DK1246826T3 - Chlorophyl- og bakteriochlorophylestere, deres fremstilling og farmaceutiske præparater omfattende disse estere - Google Patents

Chlorophyl- og bakteriochlorophylestere, deres fremstilling og farmaceutiske præparater omfattende disse estere

Info

Publication number: DK1246826T3
Authority: DK; Denmark
Prior art keywords: sub; sup; esters; coxr; chlorophyll
Prior art date: 1999-12-01

Application number

DK00979916T

Other languages

English (en)

Inventor

Avigdor Scherz

Alexander Brandis

Yoram Salomon

Hugo Scheer

Nina Kammhuber

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-01

Filing date

2000-12-01

Publication date

2006-01-02

2000-12-01 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

2006-01-02 Application granted granted Critical

2006-01-02 Publication of DK1246826T3 publication Critical patent/DK1246826T3/da

Links

DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 title abstract 2
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 title abstract 2
229930002875 chlorophyll Natural products 0.000 title 1
235000019804 chlorophyll Nutrition 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
241000894006 Bacteria Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
239000012678 infectious agent Substances 0.000 abstract 1
238000002428 photodynamic therapy Methods 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)

DK00979916T 1999-12-01 2000-12-01 Chlorophyl- og bakteriochlorophylestere, deres fremstilling og farmaceutiske præparater omfattende disse estere DK1246826T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL13325399A IL133253A0 (en)	1999-12-01	1999-12-01	Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them

Publications (1)

Publication Number	Publication Date
DK1246826T3 true DK1246826T3 (da)	2006-01-02

Family

ID=11073554

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00979916T DK1246826T3 (da)	1999-12-01	2000-12-01	Chlorophyl- og bakteriochlorophylestere, deres fremstilling og farmaceutiske præparater omfattende disse estere

Country Status (18)

Country	Link
US (1)	US7169753B2 (da)
EP (1)	EP1246826B1 (da)
JP (1)	JP2003515538A (da)
CN (1)	CN1222526C (da)
AT (1)	ATE308545T1 (da)
AU (1)	AU777761B2 (da)
BR (1)	BR0016051A (da)
CA (1)	CA2392989A1 (da)
DE (1)	DE60023748T2 (da)
DK (1)	DK1246826T3 (da)
ES (1)	ES2250214T3 (da)
HU (1)	HU224553B1 (da)
IL (1)	IL133253A0 (da)
MX (1)	MXPA02005455A (da)
NO (1)	NO323208B1 (da)
PL (1)	PL356391A1 (da)
RU (1)	RU2250905C2 (da)
WO (1)	WO2001040232A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9192780B2 (en)	1998-11-30	2015-11-24	L'oreal	Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US20060212025A1 (en)	1998-11-30	2006-09-21	Light Bioscience, Llc	Method and apparatus for acne treatment
US6887260B1 (en)	1998-11-30	2005-05-03	Light Bioscience, Llc	Method and apparatus for acne treatment
EP1318807A4 (en) *	2000-08-11	2008-02-20	Ceramoptec Gmbh	LIGHT-SENSITIVE OINTMENT
BR0304716A (pt)	2002-05-08	2004-07-13	Yeda Res & Dev	Método para formação de imagens de mri-bold on line, sensibilizada
IL152900A0 (en)	2002-11-17	2003-06-24	Yeda Res & Dev	Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
EP1648385B1 (en)	2003-07-31	2016-05-04	Gentlewaves Llc	System and method for the photodynamic treatment of skin
CA2437638A1 (en)	2003-08-20	2005-02-20	John Robert North	Photodynamic therapy
CA2457214A1 (en)	2004-02-06	2005-08-06	Qlt Inc.	Photodynamic therapy for the treatment of acne
ZA200700169B (en) *	2004-06-07	2008-05-28	Yeda Res & Dev	Cationic bacteriochlorophyll derivatives and uses thereof
AU2005251395A1 (en)	2004-06-09	2005-12-22	Qlt Inc.	Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied hydrophobic green porphyrins
GB2415372A (en) *	2004-06-23	2005-12-28	Destiny Pharma Ltd	Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
RU2303966C2 (ru) *	2005-10-11	2007-08-10	Федеральное Государственное Учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. академика С.Н. Федорова Федерального агентства по здравоохранению и социальному развитию	Способ снижения поверхностной дозы офтальмоаппликатора при проведении брахитерапии внутриглазных новообразований
RU2345803C2 (ru) *	2006-11-30	2009-02-10	Закрытое Акционерное Общество "Исследовательские лаборатории "РАДА-ФАРМА"	Способ фотоиммунотерапии фотосенсибилизатором, активируемым волновой энергией вне организма человека
RU2336917C1 (ru) *	2007-05-29	2008-10-27	Государственное образовательное учреждение дополнительного профессионального образования Российская медицинская академия последипломного образования Федерального агентства по здравоохранению и социальному развитию (ГОУДПО РМАПО Росздрава)	Способ лечения больных псориазом
US20090036952A1 (en)	2007-07-30	2009-02-05	National Yang-Ming University	Induction driven light module and use thereof
FR2924021B1 (fr) *	2007-11-27	2010-08-13	Du Vernet Michele Eymard	Composition pour le traitement de la peau par therapie photodynamique
EP2244787A1 (en) *	2008-01-28	2010-11-03	Yeda Research And Development Company Ltd.	Endoscopic imaging photodynamic therapy system and methods of use
DK2257309T3 (da)	2008-02-27	2020-01-20	Yeda Res And Development Company Ltd	Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner
CA2824768A1 (en)	2011-01-13	2012-07-19	Qlt Inc.	Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof
AU2012298156B2 (en) *	2011-08-23	2017-08-17	Yeda Research And Development Co.Ltd.	Method for photodynamic therapy of corneal thinning or scleral weakening with bacteriochlorophyll compounds
EP2872178A1 (en)	2012-07-11	2015-05-20	Dermira, Inc.	Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof
WO2015006429A1 (en)	2013-07-12	2015-01-15	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery
AU2017250732B2 (en) *	2016-04-10	2022-11-10	Memorial Sloan-Kettering Cancer Center	Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
CN108341827A (zh) *	2018-02-02	2018-07-31	浙江海正药业股份有限公司	一种制备脱镁细菌叶绿素a及脱镁细菌叶绿素a酯的方法
CN108191877A (zh) *	2018-02-05	2018-06-22	云南瑞宝生物科技股份有限公司	一种从蚕沙中提取和纯化叶绿素的方法
JP2021530492A (ja)	2018-07-12	2021-11-11	ザユナイテッドステイツオブアメリカ，アズリプレゼンテッドバイザセクレタリー，デパートメントオブヘルスアンドヒューマンサービシーズ	包埋された細胞傷害剤を含む二成分脂質二重層含有ベシクル、ならびにそれを作製および使用する方法
CN111171030B (zh) *	2018-11-12	2022-11-22	浙江海正药业股份有限公司	细菌叶绿素衍生物及其制备方法
CN111848656B (zh) *	2020-06-24	2023-03-14	天津大学	离子修饰的原卟啉镓化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU857139A1 (ru) *	1979-11-02	1981-08-23	Предприятие П/Я В-2343	Способ получени порфиринов,содержащих изоциклическое метилциклопентановое кольцо
US5171741A (en)	1989-04-21	1992-12-15	Health Research, Inc.	Bacteriochlorophyll-a derivatives useful in photodynamic therapy
DE4121876A1 (de) *	1991-07-02	1993-01-14	Scheer Hugo	Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung
DE4121867A1 (de)	1991-07-02	1993-01-07	Leifeld & Lemke Maschf	Vorrichtung zur pruefung der dichtigkeit von mit deckeln luftdicht verschlossenen bechern
IL102645A (en) *	1992-07-26	1998-02-22	Yeda Res & Dev	Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
IL116126A0 (en) *	1995-11-24	1996-01-31	Yeda Res & Dev	Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them

