DK1284740T3 - Profylaktisk og terapeutisk behandling af infektiöse sygdomme, autoimmunsygdomme og allergiske sygdomme med monosaccharidbaserede forbindelser - Google Patents

Profylaktisk og terapeutisk behandling af infektiöse sygdomme, autoimmunsygdomme og allergiske sygdomme med monosaccharidbaserede forbindelser

Info

Publication number: DK1284740T3
Authority: DK; Denmark
Prior art keywords: autoimmune; monosaccharide; prophylactic; infectious; therapeutic treatment
Prior art date: 2000-05-19

Application number

DK01948222T

Other languages

English (en)

Inventor

David H Persing

J Terry Ulrich

David A Johnson

Jory R Baldridge

Richard Thomas Crane

Gary T Elliot

Michael J Lacy

Rong Wang

Original Assignee

Corixa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-19

Filing date

2001-05-18

Publication date

2008-08-04

2001-05-18 Application filed by Corixa Corp filed Critical Corixa Corp

2008-08-04 Application granted granted Critical

2008-08-04 Publication of DK1284740T3 publication Critical patent/DK1284740T3/da

Links

208000023275 Autoimmune disease Diseases 0.000 title abstract 2
208000035473 Communicable disease Diseases 0.000 title 1
208000026935 allergic disease Diseases 0.000 title 1
230000001363 autoimmune Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
230000002458 infectious effect Effects 0.000 title 1
150000002772 monosaccharides Chemical class 0.000 title 1
230000000069 prophylactic effect Effects 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
206010027654 Allergic conditions Diseases 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
150000008271 glucosaminides Chemical class 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Crystallography & Structural Chemistry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
AIDS & HIV (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Otolaryngology (AREA)
Gastroenterology & Hepatology (AREA)
Hospice & Palliative Care (AREA)

DK01948222T 2000-05-19 2001-05-18 Profylaktisk og terapeutisk behandling af infektiöse sygdomme, autoimmunsygdomme og allergiske sygdomme med monosaccharidbaserede forbindelser DK1284740T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20582000P	2000-05-19	2000-05-19
US28156701P	2001-04-04	2001-04-04
PCT/US2001/016327 WO2001090129A2 (en)	2000-05-19	2001-05-18	Prophylactic and therapeutic treatment of infectious, autoimmune and allergic diseases with mono and disaccharide-base compounds

Publications (1)

Publication Number	Publication Date
DK1284740T3 true DK1284740T3 (da)	2008-08-04

Family

ID=26900794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01948222T DK1284740T3 (da)	2000-05-19	2001-05-18	Profylaktisk og terapeutisk behandling af infektiöse sygdomme, autoimmunsygdomme og allergiske sygdomme med monosaccharidbaserede forbindelser

Country Status (21)

