DK1305109T3 - Fremstilling af polyelektrolytkapsler ved overfladepræcipitation - Google Patents
Fremstilling af polyelektrolytkapsler ved overfladepræcipitationInfo
- Publication number
- DK1305109T3 DK1305109T3 DK01969563T DK01969563T DK1305109T3 DK 1305109 T3 DK1305109 T3 DK 1305109T3 DK 01969563 T DK01969563 T DK 01969563T DK 01969563 T DK01969563 T DK 01969563T DK 1305109 T3 DK1305109 T3 DK 1305109T3
- Authority
- DK
- Denmark
- Prior art keywords
- shell
- template particles
- preparation
- surface precipitation
- liquid phase
- Prior art date
Links
- 229920000867 polyelectrolyte Polymers 0.000 title abstract 2
- 238000001556 precipitation Methods 0.000 title abstract 2
- 239000002775 capsule Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 4
- 239000007791 liquid phase Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003094 microcapsule Substances 0.000 abstract 1
- 239000002088 nanocapsule Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
- B01J13/22—Coating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2000137707 DE10037707A1 (de) | 2000-08-02 | 2000-08-02 | Polyelektrolytkapselherstellung durch Oberflächenpräzipitation |
| DE2000150382 DE10050382A1 (de) | 2000-10-11 | 2000-10-11 | Verkapselung von Flüssigkeiten |
| PCT/EP2001/008909 WO2002009865A1 (de) | 2000-08-02 | 2001-08-01 | Polyelektrolytkapselherstellung durch oberflächenpräzipitation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1305109T3 true DK1305109T3 (da) | 2004-12-20 |
Family
ID=26006594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01969563T DK1305109T3 (da) | 2000-08-02 | 2001-08-01 | Fremstilling af polyelektrolytkapsler ved overfladepræcipitation |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040013738A1 (da) |
| EP (2) | EP1305109B1 (da) |
| JP (1) | JP2004504931A (da) |
| AT (1) | ATE273067T1 (da) |
| CA (1) | CA2417792C (da) |
| DE (1) | DE50103245D1 (da) |
| DK (1) | DK1305109T3 (da) |
| ES (1) | ES2223914T3 (da) |
| PT (1) | PT1305109E (da) |
| WO (2) | WO2002009864A1 (da) |
Families Citing this family (83)
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| US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
| ATE295156T1 (de) * | 2000-08-28 | 2005-05-15 | Max Planck Gesellschaft | Mehrlagige polyelektrolytkapseln mit gesteuerter und verzögerter freisetzung |
| WO2002020536A1 (fr) * | 2000-09-08 | 2002-03-14 | San-Ei Gen F.F.I.,Inc. | Derives de tetraphenyl-bacteriochlore et compositions les contenant |
| DE10127526A1 (de) * | 2001-05-31 | 2002-12-12 | Novosom Ag | Verfahren zur Herstellung und Auflösung von Nano- und Mikrokapseln |
| US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
| DE10151290A1 (de) * | 2001-10-22 | 2003-04-30 | Roehm Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Pellets |
| US20030119203A1 (en) * | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| US6837171B1 (en) | 2002-04-29 | 2005-01-04 | Palmer/Snyder Furniture Company | Lightweight table with unitized table top |
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| US7153754B2 (en) * | 2002-08-29 | 2006-12-26 | Micron Technology, Inc. | Methods for forming porous insulators from “void” creating materials and structures and semiconductor devices including same |
| US20040137481A1 (en) * | 2002-09-16 | 2004-07-15 | Receptors Llc | Artificial receptor building blocks, components, and kits |
| US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
| US7469076B2 (en) * | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| WO2005003326A2 (en) | 2003-03-28 | 2005-01-13 | Receptors Llc. | Artificial receptors including reversibly immobilized building blocks and methods |
| US20050037381A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors, building blocks, and methods |
| US20050136483A1 (en) * | 2003-09-03 | 2005-06-23 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
| DE10244503A1 (de) * | 2002-09-25 | 2004-04-08 | Capsulution Nanoscience Ag | Methode zur Herstellung und Stabilisierung von Mikro- und Nanosuspensionen mit Amphiphilen und Polyelektrolyten |
| DE10254636A1 (de) * | 2002-11-22 | 2004-06-09 | Capsulution Nanoscience Ag | Verfahren zum Modifizieren von Mikropartikeln sowie Vorrichtung zum Modifizieren von Mikropartikeln |
| JP4684991B2 (ja) | 2003-01-31 | 2011-05-18 | ボストン サイエンティフィック リミテッド | 薬物添加ナノカプセルを用いる局所的薬物デリバリー |