1999
- 1999-12-01 IL IL13325399A patent/IL133253A0/xx unknown
2000
- 2000-12-01 CN CNB008186030A patent/CN1222526C/zh not_active Expired - Fee Related
- 2000-12-01 WO PCT/IL2000/000811 patent/WO2001040232A1/en not_active Ceased
- 2000-12-01 AU AU17292/01A patent/AU777761B2/en not_active Ceased
- 2000-12-01 ES ES00979916T patent/ES2250214T3/es not_active Expired - Lifetime
- 2000-12-01 DE DE60023748T patent/DE60023748T2/de not_active Expired - Fee Related
- 2000-12-01 HU HU0204167A patent/HU224553B1/hu not_active IP Right Cessation
- 2000-12-01 RU RU2002117287/04A patent/RU2250905C2/ru not_active IP Right Cessation
- 2000-12-01 PL PL00356391A patent/PL356391A1/xx not_active Application Discontinuation
- 2000-12-01 AT AT00979916T patent/ATE308545T1/de not_active IP Right Cessation
- 2000-12-01 MX MXPA02005455A patent/MXPA02005455A/es active IP Right Grant
- 2000-12-01 BR BR0016051-2A patent/BR0016051A/pt not_active Application Discontinuation
- 2000-12-01 US US10/148,552 patent/US7169753B2/en not_active Expired - Fee Related
- 2000-12-01 EP EP00979916A patent/EP1246826B1/en not_active Expired - Lifetime
- 2000-12-01 DK DK00979916T patent/DK1246826T3/da active
- 2000-12-01 JP JP2001540987A patent/JP2003515538A/ja not_active Abandoned
- 2000-12-01 CA CA002392989A patent/CA2392989A1/en not_active Abandoned
2002
- 2002-05-31 NO NO20022599A patent/NO323208B1/no unknown

