DK121904B - Analogifremgangsmåde til fremstilling af spiro-(steroido-6,1'-cyclopropan)-forbindelser. - Google Patents

Analogifremgangsmåde til fremstilling af spiro-(steroido-6,1'-cyclopropan)-forbindelser.

Info

Publication number
DK121904B
DK121904B DK412365AA DK412365A DK121904B DK 121904 B DK121904 B DK 121904B DK 412365A A DK412365A A DK 412365AA DK 412365 A DK412365 A DK 412365A DK 121904 B DK121904 B DK 121904B
Authority
DK
Denmark
Prior art keywords
steroido
cyclopropane
spiro
compounds
preparation
Prior art date
Application number
DK412365AA
Other languages
English (en)
Inventor
F Colton
R Nicholson
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of DK121904B publication Critical patent/DK121904B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK412365AA 1964-08-12 1965-08-11 Analogifremgangsmåde til fremstilling af spiro-(steroido-6,1'-cyclopropan)-forbindelser. DK121904B (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US389224A US3412154A (en) 1964-08-12 1964-08-12 Amino-substituted phenone compounds
US389183A US3261829A (en) 1964-08-12 1964-08-12 Spiro(steroidal-6,3'-1-pyrazolines) and process
US39175964A 1964-08-24 1964-08-24

Publications (1)

Publication Number Publication Date
DK121904B true DK121904B (da) 1971-12-20

Family

ID=27409883

Family Applications (2)

Application Number Title Priority Date Filing Date
DK409665AA DK134222B (da) 1964-08-12 1965-08-10 Analogifremgangsmåde til fremstilling af terapeutisk virksomme aminer eller syreadditionssalte deraf.
DK412365AA DK121904B (da) 1964-08-12 1965-08-11 Analogifremgangsmåde til fremstilling af spiro-(steroido-6,1'-cyclopropan)-forbindelser.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK409665AA DK134222B (da) 1964-08-12 1965-08-10 Analogifremgangsmåde til fremstilling af terapeutisk virksomme aminer eller syreadditionssalte deraf.

Country Status (9)

Country Link
US (3) US3412154A (da)
BE (3) BE668124A (da)
BR (1) BR6571997D0 (da)
CH (3) CH450454A (da)
DE (2) DE1620111C3 (da)
DK (2) DK134222B (da)
FR (2) FR4851M (da)
GB (3) GB1078163A (da)
SE (1) SE336786B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3475417A (en) * 1965-03-24 1969-10-28 Upjohn Co 6,1'-spirocyclopropyl pregnanes
US3476745A (en) * 1965-06-04 1969-11-04 Smithkline Corp 6,6-ethylene corticoids
US3579509A (en) * 1965-06-21 1971-05-18 Smith Kline French Lab Process and 6-beta-substituted ethyl intermediates for preparing 6,6-ethylene-3-keto-delta**4 steroids
US3422097A (en) * 1965-08-27 1969-01-14 Smithkline Corp 6,6-ethylene spirolactones
US3373157A (en) * 1965-09-17 1968-03-12 Smith Kline French Lab 6, 6-ethylene-19 nortestosterones
GB1089945A (en) * 1965-09-23 1967-11-08 British Drug Houses Ltd Steroidal-6-spirocyclopropyl-4-en-3-ones
US3470156A (en) * 1967-01-30 1969-09-30 Smithkline Corp 6,6-ethylene-1,2-methylenesteroids
US4001312A (en) * 1970-12-09 1977-01-04 Sumitomo Chemical Company, Limited Aminoalcohols
LU65414A1 (da) * 1972-05-24 1973-12-04
US4018778A (en) * 1972-05-24 1977-04-19 Cassella Farbwerke Mainkur Aktiengesellschaft Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production
LU69043A1 (da) * 1973-12-20 1975-08-20
US3920635A (en) * 1974-11-27 1975-11-18 Searle & Co (6S)-17{40 -hydroxy-3{40 -oxospiro{8 oxirane-2,6{40 -{8 17{60 {9 pregn{8 4{9 ene{9 -21{40 -carboxylic acid {65 -lactone, the {66 {hu 1,4 {b analog, and intermediates
SE7807408L (sv) * 1978-06-30 1979-12-31 Haessle Ab Hjertaktiva foreningar
US5118816A (en) * 1990-12-26 1992-06-02 American Cyanamid Company 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles
US6835853B2 (en) * 2001-10-31 2004-12-28 Synthon Bv Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
EP1905758A1 (en) * 2001-10-31 2008-04-02 Synthon B.V. Tamsulosin free base and recovery process thereof
AU2002367923A1 (en) * 2002-05-07 2003-11-11 Mcm Pharma Gmbh Method for preparing 2-alkoxyphenoxyethanamines from 2-alkoxyphenoxyethylacetamides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1165845A (fr) * 1955-05-28 1958-10-29 Philips Nv Amines secondaires portant des substituants et leur préparation
NL275411A (da) * 1962-01-29

Also Published As

Publication number Publication date
US3261829A (en) 1966-07-19
FR7120M (da) 1969-07-21
DE1620111B2 (de) 1974-04-04
GB1078163A (en) 1967-08-02
DE1620111A1 (de) 1970-01-02
FR4851M (da) 1967-02-20
DE1493080B2 (de) 1974-04-25
US3499891A (en) 1970-03-10
CH460027A (de) 1968-07-31
BE668219A (da) 1966-02-14
BE668218A (da) 1966-02-14
US3412154A (en) 1968-11-19
DE1493080C3 (de) 1974-11-28
DK134222C (da) 1977-02-28
BR6571997D0 (pt) 1973-08-14
CH450454A (fr) 1968-01-31
GB1087828A (en) 1967-10-18
GB1041090A (en) 1966-09-01
BE668124A (da) 1965-12-01
DE1493080A1 (de) 1969-06-12
SE336786B (da) 1971-07-19
CH460753A (fr) 1968-08-15
DE1620111C3 (de) 1974-11-07
DK134222B (da) 1976-10-04

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