DK1224166T3 - Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid - Google Patents

Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid

Info

Publication number: DK1224166T3
Authority: DK; Denmark
Prior art keywords: preparation; methanesulfonyl; benzoyl; bis; methyl
Prior art date: 1999-10-26

Application number

DK00972725T

Other languages

English (en)

Inventor

Rolf Gericke

Manfred Baumgarth

Hans Markus Bender

Bernhard Ladstetter

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-26

Filing date

2000-10-11

Publication date

2004-01-05

2000-10-11 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2004-01-05 Application granted granted Critical

2004-01-05 Publication of DK1224166T3 publication Critical patent/DK1224166T3/da

Links

OURUCFSGKCZIPX-UHFFFAOYSA-N carbamimidoyl-[2-methyl-4,5-bis(methylsulfonyl)benzoyl]azanium;chloride Chemical compound Cl.CC1=CC(S(C)(=O)=O)=C(S(C)(=O)=O)C=C1C(=O)NC(N)=N OURUCFSGKCZIPX-UHFFFAOYSA-N 0.000 title 1
229940121988 Antiporter inhibitor Drugs 0.000 abstract 1
102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 abstract 1
108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 abstract 1
DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 abstract 1
GROMEQPXDKRRIE-UHFFFAOYSA-N n-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide Chemical compound CC1=CC(S(C)(=O)=O)=C(S(C)(=O)=O)C=C1C(=O)N=C(N)N GROMEQPXDKRRIE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK00972725T 1999-10-26 2000-10-11 Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid DK1224166T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19951418A DE19951418A1 (de)	1999-10-26	1999-10-26	Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
PCT/EP2000/009977 WO2001030750A1 (de)	1999-10-26	2000-10-11	Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid

Publications (1)

Publication Number	Publication Date
DK1224166T3 true DK1224166T3 (da)	2004-01-05

Family

ID=7926842

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00972725T DK1224166T3 (da)	1999-10-26	2000-10-11	Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid

Country Status (25)

Country	Link
US (1)	US6673968B1 (da)
EP (1)	EP1224166B1 (da)
JP (1)	JP4969750B2 (da)
KR (1)	KR100699571B1 (da)
CN (1)	CN1202078C (da)
AT (1)	ATE250026T1 (da)
AU (1)	AU782471B2 (da)
BR (1)	BR0015022A (da)
CA (1)	CA2388915C (da)
CZ (1)	CZ299201B6 (da)
DE (2)	DE19951418A1 (da)
DK (1)	DK1224166T3 (da)
ES (1)	ES2204712T3 (da)
HU (1)	HU228634B1 (da)
MX (1)	MXPA02004144A (da)
MY (1)	MY122651A (da)
NO (1)	NO328250B1 (da)
PL (1)	PL199010B1 (da)
PT (1)	PT1224166E (da)
RU (1)	RU2276134C2 (da)
SI (1)	SI1224166T1 (da)
SK (1)	SK286603B6 (da)
UA (1)	UA73329C2 (da)
WO (1)	WO2001030750A1 (da)
ZA (1)	ZA200204119B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10023405A1 (de) *	2000-05-12	2001-11-15	Merck Patent Gmbh	Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
BRPI0410022A (pt) *	2003-05-06	2006-04-25	Merck Patent Gmbh	processo para a cristalização de sais de guanidìnio
DK2271327T3 (da)	2008-05-09	2015-07-13	Merck Patent Gmbh	Farmaceutisk sammensætning omfattende rimeporid til behandling af sygdomme forbundet med beta-celle-dysfunktion
CN105358530A (zh) *	2013-06-10	2016-02-24	美国安进公司	制备mdm2抑制剂的方法及其结晶形式
EP3159347A4 (en) *	2014-06-23	2018-01-24	Nissan Chemical Industries, Ltd.	Method for producing sulfonyl-bond-containing silane compound
CN117304079A (zh) *	2016-02-08	2023-12-29	默克专利股份有限公司	N-(4,5-双甲磺酰基-2-甲基苯甲酰基)胍盐酸盐和n-(4,5-双甲磺酰基-2-甲基苯甲酰基)胍盐的结晶变体
EP3960165A1 (en) *	2020-08-25	2022-03-02	Fondation EspeRare	Nhe-1 inhibitors for the treatment of coronavirus infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59216865A (ja) *	1983-05-26	1984-12-06	Mitsui Toatsu Chem Inc	システイン塩酸塩水和物の乾燥方法
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0589336B1 (de) *	1992-09-22	1997-01-08	Hoechst Aktiengesellschaft	Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
EP0604852A1 (de) *	1992-12-28	1994-07-06	Hoechst Aktiengesellschaft	2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
JPH07206857A (ja) *	1993-12-28	1995-08-08	Synthelabo Sa	アルフゾシン塩酸塩の二水和物
JP3755908B2 (ja) *	1994-08-17	2006-03-15	塩野義製薬株式会社	セファロスポリン化合物の晶析法
EP0723956B1 (de) *	1995-01-30	1999-10-13	Hoechst Aktiengesellschaft	Basisch-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19502895A1 (de) *	1995-01-31	1996-08-01	Merck Patent Gmbh	4-Mercapto-benzoylguanidin-Derivate
DE19526381A1 (de) *	1995-07-19	1997-01-23	Hoechst Ag	4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19529612A1 (de) *	1995-08-11	1997-02-13	Merck Patent Gmbh	Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

