DK1210085T3 - Farmaceutiske oplösninger af levosimendan - Google Patents

Farmaceutiske oplösninger af levosimendan

Info

Publication number: DK1210085T3
Authority: DK; Denmark
Prior art keywords: levosimendan; pharmaceutical solutions; pharmaceutical; solutions
Prior art date: 1999-09-10

Application number

DK00958562T

Other languages

English (en)

Inventor

Reijo Baeckstroem

Ritva Haikala

Sirpa Pelttari

Eva Saukko

Reija Yrjoelae

Paeivi Granvik

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-10

Filing date

2000-09-08

Publication date

2006-05-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8555263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1210085(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-09-08 Application filed by Orion Corp filed Critical Orion Corp

2006-05-08 Application granted granted Critical

2006-05-08 Publication of DK1210085T3 publication Critical patent/DK1210085T3/da

Links

WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 title 1
229960000692 levosimendan Drugs 0.000 title 1
239000003186 pharmaceutical solution Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK00958562T 1999-09-10 2000-09-08 Farmaceutiske oplösninger af levosimendan DK1210085T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI991925A FI109659B (fi)	1999-09-10	1999-09-10	Levosimendaanin farmaseuttisia liuoksia

Publications (1)

Publication Number	Publication Date
DK1210085T3 true DK1210085T3 (da)	2006-05-08

Family

ID=8555263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00958562T DK1210085T3 (da)	1999-09-10	2000-09-08	Farmaceutiske oplösninger af levosimendan

Country Status (39)

