DK131868B - Analogifremgangsmåde til fremstilling af tri-p-toluensulfonatet af S-adenosyl-L-methionin. - Google Patents

Analogifremgangsmåde til fremstilling af tri-p-toluensulfonatet af S-adenosyl-L-methionin.

Info

Publication number: DK131868B
Authority: DK; Denmark
Prior art keywords: adenosyl; toluenesulfonate; methionine; tri; preparation
Prior art date: 1972-08-02

Application number

DK422773AA

Other languages

English (en)

Other versions

DK131868C (da

Inventor

A Fiecchi

Original Assignee

Errekappa Euroterapici Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-08-02

Filing date

1973-08-01

Publication date

1975-09-15

1973-08-01 Application filed by Errekappa Euroterapici Sas filed Critical Errekappa Euroterapici Sas

1975-09-15 Publication of DK131868B publication Critical patent/DK131868B/da

1976-03-08 Application granted granted Critical

1976-03-08 Publication of DK131868C publication Critical patent/DK131868C/da

Links

MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Diabetes (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Microbiology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK422773A 1972-08-02 1973-08-01 Analogifremgangsmade til fremstilling af tri-p-toluensulfonatet af s-adenosyl-l-methionin DK131868C (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2779372		1972-08-02

Publications (2)

Publication Number	Publication Date
DK131868B true DK131868B (da)	1975-09-15
DK131868C DK131868C (da)	1976-03-08

Family

ID=11222342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK422773A DK131868C (da)	1972-08-02	1973-08-01	Analogifremgangsmade til fremstilling af tri-p-toluensulfonatet af s-adenosyl-l-methionin

Country Status (29)

Country	Link
US (1)	US3893999A (da)
JP (1)	JPS5235726B2 (da)
AR (1)	AR195350A1 (da)
AT (1)	AT341684B (da)
AU (1)	AU474015B2 (da)
BE (1)	BE802981A (da)
CA (1)	CA1006872A (da)
CH (1)	CH592112A5 (da)
CS (1)	CS195254B2 (da)
DD (1)	DD107461A5 (da)
DE (1)	DE2336401C3 (da)
DK (1)	DK131868C (da)
ES (1)	ES417377A1 (da)
FI (1)	FI52466C (da)
FR (1)	FR2194425B1 (da)
GB (1)	GB1425384A (da)
HK (1)	HK31580A (da)
HU (1)	HU167266B (da)
IE (1)	IE37913B1 (da)
IL (1)	IL42764A (da)
MX (1)	MX4544E (da)
NL (1)	NL152864B (da)
NO (1)	NO137941C (da)
PL (1)	PL87381B1 (da)
RO (1)	RO63451A (da)
SE (1)	SE400085B (da)
SU (1)	SU646915A3 (da)
YU (1)	YU36037B (da)
ZA (1)	ZA734876B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE39517B1 (en) *	1973-06-27	1978-10-25	Bioresearch Sas	Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) *	1974-07-12	1981-03-13	Bioresearch Sas	Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
DE2646269A1 (de) *	1975-10-16	1977-04-28	Yamasa Shoyu Kk	Stabilisierte s-adenosyl-l-methionin- zubereitung und verfahren zur herstellung derselben
GB2064523B (en) *	1979-12-04	1983-06-29	Kanegafuchi Chemical Ind	Stable composition of s-adenosyl-l-methionine
IT1137640B (it) *	1981-08-24	1986-09-10	Bioresearch Srl	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) *	1981-08-24	1986-09-10	Bioresearch Srl	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) *	1981-09-11	1986-09-24	Bioresearch Srl	Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
IT1169774B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1169773B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1173992B (it) *	1984-05-16	1987-06-24	Bioresearch Spa	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1173990B (it) *	1984-05-16	1987-06-24	Bioresearch Spa	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1200589B (it) *	1985-02-14	1989-01-27	Gibipharma Spa	Derivati naturali attivita farmagologica
EP0395656B1 (en) *	1987-10-09	1992-09-02	ZAPPIA, Vincenzo	Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives
DE19515275A1 (de) *	1995-04-26	1996-10-31	Knoll Ag	Neue Verwendung von (S)-Adenosyl-L-methionin(SAMe)
US6759395B2 (en)	2000-12-18	2004-07-06	Orchid Chemicals & Pharmaceuticals, Ltd.	Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US8063024B2 (en) *	2005-01-26	2011-11-22	University Of Manitoba	Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance
US20090012036A1 (en) *	2005-05-24	2009-01-08	Hebert Rolland F	Stable S-adenosyl-L-methionine
ITMI20060026A1 (it) *	2006-01-10	2007-07-11	Truffini & Regge Farmaceutici Srl	Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento
ITMI20060629A1 (it)	2006-03-31	2007-10-01	Daniele Giovannone	Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
CA2677053C (en) *	2007-01-31	2016-03-15	Methylation Sciences International Srl	Extended release pharmaceutical formulations of s-adenosylmethionine
US20090088404A1 (en) *	2007-01-31	2009-04-02	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090197824A1 (en) *	2008-01-31	2009-08-06	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) *	2007-07-10	2009-01-11	Gnosis Spa	Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) *	2008-07-01	2010-01-07	Rolland F Hebert	Compositions of S-adenosyl-L-methionine.
US20110027342A1 (en) *	2009-07-28	2011-02-03	Msi Methylation Sciences, Inc.	S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) *	2009-07-28	2012-12-11	Methylation Sciences International Srl	Pharmacokinetics of S-adenosylmethionine formulations
CA2833043A1 (en) *	2011-04-15	2012-10-18	Scimar Ltd.	Use of s-adenosylmethionine, vitamin e, and vitamin c for the prevention and treatment of cardiovascular dysfunction
KR101748053B1 (ko)	2012-10-17	2017-06-15	메틸레이션 사이언시즈 인터내셔널 에스알엘	S-아데노실메티오닌 및 갈산 에스테르가 포함된 조성물
KR102186066B1 (ko)	2013-01-16	2020-12-04	허버트 샘-이 엘엘씨	S-아데노실-l-메티오닌의 안정한 인돌-3-프로피오네이트염
EP4712796A2 (en)	2023-05-15	2026-03-25	Bonafide Health, LLC	Sleep-improving compositions and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2946781A (en) *	1957-02-06	1960-07-26	Merck & Co Inc	Process for the preparation of adenosyl homocysteine
US3642772A (en) *	1968-09-04	1972-02-15	Boehringer Mannheim Gmbh	Process for preparing s-adenosyl homocysteine

