DK1255816T3 - Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse - Google Patents

Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse

Info

Publication number: DK1255816T3
Authority: DK; Denmark
Prior art keywords: peptide synthetases; processes; preparation; nrpss; modification
Prior art date: 1999-10-22

Application number

DK00972794T

Other languages

English (en)

Inventor

Henning Mootz

Dirk Schwarzer

Sascha Doekel

Uwe Linne

Mohamed A Marahiel

Original Assignee

Cubist Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-22

Filing date

2000-10-18

Publication date

2006-10-30

2000-10-18 Application filed by Cubist Pharmaceutical Inc filed Critical Cubist Pharmaceutical Inc

2006-10-30 Application granted granted Critical

2006-10-30 Publication of DK1255816T3 publication Critical patent/DK1255816T3/da

Links

108700018928 Peptide Synthases Proteins 0.000 title abstract 2
102000056222 Peptide Synthases Human genes 0.000 title abstract 2
108010019477 S-adenosyl-L-methionine-dependent N-methyltransferase Proteins 0.000 abstract 3
108010000785 non-ribosomal peptide synthase Proteins 0.000 abstract 3
230000004048 modification Effects 0.000 abstract 2
238000012986 modification Methods 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000010276 construction Methods 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
210000003705 ribosome Anatomy 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK00972794T 1999-10-22 2000-10-18 Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse DK1255816T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19951196A DE19951196A1 (de)	1999-10-22	1999-10-22	Massgeschneiderte Peptidsynthetasen und ihre Verwendung

Publications (1)

Publication Number	Publication Date
DK1255816T3 true DK1255816T3 (da)	2006-10-30

Family

ID=7926708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00972794T DK1255816T3 (da)	1999-10-22	2000-10-18	Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse

Country Status (13)

Country	Link
US (2)	US20100285563A1 (da)
EP (1)	EP1255816B1 (da)
JP (1)	JP2003512835A (da)
KR (1)	KR20020069509A (da)
AT (1)	ATE331027T1 (da)
AU (1)	AU1139901A (da)
CA (1)	CA2384972A1 (da)
DE (2)	DE19951196A1 (da)
DK (1)	DK1255816T3 (da)
ES (1)	ES2267579T3 (da)
IL (1)	IL149158A0 (da)
NO (1)	NO20021810L (da)
WO (1)	WO2001030985A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235651B2 (en)	2001-12-26	2007-06-26	Cubist Pharmaceuticals, Inc.	Genes and proteins involved in the biosynthesis of lipopeptides
EP1458868A2 (en) *	2001-12-26	2004-09-22	Ecopia Biosciences Inc.	Genes and proteins involved in the biosynthesis of lipopeptides
KR100762315B1 (ko) *	2006-01-24	2007-10-04	한국생명공학연구원	푸자리시딘 생합성 효소 및 이를 코딩하는 유전자
WO2008131002A2 (en) *	2007-04-16	2008-10-30	Modular Genetics, Inc.	Generation of acyl amino acids
CN104093831A (zh)	2012-01-31	2014-10-08	中化帝斯曼制药有限公司荷兰公司	半合成抗生素生产中的类MbtH蛋白
US11371066B2 (en)	2015-07-13	2022-06-28	Modular Genetics, Inc.	Generation of acyl alcohols
CN107849542A (zh)	2015-08-05	2018-03-27	默克专利股份公司	人工非核糖体肽合成酶
US11643643B2 (en)	2016-02-08	2023-05-09	Johann Wolfgang Goethe-Universität Frankfurt am Main	Artificial non-ribosomal peptide synthases and their use
EP3511445A1 (en)	2018-01-15	2019-07-17	Johann Wolfgang Goethe-Universität Frankfurt	System for the assembly and modification of non-ribosomal peptide synthases
CN114657155B (zh) *	2021-12-23	2024-01-19	中国农业科学院生物技术研究所	一种新型的非核糖体多肽合成酶拆分表达方法
JP2025526940A (ja)	2022-08-16	2025-08-15	ヨハンヴォルフガングゲーテ－ウニヴェルジテートフランクフルトアムマイン	非リボソームペプチドを工学的に生成する方法および手段

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1264712B1 (it) *	1993-07-13	1996-10-04	Eniricerche Spa	Metodo di sintesi biologica di peptidi
DE19531944A1 (de) *	1995-08-18	1997-02-20	Biopract Gmbh	Neue Endo-Xylanasen
DE19909146A1 (de) *	1999-03-03	2000-09-28	Mohamed A Marahiel	Verfahren zur gezielten biologischen Synthese von Peptiden

1999
- 1999-10-22 DE DE19951196A patent/DE19951196A1/de not_active Ceased
2000
- 2000-10-18 DE DE50013072T patent/DE50013072D1/de not_active Expired - Lifetime
- 2000-10-18 WO PCT/EP2000/010250 patent/WO2001030985A1/de not_active Ceased
- 2000-10-18 IL IL14915800A patent/IL149158A0/xx unknown
- 2000-10-18 AT AT00972794T patent/ATE331027T1/de not_active IP Right Cessation
- 2000-10-18 EP EP00972794A patent/EP1255816B1/de not_active Expired - Lifetime
- 2000-10-18 AU AU11399/01A patent/AU1139901A/en not_active Abandoned
- 2000-10-18 CA CA002384972A patent/CA2384972A1/en not_active Abandoned
- 2000-10-18 DK DK00972794T patent/DK1255816T3/da active
- 2000-10-18 KR KR1020027005167A patent/KR20020069509A/ko not_active Withdrawn
- 2000-10-18 JP JP2001533968A patent/JP2003512835A/ja active Pending
- 2000-10-18 ES ES00972794T patent/ES2267579T3/es not_active Expired - Lifetime
2002
- 2002-04-17 NO NO20021810A patent/NO20021810L/no not_active Application Discontinuation
2010
- 2010-06-21 US US12/819,751 patent/US20100285563A1/en not_active Abandoned
- 2010-06-21 US US12/819,762 patent/US20100297751A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2001030985A1 (de)	2001-05-03
DE19951196A1 (de)	2001-05-10
US20100297751A1 (en)	2010-11-25
NO20021810D0 (no)	2002-04-17
AU1139901A (en)	2001-05-08
IL149158A0 (en)	2002-11-10
ATE331027T1 (de)	2006-07-15
US20100285563A1 (en)	2010-11-11
KR20020069509A (ko)	2002-09-04
NO20021810L (no)	2002-06-19
EP1255816A1 (de)	2002-11-13
ES2267579T3 (es)	2007-03-16
CA2384972A1 (en)	2001-05-03
JP2003512835A (ja)	2003-04-08
DE50013072D1 (de)	2006-08-03
EP1255816B1 (de)	2006-06-21

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