DK129280A - Fremgangsmaade til fremstilling af pyrazincarboxamider - Google Patents

Fremgangsmaade til fremstilling af pyrazincarboxamider

Info

Publication number: DK129280A
Authority: DK; Denmark
Prior art keywords: preparing; carboxamides; preparing pyrazine; pyrazine carboxamides; eukalemic
Prior art date: 1979-03-27

Application number

DK129280A

Other languages

English (en)

Inventor

O W Woltersdorf

S J D Solms

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-27

Filing date

1980-03-26

Publication date

1980-09-28

1980-03-26 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1980-09-28 Publication of DK129280A publication Critical patent/DK129280A/da

Links

-1 PYRAZINE CARBOXAMIDES Chemical class 0.000 title 1
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical class NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
230000001452 natriuretic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK129280A 1979-03-27 1980-03-26 Fremgangsmaade til fremstilling af pyrazincarboxamider DK129280A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/024,294 US4224447A (en)	1979-03-27	1979-03-27	Novel pyrazinecarboxamides and processes for preparing same

Publications (1)

Publication Number	Publication Date
DK129280A true DK129280A (da)	1980-09-28

Family

ID=21819857

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK129280A DK129280A (da)	1979-03-27	1980-03-26	Fremgangsmaade til fremstilling af pyrazincarboxamider

Country Status (7)

Country	Link
US (1)	US4224447A (da)
EP (1)	EP0017153B1 (da)
JP (1)	JPS55130976A (da)
AT (1)	ATE2327T1 (da)
DE (1)	DE3061734D1 (da)
DK (1)	DK129280A (da)
IE (1)	IE49432B1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4512991A (en) *	1982-12-27	1985-04-23	Merck & Co., Inc.	3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858615B2 (en)	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenyl guanidine sodium channel blockers
US7745442B2 (en)	2003-08-20	2010-06-29	Parion Sciences, Inc.	Methods of reducing risk of infection from pathogens
AR086745A1 (es)	2011-06-27	2014-01-22	Parion Sciences Inc	3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
CA2895512C (en)	2012-12-17	2021-10-19	Parion Sciences, Inc.	Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
CN108658876A (zh)	2012-12-17	2018-10-16	帕里昂科学公司	3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
US9102633B2 (en)	2013-12-13	2015-08-11	Parion Sciences, Inc.	Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE639386A (da) *	1962-10-30
BE639393A (da) *	1962-10-30
NL6707564A (da) *	1966-08-25	1968-02-26
US3432502A (en) *	1966-08-25	1969-03-11	Merck & Co Inc	Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
US4087526A (en) *	1976-07-23	1978-05-02	Merck & Co., Inc.	(3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

1979
- 1979-03-27 US US06/024,294 patent/US4224447A/en not_active Expired - Lifetime
1980
- 1980-03-25 IE IE609/80A patent/IE49432B1/en unknown
- 1980-03-26 DK DK129280A patent/DK129280A/da not_active Application Discontinuation
- 1980-03-26 AT AT80101590T patent/ATE2327T1/de not_active IP Right Cessation
- 1980-03-26 DE DE8080101590T patent/DE3061734D1/de not_active Expired
- 1980-03-26 EP EP80101590A patent/EP0017153B1/en not_active Expired
- 1980-03-27 JP JP3832080A patent/JPS55130976A/ja active Pending

Also Published As

Publication number	Publication date
IE49432B1 (en)	1985-10-02
EP0017153A1 (en)	1980-10-15
US4224447A (en)	1980-09-23
IE800609L (en)	1980-09-27
DE3061734D1 (en)	1983-03-03
JPS55130976A (en)	1980-10-11
ATE2327T1 (de)	1983-02-15
EP0017153B1 (en)	1983-01-26

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Legal Events

Date	Code	Title	Description
1985-12-02	AHB	Application shelved due to non-payment