| DE10361170A1 (de) * | 2003-06-13 | 2005-01-05 | Henkel Kgaa | Lagerstabiles Polyelektrolytkapselsystem auf Basis von Peroxycarbonsäuren |
| DE10361084A1 (de) * | 2003-06-13 | 2005-01-05 | Henkel Kgaa | Lagerstabile Bleichmittelzusammensetzungen auf Basis von Peroxycarbonsäuren |
| DE10361100A1 (de) * | 2003-06-13 | 2005-01-05 | Henkel Kgaa | Lagerstabile Kapseln auf Basis von Peroxycarbonsäuren |
| US7364585B2 (en) | 2003-08-11 | 2008-04-29 | Boston Scientific Scimed, Inc. | Medical devices comprising drug-loaded capsules for localized drug delivery |
| US7544770B2 (en) * | 2003-08-29 | 2009-06-09 | Louisiana Tech Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
| US7615530B2 (en) * | 2003-08-29 | 2009-11-10 | Artificial Cell Technologies, Inc. | Immunogenic compositions and methods of use |
| US7348399B2 (en) * | 2003-08-29 | 2008-03-25 | Louisiana Tech University Foundation, Inc. | Nanofabricated polypeptide multilayer films, coatings, and microcapsules |
| US7550557B2 (en) * | 2003-08-29 | 2009-06-23 | Louisiana Tech University Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
| US7829119B2 (en) * | 2003-10-20 | 2010-11-09 | William Marsh Rice University | Method to fabricate microcapsules from polymers and charged nanoparticles |
| US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
| CA2559893A1 (en) * | 2004-03-11 | 2005-09-22 | University Of Massachusetts | Biopolymer encapsulation and stabilization of lipid systems and methods for utilization thereof |
| US7744644B2 (en) * | 2004-03-19 | 2010-06-29 | Boston Scientific Scimed, Inc. | Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release |
| DE102004013637A1 (de) * | 2004-03-19 | 2005-10-13 | Capsulution Nanoscience Ag | Verfahren zur Herstellung von CS-Partikeln und Mikrokapseln unter Verwendung poröser Template sowie CS-Partikel und Mikrokapseln |
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| US8119153B2 (en) | 2004-08-26 | 2012-02-21 | Boston Scientific Scimed, Inc. | Stents with drug eluting coatings |
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| CA2627376C (en) * | 2005-10-25 | 2016-07-05 | Donald Templeton Haynie | Immunogenic compositions and methods of use |
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| US7442439B2 (en) | 2005-12-28 | 2008-10-28 | Kimberly-Clark Worldwide, Inc. | Microencapsulated heat delivery vehicles |
| US7497351B2 (en) | 2006-05-30 | 2009-03-03 | Kimberly-Clark Worldwide, Inc. | Wet wipe dispensing system |
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| US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
| WO2008005509A2 (en) * | 2006-07-06 | 2008-01-10 | Massachusetts Institute Of Technology | Methods and compositions for altering biological surfaces |
| JP5118139B2 (ja) * | 2006-08-04 | 2013-01-16 | バクスター・インターナショナル・インコーポレイテッド | 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物 |
| EP2068845A2 (en) * | 2006-10-06 | 2009-06-17 | Baxter International Inc. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
| US7517582B2 (en) | 2006-12-14 | 2009-04-14 | Kimberly-Clark Worldwide, Inc. | Supersaturated solutions using crystallization enthalpy to impart temperature change to wet wipes |
| US8192841B2 (en) | 2006-12-14 | 2012-06-05 | Kimberly-Clark Worldwide, Inc. | Microencapsulated delivery vehicle having an aqueous core |
| WO2009016091A1 (en) * | 2007-08-01 | 2009-02-05 | Unilever Plc | Coated particles |
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| US8431508B2 (en) * | 2007-10-30 | 2013-04-30 | Cerahelix, Inc. | Inorganic structure for molecular separations |
| WO2009094060A1 (en) * | 2008-01-24 | 2009-07-30 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| EP2103313A1 (en) * | 2008-03-19 | 2009-09-23 | Koninklijke Philips Electronics N.V. | Method for the synthesis of hollow spheres |
| US7924142B2 (en) | 2008-06-30 | 2011-04-12 | Kimberly-Clark Worldwide, Inc. | Patterned self-warming wipe substrates |
| US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
| US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
| MX2011007856A (es) | 2009-01-30 | 2011-08-15 | Unilever Nv | Emulsiones de aceite en agua. |
| KR101693332B1 (ko) * | 2009-02-09 | 2017-01-17 | 셀루테크 에이비 | 중합체 쉘 |
| US8062555B2 (en) * | 2009-04-16 | 2011-11-22 | Rhodia Operations | Co-assembly method and co-assembled structures made thereby |
| US9005662B2 (en) | 2009-08-20 | 2015-04-14 | The Florida State University Research Foundation, Inc. | Biocompatible polyelectrolyte complexes and methods of use |
