DK122377A - 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a)quinoxalin-5(6h)-oner og derivater deraf samt deres fremstilling og anvendelse - Google Patents

2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a)quinoxalin-5(6h)-oner og derivater deraf samt deres fremstilling og anvendelse

Info

Publication number
DK122377A
DK122377A DK122377A DK122377A DK122377A DK 122377 A DK122377 A DK 122377A DK 122377 A DK122377 A DK 122377A DK 122377 A DK122377 A DK 122377A DK 122377 A DK122377 A DK 122377A
Authority
DK
Denmark
Prior art keywords
pyrazino
quinoxalin
tetrahydro
ones
derivatives
Prior art date
Application number
DK122377A
Other languages
English (en)
Inventor
M E Freed
J R Potoski
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of DK122377A publication Critical patent/DK122377A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK122377A 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a)quinoxalin-5(6h)-oner og derivater deraf samt deres fremstilling og anvendelse DK122377A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/668,872 US4032639A (en) 1976-03-22 1976-03-22 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension

Publications (1)

Publication Number Publication Date
DK122377A true DK122377A (da) 1977-09-23

Family

ID=24684079

Family Applications (1)

Application Number Title Priority Date Filing Date
DK122377A DK122377A (da) 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a)quinoxalin-5(6h)-oner og derivater deraf samt deres fremstilling og anvendelse

Country Status (13)

Country Link
US (1) US4032639A (da)
JP (1) JPS52114000A (da)
AT (1) AT357540B (da)
AU (1) AU506308B2 (da)
BE (1) BE852737A (da)
CA (1) CA1093557A (da)
DE (1) DE2712573A1 (da)
DK (1) DK122377A (da)
FR (1) FR2345450A1 (da)
GB (3) GB1538987A (da)
NL (1) NL7702920A (da)
SE (1) SE7703223L (da)
ZA (1) ZA771381B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182872A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-(Lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acid chemical intermediates
US4182869A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-Carbobenzoxypiperazine-2-carboxylic acid chemical intermediate
US4089958A (en) * 1976-12-20 1978-05-16 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
US4225713A (en) * 1977-08-03 1980-09-30 Freed Meier E Tetrahydro(1H)pyrazino(1,2-A)azaquinoxalin-5(6H)-ones and derivatives thereof
US4203987A (en) * 1979-05-21 1980-05-20 American Home Products Corporation 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones
ES2164639T3 (es) * 1991-04-15 2002-03-01 Aventis Pharma Gmbh Quinoxalinas, procedimiento para su preparacion y su empleo.
US6369057B1 (en) 1991-04-15 2002-04-09 Aventis Pharma Deutschland Gmbh Quinoxalines, processes for their preparation and their use
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
EA003294B1 (ru) * 1995-12-08 2003-04-24 Агурон Фармасьютикалс, Инк. Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения
US5753653A (en) 1995-12-08 1998-05-19 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
HUP0104773A3 (en) * 1998-12-17 2004-10-28 Wyeth Corp 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them
US6476032B2 (en) 1998-12-17 2002-11-05 Wyeth 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives
US6372745B1 (en) * 1999-12-06 2002-04-16 American Home Products Corporation 2,3,4,4A-tetrahydro-1H-pyrazino[1,2-A]quinoxalin-5(6H)one derivatives
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US20060211700A1 (en) * 2005-03-21 2006-09-21 Alcon, Inc. (R)-8,9-dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one for controlling IOP and treating glaucoma
PL2792667T3 (pl) * 2011-12-14 2018-05-30 Kumiai Chemical Industry Co., Ltd. Związek difenyloaminowy i sposób jego wytwarzania
WO2014208296A1 (ja) * 2013-06-25 2014-12-31 イハラケミカル工業株式会社 ニトロベンゼン化合物を製造する方法
CN114096533B (zh) * 2019-09-10 2024-03-08 四川科伦博泰生物医药股份有限公司 一种三并环类化合物，包含其的药物组合物，其制备方法及其用途

Also Published As

Publication number Publication date
AU2304877A (en) 1978-09-14
GB1538986A (en) 1979-01-24
AU506308B2 (en) 1979-12-20
DE2712573A1 (de) 1977-09-29
ATA189377A (de) 1979-12-15
FR2345450A1 (fr) 1977-10-21
AT357540B (de) 1980-07-10
BE852737A (fr) 1977-09-22
GB1538988A (en) 1979-01-24
SE7703223L (sv) 1977-09-23
ZA771381B (en) 1978-10-25
US4032639A (en) 1977-06-28
NL7702920A (nl) 1977-09-26
FR2345450B1 (da) 1980-05-09
GB1538987A (en) 1979-01-24
CA1093557A (en) 1981-01-13
JPS52114000A (en) 1977-09-24

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