DK1303521T3 - Tetrahydro-heterocycloazepinyl-pyrimidinderivater - Google Patents

Tetrahydro-heterocycloazepinyl-pyrimidinderivater

Info

Publication number: DK1303521T3
Authority: DK; Denmark
Prior art keywords: heterocycloazepinyl; pyrimidine; tetra hydro; hydro; tetra
Prior art date: 2000-07-18

Application number

DK01978247T

Other languages

English (en)

Inventor

Vincent Mutel

Alfred Binggeli

Hans-Peter Maerki

Wolfgang Wostl

Maurice Wilhelm

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-18

Filing date

2001-07-16

Publication date

2005-06-13

2001-07-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-06-13 Application granted granted Critical

2005-06-13 Publication of DK1303521T3 publication Critical patent/DK1303521T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Virology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Otolaryngology (AREA)

DK01978247T 2000-07-18 2001-07-16 Tetrahydro-heterocycloazepinyl-pyrimidinderivater DK1303521T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00115450		2000-07-18
PCT/EP2001/008186 WO2002006288A1 (en)	2000-07-18	2001-07-16	Tetrahydro-heterocycloazepinyl pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
DK1303521T3 true DK1303521T3 (da)	2005-06-13

Family

ID=8169290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01978247T DK1303521T3 (da)	2000-07-18	2001-07-16	Tetrahydro-heterocycloazepinyl-pyrimidinderivater

Country Status (17)

Country	Link
US (1)	US6369222B1 (da)
EP (1)	EP1303521B1 (da)
JP (1)	JP4060705B2 (da)
KR (1)	KR100525214B1 (da)
CN (1)	CN1187358C (da)
AR (1)	AR031715A1 (da)
AT (1)	ATE288437T1 (da)
AU (2)	AU1041802A (da)
BR (1)	BR0112586A (da)
CA (1)	CA2415966C (da)
DE (1)	DE60108759T2 (da)
DK (1)	DK1303521T3 (da)
ES (1)	ES2236317T3 (da)
MX (1)	MXPA03000428A (da)
PT (1)	PT1303521E (da)
WO (1)	WO2002006288A1 (da)
ZA (1)	ZA200300163B (da)