Also Published As

Publication number	Publication date
BR0016051A (pt)	2002-07-23
JP2003515538A (ja)	2003-05-07
HUP0204167A2 (hu)	2003-03-28
MXPA02005455A (es)	2002-11-29
CA2392989A1 (en)	2001-06-07
HK1056557A1 (en)	2004-02-20
NO20022599L (no)	2002-07-11
AU1729201A (en)	2001-06-12
ES2250214T3 (es)	2006-04-16
CN1222526C (zh)	2005-10-12
AU777761B2 (en)	2004-10-28
EP1246826B1 (en)	2005-11-02
RU2250905C2 (ru)	2005-04-27
US20030148926A1 (en)	2003-08-07
NO323208B1 (no)	2007-01-22
EP1246826A1 (en)	2002-10-09
PL356391A1 (en)	2004-06-28
CN1425015A (zh)	2003-06-18
NO20022599D0 (no)	2002-05-31
DE60023748D1 (de)	2005-12-08
HU224553B1 (hu)	2005-10-28
US7169753B2 (en)	2007-01-30
WO2001040232A9 (en)	2002-09-12
HUP0204167A3 (en)	2004-08-30
DE60023748T2 (de)	2006-08-03
IL133253A0 (en)	2001-04-30
ATE308545T1 (de)	2005-11-15
WO2001040232A1 (en)	2001-06-07

Publication	Publication Date	Title
DK1246826T3 (da)	2006-01-02	Chlorophyl- og bakteriochlorophylestere, deres fremstilling og farmaceutiske præparater omfattende disse estere
GEP20022804B (en)	2002-09-25	Erythropoietin Derivatives
BR9507506A (pt)	1997-09-02	Processo para exterminar uma célula processo para tratamento de càncer composição e kit terapéutico
ES2136673T3 (es)	1999-12-01	Utilizacion del factor de crecimiento de los queratinocitos para la obtencion de medicamentos.
NO20045521L (no)	2004-12-17	Diarylureaderivater anvendelige for behandling av proteinkinaseavhengige sykdommer
FI955552A0 (fi)	1995-11-17	Adenoviraalisia eläinperäisiä vektoreita ja niiden käyttö geeniterapiassa
CY1106152T1 (el)	2011-06-08	Νεα ανοσογονα αντι-hiv (ανατοξινες), μεθοδοι παρασκευης και εφαρμογη στην προληψη και στην αγωγη του aids
EP1226109A4 (en)	2005-01-26	PHENYLAMINE CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS FOR DISPENSING ACTIVE AGENTS
DE69822496D1 (de)	2004-04-22	Lipidkomplex-lyophilisat von wasserunlöslichen porphyrinen
BRPI0415752A (pt)	2006-12-19	métodos, composições e dispositivos para indução de estase em células, tecidos, órgãos e organismos
NO921454L (no)	1992-06-10	Fremgangsmaater og blandinger for heling av ben
DK0661987T3 (da)	1998-09-14	Morphogeninduceret leverregeneration
RU94046426A (ru)	1997-01-10	Фармацевтические композиции, способы лечения лейкоза, способ повышения уровней стволовых клеток, антагонист с - kit - лиганда, антисмысловая нуклеиновая кислота, способ лечения меланомы, способ усиления трансфекции, способ переноса гена, способ увеличения уровней периферической крови, способ повышения уровней тромбоцитов, способы модификации биологической функции, способ лечения анемии, способ улучшения приживления костного мозга, способ ускорения восстановления костного мозга, способ лечения лейкопении
EP1450771A4 (en)	2005-04-27	PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF TUMORS AND LESIONS OF SKIN AND MICE AND THESE METHOD AND KITS
AU6721998A (en)	1998-09-09	Therapeutic use of the smr1 protein and active derivatives thereof
RU2136695C1 (ru)	1999-09-10	Сывороточный гликопротеин, обладающий биологической активностью в сверхмалых дозах
DK1165102T3 (da)	2004-06-01	Matrixproteinpræparater til podning i ikke-mineraliseret væv
PT941110E (pt)	2004-07-30	Utilizacao do factor 2 de crescimento dos ceratinocitos
DK0588477T3 (da)	1998-03-30	Medicinsk præparat omfatende TCF-11
KR100488038B1 (ko)	2005-05-09	기관 보호 활성을 지닌 신규한 신체 보호 화합물 펩티드염, 이의 제조 방법 및 치료에서의 이의 용도
AU1318797A (en)	1997-08-20	Peptides and uses thereof for therapy of celiac diseases
RU95105249A (ru)	1996-10-27	Гидрохлорид ng монометил-l-аргинина, способы его получения, способ получения фармацевтического препарата и способ лечения
RU94039629A (ru)	1996-09-20	Стимулятор роста костномозговых клеток человека
UA28342A (uk)	2000-10-16	Спосіб одержання біологічно активної речовини для лікування серцевих захворювань
FI972121A0 (fi)	1997-05-19	Sammansaettningar foer reciprok oekning av immunosupperssanters och interferoners farmaceutiska aktiviteter