DK130889A - Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier - Google Patents

Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier

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Publication number
DK130889A
DK130889A DK130889A DK130889A DK130889A DK 130889 A DK130889 A DK 130889A DK 130889 A DK130889 A DK 130889A DK 130889 A DK130889 A DK 130889A DK 130889 A DK130889 A DK 130889A
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DK
Denmark
Prior art keywords
protease
iga1
proteases
influenzae
enzymes
Prior art date
Application number
DK130889A
Other languages
English (en)
Other versions
DK130889D0 (da
Inventor
Mogens Kilian
Knud Poulsen
Original Assignee
Mogens Kilian
Knud Poulsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mogens Kilian, Knud Poulsen filed Critical Mogens Kilian
Priority to DK130889A priority Critical patent/DK130889A/da
Publication of DK130889D0 publication Critical patent/DK130889D0/da
Priority to DE69032821T priority patent/DE69032821D1/de
Priority to EP90905191A priority patent/EP0463073B1/en
Priority to CA002049984A priority patent/CA2049984A1/en
Priority to JP2505143A priority patent/JPH04503756A/ja
Priority to PCT/DK1990/000073 priority patent/WO1990011367A1/en
Priority to AU53447/90A priority patent/AU630443B2/en
Priority to AT90905191T priority patent/ATE174385T1/de
Publication of DK130889A publication Critical patent/DK130889A/da
Priority to FI914356A priority patent/FI100723B/fi
Priority to NO913665A priority patent/NO304745B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK130889A 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier DK130889A (da)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK130889A DK130889A (da) 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier
AT90905191T ATE174385T1 (de) 1989-03-17 1990-03-16 Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheiten
JP2505143A JPH04503756A (ja) 1989-03-17 1990-03-16 免疫グロブリンＡ１プロテアーゼ（ＩｇＡ１プロテアーゼ）、このタイプの酵素を遺伝子工学的に製造するための方法及びＩｇＡ１プロテアーゼ生成細菌により引き起こされる細菌性脳膜炎及び他の疾患に対して免疫化するために前記酵素及びそのフラグメントを含むワクチン
EP90905191A EP0463073B1 (en) 1989-03-17 1990-03-16 IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
CA002049984A CA2049984A1 (en) 1989-03-17 1990-03-16 Immunoglobulin al proteases (iga1 proteases), method of gene-technologically producing this type of enzyme and vaccines containing the enzymes and fragments thereof for immunizingagainst bacterial meningitis and other diseases caused by iga1 protease-producing bacteria
DE69032821T DE69032821D1 (de) 1989-03-17 1990-03-16 Immunglobulin-a1-proteasen (iga1-proteasen), verfahren zur gentechnologischen herstellung dieses enzymtyps sowie impfstoffe, die die enzyme und fragmente davon enthalten, zur immunisierung gegen bakterielle meningitis und andere, durch iga1-proteaseproduzierende bakterien verursachte krankheiten
PCT/DK1990/000073 WO1990011367A1 (en) 1989-03-17 1990-03-16 IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
AU53447/90A AU630443B2 (en) 1989-03-17 1990-03-16 Immunoglobulin a1 proteases (iga1 proteases), method of gene-technologically producing this type of enzyme and vaccines containing the enzymes and fragments thereof for immunizing against bacterial meningitis and other diseases caused by iga1 protease-producing bacteria
FI914356A FI100723B (fi) 1989-03-17 1991-09-17 Menetelmä immunoglobuliini-A1-proteaasin (IgA1-proteaasin) tai sen fra gmenttien valmistamiseksi geenitekniikalla ja IgA1-proteaasia koodaava geeni
NO913665A NO304745B1 (no) 1989-03-17 1991-09-17 Fremgangsmaate for fremstilling av immunglobulin A1-protease (IgA1-protease) eller immunogene fragmen ter derav

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK130889A DK130889A (da) 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier

Publications (2)

Publication Number Publication Date
DK130889D0 DK130889D0 (da) 1989-03-17
DK130889A true DK130889A (da) 1990-09-18

Family

ID=8103403

Family Applications (1)