Country	Link
US (1)	US6800613B2 (da)
EP (2)	EP2000144A1 (da)
JP (1)	JP5004261B2 (da)
KR (1)	KR100829674B1 (da)
CN (1)	CN1606446A (da)
AT (1)	ATE395923T1 (da)
AU (3)	AU2001269695B2 (da)
BR (1)	BR0110975A (da)
CA (1)	CA2409221C (da)
CY (1)	CY1108211T1 (da)
DE (1)	DE60134134D1 (da)
DK (1)	DK1284740T3 (da)
ES (1)	ES2305086T3 (da)
HU (1)	HU230847B1 (da)
IL (3)	IL152935A0 (da)
MX (1)	MXPA02011486A (da)
NO (1)	NO331939B1 (da)
NZ (1)	NZ522755A (da)
PL (1)	PL206832B1 (da)
PT (1)	PT1284740E (da)
WO (1)	WO2001090129A2 (da)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6835721B2 (en)	1999-02-01	2004-12-28	Eisai Co., Ltd.	Immunomodulatory compounds and methods of use thereof
US20040006242A1 (en) *	1999-02-01	2004-01-08	Hawkins Lynn D.	Immunomodulatory compounds and method of use thereof
US7915238B2 (en)	1999-02-01	2011-03-29	Eisai R & D Management Co., Ltd.	Immunomodulatory compounds and methods of use thereof
US20030105032A1 (en) *	2000-05-19	2003-06-05	Persing David H.	Phophylactic and therapeutic treatment of infectious and other diseases with mono-and disaccharide-based compounds
AU2002324937B2 (en) *	2001-09-07	2008-11-13	The Trustees Of Boston Univeristy	Method and composition for treating immune complex associated disorders
EP1302206A1 (en) *	2001-10-11	2003-04-16	Universitair Medisch Centrum Utrecht	Methods and means for the use of the adventitial toll-like receptor
CA2474402C (en)	2002-02-04	2012-09-11	Corixa Corporation	Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
US6911434B2 (en)	2002-02-04	2005-06-28	Corixa Corporation	Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
BR0312656A (pt)	2002-07-08	2005-06-07	Corixa Corp	Processos para a produção de imunoefetores fosfato glicosaminìdeo de aminoalquila e dissacarìdeos e seus intermediários
DK1589934T3 (da)	2003-01-06	2015-12-21	Corixa Corp	Visse aminoalkylglucosaminidphosphatforbindelser og anvendelse deraf
US7960522B2 (en)	2003-01-06	2011-06-14	Corixa Corporation	Certain aminoalkyl glucosaminide phosphate compounds and their use
US20060263778A1 (en) *	2004-03-05	2006-11-23	Johnson Geoffrey B	Animals with reduced body fat and increased bone density
BRPI0606772A2 (pt)	2005-01-27	2009-07-14	Novartis Vaccines & Diagnostic	método para a caracterização da eficácia de um agente contra um efeito da fibrose cìstica
CA2605749C (en)	2005-04-26	2015-06-30	Eisai Co., Ltd.	Compositions and methods for cancer immunotherapy
GB0510463D0 (en) *	2005-05-23	2005-06-29	Britania Pharmaceuticals Ltd	Improvements in or relating to organic materials
US7622128B2 (en) *	2005-12-13	2009-11-24	University Of Washington	Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
KR101378872B1 (ko)	2006-09-26	2014-04-11	인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이)	합성 애주번트를 함유하는 백신 조성물
US20090181078A1 (en) *	2006-09-26	2009-07-16	Infectious Disease Research Institute	Vaccine composition containing synthetic adjuvant
US20090215710A1 (en) *	2007-09-24	2009-08-27	Reliance Life Sciences Pvt. Ltd.	Carbohydrate based toll-like receptor (tlr) antagonists
WO2009059143A2 (en) *	2007-10-31	2009-05-07	Centocor, Inc.	Use of toll-like receptor 4 antagonists for the treatment or prevention of osteoarthritic conditions
SI2437753T1 (sl)	2009-06-05	2016-12-30	Infectious Disease Research Institute	Sintetični glukopiranozil-lipidni adjuvansi in cepivni sestavki, ki jih vsebujejo
WO2011119920A2 (en)	2010-03-25	2011-09-29	Oregon Health & Science University	Cmv glycoproteins and recombinant vectors
WO2012037612A1 (en)	2010-09-22	2012-03-29	The University Of Melbourne	Novel immunostimulatory method