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EP1074549B1 (en) *	1999-08-06	2003-11-19	F. Hoffmann-La Roche Ag	Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors
DE10238724A1 (de)	2002-08-23	2004-03-04	Bayer Ag	Alkyl-substituierte Pyrazolpyrimidine
DE10238722A1 (de)	2002-08-23	2004-03-11	Bayer Ag	Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US20040215284A1 (en) *	2003-01-30	2004-10-28	Recordati S.A.	Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists
DE10320785A1 (de)	2003-05-09	2004-11-25	Bayer Healthcare Ag	6-Arylmethyl-substituierte Pyrazolopyrimidine
DE10328479A1 (de)	2003-06-25	2005-01-13	Bayer Ag	6-Arylamino-5-cyano-4-pyrimidinone
DE102004001873A1 (de)	2004-01-14	2005-09-29	Bayer Healthcare Ag	Cyanopyrimidinone
DE102004019708A1 (de) *	2004-04-20	2005-11-17	Basf Ag	Offenzellige Schaumstoffe und Verfahren zu ihrer Herstellung
DK1778243T3 (da) *	2004-06-30	2013-02-04	Athersys Inc	Substituerede azepinderivater som serotoninreceptormodulatorer
EP1799684B1 (en)	2004-10-04	2014-12-03	Millennium Pharmaceuticals, Inc.	Lactam compounds useful as protein kinase inhibitors
JP2009520016A (ja) *	2005-12-20	2009-05-21	リヒターゲデオンニュルト	新規な化合物
PE20080145A1 (es)	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
WO2009015897A1 (en) *	2007-08-02	2009-02-05	Recordati Ireland Limited	Novel heterocyclic compounds as mglu5 antagonists
JP5498392B2 (ja)	2007-11-30	2014-05-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用
WO2009078999A1 (en)	2007-12-17	2009-06-25	Janssen Pharmaceutica N.V.	Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
UA105362C2 (en)	2008-04-02	2014-05-12	Бьорингер Ингельхайм Интернациональ Гмбх	1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
CN102143965A (zh)	2008-09-08	2011-08-03	贝林格尔.英格海姆国际有限公司	吡唑并嘧啶酮及其在治疗中枢神经系统疾病中的用途
TW201026703A (en)	2008-12-05	2010-07-16	Millennium Pharm Inc	Thiolactams and uses thereof
WO2010089119A1 (en)	2009-02-04	2010-08-12	Recordati Ireland Limited	Heterocyclic derivatives as m-glu5 antagonists
PT2414363E (pt)	2009-03-31	2014-02-26	Boehringer Ingelheim Int	Derivados de 1-heterociclil-1,5-di-hidro-pirazolo[3,4- d]pirimidin-4-ona e sua utilização como moduladores de pde9a
US20120028931A1 (en)	2009-09-14	2012-02-02	Recordati Ireland Limited	Heterocyclic m-glu5 antagonists
EA023020B1 (ru)	2010-07-09	2016-04-29	Рекордати Айерленд Лимитед	Спирогетероциклические соединения и их применение в качестве антагонистов mglu5
UA110347C2 (uk)	2010-08-12	2015-12-25	Бьорінгер Інгельхайм Інтернаціональ Гмбх	ПОХІДНІ 6-ЦИКЛОАЛКІЛ-1,5-ДИГІДРОПІРАЗОЛО[3,4-d]ПІРИМІДИН-4-ОНУ І ЇХ ЗАСТОСУВАННЯ ЯК ІНГІБІТОРІВ PDE9A
US8809345B2 (en)	2011-02-15	2014-08-19	Boehringer Ingelheim International Gmbh	6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US8822464B2 (en)	2011-11-28	2014-09-02	Boehringer Ingelheim International Gmbh	N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8741892B2 (en)	2011-12-05	2014-06-03	Boehringer Ingelheim International Gmbh	Compounds
US8846948B2 (en)	2011-12-13	2014-09-30	Boehringer Ingelheim International Gmbh	Compounds
US8796467B2 (en) *	2011-12-13	2014-08-05	Boehringer Ingelheim International Gmbh	Compounds
US8716277B2 (en)	2011-12-14	2014-05-06	Boehringer Ingelheim International Gmbh	Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8937176B2 (en)	2011-12-14	2015-01-20	Boehringer Ingelheim International Gmbh	Compounds
US8883789B2 (en)	2011-12-14	2014-11-11	Boehringer Ingelheim International Gmbh	Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8889677B2 (en)	2012-01-17	2014-11-18	Boehringer Ingellheim International GmbH	Substituted triazoles useful as mGlu5 receptor modulators

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Publication number	Priority date	Publication date	Assignee	Title
US3940395A (en) *	1969-08-29	1976-02-24	American Home Products Corporation	4-Amino-2-phenyl-6-thiopryimidines
BG17968A3 (bg) *	1970-08-14	1974-03-05	Dr. Karl Thomae Gmbh	Метод за получаване на производни на азепина
BE790287A (fr) *	1971-10-28	1973-04-19	Delalande Sa	Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
FR2608607B1 (fr)	1986-12-23	1989-04-28	Sanofi Sa	Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
DE3820775A1 (de)	1988-06-20	1989-12-21	Thomae Gmbh Dr K	Neue 4,5,7,8-tetrahydro-6h-thiazolo(5,4,-d)azepine, ihre herstellung und ihre verwendung als arzneimittel
DK0556310T3 (da) *	1990-11-06	1995-08-21	Pfizer	Quinazolinderivater til forhøjelse af antitumoraktivitet