1973
- 1973-07-16 IE IE1192/73A patent/IE37913B1/xx unknown
- 1973-07-17 US US380097A patent/US3893999A/en not_active Expired - Lifetime
- 1973-07-17 IL IL42764A patent/IL42764A/en unknown
- 1973-07-17 ZA ZA734876A patent/ZA734876B/xx unknown
- 1973-07-17 DE DE2336401A patent/DE2336401C3/de not_active Expired
- 1973-07-19 GB GB3449973A patent/GB1425384A/en not_active Expired
- 1973-07-19 FR FR7326500A patent/FR2194425B1/fr not_active Expired
- 1973-07-25 RO RO7300075582A patent/RO63451A/ro unknown
- 1973-07-26 CS CS735374A patent/CS195254B2/cs unknown
- 1973-07-26 YU YU2030/73A patent/YU36037B/xx unknown
- 1973-07-27 AR AR249310A patent/AR195350A1/es active
- 1973-07-27 CA CA177,689A patent/CA1006872A/en not_active Expired
- 1973-07-27 AT AT664173A patent/AT341684B/de not_active IP Right Cessation
- 1973-07-30 ES ES417377A patent/ES417377A1/es not_active Expired
- 1973-07-30 AU AU58680/73A patent/AU474015B2/en not_active Expired
- 1973-07-30 BE BE134028A patent/BE802981A/xx not_active IP Right Cessation
- 1973-08-01 NO NO3084/73A patent/NO137941C/no unknown
- 1973-08-01 HU HUEE2163A patent/HU167266B/hu unknown
- 1973-08-01 DK DK422773A patent/DK131868C/da not_active IP Right Cessation
- 1973-08-01 SU SU731945967A patent/SU646915A3/ru active
- 1973-08-01 DD DD172669A patent/DD107461A5/xx unknown
- 1973-08-01 SE SE7310587A patent/SE400085B/xx unknown
- 1973-08-01 PL PL1973164439A patent/PL87381B1/pl unknown
- 1973-08-01 MX MX737933U patent/MX4544E/es unknown
- 1973-08-02 JP JP48086440A patent/JPS5235726B2/ja not_active Expired
- 1973-08-02 NL NL737310706A patent/NL152864B/xx not_active IP Right Cessation
- 1973-08-02 CH CH1125173A patent/CH592112A5/xx not_active IP Right Cessation
- 1973-08-02 FI FI732438A patent/FI52466C/fi active
1980
- 1980-06-12 HK HK315/80A patent/HK31580A/xx unknown