GB201101331D0 (en)	2011-01-26	2011-03-09	Glaxosmithkline Biolog Sa	Compositions and uses
SMT201800284T1 (it)	2011-06-10	2018-07-17	Univ Oregon Health & Science	Glicoproteine cmv e vettori ricombinanti
GB201113570D0 (en)	2011-08-05	2011-09-21	Glaxosmithkline Biolog Sa	Vaccine
EP2568289A3 (en)	2011-09-12	2013-04-03	International AIDS Vaccine Initiative	Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en)	2011-10-27	2013-05-01	Christopher L. Parks	Viral particles derived from an enveloped virus
US9241988B2 (en) *	2012-04-12	2016-01-26	Avanti Polar Lipids, Inc.	Disaccharide synthetic lipid compounds and uses thereof
PT2850431T (pt)	2012-05-16	2018-07-23	Immune Design Corp	Vacinas para hsv-2
ES2631608T3 (es)	2012-06-27	2017-09-01	International Aids Vaccine Initiative	Variante de la glicoproteína Env del VIH-1
ES2743465T3 (es) *	2013-03-15	2020-02-19	Glaxosmithkline Biologicals Sa	Composición que contiene derivados fosfato de aminoalquil glucosaminida tamponados y su uso para potenciar una respuesta inmunitaria
EP3711768A1 (en)	2013-04-18	2020-09-23	Immune Design Corp.	Gla monotherapy for use in cancer treatment
US9463198B2 (en)	2013-06-04	2016-10-11	Infectious Disease Research Institute	Compositions and methods for reducing or preventing metastasis
EP2848937A1 (en)	2013-09-05	2015-03-18	International Aids Vaccine Initiative	Methods of identifying novel HIV-1 immunogens
EP2873423B1 (en)	2013-10-07	2017-05-31	International Aids Vaccine Initiative	Soluble hiv-1 envelope glycoprotein trimers
JP2017511802A (ja)	2014-03-12	2017-04-27	グラクソスミスクラインバイオロジカルズソシエテアノニム	免疫原リポソーム製剤
JP2017507968A (ja)	2014-03-12	2017-03-23	グラクソスミスクラインバイオロジカルズソシエテアノニム	粘膜送達用のリポソーム組成物
MA41414A (fr)	2015-01-28	2017-12-05	Centre Nat Rech Scient	Protéines de liaison agonistes d' icos
US10174292B2 (en)	2015-03-20	2019-01-08	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en)	2015-03-23	2018-04-03	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
WO2017013603A1 (en)	2015-07-21	2017-01-26	Glaxosmithkline Biologicals Sa	Adjuntive immunotherapy for the prevention or treatment of infectious disease
WO2017021912A1 (en)	2015-08-06	2017-02-09	Glaxosmithkline Intellectual Property Development Limited	Combined tlrs modulators with anti ox40 antibodies
TW201716084A (zh)	2015-08-06	2017-05-16	葛蘭素史克智慧財產發展有限公司	組合物及其用途與治療
BR112018002520A2 (pt)	2015-08-06	2018-09-18	Glaxosmithkline Ip Dev Ltd	Agonistas de tlr4 e composições dos mesmos e seuuso no tratamento de câncer
JP6411676B2 (ja)	2015-12-03	2018-10-24	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド
WO2017098421A1 (en)	2015-12-08	2017-06-15	Glaxosmithkline Intellectual Property Development Limited	Benzothiadiazine compounds
WO2017153952A1 (en)	2016-03-10	2017-09-14	Glaxosmithkline Intellectual Property Development Limited	5-sulfamoyl-2-hydroxybenzamide derivatives
KR20180132783A (ko)	2016-04-07	2018-12-12	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	단백질 조절제로서 유용한 헤테로사이클릭 아미드
CN113549110B (zh)	2016-04-07	2024-08-16	葛兰素史密斯克莱知识产权发展有限公司	用作蛋白质调节剂的杂环酰胺
MX2018013519A (es)	2016-05-05	2019-03-14	Glaxosmithkline Ip No 2 Ltd	Inhibidores del potenciador del homologo zeste 2.
AU2017300123A1 (en)	2016-07-20	2019-01-31	Glaxosmithkline Intellectual Property Development Limited	Isoquinoline derivatives as PERK inhibitors
KR20190090824A (ko)	2016-12-01	2019-08-02	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	암을 치료하는 방법
US11389465B2 (en)	2017-05-01	2022-07-19	Vanderbilt University	Phosphorylated hexaacyl disaccharides (PHADs) for treating or preventing infections