2001
- 2001-07-11 US US09/902,916 patent/US6369222B1/en not_active Expired - Fee Related
- 2001-07-16 PT PT01978247T patent/PT1303521E/pt unknown
- 2001-07-16 WO PCT/EP2001/008186 patent/WO2002006288A1/en not_active Ceased
- 2001-07-16 EP EP01978247A patent/EP1303521B1/en not_active Expired - Lifetime
- 2001-07-16 AR ARP010103373A patent/AR031715A1/es not_active Application Discontinuation
- 2001-07-16 AU AU1041802A patent/AU1041802A/xx active Pending
- 2001-07-16 CA CA002415966A patent/CA2415966C/en not_active Expired - Fee Related
- 2001-07-16 MX MXPA03000428A patent/MXPA03000428A/es active IP Right Grant
- 2001-07-16 AT AT01978247T patent/ATE288437T1/de not_active IP Right Cessation
- 2001-07-16 AU AU2002210418A patent/AU2002210418B2/en not_active Ceased
- 2001-07-16 JP JP2002512190A patent/JP4060705B2/ja not_active Expired - Fee Related
- 2001-07-16 DE DE60108759T patent/DE60108759T2/de not_active Expired - Lifetime
- 2001-07-16 CN CNB018128459A patent/CN1187358C/zh not_active Expired - Fee Related
- 2001-07-16 DK DK01978247T patent/DK1303521T3/da active
- 2001-07-16 ES ES01978247T patent/ES2236317T3/es not_active Expired - Lifetime
- 2001-07-16 BR BR0112586-9A patent/BR0112586A/pt not_active Application Discontinuation
- 2001-07-16 KR KR10-2003-7000783A patent/KR100525214B1/ko not_active Expired - Fee Related
2003
- 2003-01-07 ZA ZA200300163A patent/ZA200300163B/en unknown

Also Published As

Publication number	Publication date
PT1303521E (pt)	2005-05-31
KR20030015397A (ko)	2003-02-20
DE60108759T2 (de)	2006-05-11
US20020045635A1 (en)	2002-04-18
AU1041802A (en)	2002-01-30
ES2236317T3 (es)	2005-07-16
KR100525214B1 (ko)	2005-11-01
JP4060705B2 (ja)	2008-03-12
CA2415966C (en)	2009-10-27
MXPA03000428A (es)	2003-06-24
CA2415966A1 (en)	2002-01-24
EP1303521B1 (en)	2005-02-02
AU2002210418B2 (en)	2006-08-17
AR031715A1 (es)	2003-10-01
EP1303521A1 (en)	2003-04-23
DE60108759D1 (de)	2005-03-10
CN1441804A (zh)	2003-09-10
ATE288437T1 (de)	2005-02-15
WO2002006288A1 (en)	2002-01-24
JP2004504324A (ja)	2004-02-12
US6369222B1 (en)	2002-04-09
BR0112586A (pt)	2003-05-20
ZA200300163B (en)	2004-04-07
CN1187358C (zh)	2005-02-02

Publication	Publication Date	Title
ATE290000T1 (de)	2005-03-15	Muscarinagonisten
ATE252099T1 (de)	2003-11-15	Biarylcarboxamide
LU91910I2 (fr)	2012-02-02	Bocéprévir - Victrelis
DE10136334B8 (de)	2009-11-26	Hochgeschwindigkeitsvertikalresonatoroberflächenemissionslaser
NO20025176D0 (no)	2002-10-28	Multippelstigerörreaktor
ATA2932001A (de)	2004-11-15	Schneefräse
DE60108759D1 (de)	2005-03-10	Tetrahydro-heterocycloazepinyl-pyrimidin-derivate
DE50102988D1 (de)	2004-09-02	Bodenwischer
DE50104056D1 (de)	2004-11-18	Gewichtsmanschette
DE50100710D1 (de)	2003-11-06	Wischblatt
ATE262530T1 (de)	2004-04-15	Indolochinazolinone
NO20030276L (no)	2003-03-18	Fremgangsmåte
ATE298751T1 (de)	2005-07-15	7-oxopyridoryrimidine
AR028336A1 (es)	2003-05-07	4-hidroxi-tetrahidropiridonas fenilsubstituidas
DE10192638T1 (de)	2002-10-31	Bohrstangenladevorrichtung
ATE509008T1 (de)	2011-05-15	Sulfonylguanidine
DE10196064T1 (de)	2003-03-13	Halbleiterfotodektionsgerät
DE50100817D1 (de)	2003-11-27	Kugelgelenk
DE50011511D1 (de)	2005-12-08	Blowby-Heizung
AR028061A1 (es)	2003-04-23	2-enamino-cetonitrilos fenil-substituidos
DE10052925B4 (de)	2005-03-10	Schaukelbett
ATE476423T1 (de)	2010-08-15	Benzoylpyridazine
DE50007634D1 (de)	2004-10-07	Kardioplegieballonkatheter
DE10195909T1 (de)	2003-02-20	Viehfüttervorrichtung
DE10085445T1 (de)	2003-02-27	Drahterodierbearbeitungseinrichtung