DK1242452T3 - Kimære natriuretiske peptider - Google Patents
Kimære natriuretiske peptiderInfo
- Publication number
- DK1242452T3 DK1242452T3 DK00988092T DK00988092T DK1242452T3 DK 1242452 T3 DK1242452 T3 DK 1242452T3 DK 00988092 T DK00988092 T DK 00988092T DK 00988092 T DK00988092 T DK 00988092T DK 1242452 T3 DK1242452 T3 DK 1242452T3
- Authority
- DK
- Denmark
- Prior art keywords
- natriuretic peptides
- chimeric natriuretic
- peptides
- chimeric
- natriuretics
- Prior art date
Links
- 108020001621 Natriuretic Peptide Proteins 0.000 title 1
- 102000004571 Natriuretic peptide Human genes 0.000 title 1
- 239000000692 natriuretic peptide Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000272093 Dendroaspis Species 0.000 abstract 1
- 108091006116 chimeric peptides Proteins 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 230000001452 natriuretic effect Effects 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/466,268 US6407211B1 (en) | 1999-12-17 | 1999-12-17 | Chimeric natriuretic peptides |
| PCT/US2000/034080 WO2001044284A2 (en) | 1999-12-17 | 2000-12-15 | Chimeric natriuretic peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1242452T3 true DK1242452T3 (da) | 2007-06-11 |
Family
ID=23851133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00988092T DK1242452T3 (da) | 1999-12-17 | 2000-12-15 | Kimære natriuretiske peptider |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6407211B1 (da) |
| EP (1) | EP1242452B1 (da) |
| JP (1) | JP5031964B2 (da) |
| AT (1) | ATE353916T1 (da) |
| AU (1) | AU2433901A (da) |
| CA (1) | CA2395585C (da) |
| DE (1) | DE60033431T2 (da) |
| DK (1) | DK1242452T3 (da) |
| ES (1) | ES2282160T3 (da) |
| PT (1) | PT1242452E (da) |
| WO (1) | WO2001044284A2 (da) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000071576A2 (en) * | 1999-05-24 | 2000-11-30 | Mayo Foundation For Medical Education And Research | Adenovirus vectors encoding brain natriuretic peptide |
| US6407211B1 (en) * | 1999-12-17 | 2002-06-18 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides |
| US20040063630A1 (en) * | 2002-03-18 | 2004-04-01 | Scios, Inc. | Treatment of congestive heart failure with natriuretic peptide and a diuretic |
| US20050113286A1 (en) * | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| WO2004022579A2 (en) * | 2002-09-06 | 2004-03-18 | University Of South Florida | Cellular delivery of natriuretic peptides |
| AU2003268531A1 (en) | 2002-09-06 | 2004-03-29 | University Of South Florida | Materials and methods for treatment of allergic diseases |
| US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| BR0316560A (pt) * | 2002-11-26 | 2005-10-04 | Nobex Corp | Conjugado de composto natriurético, formulação farmacêutica, método de tratar uma condição, método de preparação do conjugado de composto natriurético, conjugado de peptìdeo pró-polinatriurético modificado, análogo de peptìdeo natriurético, análogo de hbnp, composto, e, método de preparar um composto |
| WO2004097368A2 (en) * | 2003-04-28 | 2004-11-11 | Ciphergen Biosystems, Inc. | Improved immunoassays |
| CN101208353B (zh) | 2003-06-20 | 2011-12-14 | 梅约医学教育与研究基金会 | 脑利尿钠肽的同种型 |
| GB2403533A (en) * | 2003-06-30 | 2005-01-05 | Orion Corp | Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof |
| US7291501B2 (en) * | 2003-07-16 | 2007-11-06 | Abbott Laboratories | Stable compositions for measuring human natriuretic peptides |