WO2019021208A1 (en)	2017-07-27	2019-01-31	Glaxosmithkline Intellectual Property Development Limited	USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS
WO2019053617A1 (en)	2017-09-12	2019-03-21	Glaxosmithkline Intellectual Property Development Limited	CHEMICAL COMPOUNDS
WO2019069270A1 (en)	2017-10-05	2019-04-11	Glaxosmithkline Intellectual Property Development Limited	GENERATOR STIMULATOR MODULATORS (STING) INTERFERON
EP3692033A1 (en)	2017-10-05	2020-08-12	GlaxoSmithKline Intellectual Property Development Limited	Modulators of stimulator of interferon genes (sting) useful in treating hiv
PL3728289T3 (pl)	2017-12-21	2026-01-26	Axelia Oncology Pty Ltd	Zoptymalizowane związki
PL3752182T3 (pl)	2018-02-12	2024-11-25	Inimmune Corporation	Ligandy receptorów toll-podobnych
GB201807924D0 (en)	2018-05-16	2018-06-27	Ctxt Pty Ltd	Compounds
WO2020031087A1 (en)	2018-08-06	2020-02-13	Glaxosmithkline Intellectual Property Development Limited	Combination therapy
WO2020030570A1 (en)	2018-08-06	2020-02-13	Glaxosmithkline Intellectual Property Development Limited	Combinations of an ox40 antibody and a tlr4 modulator and uses thereof
WO2020030571A1 (en)	2018-08-06	2020-02-13	Glaxosmithkline Intellectual Property Development Limited	Combinations of a pd-1 antibody and a tlr4 modulator and uses thereof
WO2020109365A1 (en)	2018-11-29	2020-06-04	Glaxosmithkline Biologicals Sa	Methods for manufacturing an adjuvant
JP2022539091A (ja)	2019-06-26	2022-09-07	アクセリアオンコロジーピーティーワイリミテッド	新規な分子
KR20220026585A (ko)	2019-06-26	2022-03-04	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	Il1rap 결합 단백질
GB201910305D0 (en)	2019-07-18	2019-09-04	Ctxt Pty Ltd	Compounds
GB201910304D0 (en)	2019-07-18	2019-09-04	Ctxt Pty Ltd	Compounds
CN114206909A (zh)	2019-07-21	2022-03-18	葛兰素史克生物有限公司	治疗性病毒疫苗
WO2021018941A1 (en)	2019-07-31	2021-02-04	Glaxosmithkline Intellectual Property Development Limited	Methods of treating cancer
WO2021043961A1 (en)	2019-09-06	2021-03-11	Glaxosmithkline Intellectual Property Development Limited	Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy
EP4028051A1 (en)	2019-09-09	2022-07-20	GlaxoSmithKline Biologicals S.A.	Immunotherapeutic compositions
BR112022005787A2 (pt)	2019-09-27	2022-06-21	Glaxosmithkline Ip Dev Ltd	Proteínas de ligação a antígeno
WO2021119753A1 (en)	2019-12-18	2021-06-24	Ctxt Pty Limited	Compounds
CN112999233B (zh) *	2019-12-19	2023-10-20	中国医学科学院药物研究所	一类来源于赤芍的单萜苷类化合物及其制法和应用
PL4117790T3 (pl) *	2020-03-13	2025-05-05	Hephaistos-Pharma	Lipopolisacharydy (lps) pozbawione toksyczności, naturalnie nietoksyczne lps i ich zastosowania
US20230234992A1 (en)	2020-06-05	2023-07-27	Glaxosmithkline Biologicals Sa	Modified betacoronavirus spike proteins
TW202233200A (zh) *	2020-11-11	2022-09-01	日商第一三共股份有限公司	新穎胺基烷基葡萄胺糖苷4-磷酸衍生物
EP4032547A1 (en)	2021-01-20	2022-07-27	GlaxoSmithKline Biologicals S.A.	Hsv1 fce derived fragements for the treatment of hsv
CA3212345A1 (en)	2021-03-02	2022-09-09	Glaxosmithkline Intellectual Property Development Limited	Substituted pyridines as dnmt1 inhibitors
WO2022208353A1 (en)	2021-03-31	2022-10-06	Glaxosmithkline Intellectual Property Development Limited	Antigen binding proteins and combinations thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4603112A (en)	1981-12-24	1986-07-29	Health Research, Incorporated	Modified vaccinia virus
US4769330A (en)	1981-12-24	1988-09-06	Health Research, Incorporated	Modified vaccinia virus and methods for making and using the same
US4436727A (en)	1982-05-26	1984-03-13	Ribi Immunochem Research, Inc.	Refined detoxified endotoxin product
US4866034A (en)	1982-05-26	1989-09-12	Ribi Immunochem Research Inc.	Refined detoxified endotoxin
