DK124488A - 1-alkylsubstituerede benzimidazolderivater - Google Patents

1-alkylsubstituerede benzimidazolderivater

Info

Publication number: DK124488A
Authority: DK; Denmark
Prior art keywords: alk; compounds; formula; alkyl; substituted
Prior art date: 1987-03-09

Application number

DK124488A

Other languages

English (en)

Other versions

DK124488D0 (da

DK171181B1 (da

Inventor

Frans Eduard Janssens

Gaston Stanislas Marcell Diels

Joseph Leo Ghislanus Torremans

Francois Maria Sommen

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-09

Filing date

1988-03-08

Publication date

1988-09-10

1988-03-08 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1988-03-08 Publication of DK124488D0 publication Critical patent/DK124488D0/da

1988-09-10 Publication of DK124488A publication Critical patent/DK124488A/da

1996-07-15 Application granted granted Critical

1996-07-15 Publication of DK171181B1 publication Critical patent/DK171181B1/da

Links

150000001875 compounds Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
229940058303 antinematodal benzimidazole derivative Drugs 0.000 abstract 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK124488A 1987-03-09 1988-03-08 Substituerede benzimidazol- eller imidazopyridinforbindelser, fremgangsmåde til fremstilling deraf og anti-allergiske præparater indeholdende forbindelserne DK171181B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2373987A	1987-03-09	1987-03-09
US2373987		1987-03-09

Publications (3)

Publication Number	Publication Date
DK124488D0 DK124488D0 (da)	1988-03-08
DK124488A true DK124488A (da)	1988-09-10
DK171181B1 DK171181B1 (da)	1996-07-15

Family

ID=21816923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK124488A DK171181B1 (da)	1987-03-09	1988-03-08	Substituerede benzimidazol- eller imidazopyridinforbindelser, fremgangsmåde til fremstilling deraf og anti-allergiske præparater indeholdende forbindelserne

Country Status (20)

Country	Link
EP (1)	EP0282133B1 (da)
JP (1)	JPS63301879A (da)
KR (1)	KR960009430B1 (da)
CN (1)	CN1026588C (da)
AT (1)	ATE92065T1 (da)
AU (1)	AU593720B2 (da)
CA (1)	CA1266048A (da)
DE (1)	DE3882556T2 (da)
DK (1)	DK171181B1 (da)
ES (1)	ES2059489T3 (da)
FI (1)	FI93728C (da)
HU (1)	HU204270B (da)
IE (1)	IE61595B1 (da)
IL (1)	IL85661A (da)
NO (1)	NO170485C (da)
NZ (1)	NZ223654A (da)
PH (1)	PH26652A (da)
PT (1)	PT86917B (da)
SU (1)	SU1637663A3 (da)
ZA (1)	ZA881660B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL90879A0 (en) *	1988-09-02	1990-02-09	Janssen Pharmaceutica Nv	3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
GB8900380D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives
ES2013411A6 (es) *	1989-03-28	1990-05-01	Espanola Prod Quimicos	Procedimientos de preparacion de nuevos derivados de la 1-difenilmetilpiperidina.
IT1229230B (it) *	1989-05-08	1991-07-26	Dompe Farmaceutici Spa	Piperidinilimidazopiridine farmacologicamente attive.
IT1229231B (it) *	1989-05-08	1991-07-26	Dompe Farmaceutici Spa	Aminoimidazopiridine farmacologicamente attive
DE3915025A1 (de) *	1989-05-08	1990-11-15	Dompe Farmaceutici Spa	2-substituierte 3-(2'aethoxy)-aethyl)-imidazo(4,5-b)pyridinderivate und diese enthaltende arzneimittel
GB9008850D0 (en) *	1990-04-19	1990-06-13	Janssen Pharmaceutica Nv	Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
FR2668150B1 (fr) *	1990-10-17	1994-11-18	Theramex	Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
TW231291B (da) *	1992-01-09	1994-10-01	Janssen Pharmaceutica Nv
WO1995031431A1 (en) *	1994-05-18	1995-11-23	Nisshin Flour Milling Co., Ltd.	Novel diaminomethylidene derivative
DE4425145A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung von Thiazol- und Thiadiazolverbindungen
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
TW429256B (en) *	1995-12-27	2001-04-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
US5998439A (en)	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
FR2771093B1 (fr)	1997-11-19	2000-01-21	Synthelabo	Derives d'imidazole, leur preparation et leur application en therapeutique
IL147327A0 (en)	1999-06-28	2002-08-14	Janssen Pharmaceutica Nv	Respiratory syncytial virus replication inhibitors
KR100453916B1 (ko) *	2002-03-11	2004-10-20	주식회사 코오롱	1,2,5,6-테트라히드로피리디닐벤즈이미다졸 유도체 및 그제조방법
EP1543011B1 (en) *	2002-09-06	2006-05-03	Janssen Pharmaceutica N.V.	Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands
RU2381224C2 (ru) *	2003-12-18	2010-02-10	Тиботек Фармасьютикалз Лтд.	Пиперидинаминобензимидазольные производные как ингибиторы репликации респираторного синцитиального вируса
AR046770A1 (es) *	2003-12-18	2005-12-21	Tibotec Pharm Ltd	Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio
EP1838706A1 (en) *	2004-12-24	2007-10-03	Prosidion Limited	G-protein coupled receptor agonists
NZ556628A (en)	2005-03-08	2009-09-25	Janssen Pharmaceutica Nv	Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
RU2540074C2 (ru) *	2007-06-21	2015-01-27	Кара Терапеутикс, Инк	Производные имидазопиразина или имидазодиазепина, активные в отношении рецептора св2
CZ307500B6 (cs) *	2012-08-15	2018-10-24	Zentiva, K.S.	Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1140119A (en) *	1978-04-03	1983-01-25	Joseph Torremans	N-heterocyclyl-4-piperidinamines
US4556660A (en) *	1982-07-12	1985-12-03	Janssen Pharmaceutica N.V.	N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
DE3484096D1 (de) *	1983-11-30	1991-03-14	Janssen Pharmaceutica Nv	Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
US4588722A (en) *	1984-01-09	1986-05-13	Janssen Pharmaceutica N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
GB8515934D0 (en) *	1985-06-24	1985-07-24	Janssen Pharmaceutica Nv	(4-piperidinomethyl and-hetero)purines
CA1327579C (en) *	1986-02-03	1994-03-08	Frans Eduard Janssens	Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines

1988
- 1988-02-25 NZ NZ223654A patent/NZ223654A/xx unknown
- 1988-02-26 CA CA000559907A patent/CA1266048A/en not_active Expired - Fee Related
- 1988-03-02 ES ES88200398T patent/ES2059489T3/es not_active Expired - Lifetime
- 1988-03-02 DE DE88200398T patent/DE3882556T2/de not_active Expired - Fee Related
- 1988-03-02 AT AT88200398T patent/ATE92065T1/de not_active IP Right Cessation
- 1988-03-02 EP EP88200398A patent/EP0282133B1/en not_active Expired - Lifetime
- 1988-03-04 AU AU12702/88A patent/AU593720B2/en not_active Ceased
- 1988-03-05 SU SU884355374A patent/SU1637663A3/ru active
- 1988-03-08 PT PT86917A patent/PT86917B/pt not_active IP Right Cessation
- 1988-03-08 IE IE66888A patent/IE61595B1/en not_active IP Right Cessation
- 1988-03-08 NO NO881027A patent/NO170485C/no unknown
- 1988-03-08 IL IL85661A patent/IL85661A/xx not_active IP Right Cessation
- 1988-03-08 ZA ZA881660A patent/ZA881660B/xx unknown
- 1988-03-08 FI FI881063A patent/FI93728C/fi not_active IP Right Cessation
- 1988-03-08 DK DK124488A patent/DK171181B1/da active
- 1988-03-08 JP JP63052762A patent/JPS63301879A/ja active Pending
- 1988-03-08 HU HU881121A patent/HU204270B/hu not_active IP Right Cessation
- 1988-03-09 CN CN88101286A patent/CN1026588C/zh not_active Expired - Fee Related
- 1988-03-09 KR KR88002449A patent/KR960009430B1/ko not_active Expired - Fee Related
- 1988-03-09 PH PH36609A patent/PH26652A/en unknown

Also Published As

Publication number	Publication date
KR880011143A (ko)	1988-10-26
ZA881660B (en)	1989-11-29
NZ223654A (en)	1990-03-27
FI93728C (fi)	1995-05-26
SU1637663A3 (ru)	1991-03-23
PH26652A (en)	1992-09-04
IL85661A (en)	1992-07-15
ATE92065T1 (de)	1993-08-15
NO881027L (no)	1988-09-12
CN1026588C (zh)	1994-11-16
DK124488D0 (da)	1988-03-08
NO170485B (no)	1992-07-13
EP0282133A2 (en)	1988-09-14
PT86917A (pt)	1988-04-01
FI93728B (fi)	1995-02-15
EP0282133A3 (en)	1989-06-07
HU204270B (en)	1991-12-30
DE3882556D1 (de)	1993-09-02
CN88101286A (zh)	1988-09-28
FI881063A0 (fi)	1988-03-08
KR960009430B1 (en)	1996-07-19
AU593720B2 (en)	1990-02-15
IL85661A0 (en)	1988-08-31
NO881027D0 (no)	1988-03-08
CA1266048A (en)	1990-02-20
AU1270288A (en)	1988-09-08
NO170485C (no)	1992-10-21
PT86917B (pt)	1992-05-29
FI881063A7 (fi)	1988-09-10
EP0282133B1 (en)	1993-07-28
JPS63301879A (ja)	1988-12-08
DK171181B1 (da)	1996-07-15
DE3882556T2 (de)	1993-11-18
IE61595B1 (en)	1994-11-16
IE880668L (en)	1988-09-09
ES2059489T3 (es)	1994-11-16
HUT46679A (en)	1988-11-28

Publication	Publication Date	Title
ATE92065T1 (de)	1993-08-15	1-alkyl-substituierte benzimidazolderivate.
FI102753B1 (fi)	1999-02-15	Menetelmä uusien, terapeuttisesti käyttökelpoisten substituoitujen tiatsolyyli- ja pyridinyylijohdannaisten valmistamiseksi
DE3874626D1 (de)	1992-10-22	((bizyklisch-heterozyklyl)methyl und -hetero)substituierte hexahydro-1h-azepine und pyrrolidine.
DE69010015D1 (de)	1994-07-28	2-Aminopyrimidinon-Derivate.