CN102533893A (zh) *	2010-12-09	2012-07-04	浙江海正药业股份有限公司	一种制备莫那可林j的方法

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DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS572240A (en) *	1980-06-06	1982-01-07	Sankyo Co Ltd	Ml-236b derivative
JPS5889191A (ja) *	1981-11-20	1983-05-27	Sankyo Co Ltd	３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
CA2040865C (en)	1990-05-15	2002-07-23	James L. Bergey	Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
NZ250609A (en) *	1992-12-28	1995-07-26	Sankyo Co	Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
KR100210482B1 (ko) *	1997-04-10	1999-07-15	김종인	스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
US6098031A (en)	1998-03-05	2000-08-01	Gsi Lumonics, Inc.	Versatile method and system for high speed, 3D imaging of microscopic targets
SI20305A (sl) *	1999-08-06	2001-02-28	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Kristali natrijeve soli pravastatina
SI20070A (sl) *	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Nove soli inhibitorjev HMG-CoA reduktaze
SI20072A (sl) *	1998-09-18	2000-04-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) *	1999-02-03	2004-01-27	Institute For Drug Research Ltd.	Microbial process for preparing pravastatin
CA2361701C (en) *	1999-02-03	2007-04-10	Institute For Drug Research Ltd.	Microbial process for preparing pravastatin

1999
- 1999-08-06 SI SI9900191A patent/SI20305A/sl not_active IP Right Cessation
2000
- 2000-08-04 SI SI200030653T patent/SI1200385T2/sl unknown
- 2000-08-04 KR KR1020077015051A patent/KR20070086847A/ko not_active Withdrawn
- 2000-08-04 AT AT00946239T patent/ATE287389T1/de not_active IP Right Cessation
- 2000-08-04 HU HU0202536A patent/HUP0202536A3/hu unknown
- 2000-08-04 DK DK00946239T patent/DK1200385T3/da active
- 2000-08-04 RU RU2002102862/04A patent/RU2247711C2/ru not_active IP Right Cessation
- 2000-08-04 KR KR1020027001231A patent/KR100766928B1/ko not_active Expired - Fee Related
- 2000-08-04 IL IL14805000A patent/IL148050A0/xx unknown
- 2000-08-04 CZ CZ2002414A patent/CZ2002414A3/cs unknown
- 2000-08-04 CN CNB008113653A patent/CN1205172C/zh not_active Expired - Fee Related
- 2000-08-04 EP EP00946239A patent/EP1200385B2/en not_active Expired - Lifetime
- 2000-08-04 JP JP2001515281A patent/JP2003506424A/ja active Pending
- 2000-08-04 PT PT00946239T patent/PT1200385E/pt unknown
- 2000-08-04 PL PL00365850A patent/PL365850A1/xx not_active Application Discontinuation
- 2000-08-04 ES ES00946239T patent/ES2235911T5/es not_active Expired - Lifetime
- 2000-08-04 SK SK174-2002A patent/SK1742002A3/sk not_active Application Discontinuation
- 2000-08-04 WO PCT/IB2000/001103 patent/WO2001010813A1/en not_active Ceased
- 2000-08-04 NZ NZ516685A patent/NZ516685A/en not_active IP Right Cessation
- 2000-08-04 CA CA002379335A patent/CA2379335A1/en not_active Abandoned
- 2000-08-04 US US10/049,093 patent/US7078558B1/en not_active Expired - Fee Related
- 2000-08-04 DE DE60017568T patent/DE60017568T2/de not_active Expired - Lifetime
- 2000-08-04 YU YU5402A patent/YU5402A/sh unknown
- 2000-08-04 HR HR20020106A patent/HRP20020106A2/hr not_active Application Discontinuation
2002
- 2002-01-17 ZA ZA200200437A patent/ZA200200437B/en unknown
- 2002-02-05 BG BG106389A patent/BG65368B1/bg unknown
- 2002-02-06 IL IL148050A patent/IL148050A/en not_active IP Right Cessation
2003
- 2003-04-04 US US10/408,012 patent/US6740775B1/en not_active Expired - Fee Related
2006
- 2006-04-10 US US11/400,872 patent/US20060183929A1/en not_active Abandoned
2007
- 2007-11-08 IL IL187261A patent/IL187261A0/en unknown

Also Published As

Publication number	Publication date
SI20305A (sl)	2001-02-28
PL365850A1 (en)	2005-01-10
DE60017568D1 (de)	2005-02-24
NZ516685A (en)	2004-01-30
ATE287389T1 (de)	2005-02-15
CZ2002414A3 (cs)	2002-07-17
YU5402A (sh)	2005-03-15
HUP0202536A3 (en)	2003-04-28
IL148050A0 (en)	2002-09-12
CA2379335A1 (en)	2001-02-15
PT1200385E (pt)	2005-04-29
ES2235911T3 (es)	2005-07-16
KR20070086847A (ko)	2007-08-27
HUP0202536A2 (hu)	2003-01-28
EP1200385A1 (en)	2002-05-02
JP2003506424A (ja)	2003-02-18
SK1742002A3 (en)	2002-06-04
KR100766928B1 (ko)	2007-10-17
DE60017568T2 (de)	2006-03-30
ES2235911T5 (es)	2012-02-27
HRP20020106A2 (en)	2003-04-30
RU2247711C2 (ru)	2005-03-10
KR20020025204A (ko)	2002-04-03
WO2001010813A1 (en)	2001-02-15
US20060183929A1 (en)	2006-08-17
ZA200200437B (en)	2003-03-26
IL148050A (en)	2008-11-03
US6740775B1 (en)	2004-05-25
EP1200385B2 (en)	2011-09-21
SI1200385T1 (en)	2005-08-31
EP1200385B1 (en)	2005-01-19
BG106389A (en)	2002-09-30
SI1200385T2 (sl)	2012-02-29
CN1205172C (zh)	2005-06-08
IL187261A0 (en)	2008-02-09
US7078558B1 (en)	2006-07-18
BG65368B1 (bg)	2008-04-30
CN1368948A (zh)	2002-09-11

Publication	Publication Date	Title
IL187261A0 (en)	2008-02-09	Crystals of the sodium salt of pravastatin
ATE380020T1 (de)	2007-12-15	Stabile arzneiformulierungen enthaltend pravastatin or atorvastatin
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