DK1301501T3 - Tocotrienolchinoncykliseringsprodukter med antihyperkolesterolvirkning - Google Patents

Tocotrienolchinoncykliseringsprodukter med antihyperkolesterolvirkning

Info

Publication number: DK1301501T3
Authority: DK; Denmark
Prior art keywords: antihypercholesterol; effect; sup; tocotrienol quinone; cyclization products
Prior art date: 2000-07-14

Application number

DK01969391T

Other languages

English (en)

Inventor

Kai-Uwe Baldenius

Hartwig Schroeder

Klaus Kraemer

Karin Schein

Rainer Stuermer

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-14

Filing date

2001-07-13

Publication date

2004-07-19

2001-07-13 Application filed by Basf Ag filed Critical Basf Ag

2004-07-19 Application granted granted Critical

2004-07-19 Publication of DK1301501T3 publication Critical patent/DK1301501T3/da

Links

AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 title 2
GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 title 1
238000007363 ring formation reaction Methods 0.000 title 1
229930003802 tocotrienol Natural products 0.000 title 1
239000011731 tocotrienol Substances 0.000 title 1
235000019148 tocotrienols Nutrition 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Botany (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Furan Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

DK01969391T 2000-07-14 2001-07-13 Tocotrienolchinoncykliseringsprodukter med antihyperkolesterolvirkning DK1301501T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10034233A DE10034233A1 (de)	2000-07-14	2000-07-14	Tocotrienolchinon-Cyclisierungsprodukte
PCT/EP2001/008163 WO2002006261A1 (de)	2000-07-14	2001-07-13	Tocotrienolchinon-zyklisierungsprodukte mit antihypercholesterin wirkung

Publications (1)

Publication Number	Publication Date
DK1301501T3 true DK1301501T3 (da)	2004-07-19

Family

ID=7648895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01969391T DK1301501T3 (da)	2000-07-14	2001-07-13	Tocotrienolchinoncykliseringsprodukter med antihyperkolesterolvirkning

Country Status (10)

Country	Link
US (1)	US6977270B2 (da)
EP (1)	EP1301501B1 (da)
JP (1)	JP2004504313A (da)
CN (1)	CN1441793A (da)
AT (1)	ATE263160T1 (da)
AU (1)	AU2001289659A1 (da)
DE (2)	DE10034233A1 (da)
DK (1)	DK1301501T3 (da)
ES (1)	ES2218448T3 (da)
WO (1)	WO2002006261A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120046237A1 (en) *	1998-04-08	2012-02-23	Theoharides Theoharis C	Compositions for protection against superficial vasodilator flush syndrome, and methods of use
EA035619B1 (ru)	2005-06-01	2020-07-16	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Композиции для использования в способе лечения митохондриальных нарушений
JP2009508867A (ja) *	2005-09-15	2009-03-05	エジソンファーマシューティカルズ，インコーポレイテッド	ミトコンドリア病および関連した様態の治療ならびにエネルギーバイオマーカーの調節のための酸化還元活性治療剤のテイル改変体
EP1986636B1 (en)	2006-02-22	2013-04-24	Edison Pharmaceuticals, Inc.	Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
EP2344142B1 (en)	2008-09-10	2024-06-26	PTC Therapeutics, Inc.	Treatment of pervasive developmental disorders with redox-active therapeutics
WO2010051277A1 (en) *	2008-10-28	2010-05-06	Edison Pharmaceuticals, Inc.	Process for the production of alpha-tocotrienol and derivatives
CA2777479C (en)	2009-04-28	2017-10-17	Ptc Therapeutics, Inc.	Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones
NO2470168T3 (da) *	2009-08-26	2018-06-30
CA2842486C (en) *	2011-07-19	2022-09-06	Edison Pharmaceuticals, Inc.	Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
WO2013185024A1 (en)	2012-06-08	2013-12-12	The Ohio State University	Treating burn and scar injury using tocotrienol
JP7117241B2 (ja)	2015-12-16	2022-08-12	ピーティーシーセラピューティクス，インコーポレイテッド	混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法
EP3389646A1 (en)	2015-12-17	2018-10-24	BioElectron Technology Corporation	Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR910007523A (ko)	1989-10-04	1991-05-30	브리스톨-마이어즈 스퀴브 컴페니	과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올
US5217992A (en) *	1989-10-04	1993-06-08	Bristol-Myers Squibb Company	Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
CA2050514A1 (en) *	1990-09-14	1992-03-15	Bradley C. Pearce	Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
CA2096496A1 (en) *	1992-05-29	1993-11-30	Bradley C. Pearce	Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
US5318993A (en) *	1993-04-16	1994-06-07	Bristol-Myers Squibb Company	Antihyperlipidemic benzoquinones
EP0669132A1 (en) *	1994-02-23	1995-08-30	van der Kraaij, Antonius Marinus Maria	Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis
JP3926888B2 (ja) *	1997-05-27	2007-06-06	株式会社カネカ	コレステロール低下剤

2000
- 2000-07-14 DE DE10034233A patent/DE10034233A1/de not_active Withdrawn
2001
- 2001-07-13 EP EP01969391A patent/EP1301501B1/de not_active Expired - Lifetime
- 2001-07-13 US US10/332,863 patent/US6977270B2/en not_active Expired - Lifetime
- 2001-07-13 AT AT01969391T patent/ATE263160T1/de not_active IP Right Cessation
- 2001-07-13 AU AU2001289659A patent/AU2001289659A1/en not_active Abandoned
- 2001-07-13 DE DE50101861T patent/DE50101861D1/de not_active Expired - Fee Related
- 2001-07-13 JP JP2002512165A patent/JP2004504313A/ja not_active Withdrawn
- 2001-07-13 CN CN01812696A patent/CN1441793A/zh active Pending
- 2001-07-13 WO PCT/EP2001/008163 patent/WO2002006261A1/de not_active Ceased
- 2001-07-13 DK DK01969391T patent/DK1301501T3/da active
- 2001-07-13 ES ES01969391T patent/ES2218448T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20040116715A1 (en)	2004-06-17
DE10034233A1 (de)	2002-01-24
EP1301501B1 (de)	2004-03-31
US6977270B2 (en)	2005-12-20
AU2001289659A1 (en)	2002-01-30
EP1301501A1 (de)	2003-04-16
ATE263160T1 (de)	2004-04-15
DE50101861D1 (de)	2004-05-06
CN1441793A (zh)	2003-09-10
ES2218448T3 (es)	2004-11-16
JP2004504313A (ja)	2004-02-12
WO2002006261A1 (de)	2002-01-24

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DK1392666T3 (da)	2007-05-07	Biologisk aktive methylenblåt-derivater
FI902555A0 (fi)	1990-05-23	Diarylstyrylkinolindisyror.
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
ATE346067T1 (de)	2006-12-15	Carbolinderivate
IT1285770B1 (it)	1998-06-18	Composti corticoidei
DE69214127D1 (de)	1996-10-31	Überbrückte, cyclische ketale
DE50101861D1 (de)	2004-05-06	Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
AU2001263278A1 (en)	2002-01-08	Cyclic gmp-specific phosphodiesterase inhibitors
DK1204658T3 (da)	2003-09-01	Benzofurylpiperazin-serotoninagonister
PT1204659E (pt)	2004-04-30	Benzofuranos serotoninergicos
SE9903290D0 (sv)	1999-09-15	Novel compounds
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
AU2002211493A1 (en)	2002-05-15	Indole derivatives as pde5-inhibitors
DE69927813D1 (de)	2006-03-02	Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen
BG103271A (en)	2000-05-31	Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means