1999
- 1999-10-26 DE DE19951418A patent/DE19951418A1/de not_active Withdrawn
2000
- 2000-10-11 MX MXPA02004144A patent/MXPA02004144A/es active IP Right Grant
- 2000-10-11 DK DK00972725T patent/DK1224166T3/da active
- 2000-10-11 HU HU0203132A patent/HU228634B1/hu not_active IP Right Cessation
- 2000-10-11 WO PCT/EP2000/009977 patent/WO2001030750A1/de not_active Ceased
- 2000-10-11 EP EP00972725A patent/EP1224166B1/de not_active Expired - Lifetime
- 2000-10-11 CN CNB008147892A patent/CN1202078C/zh not_active Expired - Lifetime
- 2000-10-11 AT AT00972725T patent/ATE250026T1/de active
- 2000-10-11 DE DE50003759T patent/DE50003759D1/de not_active Expired - Lifetime
- 2000-10-11 KR KR1020027005249A patent/KR100699571B1/ko not_active Expired - Fee Related
- 2000-10-11 PT PT00972725T patent/PT1224166E/pt unknown
- 2000-10-11 AU AU11361/01A patent/AU782471B2/en not_active Expired
- 2000-10-11 BR BR0015022-3A patent/BR0015022A/pt not_active Application Discontinuation
- 2000-10-11 SK SK546-2002A patent/SK286603B6/sk not_active IP Right Cessation
- 2000-10-11 CZ CZ20021354A patent/CZ299201B6/cs not_active IP Right Cessation
- 2000-10-11 JP JP2001533105A patent/JP4969750B2/ja not_active Expired - Lifetime
- 2000-10-11 CA CA002388915A patent/CA2388915C/en not_active Expired - Lifetime
- 2000-10-11 RU RU2002112756/04A patent/RU2276134C2/ru active
- 2000-10-11 ES ES00972725T patent/ES2204712T3/es not_active Expired - Lifetime
- 2000-10-11 SI SI200030273T patent/SI1224166T1/xx unknown
- 2000-10-11 US US10/111,542 patent/US6673968B1/en not_active Expired - Lifetime
- 2000-10-11 PL PL355149A patent/PL199010B1/pl unknown
- 2000-10-23 MY MYPI20004986A patent/MY122651A/en unknown
- 2000-11-10 UA UA2002054204A patent/UA73329C2/uk unknown
2002
- 2002-04-25 NO NO20021950A patent/NO328250B1/no not_active IP Right Cessation
- 2002-05-23 ZA ZA200204119A patent/ZA200204119B/xx unknown

Also Published As

Publication number	Publication date
MY122651A (en)	2006-04-29
NO20021950D0 (no)	2002-04-25
CN1202078C (zh)	2005-05-18
PL355149A1 (en)	2004-04-05
ATE250026T1 (de)	2003-10-15
ES2204712T3 (es)	2004-05-01
DE19951418A1 (de)	2001-05-03
KR20020044572A (ko)	2002-06-15
AU782471B2 (en)	2005-08-04
ZA200204119B (en)	2003-10-29
MXPA02004144A (es)	2006-01-12
SI1224166T1 (en)	2004-04-30
CZ299201B6 (cs)	2008-05-14
HUP0203132A2 (hu)	2003-01-28
CA2388915A1 (en)	2001-05-03
CN1382120A (zh)	2002-11-27
CA2388915C (en)	2009-12-15
BR0015022A (pt)	2002-06-18
AU1136101A (en)	2001-05-08
NO328250B1 (no)	2010-01-18
HUP0203132A3 (en)	2004-12-28
NO20021950L (no)	2002-04-25
EP1224166A1 (de)	2002-07-24
SK5462002A3 (en)	2002-10-08
DE50003759D1 (de)	2003-10-23
US6673968B1 (en)	2004-01-06
RU2276134C2 (ru)	2006-05-10
PL199010B1 (pl)	2008-08-29
WO2001030750A1 (de)	2001-05-03
SK286603B6 (sk)	2009-02-05
HK1051358A1 (en)	2003-08-01
UA73329C2 (uk)	2005-07-15
PT1224166E (pt)	2004-02-27
CZ20021354A3 (cs)	2002-09-11
JP4969750B2 (ja)	2012-07-04
HU228634B1 (en)	2013-04-29
JP2003512451A (ja)	2003-04-02
EP1224166B1 (de)	2003-09-17
KR100699571B1 (ko)	2007-03-23

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