| US7445933B2 (en) * | 2003-07-16 | 2008-11-04 | Abbott Laboratories, Inc. | Stable calibrators or controls for measuring human natriuretic peptides |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| WO2005094420A2 (en) * | 2004-02-17 | 2005-10-13 | University Of South Florida | Materials and methods for treatment of inflammatory and cell proliferation disorders |
| PL2348114T3 (pl) | 2004-04-21 | 2019-08-30 | Alexion Pharmaceuticals, Inc. | Koniugaty do dostarczania do kości i sposób ich wykorzystania do nakierowywania białek na kość |
| ATE496060T1 (de) * | 2004-07-15 | 2011-02-15 | Univ Queensland | Proteinartige verbindungen und anwendungen davon |
| AT500800B1 (de) * | 2004-09-08 | 2008-07-15 | Biomedica Medizinprodukte Gmbh | Verfahren zur bestimmung von probnp |
| WO2006076471A2 (en) * | 2005-01-12 | 2006-07-20 | Nobex Corporation | Bnp conjugates and methods of use |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| BRPI0606992A2 (pt) | 2005-02-11 | 2009-07-28 | Amylin Pharmaceuticals Inc | análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis |
| EP2510942B1 (en) | 2005-04-07 | 2015-09-02 | Cardiorentis AG | Use of natriuretic peptide for treating heart failure |
| AU2006279680B2 (en) * | 2005-08-11 | 2012-12-06 | Amylin Pharmaceuticals, Llc | Hybrid polypeptides with selectable properties |
| US7803901B2 (en) * | 2005-09-16 | 2010-09-28 | Mayo Foundation For Medical Education And Research | Polypeptides with natriuresis activity |
| US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| MX2008012663A (es) | 2006-03-30 | 2008-10-13 | Palatin Technologies Inc | Constructos ciclicos de peptidos natriureticos. |
| AU2007233123A1 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
| CA2656990A1 (en) * | 2006-04-28 | 2007-11-08 | University Of South Florida | Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor |
| BRPI0716416A2 (pt) | 2006-08-08 | 2016-10-11 | Mayo Foundation | polipeptídeo substancialmente puro entre 37 e 47 besíduos de aminoácido de comprimento, ácido nucléico isolado, vetor: célula hospedeira e composição farmacêutica |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| MX2009002504A (es) * | 2006-09-08 | 2009-05-22 | Mayo Foundation | Polipeptidos acuareticos y natriureticos que carecen de actividad vasodilatadora. |
| US20100062984A1 (en) * | 2007-01-25 | 2010-03-11 | Rajiv Kumar | Fgf-23 polypeptides |
| AU2008279379B2 (en) * | 2007-07-20 | 2016-03-24 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides |
| WO2009036448A2 (en) | 2007-09-15 | 2009-03-19 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-c agonists |
| WO2009055644A2 (en) * | 2007-10-24 | 2009-04-30 | California Institute Of Technology | Methods using the grueneberg ganglion chemosensory system |
| EP2217620A2 (en) * | 2007-11-21 | 2010-08-18 | BioMarin Pharmaceutical Inc. | Variants of c-type natriuretic peptide |
| WO2009086126A2 (en) * | 2007-12-21 | 2009-07-09 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides |
| US9482677B2 (en) | 2008-02-27 | 2016-11-01 | Scios Inc. | Method, composition and device for sampling natriuretic peptides in a biological fluid |
| KR20110020903A (ko) * | 2008-06-06 | 2011-03-03 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 키메라 나트륨이뇨성 폴리펩티드 및 심장 리모델링 억제 방법 |
| WO2010033216A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
| EP2898900B1 (en) | 2008-09-19 | 2017-11-15 | Nektar Therapeutics | Polymer conjugates of ziconotide |
| US8642550B2 (en) * | 2008-10-24 | 2014-02-04 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides without hypotensive inducing capability |
