DK1255559T3 - Anvendelse af inhibitorer af caspase-3 eller den caspaseaktiverede desoxyribonuclease (CAD) til behandlingen af hjertesygdomme - Google Patents

Anvendelse af inhibitorer af caspase-3 eller den caspaseaktiverede desoxyribonuclease (CAD) til behandlingen af hjertesygdomme

Info

Publication number
DK1255559T3
DK1255559T3 DK01913667T DK01913667T DK1255559T3 DK 1255559 T3 DK1255559 T3 DK 1255559T3 DK 01913667 T DK01913667 T DK 01913667T DK 01913667 T DK01913667 T DK 01913667T DK 1255559 T3 DK1255559 T3 DK 1255559T3
Authority
DK
Denmark
Prior art keywords
caspase
cad
inhibitor
inhibitors
treatment
Prior art date
Application number
DK01913667T
Other languages
Danish (da)
English (en)
Inventor
Karl-Ludwig Laugwitz
Alessandra Moretti
Martin Ungerer
Original Assignee
Procorde Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procorde Gmbh filed Critical Procorde Gmbh
Application granted granted Critical
Publication of DK1255559T3 publication Critical patent/DK1255559T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01913667T 2000-02-16 2001-02-16 Anvendelse af inhibitorer af caspase-3 eller den caspaseaktiverede desoxyribonuclease (CAD) til behandlingen af hjertesygdomme DK1255559T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10006889A DE10006889A1 (de) 2000-02-16 2000-02-16 Verwendung von Inhibitoren von Caspase-3 oder der Caspase-aktivierten Desoxyribonuclease (CAD) zur Behandlung von Herzerkrankungen
PCT/DE2001/000616 WO2001060400A2 (fr) 2000-02-16 2001-02-16 Utilisation d'inhibiteurs de la caspase-3 ou de la desoxyribonuclease activee par la caspase (cad) pour le traitement de maladies cardiaques

Publications (1)

Publication Number Publication Date
DK1255559T3 true DK1255559T3 (da) 2004-06-01

Family

ID=7631089

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01913667T DK1255559T3 (da) 2000-02-16 2001-02-16 Anvendelse af inhibitorer af caspase-3 eller den caspaseaktiverede desoxyribonuclease (CAD) til behandlingen af hjertesygdomme

Country Status (9)

Country Link
US (1) US20030130216A1 (fr)
EP (1) EP1255559B1 (fr)
JP (1) JP2003522801A (fr)
AT (1) ATE265227T1 (fr)
AU (1) AU2001239183A1 (fr)
DE (2) DE10006889A1 (fr)
DK (1) DK1255559T3 (fr)
ES (1) ES2220736T3 (fr)
WO (1) WO2001060400A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160859B2 (en) * 2002-10-11 2007-01-09 University Of Medicine & Dentistry Of New Jersey Mst1 modulation of apoptosis in cardiac tissue and modulators of Mst1 for treatment and prevention of cardiac disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2218679A1 (fr) * 1995-04-21 1996-10-24 Merck & Co., Inc. Apopa?ne
AU8915698A (en) * 1997-08-22 1999-03-16 Chiron Corporation Apoptosis-associated nuclease cpan
CN1138472C (zh) * 1997-10-10 2004-02-18 西托维亚公司 二肽型编程性细胞死亡抑制剂及其用途
JPH11239495A (ja) * 1997-12-25 1999-09-07 Osaka Bio Science Kenkyusho カスパ―ゼ活性化ｄｎア―ゼの阻害物質
KR20010041905A (ko) * 1998-03-16 2001-05-25 시토비아 인크. 디펩티드 카스파제 억제제 및 이의 용도
AU7137498A (en) * 1998-04-16 1999-11-08 Board Of Regents, The University Of Texas System Dna fragmentation factor involved in apoptosis

Also Published As

Publication number Publication date
EP1255559B1 (fr) 2004-04-28
US20030130216A1 (en) 2003-07-10
DE10006889A1 (de) 2001-09-06
WO2001060400B1 (fr) 2002-07-18
JP2003522801A (ja) 2003-07-29
DE50102129D1 (de) 2004-06-03
WO2001060400A3 (fr) 2002-04-18
EP1255559A2 (fr) 2002-11-13
ES2220736T3 (es) 2004-12-16
WO2001060400A2 (fr) 2001-08-23
AU2001239183A1 (en) 2001-08-27
ATE265227T1 (de) 2004-05-15

Similar Documents

Publication Publication Date Title
ATE422357T1 (de) Verwendung von allopurinol zur behandlung von bluthochdruck
NO20034204D0 (no) Farmasöytiske kombinasjoner til behandling av kreft
BR0209365A (pt) Usos farmacêuticos de bisfosfonatos
NO962791D0 (no) Preparater inneholdende nukleinsyrer, deres fremstilling og anvendelse
ES2097208T3 (es) Composiciones y procedimientos terapeuticos y sinergicos.
BR9806752A (pt) Ftalazinonas.
BRPI0213786B8 (pt) peptídeos efetivos no tratamento de tumores e outras condições que requerem a remoção ou destruição de células
NO20050450L (no) Kombinasjon av ZD6474, en inhibitor av vaskulaer endotelial vekst faktor reseptor, med radioterapi ved behandling av kreft
DE59510466D1 (de) Lebendvakzine zur behandlung von tumorerkrankungen
DE50010519D1 (de) Pharmazeutische Zusammensetzungen zur Therapie der Herzinsuffizienz
DE60218843D1 (de) Verfahren zur identifizierung von mitteln zur behandlung von diabetes
EA200200533A1 (ru) СПОСОБЫ И КОМПОЗИЦИИ ДЛЯ ЛЕЧЕНИЯ СЕРДЕЧНО-СОСУДИСТОГО ЗАБОЛЕВАНИЯ ДОСТАВКОЙ ГЕНОВ in vivo
DK1255559T3 (da) Anvendelse af inhibitorer af caspase-3 eller den caspaseaktiverede desoxyribonuclease (CAD) til behandlingen af hjertesygdomme
EA200501549A1 (ru) Применение экспрессирующего вектора, кодирующего ингибитор il-18, для лечения и/или профилактики заболевания сердца и способ лечения заболевания сердца
DE69737062D1 (de) Gentherapie für kongestives herzversagen
DE60111620D1 (de) Aktiviertes protein c zur behandlung von pankreatitis
BR0014667A (pt) Prevenção e tratamento de doenças relacionadas à coagulação sanguìnea
ATE344662T1 (de) Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen
ATE395073T1 (de) Behandlung von nicht-alkoholischer steatotischer hepatitis (nash)
EP1143996A4 (fr) Therapie contre une affection cardiaque chronique
WO2003016343A3 (fr) UTILISATION DE αCP1, DE αCP2, ET DE HUR POUR MODULER L'EXPRESSION GENIQUE ET ACTIVER L'ANGIOGENESE
ATE546548T1 (de) Verfahren zur prognose des nutzens einer antioxidationshemmenden therapie zur vorbeugung von herz-kreislauf-erkrankungen bei hyperglykämischen patienten
MX2022000349A (es) Cardioterápico.
NO986041L (no) FremgangsmÕte ved behandling av plantesykdom
SE0100873D0 (sv) Method of treatment