US4987237A (en)	1983-08-26	1991-01-22	Ribi Immunochem Research, Inc.	Derivatives of monophosphoryl lipid A
US4844894A (en) *	1984-07-12	1989-07-04	Ribi Immunochem Research Inc.	Method of inhibiting the onset of septicemia and endotoxemia
GB8508845D0 (en)	1985-04-04	1985-05-09	Hoffmann La Roche	Vaccinia dna
US4777127A (en)	1985-09-30	1988-10-11	Labsystems Oy	Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
US4877611A (en)	1986-04-15	1989-10-31	Ribi Immunochem Research Inc.	Vaccine containing tumor antigens and adjuvants
GB8702816D0 (en)	1987-02-07	1987-03-11	Al Sumidaie A M K	Obtaining retrovirus-containing fraction
WO1989001973A2 (en)	1987-09-02	1989-03-09	Applied Biotechnology, Inc.	Recombinant pox virus for immunization against tumor-associated antigens
EP0324455A3 (en) *	1988-01-15	1991-03-27	Hans O. Ribi	Novel polymeric immunological adjuvants
AP129A (en)	1988-06-03	1991-04-17	Smithkline Biologicals S A	Expression of retrovirus gag protein eukaryotic cells
US4912094B1 (en)	1988-06-29	1994-02-15	Ribi Immunochem Research Inc.	Modified lipopolysaccharides and process of preparation
EP0487587A1 (en)	1989-08-18	1992-06-03	Chiron Corporation	Recombinant retroviruses delivering vector constructs to target cells
AU660325B2 (en) *	1991-10-11	1995-06-22	Eisai Co. Ltd.	Anti-endotoxin compounds and related molecules and methods
WO1996002555A1 (en)	1994-07-15	1996-02-01	The University Of Iowa Research Foundation	Immunomodulatory oligonucleotides
US6887483B2 (en) *	1995-12-01	2005-05-03	University Of Iowa Research Foundation	Non-toxic mutants of pathogenic gram-negative bacteria
US5762943A (en)	1996-05-14	1998-06-09	Ribi Immunochem Research, Inc.	Methods of treating type I hypersensitivity using monophosphoryl lipid A
US5856462A (en)	1996-09-10	1999-01-05	Hybridon Incorporated	Oligonucleotides having modified CpG dinucleosides
US6491919B2 (en) *	1997-04-01	2002-12-10	Corixa Corporation	Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
US6764840B2 (en) *	1997-05-08	2004-07-20	Corixa Corporation	Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6113918A (en)	1997-05-08	2000-09-05	Ribi Immunochem Research, Inc.	Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6303347B1 (en) *	1997-05-08	2001-10-16	Corixa Corporation	Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6355257B1 (en) *	1997-05-08	2002-03-12	Corixa Corporation	Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6368604B1 (en) *	1997-09-26	2002-04-09	University Of Maryland Biotechnology Institute	Non-pyrogenic derivatives of lipid A
GB9727262D0 (en)	1997-12-24	1998-02-25	Smithkline Beecham Biolog	Vaccine
WO1999052549A1 (en)	1998-04-09	1999-10-21	Smithkline Beecham Biologicals S.A.	Adjuvant compositions
AU763770B2 (en) *	1998-07-14	2003-07-31	Wyeth Holdings Corporation	Adjuvant and vaccine compositions containing monophosphoryl lipid A
US6013640A (en)	1998-08-21	2000-01-11	Ribi Immunochem Research, Inc.	Phosphoglycolipid and methods for its use
US6261573B1 (en) *	1998-10-30	2001-07-17	Avant Immunotherapeutics, Inc.	Immunoadjuvants
PT1127137E (pt) *	1998-11-03	2007-12-28	Staat Nl Verteg Door Min Welzi	Lps com toxicidade reduzida a partir de bactérias gramnegativas modificadas geneticamente
JP2003510335A (ja)	1999-08-06	2003-03-18	コリクサコーポレイション	自己免疫疾患の処置のためのワクチン
WO2001034794A1 (en)	1999-11-10	2001-05-17	Smithkline Beecham Biologicals S.A.	Casb7434, an antigen over-expressed in colon cancer
US6699846B2 (en)	2000-03-17	2004-03-02	Corixa Corporation	Mono- and disaccharides for the treatment of nitric oxide related disorders