Application Number Title Priority Date Filing Date
DK130889A DK130889A (da) 1989-03-17 1989-03-17 Immunoglobulin a1-proteaser (iga1-proteaser), fremgangsmaade til genteknologisk fremstilling af saadanne enzymer samt vaccine indeholdende enzymerne og fragmenter deraf til immunisering mod bakteriel meningitis og andre sygdomme fremkaldt af iga1-protease-producerende bakterier

Country Status (10)

Country Link
EP (1) EP0463073B1 (da)
JP (1) JPH04503756A (da)
AT (1) ATE174385T1 (da)
AU (1) AU630443B2 (da)
CA (1) CA2049984A1 (da)
DE (1) DE69032821D1 (da)
DK (1) DK130889A (da)
FI (1) FI100723B (da)
NO (1) NO304745B1 (da)
WO (1) WO1990011367A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4140699A1 (de) * 1991-01-11 1992-07-16 Boehringer Mannheim Gmbh Rekombinante iga-protease
US5965424A (en) * 1991-01-11 1999-10-12 Boehringer Mannheim Gmbh Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases
GB9201013D0 (en) * 1992-01-17 1992-03-11 Animal Health Inst Vaccines
US6245337B1 (en) 1994-08-25 2001-06-12 Washington University Haemophilus adherence and penetration proteins
US6676948B2 (en) 1994-08-25 2004-01-13 Washington University Haemophilus adherence and penetration proteins
WO1996009395A2 (de) * 1994-09-21 1996-03-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Arzneimittel zur prophylaxe und behandlung von und diagnostika zur erkennung von autoimmunkrankheiten und viralen erkrankungen
US6559359B1 (en) * 1996-09-09 2003-05-06 Loyola University Of Chicago Plant retroviral polynucleotides and methods for use thereof
JP2000507274A (ja) 1997-01-21 2000-06-13 マックス―プランク―ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・アインゲトラーゲナー・フェアアイン・ベルリン キャリヤーペプチドとしてのｉｇａ１プロテアーゼフラグメント
DE19741955A1 (de) * 1997-09-23 1999-04-01 Max Planck Gesellschaft Mittel gegen bakterielle Meningitis
CA2558873C (en) 2003-03-07 2015-10-20 New England Medical Center Hospitals, Inc. Treatment of iga1 deposition diseases
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
WO2007061936A2 (en) 2005-11-18 2007-05-31 New England Medical Center Hospitals, Inc. Clearance of abnormal iga1 in iga1 deposition diseases
US8841109B2 (en) 2009-04-20 2014-09-23 The University Of Kansas IGA1 protease polypeptide agents and uses thereof
RU2407792C1 (ru) * 2009-10-05 2010-12-27 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН СПОСОБ ПОЛУЧЕНИЯ IgAl-ПРОТЕАЗЫ ИЗ КУЛЬТУРЫ NEISSERIA MENINGITIDIS СЕРОГРУППЫ А И ИММУНОГЕННЫЙ ПРЕПАРАТ НА ЕЕ ОСНОВЕ
RU2426126C1 (ru) * 2010-05-28 2011-08-10 Федеральное государственное учреждение науки "Казанский научно-исследовательский институт эпидемиологии и микробиологии" Роспотребнадзора СПОСОБ ОПРЕДЕЛЕНИЯ IgA-ПРОТЕИНАЗНОЙ АКТИВНОСТИ
GB201120634D0 (en) * 2011-11-30 2012-01-11 Univ Sheffield Adjuvant polypeptide
WO2017137085A1 (en) 2016-02-11 2017-08-17 Sanofi Pasteur Meningitidis vaccines comprising subtilinases

Also Published As

Publication number Publication date
NO304745B1 (no) 1999-02-08
FI914356A0 (fi) 1991-09-17
AU630443B2 (en) 1992-10-29
WO1990011367A1 (en) 1990-10-04
AU5344790A (en) 1990-10-22
DK130889D0 (da) 1989-03-17
CA2049984A1 (en) 1990-09-18
ATE174385T1 (de) 1998-12-15
NO913665L (no) 1991-11-18
EP0463073B1 (en) 1998-12-09
EP0463073A1 (en) 1992-01-02
JPH04503756A (ja) 1992-07-09
NO913665D0 (no) 1991-09-17
FI100723B (fi) 1998-02-13
DE69032821D1 (de) 1999-01-21

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