DK1224166T3 - Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid - Google Patents

Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid

Info

Publication number
DK1224166T3
DK1224166T3 DK00972725T DK00972725T DK1224166T3 DK 1224166 T3 DK1224166 T3 DK 1224166T3 DK 00972725 T DK00972725 T DK 00972725T DK 00972725 T DK00972725 T DK 00972725T DK 1224166 T3 DK1224166 T3 DK 1224166T3
Authority
DK
Denmark
Prior art keywords
preparation
methanesulfonyl
benzoyl
bis
methyl
Prior art date
Application number
DK00972725T
Other languages
English (en)
Inventor
Rolf Gericke
Manfred Baumgarth
Hans Markus Bender
Bernhard Ladstetter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1224166T3 publication Critical patent/DK1224166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00972725T 1999-10-26 2000-10-11 Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid DK1224166T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19951418A DE19951418A1 (de) 1999-10-26 1999-10-26 Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
PCT/EP2000/009977 WO2001030750A1 (de) 1999-10-26 2000-10-11 Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid

Publications (1)

Publication Number Publication Date
DK1224166T3 true DK1224166T3 (da) 2004-01-05

Family

ID=7926842

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00972725T DK1224166T3 (da) 1999-10-26 2000-10-11 Fremgangsmåde til fremstilling af N-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin-hydrochlorid

Country Status (25)

Country Link
US (1) US6673968B1 (da)
EP (1) EP1224166B1 (da)
JP (1) JP4969750B2 (da)
KR (1) KR100699571B1 (da)
CN (1) CN1202078C (da)
AT (1) ATE250026T1 (da)
AU (1) AU782471B2 (da)
BR (1) BR0015022A (da)
CA (1) CA2388915C (da)
CZ (1) CZ299201B6 (da)
DE (2) DE19951418A1 (da)
DK (1) DK1224166T3 (da)
ES (1) ES2204712T3 (da)
HU (1) HU228634B1 (da)
MX (1) MXPA02004144A (da)
MY (1) MY122651A (da)
NO (1) NO328250B1 (da)
PL (1) PL199010B1 (da)
PT (1) PT1224166E (da)
RU (1) RU2276134C2 (da)
SI (1) SI1224166T1 (da)
SK (1) SK286603B6 (da)
UA (1) UA73329C2 (da)
WO (1) WO2001030750A1 (da)
ZA (1) ZA200204119B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
CA2524718A1 (en) * 2003-05-06 2004-11-18 Michael Kirschbaum Method for crystallizing guanidinium salts
WO2009135583A1 (en) * 2008-05-09 2009-11-12 Merck Patent Gmbh Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
MA53572A1 (fr) * 2013-06-10 2021-10-29 Amgen Inc Procédés de production et formes cristallines d'un inhibiteur mdm2
WO2015198945A1 (ja) * 2014-06-23 2015-12-30 日産化学工業株式会社 スルホニル結合を有するシラン化合物の製造方法
CA3228796A1 (en) * 2016-02-08 2017-08-17 Merck Patent Gmbh Crystalline modifications of n-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride and n-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts
EP3960165A1 (en) * 2020-08-25 2022-03-02 Fondation EspeRare Nhe-1 inhibitors for the treatment of coronavirus infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59216865A (ja) * 1983-05-26 1984-12-06 Mitsui Toatsu Chem Inc システイン塩酸塩水和物の乾燥方法
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DK0589336T3 (da) * 1992-09-22 1997-06-16 Hoechst Ag Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
JP3755908B2 (ja) * 1994-08-17 2006-03-15 塩野義製薬株式会社 セファロスポリン化合物の晶析法
DE59603311D1 (de) * 1995-01-30 1999-11-18 Hoechst Ag Basisch-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19502895A1 (de) * 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
DE19526381A1 (de) * 1995-07-19 1997-01-23 Hoechst Ag 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19529612A1 (de) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
HUP0203132A2 (hu) 2003-01-28
ATE250026T1 (de) 2003-10-15
SI1224166T1 (en) 2004-04-30
AU1136101A (en) 2001-05-08
CA2388915A1 (en) 2001-05-03
KR100699571B1 (ko) 2007-03-23
NO20021950L (no) 2002-04-25
PL355149A1 (en) 2004-04-05
HK1051358A1 (en) 2003-08-01
EP1224166B1 (de) 2003-09-17
UA73329C2 (uk) 2005-07-15
KR20020044572A (ko) 2002-06-15
JP4969750B2 (ja) 2012-07-04
ES2204712T3 (es) 2004-05-01
CZ299201B6 (cs) 2008-05-14
CA2388915C (en) 2009-12-15
US6673968B1 (en) 2004-01-06
PT1224166E (pt) 2004-02-27
CN1382120A (zh) 2002-11-27
DE19951418A1 (de) 2001-05-03
PL199010B1 (pl) 2008-08-29
NO20021950D0 (no) 2002-04-25
AU782471B2 (en) 2005-08-04
HU228634B1 (en) 2013-04-29
CN1202078C (zh) 2005-05-18
MXPA02004144A (es) 2006-01-12
WO2001030750A1 (de) 2001-05-03
BR0015022A (pt) 2002-06-18
HUP0203132A3 (en) 2004-12-28
CZ20021354A3 (cs) 2002-09-11
MY122651A (en) 2006-04-29
SK286603B6 (sk) 2009-02-05
DE50003759D1 (de) 2003-10-23
NO328250B1 (no) 2010-01-18
EP1224166A1 (de) 2002-07-24
SK5462002A3 (en) 2002-10-08
RU2276134C2 (ru) 2006-05-10
ZA200204119B (en) 2003-10-29
JP2003512451A (ja) 2003-04-02

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