Country	Link
US (2)	US6730673B1 (da)
EP (1)	EP1210085B1 (da)
JP (1)	JP4708648B2 (da)
KR (1)	KR100869752B1 (da)
CN (1)	CN1203855C (da)
AR (1)	AR025449A1 (da)
AT (1)	ATE315937T1 (da)
AU (1)	AU771027B2 (da)
BG (1)	BG65827B1 (da)
BR (1)	BRPI0013924B8 (da)
CA (1)	CA2382013C (da)
CO (1)	CO5180582A1 (da)
CZ (1)	CZ303095B6 (da)
DE (1)	DE60025627T2 (da)
DK (1)	DK1210085T3 (da)
EA (1)	EA005067B1 (da)
EE (1)	EE05375B1 (da)
ES (1)	ES2256034T3 (da)
FI (1)	FI109659B (da)
HK (1)	HK1049282B (da)
HR (1)	HRP20020298B1 (da)
HU (1)	HU228340B1 (da)
IL (2)	IL148379A0 (da)
IS (1)	IS2244B (da)
ME (1)	ME00523B (da)
MX (1)	MXPA02002423A (da)
MY (1)	MY125984A (da)
NO (1)	NO331989B1 (da)
NZ (1)	NZ517605A (da)
PL (1)	PL202356B1 (da)
PT (1)	PT1210085E (da)
RS (1)	RS50445B (da)
SI (1)	SI1210085T1 (da)
SK (1)	SK287154B6 (da)
TR (1)	TR200200620T2 (da)
TW (1)	TWI242434B (da)
UA (1)	UA73954C2 (da)
WO (1)	WO2001019334A2 (da)
ZA (1)	ZA200201828B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI109659B (fi) *	1999-09-10	2002-09-30	Orion Yhtymae Oyj	Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) *	2001-02-08	2001-02-08	Orion Corp	Menetelmä sydämen vajaatoiminnan hoitoon
CN100428937C (zh) *	2003-10-30	2008-10-29	北京海合天科技开发有限公司	左西孟旦冷冻干燥组合物
CN100367964C (zh) *	2004-04-29	2008-02-13	王思清	左西孟旦-β环糊精包含物制剂
US20070010518A1 (en) *	2005-02-18	2007-01-11	Matti Kivikko	Method for administering levosimendan
WO2008082871A1 (en) *	2006-12-28	2008-07-10	Orion Corporation	Formulations of levosimendan for parenteral administration
US10046081B2 (en)	2008-04-11	2018-08-14	The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc.	Electrospun dextran fibers and devices formed therefrom
WO2012093404A2 (en)	2011-01-03	2012-07-12	Gufic Biosciences Limited	Parenteral formulations of levosimendan
US20130096479A1 (en) *	2011-10-18	2013-04-18	St. Teresa Medical, Inc.	Method of forming hemostatic products
CN104619345A (zh) *	2012-05-18	2015-05-13	罗达制药有限公司	液体制剂
CN105106113B (zh) *	2015-09-30	2019-07-26	济南康和医药科技有限公司	一种左西孟旦注射液及其制备方法
PT3370693T (pt) *	2015-11-06	2020-04-08	Carinopharm Gmbh	Formulações melhoradas de levossimendano para administração intravenosa como infusão ou injeção e de concentrado de infusão
WO2017083050A1 (en)	2015-11-12	2017-05-18	St. Teresa Medical, Inc.	A method of sealing a durotomy
CN108261398A (zh) *	2016-12-30	2018-07-10	齐鲁制药有限公司	一种含有左西孟旦的供注射用药物制剂及其制备方法
WO2019089717A1 (en)	2017-11-02	2019-05-09	St. Teresa Medical, Inc.	Fibrin sealant products
CN111474289A (zh) *	2019-10-31	2020-07-31	武汉嘉诺康医药技术有限公司	一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
JP2023507626A (ja)	2019-12-16	2023-02-24	テナックス・セラピューティクス，インコーポレイテッド	駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン
CN111514147B (zh) *	2020-05-12	2021-09-17	成都欣捷高新技术开发股份有限公司	用于急性失代偿心力衰竭症状的左西孟旦钠药用组合物及制备方法
US11760730B2 (en)	2021-01-11	2023-09-19	Navinta, Llc	Process for the preparation of high purity Levosimendan
TR2021013305A2 (tr) *	2021-08-23	2023-03-21	Tuem Ekip Ilac Anonim Sirketi	Li̇yofi̇li̇ze levosi̇mendan formülasyonlari
CN115518037A (zh) *	2022-10-14	2022-12-27	上药东英（江苏）药业有限公司	一种安全质量稳定的左西孟旦注射剂组合物及其制备方法
CN116473930B (zh) *	2023-05-17	2023-12-15	山东泰合医药科技有限公司	一种注射用左西孟旦及其制备方法
CN117919246A (zh) *	2024-01-26	2024-04-26	重庆东得医药科技有限公司	一种以左西孟旦为活性成分的组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2251615B (en)	1991-01-03	1995-02-08	Orion Yhtymae Oy	(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en)	1992-05-06	1993-11-17	Orion Yhtymae Oy	Compounds for use as anti-ischemic medicaments
GB9606474D0 (en)	1996-03-27	1996-06-05	Orion Yhytmo Oy	Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) *	1996-07-05	1996-09-04	Orion Yhtymae Oy	Transdermal delivery of levosimendan
FI980902A7 (fi) *	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaanin stabiileja koostumuksia
FI109659B (fi) *	1999-09-10	2002-09-30	Orion Yhtymae Oyj	Levosimendaanin farmaseuttisia liuoksia