| WO2010078325A2 (en) * | 2008-12-29 | 2010-07-08 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides for reducing or preventing restenosis |
| US20120053123A1 (en) * | 2009-05-05 | 2012-03-01 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides having mutations within their disulfide rings |
| HUE032582T2 (en) | 2009-05-20 | 2017-09-28 | Biomarin Pharm Inc | Variants of c-type natriuretic peptide |
| WO2011005939A2 (en) | 2009-07-09 | 2011-01-13 | Mayo Foundation For Medical Education And Research | Long acting atrial natriuretic peptide (la-anp) and methods for use thereof |
| KR101226165B1 (ko) * | 2009-07-23 | 2013-01-24 | 가부시키가이샤 이기스 | 피부 외용제 조성물 |
| JP4790096B2 (ja) | 2009-08-27 | 2011-10-12 | 株式会社 イギス | 鼻炎治療剤 |
| WO2012013597A1 (de) | 2010-07-28 | 2012-02-02 | Justus-Liebig-Universität Giessen | Stoffe und deren verwendung zur beeinflussung natriuretischer peptidrezeptoren |
| DE102010032482A1 (de) | 2010-07-28 | 2012-02-02 | Justus-Liebig-Universität Giessen | Stoffe zur Beeinflussung der natriuretischen Peptid-Rezeptoren A und B und deren Verwendung |
| EP2601531A1 (en) | 2010-08-04 | 2013-06-12 | IDEXX Laboratories, Inc. | Detection of degradation products of canine nt-probnp |
| US9314507B2 (en) | 2010-10-29 | 2016-04-19 | Capricor Therapeutics, Inc. | Methods of treatment of heart failure with natriuretic peptides |
| EP2658979B1 (en) | 2010-12-27 | 2018-02-14 | Alexion Pharmaceuticals, Inc. | Compositions comprising natriuretic peptides and methods of use thereof |
| DK2666475T3 (da) | 2011-01-21 | 2017-11-20 | Igisu Co Ltd | Terapeutisk middel til skaldethed |
| EP2678002A2 (en) | 2011-02-25 | 2014-01-01 | Medtronic, Inc. | Therapy for kidney disease and/or heart failure |
| US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
| US8481333B2 (en) | 2011-05-31 | 2013-07-09 | Idexx Laboratories, Inc. | Detection of degradation products of feline NT-proBNP |
| CN107090028A (zh) | 2011-08-30 | 2017-08-25 | 梅约医学教育与研究基金会 | 利钠多肽 |
| EP2750697A4 (en) | 2011-09-02 | 2015-03-25 | Medtronic Inc | CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
| SG11201401605QA (en) | 2011-10-19 | 2014-09-26 | Alexion Pharma Holding | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| WO2013070741A1 (en) * | 2011-11-11 | 2013-05-16 | Mayo Foundation For Medical Education And Research | Methods and materials for regulating natriuretic polypeptide function |
| WO2013103896A1 (en) | 2012-01-06 | 2013-07-11 | Mayo Foundation For Medical Education And Research | Treating cardiovascular or renal diseases |
| EP2833957A4 (en) * | 2012-04-02 | 2016-03-09 | Capricor Therapeutics Inc | THERAPY FOR CHILDREN'S DISEASE AND / OR HEART FAILURE THROUGH INTRADERMAL INFUSION |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US8835601B2 (en) * | 2012-12-21 | 2014-09-16 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptide delivery systems |
| JP2016505065A (ja) * | 2013-01-25 | 2016-02-18 | カーディオレンティス リミテッド | 心血管症候の治療方法 |
| CN103159847B (zh) * | 2013-04-12 | 2014-05-28 | 叶亮 | 一种利钠肽及其基因与用途 |
| WO2014209229A1 (en) * | 2013-06-25 | 2014-12-31 | National University Of Singapore | Vasodilation peptides and uses thereof |
| US9863900B2 (en) | 2014-01-28 | 2018-01-09 | Transtech Systems, Inc. | Planar sensor array for non-destructive evaluation of material using electromagnetic impedance |
| US10822596B2 (en) | 2014-07-11 | 2020-11-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for treating craniosynostosis |
| US10161893B2 (en) | 2014-08-19 | 2018-12-25 | Transtech Systems, Inc. | Characterization of material under test (MUT) with electromagnetic impedance spectroscopy |