Also Published As

Publication number	Publication date
CH592112A5 (da)	1977-10-14
JPS5235726B2 (da)	1977-09-10
NL152864B (nl)	1977-04-15
CS195254B2 (en)	1980-01-31
DK131868C (da)	1976-03-08
HU167266B (da)	1975-09-27
DE2336401B2 (de)	1979-07-12
YU36037B (en)	1981-11-13
FI52466B (da)	1977-05-31
ZA734876B (en)	1974-06-26
AU5868073A (en)	1975-01-30
SE400085B (sv)	1978-03-13
ES417377A1 (es)	1976-02-16
NO137941B (no)	1978-02-13
IE37913B1 (en)	1977-11-09
DD107461A5 (da)	1974-08-05
FR2194425B1 (da)	1976-04-09
SU646915A3 (ru)	1979-02-05
AR195350A1 (es)	1973-09-28
US3893999A (en)	1975-07-08
AT341684B (de)	1978-02-27
ATA664173A (de)	1977-06-15
CA1006872A (en)	1977-03-15
IL42764A0 (en)	1974-01-14
FI52466C (fi)	1977-09-12
NL7310706A (da)	1974-02-05
YU203073A (en)	1981-04-30
IE37913L (en)	1974-02-02
IL42764A (en)	1976-04-30
DE2336401C3 (de)	1980-03-13
NO137941C (no)	1978-05-31
DE2336401A1 (de)	1974-02-14
FR2194425A1 (da)	1974-03-01
HK31580A (en)	1980-06-20
GB1425384A (en)	1976-02-18
MX4544E (es)	1982-06-08
JPS4992215A (da)	1974-09-03
RO63451A (fr)	1978-07-15
AU474015B2 (en)	1976-07-08
BE802981A (fr)	1973-11-16
PL87381B1 (da)	1976-06-30

Legal Events

Date	Code	Title	Description
1993-09-13	PUP	Patent expired

Publication	Publication Date	Title
DK134607B (da)	1976-12-06	Fremgangsmåde til fremstilling af rapamycin.
DK137329B (da)	1978-02-20	Analogifremgangsmåde til fremstilling af 2-karbalkoksyaminobenzimidazolderivater.
DK138951B (da)	1978-11-20	Fremgangsmåde til fremstilling af N-phosphonomethyl-glycin.
DK135775B (da)	1977-06-20	Analogifremgangsmåde til fremstilling af mættede 3alfa-hydroxy-5alfa-pregnaner.
DK138537B (da)	1978-09-25	Analogifremgangsmåde til fremstilling af carbazoler.
DK134604B (da)	1976-12-06	Fremgangsmåde til fremstilling af indenyl-3-acetoglucuronider.
DK138796B (da)	1978-10-30	Analogifremgangsmåde til fremstilling af 2-carboxypyrazin-4-oxidderivater.
DK137639B (da)	1978-04-10	Analogifremgangsmåde til fremstilling af 1-aminomethyl-2,2-diaryl-cyclopropancarboxamider.
DK129088B (da)	1974-08-19	Fremgangsmåde til fremstilling af peptider.
DK131942B (da)	1975-09-29	Fremgangsmåde til fremstilling af delta4,16-11beta-hydroxy-3,20-diketopregnadiener.
DK138898B (da)	1978-11-13	Fremgangsmåde til fremstilling af N-phosphonomethylglycin.
DK140668B (da)	1979-10-22	Analogifremgangsmåde til fremstilling af kondenserede pyriminderivater.
DK132233B (da)	1975-11-10	Fremgangsmåde til fremstilling af antibiotikum A-2315.
DK131575B (da)	1975-06-04	Analogifremgangsmåde til fremstilling af 2beta-hydroxy-3alfa-aminosteroider.
DK138645B (da)	1978-10-09	Analogifremgangsmåde til fremstilling af sulfamoylfenyl-imidazolidiner.
DK135122B (da)	1977-03-07	Analogifremgangsmåde til fremstilling af 4-aryl-5-aminoalkyl-4-oxazolin-2-onderivater.
DK131864B (da)	1975-09-15	Fremgangsmåde til fremstilling af pregnan-21-syrederivater.
DK132410B (da)	1975-12-01	Analogifremgangsmåde til fremstilling af 2-amino-4H-pyraner.
DK135166B (da)	1977-03-14	Analogifremgangsmåde til fremstilling af 2-methyl-5-nitro-imidazoler.
DK129657B (da)	1974-11-04	Analogifremgangsmåde til fremstilling af 3-methylpyrazol-5-carboxamider.
DK131855B (da)	1975-09-15	Fremgangsmåde til fremstilling af 3,4-dihydropyridoner.
DK127812B (da)	1974-01-14	Analogifremgangsmåde til fremstilling af 3,5-dibrom-zearalan.
DK134236B (da)	1976-10-04	Analogifremgangsmåde til fremstilling af 3-cycloalkoxy-16alfa-cyanopregn-5-en-20-oner.
DK139677B (da)	1979-03-26	Fremgangsmåde til fremstilling af 7-benzoylindolin-2-oner.
DK139225B (da)	1979-01-15	Fremgangsmåde til fremstilling af morphanthridiner.