1999
- 1999-09-10 FI FI991925A patent/FI109659B/fi active
2000
- 2000-08-09 UA UA2002042873A patent/UA73954C2/uk unknown
- 2000-08-11 MY MYPI20003682A patent/MY125984A/en unknown
- 2000-08-30 AR ARP000104525A patent/AR025449A1/es not_active Application Discontinuation
- 2000-08-30 TW TW089117581A patent/TWI242434B/zh not_active IP Right Cessation
- 2000-09-06 CO CO00067212A patent/CO5180582A1/es active IP Right Grant
- 2000-09-08 JP JP2001522969A patent/JP4708648B2/ja not_active Expired - Lifetime
- 2000-09-08 HK HK03101189.6A patent/HK1049282B/zh not_active IP Right Cessation
- 2000-09-08 EA EA200200348A patent/EA005067B1/ru not_active IP Right Cessation
- 2000-09-08 CN CNB008126453A patent/CN1203855C/zh not_active Expired - Lifetime
- 2000-09-08 AT AT00958562T patent/ATE315937T1/de active
- 2000-09-08 KR KR20027002923A patent/KR100869752B1/ko not_active Expired - Lifetime
- 2000-09-08 NZ NZ517605A patent/NZ517605A/en not_active IP Right Cessation
- 2000-09-08 SI SI200030801T patent/SI1210085T1/sl unknown
- 2000-09-08 US US10/070,689 patent/US6730673B1/en not_active Expired - Lifetime
- 2000-09-08 TR TR2002/00620T patent/TR200200620T2/xx unknown
- 2000-09-08 AU AU70044/00A patent/AU771027B2/en not_active Expired
- 2000-09-08 MX MXPA02002423A patent/MXPA02002423A/es active IP Right Grant
- 2000-09-08 CA CA002382013A patent/CA2382013C/en not_active Expired - Lifetime
- 2000-09-08 WO PCT/FI2000/000761 patent/WO2001019334A2/en not_active Ceased
- 2000-09-08 PT PT00958562T patent/PT1210085E/pt unknown
- 2000-09-08 EE EEP200200129A patent/EE05375B1/xx unknown
- 2000-09-08 PL PL354028A patent/PL202356B1/pl unknown
- 2000-09-08 HR HR20020298A patent/HRP20020298B1/xx not_active IP Right Cessation
- 2000-09-08 DE DE60025627T patent/DE60025627T2/de not_active Expired - Lifetime
- 2000-09-08 EP EP00958562A patent/EP1210085B1/en not_active Expired - Lifetime
- 2000-09-08 IL IL14837900A patent/IL148379A0/xx active IP Right Grant
- 2000-09-08 CZ CZ20020788A patent/CZ303095B6/cs not_active IP Right Cessation
- 2000-09-08 HU HU0202749A patent/HU228340B1/hu unknown
- 2000-09-08 SK SK327-2002A patent/SK287154B6/sk not_active IP Right Cessation
- 2000-09-08 RS YUP-169/02A patent/RS50445B/sr unknown
- 2000-09-08 DK DK00958562T patent/DK1210085T3/da active
- 2000-09-08 BR BRPI0013924A patent/BRPI0013924B8/pt not_active IP Right Cessation
- 2000-09-08 ES ES00958562T patent/ES2256034T3/es not_active Expired - Lifetime
- 2000-09-08 ME MEP-2008-866A patent/ME00523B/me unknown
2002
- 2002-02-26 IL IL148379A patent/IL148379A/en unknown
- 2002-03-05 ZA ZA200201828A patent/ZA200201828B/xx unknown
- 2002-03-05 NO NO20021090A patent/NO331989B1/no not_active IP Right Cessation
- 2002-03-06 IS IS6296A patent/IS2244B/is unknown
- 2002-04-05 BG BG106589A patent/BG65827B1/bg unknown
2003
- 2003-11-10 US US10/703,565 patent/US6943164B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
TR200200620T2 (tr)	2002-09-23
FI19991925L (fi)	2001-03-10
MXPA02002423A (es)	2002-08-12
RS50445B (sr)	2010-03-02
ES2256034T3 (es)	2006-07-16
BR0013924A (pt)	2002-05-21
HU228340B1 (en)	2013-03-28
UA73954C2 (uk)	2005-10-17
US6730673B1 (en)	2004-05-04
ME00523B (me)	2011-10-10
NO331989B1 (no)	2012-05-21
IL148379A (en)	2006-12-10
AU771027B2 (en)	2004-03-11
HUP0202749A3 (en)	2003-03-28
DE60025627T2 (de)	2006-11-16
YU16902A (sh)	2004-09-03
IL148379A0 (en)	2002-09-12
HK1049282B (zh)	2005-12-30
SI1210085T1 (sl)	2006-04-30
US20040106617A1 (en)	2004-06-03
HK1049282A1 (en)	2003-05-09
EA200200348A1 (ru)	2002-08-29
JP2003509351A (ja)	2003-03-11
CA2382013A1 (en)	2001-03-22
MY125984A (en)	2006-09-29
AU7004400A (en)	2001-04-17
CN1373665A (zh)	2002-10-09
IS2244B (is)	2007-05-15
PT1210085E (pt)	2006-05-31
WO2001019334A2 (en)	2001-03-22
AR025449A1 (es)	2002-11-27
PL354028A1 (pl)	2003-12-15
NO20021090D0 (no)	2002-03-05
ZA200201828B (en)	2003-08-27
CA2382013C (en)	2009-08-11
DE60025627D1 (de)	2006-04-06
EP1210085A2 (en)	2002-06-05
JP4708648B2 (ja)	2011-06-22
IS6296A (is)	2002-03-06
CO5180582A1 (es)	2002-07-30
TWI242434B (en)	2005-11-01
US6943164B2 (en)	2005-09-13
KR20020048400A (ko)	2002-06-22
BG106589A (bg)	2002-11-29
SK287154B6 (sk)	2010-01-07
BR0013924B1 (pt)	2013-09-24
FI109659B (fi)	2002-09-30
KR100869752B1 (ko)	2008-11-21
SK3272002A3 (en)	2002-12-03
NZ517605A (en)	2003-08-29
BRPI0013924B8 (pt)	2021-05-25
HUP0202749A2 (hu)	2003-02-28
HRP20020298B1 (hr)	2007-02-28
CZ303095B6 (cs)	2012-03-28
ATE315937T1 (de)	2006-02-15
CN1203855C (zh)	2005-06-01
EE05375B1 (et)	2011-02-15
EA005067B1 (ru)	2004-10-28
CZ2002788A3 (cs)	2002-11-13
HRP20020298A2 (en)	2003-06-30
NO20021090L (no)	2002-03-05
PL202356B1 (pl)	2009-06-30
EE200200129A (et)	2003-04-15
BG65827B1 (bg)	2010-02-26
EP1210085B1 (en)	2006-01-18
WO2001019334A3 (en)	2001-11-15