| WO2016090251A1 (en) | 2014-12-05 | 2016-06-09 | Alexion Pharmaceuticals, Inc. | Treating seizure with recombinant alkaline phosphatase |
| US10603361B2 (en) | 2015-01-28 | 2020-03-31 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| AU2016272282A1 (en) | 2015-05-29 | 2018-01-25 | Igisu Co., Ltd. | Cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide |
| AU2016308624B2 (en) | 2015-08-17 | 2022-06-23 | Alexion Pharmaceuticals, Inc. | Manufacturing of alkaline phosphatases |
| EP3355904A4 (en) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| EP3426286A4 (en) | 2016-03-08 | 2019-12-04 | Alexion Pharmaceuticals, Inc. | PROCESS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN |
| WO2017173395A1 (en) | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| KR20180125979A (ko) | 2016-04-01 | 2018-11-26 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| US10988744B2 (en) | 2016-06-06 | 2021-04-27 | Alexion Pharmaceuticals, Inc. | Method of producing alkaline phosphatase |
| EP4403566A3 (en) * | 2016-08-18 | 2024-08-21 | National University of Singapore | Peptides with vasodilatory and/or diuretic functions |
| JP7018933B2 (ja) | 2016-08-18 | 2022-02-14 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 気管気管支軟化症の治療方法 |
| MX2019011508A (es) | 2017-03-31 | 2019-11-01 | Alexion Pharma Inc | Metodos para tratar la hipofosfatasia (hpp) en adultos y adolescentes. |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| JP7820148B2 (ja) | 2018-08-10 | 2026-02-25 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | アルカリホスファターゼを用いて神経線維腫症1型および関連状態を治療する方法 |
| MX2022007114A (es) | 2019-12-09 | 2022-07-11 | Alexion Pharma Inc | Polipeptidos de fosfatasa alcalina y metodos de uso de los mismos. |
| MX2023002673A (es) | 2020-09-04 | 2023-05-12 | Alexion Pharma Inc | Métodos para el tratamiento de trastornos de mineralización ósea. |
| EP4291224A4 (en) | 2021-02-12 | 2025-01-01 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12077561B2 (en) | 2022-11-02 | 2024-09-03 | Novo Nordisk A/S | CNP compounds |
| WO2025054172A1 (en) | 2023-09-05 | 2025-03-13 | E-Star Biotech, LLC | Formulations of manp and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862925A (en) | 1973-07-05 | 1975-01-28 | American Home Prod | Preparation of somatotropin release inhibiting factor and intermediates therefor |
| US3842067A (en) | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
| JPS5726506B2 (da) | 1974-03-08 | 1982-06-04 | ||
| US4105602A (en) | 1975-02-10 | 1978-08-08 | Armour Pharmaceutical Company | Synthesis of peptides with parathyroid hormone activity |
| US4161521A (en) | 1975-08-08 | 1979-07-17 | Merck & Co., Inc. | Somatostatin analogs |
| US4051842A (en) | 1975-09-15 | 1977-10-04 | International Medical Corporation | Electrode and interfacing pad for electrical physiological systems |
| DE2626348C3 (de) | 1976-06-11 | 1980-01-31 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Implantierbare Dosiereinrichtung |
| NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| US4383529A (en) | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4757048A (en) | 1985-11-05 | 1988-07-12 | Biotechnology Research Associates J.V. | Synthetic analogs of atrial natriuretic peptides |
| US5560922A (en) | 1986-05-30 | 1996-10-01 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process |
| US4804650A (en) | 1986-10-28 | 1989-02-14 | Biotechnology Research Associates, J.V. | Analogs of atrial natriuretic peptides |
