DK1237549T3 - Lipoxin A4 og dets analoger til behandling af törre öjne - Google Patents

Lipoxin A4 og dets analoger til behandling af törre öjne

Info

Publication number
DK1237549T3
DK1237549T3 DK00977069T DK00977069T DK1237549T3 DK 1237549 T3 DK1237549 T3 DK 1237549T3 DK 00977069 T DK00977069 T DK 00977069T DK 00977069 T DK00977069 T DK 00977069T DK 1237549 T3 DK1237549 T3 DK 1237549T3
Authority
DK
Denmark
Prior art keywords
lipoxin
analogues
treatment
dry eyes
eyes
Prior art date
Application number
DK00977069T
Other languages
Danish (da)
English (en)
Inventor
Daniel A Gamache
Gustav Graff
Mark R Hellberg
Peter G Klimko
John M Yanni
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DK1237549T3 publication Critical patent/DK1237549T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK00977069T 1999-11-09 2000-11-08 Lipoxin A4 og dets analoger til behandling af törre öjne DK1237549T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16440699P 1999-11-09 1999-11-09
PCT/US2000/030707 WO2001034144A1 (en) 1999-11-09 2000-11-08 Lipoxin a4 and its analogs for the treatment of dry eye

Publications (1)

Publication Number Publication Date
DK1237549T3 true DK1237549T3 (da) 2004-06-07

Family

ID=22594348

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00977069T DK1237549T3 (da) 1999-11-09 2000-11-08 Lipoxin A4 og dets analoger til behandling af törre öjne

Country Status (17)

Country Link
US (1) US6645978B1 (pl)
EP (1) EP1237549B1 (pl)
JP (1) JP2003514782A (pl)
CN (1) CN1387435A (pl)
AT (1) ATE258791T1 (pl)
AU (1) AU1475701A (pl)
BR (1) BR0015392A (pl)
CA (1) CA2386878A1 (pl)
DE (1) DE60008143T2 (pl)
DK (1) DK1237549T3 (pl)
ES (1) ES2215752T3 (pl)
HK (1) HK1046365A1 (pl)
MX (1) MXPA02004617A (pl)
PL (1) PL356100A1 (pl)
PT (1) PT1237549E (pl)
TR (2) TR200201244T2 (pl)
WO (1) WO2001034144A1 (pl)

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US8722654B2 (en) * 2001-03-02 2014-05-13 The Brigham And Women's Hospital, Inc. Lipoxin analogs as novel inhibitors of angiogenesis
MXPA04003299A (es) * 2001-10-11 2004-07-23 Alcon Inc Metodos para tratar la resequedad ocular mediante una combinacion de un esteroide antiinflamatorio y un secretagogo muc-1.
US6831186B2 (en) 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
WO2004028536A1 (en) * 2002-09-30 2004-04-08 Babizhayev Mark A Method for topical treatment of eye disease and composition and device for said treatment
US20050208102A1 (en) * 2003-04-09 2005-09-22 Schultz Clyde L Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) * 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
CN100522147C (zh) 2004-05-14 2009-08-05 爱尔康公司 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
ATE452659T1 (de) * 2004-10-01 2010-01-15 Menicon Co Ltd Verfahren zur sterilisation verpackter kontaktlinsen mit verpackungslösung
BRPI0517972A (pt) * 2004-11-09 2008-10-21 Alcon Inc ácido 5,6,7-triidroxiheptanóico e análogos para o tratamento de doenças oculares e doenças associadas com respostas hiperproliferativas e angiogênicas
US20060134171A1 (en) * 2004-12-16 2006-06-22 Alcon, Inc. Agents which regulate, inhibit, or modulate the activity and/or expression of formyl peptide receptors as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
US20060154981A1 (en) * 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
US7687539B1 (en) 2005-11-07 2010-03-30 Alcon Research, Ltd. Method of treating ocular allergy
US7906678B2 (en) 2006-12-04 2011-03-15 Bayer Schering Pharma Aktiengesellschaft Crystalline potassium salt of lipoxin A4 analogs
AU2014201375B2 (en) * 2007-10-12 2015-11-05 Resolvyx Pharmaceuticals, Inc. Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions
EP2214660A2 (en) * 2007-10-12 2010-08-11 Resolvyx Pharmaceuticals, Inc. Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions
US20100324138A1 (en) * 2007-10-29 2010-12-23 Bazan Nicolas G Lipoxin A4 Protection for Retinal Cells
EP2209471A4 (en) * 2007-10-30 2010-11-10 Univ Louisiana State LIPOXIN A4 PROTECTION FOR ENDOTHELIAL CELLS OF THE HORN SKIN
US10383839B2 (en) * 2011-06-30 2019-08-20 Johnson & Johnson Vision Care, Inc. Esters for treatment of ocular inflammatory conditions
US20180116990A1 (en) * 2016-10-04 2018-05-03 UND Life Sciences, LLC Composition of bioactive lipids and methods of use thereof
US11439615B2 (en) * 2017-03-09 2022-09-13 University Health Network Lipoxin and lipoxin analogue mediated neuroprotection and treatments

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US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
US4576758A (en) * 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4744980A (en) 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4818537A (en) 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US5075104A (en) 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5079261A (en) 1989-04-28 1992-01-07 Brigham And Women's Hospital Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis
US5174988A (en) 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
ZA912797B (en) 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
EP0459148B1 (en) * 1990-05-29 1996-01-03 Ocular Research Of Boston Inc. Dry eye treatment composition
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
ZA927277B (en) 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
EP0643581B1 (en) 1992-04-21 1999-10-20 The Schepens Eye Research Institute, Inc. Ocular androgen therapy in sjögren's syndrome
US5290572A (en) 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5441951A (en) 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
DE69435125D1 (de) * 1993-06-15 2008-10-02 Brigham & Womens Hospital Lipoxinverbindungen mit verlängerter halbwertszeit
US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
US5696166A (en) 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol

Also Published As

Publication number Publication date
EP1237549B1 (en) 2004-02-04
CA2386878A1 (en) 2001-05-17
MXPA02004617A (es) 2004-09-10
JP2003514782A (ja) 2003-04-22
EP1237549A1 (en) 2002-09-11
AU1475701A (en) 2001-06-06
CN1387435A (zh) 2002-12-25
PL356100A1 (pl) 2004-06-14
DE60008143T2 (de) 2004-12-30
US6645978B1 (en) 2003-11-11
BR0015392A (pt) 2002-06-25
ATE258791T1 (de) 2004-02-15
TR200400526T4 (tr) 2004-04-21
DE60008143D1 (de) 2004-03-11
HK1046365A1 (zh) 2003-01-10
ES2215752T3 (es) 2004-10-16
WO2001034144A1 (en) 2001-05-17
PT1237549E (pt) 2004-06-30
TR200201244T2 (tr) 2002-08-21

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