| WO2011149907A1 (en) | 2010-05-24 | 2011-12-01 | University Of Utah Research Foundation | Reinforced adhesive complex coacervates and methods of making and using thereof |
| EP2637708A2 (en) | 2010-11-12 | 2013-09-18 | University of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| RU2567320C2 (ru) * | 2011-01-28 | 2015-11-10 | Учреждение Российской академии наук Институт теоретической и Экспериментальной биофизики РАН (ИТЭБ РАН) | Способ получения подложек с мнонослойным покрытием на основе полиэлектролитных микрокапсул, содержащих биологически активные материалы |
| US20140206587A1 (en) * | 2011-08-24 | 2014-07-24 | Honggang Chen | Benefit agent delivery particles comprising non-ionic polysaccharides |
| CA2843039A1 (en) * | 2011-08-24 | 2013-02-28 | Unilever Plc | Benefit agent delivery particles comprising dextran |
| FR2986165B1 (fr) * | 2012-01-31 | 2015-07-24 | Capsum | Procede de preparation de capsules rigidifiees |
| EP2909298B1 (en) * | 2012-10-17 | 2017-06-28 | The Procter and Gamble Company | Non-spherical droplet |
| CN104736688A (zh) * | 2012-10-17 | 2015-06-24 | 宝洁公司 | 变形小滴 |
| WO2014123665A1 (en) | 2013-02-06 | 2014-08-14 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| FR3013218B1 (fr) * | 2013-11-18 | 2016-07-29 | Capsum | Composition comprenant des capsules gelifiees stabilisees par un tampon |
| EP3169374B1 (en) | 2014-07-14 | 2022-01-05 | University of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| CA3089480C (en) | 2018-01-26 | 2025-05-27 | Fluidx Medical Technology, Inc. | APPARATUS AND METHOD FOR USING COMPLEX COACERVATES WITH IN SITU SOLIDIFICATION FOR VASCULAR OCLUSION |
| CN118599379B (zh) * | 2024-07-29 | 2025-01-03 | 济南市市政工程建设集团有限公司 | 一种自修复超疏水纳米防腐涂料及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4640709A (en) * | 1984-06-12 | 1987-02-03 | Monsanto Company | High concentration encapsulation by interfacial polycondensation |
| WO1999047253A1 (en) * | 1998-03-19 | 1999-09-23 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates |
| EP0972563A1 (en) * | 1998-07-15 | 2000-01-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates |
| US7101575B2 (en) * | 1998-03-19 | 2006-09-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly |
| DE29924358U1 (de) * | 1998-03-19 | 2003-01-02 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 80539 München | Nano- und Mikrokapseln mit einer Polyelektrolythülle aus mehreren Polyelektrolytschichten |
| DE10001172A1 (de) | 2000-01-13 | 2001-07-26 | Max Planck Gesellschaft | Templatieren von Feststoffpartikeln mit Polymermultischichten |
| DE10010264A1 (de) | 2000-03-02 | 2001-09-13 | Novosom Gmbh | Stabilisierte Liposomen und Hüllstrukturen |
-
2001
- 2001-08-01 US US10/343,583 patent/US20040013738A1/en not_active Abandoned
- 2001-08-01 DK DK01969563T patent/DK1305109T3/da active
- 2001-08-01 EP EP01969563A patent/EP1305109B1/de not_active Expired - Lifetime
- 2001-08-01 WO PCT/EP2001/008899 patent/WO2002009864A1/de not_active Ceased
- 2001-08-01 PT PT01969563T patent/PT1305109E/pt unknown
- 2001-08-01 US US10/343,670 patent/US7056554B2/en not_active Expired - Fee Related
- 2001-08-01 AT AT01969563T patent/ATE273067T1/de not_active IP Right Cessation
- 2001-08-01 CA CA002417792A patent/CA2417792C/en not_active Expired - Fee Related
- 2001-08-01 ES ES01969563T patent/ES2223914T3/es not_active Expired - Lifetime
- 2001-08-01 JP JP2002515408A patent/JP2004504931A/ja not_active Withdrawn
- 2001-08-01 EP EP01971841A patent/EP1307282A1/de not_active Withdrawn
- 2001-08-01 DE DE50103245T patent/DE50103245D1/de not_active Expired - Lifetime
- 2001-08-01 WO PCT/EP2001/008909 patent/WO2002009865A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004504931A (ja) | 2004-02-19 |
| CA2417792C (en) | 2009-09-08 |
| WO2002009864A9 (de) | 2002-09-19 |
| EP1305109A1 (de) | 2003-05-02 |
| PT1305109E (pt) | 2004-11-30 |
| US7056554B2 (en) | 2006-06-06 |
| ES2223914T3 (es) | 2005-03-01 |
| DE50103245D1 (de) | 2004-09-16 |
| WO2002009864A1 (de) | 2002-02-07 |
| CA2417792A1 (en) | 2003-01-30 |
| ATE273067T1 (de) | 2004-08-15 |
| EP1305109B1 (de) | 2004-08-11 |
| WO2002009865A1 (de) | 2002-02-07 |
| US20030175517A1 (en) | 2003-09-18 |
| EP1307282A1 (de) | 2003-05-07 |
| US20040013738A1 (en) | 2004-01-22 |
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