2001
- 2001-05-18 WO PCT/US2001/016327 patent/WO2001090129A2/en not_active Ceased
- 2001-05-18 CN CNA018114881A patent/CN1606446A/zh active Pending
- 2001-05-18 PT PT01948222T patent/PT1284740E/pt unknown
- 2001-05-18 BR BR0110975-8A patent/BR0110975A/pt not_active IP Right Cessation
- 2001-05-18 AU AU2001269695A patent/AU2001269695B2/en not_active Expired
- 2001-05-18 PL PL365169A patent/PL206832B1/pl not_active IP Right Cessation
- 2001-05-18 AU AU6969501A patent/AU6969501A/xx active Pending
- 2001-05-18 ES ES01948222T patent/ES2305086T3/es not_active Expired - Lifetime
- 2001-05-18 DE DE60134134T patent/DE60134134D1/de not_active Expired - Lifetime
- 2001-05-18 KR KR1020027015626A patent/KR100829674B1/ko not_active Expired - Lifetime
- 2001-05-18 EP EP08153476A patent/EP2000144A1/en not_active Withdrawn
- 2001-05-18 DK DK01948222T patent/DK1284740T3/da active
- 2001-05-18 AT AT01948222T patent/ATE395923T1/de active
- 2001-05-18 MX MXPA02011486A patent/MXPA02011486A/es active IP Right Grant
- 2001-05-18 IL IL15293501A patent/IL152935A0/xx unknown
- 2001-05-18 HU HU0301815A patent/HU230847B1/hu unknown
- 2001-05-18 CA CA2409221A patent/CA2409221C/en not_active Expired - Lifetime
- 2001-05-18 NZ NZ522755A patent/NZ522755A/en not_active IP Right Cessation
- 2001-05-18 JP JP2001586316A patent/JP5004261B2/ja not_active Expired - Lifetime
- 2001-05-18 US US09/861,466 patent/US6800613B2/en not_active Expired - Lifetime
- 2001-05-18 EP EP01948222A patent/EP1284740B1/en not_active Expired - Lifetime
2002
- 2002-11-19 IL IL152935A patent/IL152935A/en unknown
- 2002-11-19 NO NO20025543A patent/NO331939B1/no not_active IP Right Cessation
2007
- 2007-05-11 AU AU2007202117A patent/AU2007202117B2/en not_active Expired
- 2007-10-08 IL IL186495A patent/IL186495A/en active IP Right Grant
2008
- 2008-07-24 CY CY20081100772T patent/CY1108211T1/el unknown