| US5691310A (en) * | 1987-09-29 | 1997-11-25 | Vesely; David L. | Methods of treatment using proANF peptides |
| US5047397A (en) | 1988-08-26 | 1991-09-10 | California Biotechnology Inc. | Linear analogs of atrial natriuretic peptides |
| US4935492A (en) | 1987-12-24 | 1990-06-19 | California Biotechnology Inc. | Cyclic analogs of atrial natriuretic peptides |
| CA1339210C (en) | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| US5114923A (en) | 1988-05-31 | 1992-05-19 | California Biotechnology Inc. | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5202239A (en) | 1990-08-07 | 1993-04-13 | Scios Nova Inc. | Expression of recombinant polypeptides with improved purification |
| EP0659209A1 (en) | 1991-07-26 | 1995-06-28 | The University Of Rochester | Cancer therapy utilizing malignant cells |
| AU6360394A (en) | 1993-03-03 | 1994-09-26 | Mayo Foundation For Medical Education And Research | Vasonatrin peptide and analogs thereof |
| AU1981597A (en) | 1996-03-04 | 1997-09-22 | Scios Inc. | Assay and reagents for quantifying hbnp |
| US5848956A (en) | 1997-03-18 | 1998-12-15 | Grettner; Norman L. | Multi-purpose lat sling |
| AU9487698A (en) * | 1997-09-11 | 1999-03-29 | Music Foundation For Research Development | Methods and compositions for treating cardiac and renal disorders with atrial natriuretic peptide and tissue kallikrein gene therapy |
| WO2000071576A2 (en) * | 1999-05-24 | 2000-11-30 | Mayo Foundation For Medical Education And Research | Adenovirus vectors encoding brain natriuretic peptide |
| US6407211B1 (en) * | 1999-12-17 | 2002-06-18 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides |
-
1999
- 1999-12-17 US US09/466,268 patent/US6407211B1/en not_active Expired - Lifetime
-
2000
- 2000-12-15 DK DK00988092T patent/DK1242452T3/da active
- 2000-12-15 PT PT00988092T patent/PT1242452E/pt unknown
- 2000-12-15 WO PCT/US2000/034080 patent/WO2001044284A2/en not_active Ceased
- 2000-12-15 ES ES00988092T patent/ES2282160T3/es not_active Expired - Lifetime
- 2000-12-15 AU AU24339/01A patent/AU2433901A/en not_active Abandoned
- 2000-12-15 AT AT00988092T patent/ATE353916T1/de active
- 2000-12-15 JP JP2001544773A patent/JP5031964B2/ja not_active Expired - Fee Related
- 2000-12-15 DE DE60033431T patent/DE60033431T2/de not_active Expired - Lifetime
- 2000-12-15 EP EP00988092A patent/EP1242452B1/en not_active Expired - Lifetime
- 2000-12-15 CA CA2395585A patent/CA2395585C/en not_active Expired - Fee Related
-
2002
- 2002-03-26 US US10/106,806 patent/US6818619B2/en not_active Expired - Lifetime
-
2004
- 2004-09-23 US US10/947,730 patent/US7384917B2/en not_active Expired - Lifetime
-
2008
- 2008-05-15 US US12/120,842 patent/US7964564B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE353916T1 (de) | 2007-03-15 |
| US7384917B2 (en) | 2008-06-10 |
| PT1242452E (pt) | 2007-05-31 |
| JP5031964B2 (ja) | 2012-09-26 |
| CA2395585C (en) | 2014-09-09 |
| US6818619B2 (en) | 2004-11-16 |
| WO2001044284A2 (en) | 2001-06-21 |
| US20020082219A1 (en) | 2002-06-27 |
| US20090170756A1 (en) | 2009-07-02 |
| WO2001044284A3 (en) | 2002-01-31 |
| AU2433901A (en) | 2001-06-25 |
| US20030069186A1 (en) | 2003-04-10 |
| DE60033431D1 (de) | 2007-03-29 |
| JP2003517005A (ja) | 2003-05-20 |
| US6407211B1 (en) | 2002-06-18 |
| ES2282160T3 (es) | 2007-10-16 |
| CA2395585A1 (en) | 2001-06-21 |
| EP1242452B1 (en) | 2007-02-14 |
| EP1242452A2 (en) | 2002-09-25 |
| DE60033431T2 (de) | 2007-11-29 |
| US20050059600A1 (en) | 2005-03-17 |
| US7964564B2 (en) | 2011-06-21 |
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