DK1283051T3 - Stabile insulinformuleringer - Google Patents

Stabile insulinformuleringer

Info

Publication number: DK1283051T3
Authority: DK; Denmark
Prior art keywords: insulin formulations; stable insulin; stable; formulations; insulin
Prior art date: 1997-06-13

Application number

DK02022956T

Other languages

English (en)

Inventor

Michael Allen Dobbins

Bruce Hill Frank

Dawn Marie Rebhun

Michael Rosario Defelippis

Shun Li

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-13

Filing date

1998-06-12

Publication date

2006-10-16

1998-06-12 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1998-06-12 Priority claimed from EP98304661A external-priority patent/EP0884053B1/en

2006-10-16 Application granted granted Critical

2006-10-16 Publication of DK1283051T3 publication Critical patent/DK1283051T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
238000009472 formulation Methods 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Inorganic Chemistry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02022956T 1997-06-13 1998-06-12 Stabile insulinformuleringer DK1283051T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5308997P	1997-06-13	1997-06-13
EP98304661A EP0884053B1 (en)	1997-06-13	1998-06-12	Stable insulin formulations

Publications (1)

Publication Number	Publication Date
DK1283051T3 true DK1283051T3 (da)	2006-10-16

Family

ID=26151292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02022956T DK1283051T3 (da)	1997-06-13	1998-06-12	Stabile insulinformuleringer

Country Status (4)

Country	Link
EP (1)	EP1283051B1 (da)
CY (1)	CY1105185T1 (da)
DK (1)	DK1283051T3 (da)
SI (1)	SI0884053T1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004261353B2 (en)	2003-08-05	2009-12-10	Novo Nordisk A/S	Novel insulin derivatives
EP1969004B1 (en)	2005-12-28	2011-08-10	Novo Nordisk A/S	Compositions comprising an acylated insulin and zinc and method of making the said compositions
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
EP2158927A1 (en)	2008-08-25	2010-03-03	Debiotech S.A.	Drug delivery device with a module for preventing fibrillation downstream of its reservoir
CN102202683A (zh)	2008-10-30	2011-09-28	诺沃-诺迪斯克有限公司	用少于每日一次的注射频率注射胰岛素来治疗糖尿病
ES2543705T3 (es) *	2009-06-26	2015-08-21	Novo Nordisk A/S	Preparación que contiene insulina, nicotinamida y arginina
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
KR20140030125A (ko)	2010-12-14	2014-03-11	노보 노르디스크 에이/에스	인슐린, 니코틴아미드 및 아미노산을 포함하는 제제
WO2012080320A1 (en) *	2010-12-14	2012-06-21	Novo Nordisk A/S	Fast-acting insulin in combination with long-acting insulin
WO2013186138A1 (en) *	2012-06-14	2013-12-19	Novo Nordisk A/S	Preparation comprising insulin, nicotinamide and arginine
EP2991672A1 (en)	2013-04-30	2016-03-09	Novo Nordisk A/S	Novel administration regime
GB201607918D0 (en)	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
EP4265296A3 (en)	2016-09-29	2023-12-20	Arecor Limited	Pharmaceutical formulation comprising an insulin compound
EP3773474B1 (en)	2018-04-04	2026-01-07	Arecor Limited	Medical infusion pump system for the delivery of an insulin compound
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
CN114096269B (zh)	2019-07-12	2024-06-11	诺和诺德股份有限公司	高浓度胰岛素制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5767548A (en) *	1980-10-14	1982-04-24	Shionogi & Co Ltd	Insulin analog and its preparation
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DK179286D0 (da) *	1986-04-18	1986-04-18	Nordisk Gentofte	Insulinpraeparat
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
AR002976A1 (es) *	1995-03-31	1998-05-27	Lilly Co Eli	Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas

1998
- 1998-06-12 DK DK02022956T patent/DK1283051T3/da active
- 1998-06-12 EP EP02022956A patent/EP1283051B1/en not_active Expired - Lifetime
- 1998-06-12 SI SI9830275T patent/SI0884053T1/xx unknown
2006
- 2006-08-30 CY CY20061101226T patent/CY1105185T1/el unknown

Also Published As

Publication number	Publication date
CY1105185T1 (el)	2010-03-03
EP1283051A1 (en)	2003-02-12
SI0884053T1 (en)	2003-02-28
EP1283051B1 (en)	2006-06-14

Publication	Publication Date	Title
DE69834956D1 (de)	2006-07-27	Stabile Insulinformulierungen
DE69808011D1 (de)	2002-10-24	Stabile mikrobizide Formulierung
DK0941067T3 (da)	2003-11-17	Stabile glasagtige pulverformuleringer
NO2006014I1 (no)	2006-11-13	Insulin glulisin
DE69825982D1 (de)	2004-10-07	Spritze
DK0853945T3 (da)	2003-08-04	Flydende gonadotropinholdige formuleringer
MA24473A1 (fr)	1998-10-01	Formulations
NO20002038D0 (no)	2000-04-18	Uløselig insulinsammensetning
FI952931L (fi)	1995-12-17	Insuliinianalogiformulaatioita
DE69813601D1 (de)	2003-05-22	Stabile kosmetische zusammensetzungen
ID25533A (id)	2000-10-12	Formulasi 2-metil-tieno-benzodiazepin
IS5555A (is)	2000-06-30	Selekoxib lyfjablöndur
ID30031A (id)	2001-11-01	Formulasi-formulasi agrokimia
ID23546A (id)	2000-05-04	Formulasi-formulasi ziprasidon
DE60025198D1 (de)	2006-02-02	Stabile biozidale zusammensetzung
NO20004240L (no)	2000-10-18	Formuleringer
DE69837487D1 (de)	2007-05-16	Stabile atmungsaktive elastische artikel
ATE224703T1 (de)	2002-10-15	Brauseformulierungen
PT1130966E (pt)	2005-04-29	Formulacoes antiparasitarias
DE69919784D1 (de)	2004-10-07	Spritze
DE69935609D1 (de)	2007-05-03	Formulierungen enthaltend cefuroxim-axetil
SI0884053T1 (en)	2003-02-28	Stable insulin formulations
DE69809016D1 (de)	2002-12-05	Stabile mikrobizide Formulierung
DE60000804D1 (de)	2003-01-02	Stabile mikrobizide Formulierung
DE69815935D1 (de)	2003-08-07	Stabile pestizide Dispersionen