Publication	Publication Date	Title
PL354028A1 (pl)	2003-12-15	Farmaceutyczne roztwory levosimendanuFarmaceutyczne roztwory levosimendanu
DE60019770D1 (de)	2005-06-02	Photochrome naphtopyranen
DK1147083T3 (da)	2004-08-16	Arylpiperazinyl-cyclohexylindolderivater til behandling af depression
DE60034307D1 (de)	2007-05-24	Kombinierte kamera
DE60010606D1 (de)	2004-06-17	Verschluss
DE60033989D1 (de)	2007-05-03	Zoomobjektiv
DE60037233D1 (de)	2008-01-10	Hämofiltrationsvorrichtung
NO20014926D0 (no)	2001-10-10	Farmasöytiske forbindelser
IS2162B (is)	2006-11-15	Fjölbrigðasalt af lyfi gegn mígreni
DE60029273D1 (de)	2006-08-24	Titan-Tinoxidfilme
DK1043025T3 (da)	2005-07-04	Behandling af nyrecellekarcinom
NO20016430L (no)	2002-02-26	Farmasöytisk kompleks
EE200100381A (et)	2002-12-16	Morfolinobensamiidi uued soolad
ATA11152000A (de)	2002-07-15	Rolladen
FI19992686A7 (fi)	2001-06-15	Synkronitasasuuntaus
FI991256A0 (fi)	1999-06-02	Apulaite tarjoilua varten
DE50002916D1 (de)	2003-08-21	Fokussiereinrichtung
DE60027681D1 (de)	2006-06-08	Oszillator
NO20022446D0 (no)	2002-05-23	Etere av O-desmetyl-venlafaxine
DE69919756D1 (de)	2004-09-30	Oszillator
DK1227795T3 (da)	2004-04-26	Lipidkompleks af alkycycliner
ITMI20000412A0 (it)	2000-03-02	Doccia
DK1267849T3 (da)	2005-06-20	Begrænsning af genoptagelse af lægemiddelanvendelse
FI106779B (fi)	2001-04-12	Erityissuodatin
IT249905Y1 (it)	2003-06-09	Tapparella