Also Published As

Publication number	Publication date
KR20030031485A (ko)	2003-04-21
EP1284740B1 (en)	2008-05-21
IL152935A0 (en)	2003-06-24
EP2000144A1 (en)	2008-12-10
NZ522755A (en)	2004-05-28
NO20025543D0 (no)	2002-11-19
EP1284740A2 (en)	2003-02-26
HU230847B1 (en)	2018-08-28
KR100829674B1 (ko)	2008-05-16
ATE395923T1 (de)	2008-06-15
DE60134134D1 (de)	2008-07-03
JP2004508292A (ja)	2004-03-18
CA2409221C (en)	2010-10-26
PL365169A1 (en)	2004-12-27
CA2409221A1 (en)	2001-11-29
MXPA02011486A (es)	2004-01-26
CN1606446A (zh)	2005-04-13
PL206832B1 (pl)	2010-09-30
AU2007202117B2 (en)	2011-01-27
US6800613B2 (en)	2004-10-05
AU6969501A (en)	2001-12-03
US20020077304A1 (en)	2002-06-20
BR0110975A (pt)	2004-03-23
WO2001090129A2 (en)	2001-11-29
HUP0301815A2 (hu)	2003-09-29
AU2001269695B2 (en)	2007-02-15
IL152935A (en)	2009-08-03
ES2305086T3 (es)	2008-11-01
AU2007202117A1 (en)	2007-05-31
IL186495A0 (en)	2008-01-20
WO2001090129A3 (en)	2002-06-06
JP5004261B2 (ja)	2012-08-22
PT1284740E (pt)	2008-07-09
IL186495A (en)	2010-12-30
CY1108211T1 (el)	2014-02-12
NO331939B1 (no)	2012-05-07
HUP0301815A3 (en)	2009-08-28
NO20025543L (no)	2003-01-08

Publication	Publication Date	Title
PT1284740E (pt)	2008-07-09	Tratamento profiláctico e terapêutico de doenças infecciosas, autoimunes e alérgicas com compostos à base de monossacáridos
UA81676C2 (ru)	2008-01-25	Композиция для лечения инфекций у крупного рогатого скота и свиней
EA200201247A1 (ru)	2003-10-30	Соединения для лечения болезни альцгеймера
ATE472325T1 (de)	2010-07-15	Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen
CY1112425T1 (el)	2015-12-09	Αντισωματα αντι-ngf για την θεραπευτικη αγωγη διαφορων διαταραχων
LU91928I2 (fr)	2012-03-09	Ipilimumab et ses dérivés pharmaceutiquement acceptables (YERVOY®)
FIU20060389U0 (fi)	2006-09-22	Luusairauksien hoito
DK1317479T3 (da)	2009-11-23	Fremgangsmåder og sammensætninger for sygdomme, der er associeret med amyloidosis
DK1381382T3 (da)	2009-02-02	Fremgangsmåder og præparater til behandling af öjensygdomme
ATE392214T1 (de)	2008-05-15	Impfstoff gegen geschlechtlich übertragene krankheiten
DE60220220D1 (de)	2007-07-05	Blutbehandlungssystem
ATE304886T1 (de)	2005-10-15	Oxazolidinones zur behandlung von augeninfektionen
PT874843E (pt)	2002-12-31	4-(1h-benzimidazol-2-il)¬1,4\|diazepinos substituidos uteis para o tratamento de doencas alergicas
DK0948967T3 (da)	2005-02-14	Behandling af virussygdom hos svin
ATE375168T1 (de)	2007-10-15	Die synergistischen wirkungen von hgf und antibakterieller behandlung
DK1222854T3 (da)	2011-03-14	Forebyggelse og behandling af sygdomme forbundet med blodkoagulering
DK1133296T3 (da)	2003-11-17	Ny terapeutisk anvendelse af nicergolin
BR0113646A (pt)	2004-01-06	Tratamento de distúrbios inflamatórios
DE60129552D1 (de)	2007-09-06	E-selectin zur behandlung oder vorbeugung von schlaganfall
EA200200987A1 (ru)	2003-04-24	Лечение заболеваний, связанных с серотонинергической системой
UA25749A (uk)	1998-12-25	Спосіб хірургічhого лікуваhhя виразкової хвороби шлуhка
DE60111519D1 (de)	2005-07-21	Chemische modifizierung von harn von säugern
DK1133297T3 (da)	2003-11-24	Ny terapeutisk anvendelse af 1,6-dimethyl-8beta-hydroxymethyl-10alpha-methoxyergolin
BR0001620A (pt)	2001-12-04	Conjunto de rodas para andador infantil
UA25252A (uk)	1998-12-25	Хірургічhий спосіб лікуваhhя захворюваhь артерій hижhіх кіhцівок