DK1200442T3 - Derivater af 2,3-benzodiazepin - Google Patents

Derivater af 2,3-benzodiazepin

Info

Publication number: DK1200442T3
Authority: DK; Denmark
Prior art keywords: sup; bond; positions; hydrogen; lower alkyl
Prior art date: 1999-07-07

Application number

DK00944129T

Other languages

English (en)

Inventor

Zoltan Greff

Geza Szab

Czy Jozsef Bark

Tkai Zoltan R

Gabor Blask

Gyula Simig

Gabor Gigler

Mark Bernadett Martonn

Vay Gyoergy L

Karoly Tihanyi

Andras Egyed

Annamaria Sim

Original Assignee

Egyt Gyogyszervegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-07

Filing date

2000-07-04

Publication date

2003-10-20

2000-07-04 Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar

2003-10-20 Application granted granted Critical

2003-10-20 Publication of DK1200442T3 publication Critical patent/DK1200442T3/da

Links

RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
229910052757 nitrogen Inorganic materials 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
239000011593 sulfur Substances 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

DK00944129T 1999-07-07 2000-07-04 Derivater af 2,3-benzodiazepin DK1200442T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9902291A HU227128B1 (en)	1999-07-07	1999-07-07	New 2,3-benzodiazepine derivatives
PCT/HU2000/000074 WO2001004122A2 (en)	1999-07-07	2000-07-04	New 2,3-benzodiazepine derivatives

Publications (1)

Publication Number	Publication Date
DK1200442T3 true DK1200442T3 (da)	2003-10-20

Family

ID=89998666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00944129T DK1200442T3 (da)	1999-07-07	2000-07-04	Derivater af 2,3-benzodiazepin

Country Status (22)

Country	Link
US (1)	US7053082B1 (da)
EP (1)	EP1200442B8 (da)
JP (1)	JP2003504372A (da)
KR (1)	KR100818001B1 (da)
CN (1)	CN1162432C (da)
AT (1)	ATE243699T1 (da)
AU (1)	AU5836300A (da)
BG (1)	BG65405B1 (da)
CA (1)	CA2378305A1 (da)
CZ (1)	CZ20014698A3 (da)
DE (1)	DE60003561T2 (da)
DK (1)	DK1200442T3 (da)
HK (1)	HK1047581B (da)
HR (1)	HRP20020015B1 (da)
HU (1)	HU227128B1 (da)
PL (1)	PL351839A1 (da)
RO (1)	RO121853B1 (da)
RU (1)	RU2243228C2 (da)
SK (1)	SK286680B6 (da)
UA (1)	UA72261C2 (da)
WO (1)	WO2001004122A2 (da)
YU (1)	YU402A (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU225100B1 (hu) *	2000-12-21	2006-06-28	Egyt Gyogyszervegyeszeti Gyar	2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6858605B2 (en)	2003-02-04	2005-02-22	Ivax Drug Research Institute, Ltd.	Substituted 2,3-benzodiazepine derivatives
EP1979308A1 (en) *	2005-12-30	2008-10-15	EGIS Gyógyszergyár Nyrt	Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
FR2972454B1 (fr) *	2011-03-08	2013-03-01	Servier Lab	Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU179018B (en) *	1978-10-19	1982-08-28	Gyogyszerkutato Intezet	Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en) *	1984-06-27	1987-03-30	Gyogyszerkutato Intezet	New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) *	1984-07-27	1987-03-30	Gyogyszerkutato Intezet	Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) *	1986-05-21	1988-07-28	Gyogyszerkutato Intezet	Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU206719B (en) *	1990-12-21	1992-12-28	Gyogyszerkutato Intezet	Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU219777B (hu) *	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE4428835A1 (de) *	1994-08-01	1996-02-08	Schering Ag	Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
CA2198751C (en) *	1994-08-31	2006-07-11	Benjamin Alan Anderson	Dihydro-2,3-benzodiazepine derivatives
US5891871A (en) *	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) *	1997-08-12	2004-07-15	Егіш Дьйодьсердьяр Рт.	Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
EP1015457B1 (en) *	1997-08-12	2003-11-26	Egis Gyogyszergyar Rt.	1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors

1999
- 1999-07-07 HU HU9902291A patent/HU227128B1/hu not_active IP Right Cessation
2000
- 2000-04-07 UA UA2002020975A patent/UA72261C2/uk unknown
- 2000-07-04 DE DE60003561T patent/DE60003561T2/de not_active Expired - Lifetime
- 2000-07-04 RU RU2002103311/04A patent/RU2243228C2/ru not_active IP Right Cessation
- 2000-07-04 AU AU58363/00A patent/AU5836300A/en not_active Abandoned
- 2000-07-04 HR HR20020015A patent/HRP20020015B1/xx not_active IP Right Cessation
- 2000-07-04 HK HK02107601.4A patent/HK1047581B/en not_active IP Right Cessation
- 2000-07-04 CA CA002378305A patent/CA2378305A1/en not_active Abandoned
- 2000-07-04 DK DK00944129T patent/DK1200442T3/da active
- 2000-07-04 YU YU402A patent/YU402A/sh unknown
- 2000-07-04 JP JP2001509731A patent/JP2003504372A/ja active Pending
- 2000-07-04 CN CNB008100152A patent/CN1162432C/zh not_active Expired - Fee Related
- 2000-07-04 AT AT00944129T patent/ATE243699T1/de not_active IP Right Cessation
- 2000-07-04 RO ROA200200003A patent/RO121853B1/ro unknown
- 2000-07-04 WO PCT/HU2000/000074 patent/WO2001004122A2/en not_active Ceased
- 2000-07-04 KR KR1020027000200A patent/KR100818001B1/ko not_active Expired - Fee Related
- 2000-07-04 SK SK17-2002A patent/SK286680B6/sk not_active IP Right Cessation
- 2000-07-04 PL PL00351839A patent/PL351839A1/xx not_active Application Discontinuation
- 2000-07-04 CZ CZ20014698A patent/CZ20014698A3/cs unknown
- 2000-07-04 EP EP00944129A patent/EP1200442B8/en not_active Expired - Lifetime
- 2000-07-04 US US10/030,436 patent/US7053082B1/en not_active Expired - Fee Related
2002
- 2002-01-07 BG BG106281A patent/BG65405B1/bg unknown

Also Published As

Publication number	Publication date
EP1200442B8 (en)	2003-08-20
AU5836300A (en)	2001-01-30
KR100818001B1 (ko)	2008-03-31
CZ20014698A3 (cs)	2002-06-12
ATE243699T1 (de)	2003-07-15
HRP20020015B1 (en)	2005-02-28
HU9902291D0 (en)	1999-09-28
RU2243228C2 (ru)	2004-12-27
CN1162432C (zh)	2004-08-18
DE60003561T2 (de)	2004-04-29
SK172002A3 (en)	2002-06-04
KR20020022765A (ko)	2002-03-27
WO2001004122A3 (en)	2001-05-10
SK286680B6 (sk)	2009-03-05
HK1047581B (en)	2004-04-30
DE60003561D1 (de)	2003-07-31
WO2001004122A2 (en)	2001-01-18
PL351839A1 (en)	2003-06-16
EP1200442A1 (en)	2002-05-02
EP1200442B1 (en)	2003-06-25
HU227128B1 (en)	2010-07-28
HUP9902291A2 (hu)	2001-12-28
CA2378305A1 (en)	2001-01-18
HK1047581A1 (en)	2003-02-28
JP2003504372A (ja)	2003-02-04
US7053082B1 (en)	2006-05-30
UA72261C2 (uk)	2005-02-15
RO121853B1 (ro)	2008-06-30
BG65405B1 (bg)	2008-06-30
YU402A (sh)	2004-11-25
HRP20020015A2 (en)	2004-08-31
CN1370174A (zh)	2002-09-18
BG106281A (en)	2003-01-31

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