DK13189A - Hirudin-derivat, dets fremstilling og anvendelse - Google Patents

Hirudin-derivat, dets fremstilling og anvendelse

Info

Publication number: DK13189A
Authority: DK; Denmark
Prior art keywords: hirudin derivative; manufacturing; thr; hirudin; derivative
Prior art date: 1985-04-11

Application number

DK013189A

Other languages

English (en)

Other versions

DK13189D0 (da

DK172350B1 (da

Inventor

Peter Crause

Paul Habermann

Dominique Tripier

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-11

Filing date

1989-01-12

Publication date

1989-07-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK13189(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-04-11 Priority claimed from HU851341A external-priority patent/HU198085B/hu

1989-01-12 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-01-12 Publication of DK13189D0 publication Critical patent/DK13189D0/da

1989-07-14 Publication of DK13189A publication Critical patent/DK13189A/da

1998-04-06 Application granted granted Critical

1998-04-06 Publication of DK172350B1 publication Critical patent/DK172350B1/da

Links

WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK013189A 1985-04-11 1989-01-12 Hirudin-derivat, DNA, der koder derfor, vektorer, der indeholder en sådan DNA, fremstilling af hirudin-derivatet samt lægemiddel indeholdende dette DK172350B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
HU134185		1985-04-11
HU851341A HU198085B (en)	1984-04-18	1985-04-11	Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
DE3805540		1988-02-23
DE3805540		1988-02-23

Publications (3)

Publication Number	Publication Date
DK13189D0 DK13189D0 (da)	1989-01-12
DK13189A true DK13189A (da)	1989-07-14
DK172350B1 DK172350B1 (da)	1998-04-06

Family

ID=25865106

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK013189A DK172350B1 (da)	1985-04-11	1989-01-12	Hirudin-derivat, DNA, der koder derfor, vektorer, der indeholder en sådan DNA, fremstilling af hirudin-derivatet samt lægemiddel indeholdende dette

Country Status (9)

Country	Link
EP (1)	EP0324712B1 (da)
AT (1)	ATE87938T1 (da)
DE (2)	DE58903988D1 (da)
DK (1)	DK172350B1 (da)
ES (1)	ES2055149T3 (da)
FI (1)	FI96956C (da)
IL (1)	IL88925A (da)
LU (1)	LU90127I2 (da)
NL (1)	NL970027I2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
ES2084149T3 (es) *	1989-12-01	1996-05-01	Basf Ag	Conjugados de hirudinpolialquilenglicol.
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de)	1995-08-16	1997-04-10	Hoechst Ag	Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de)	1995-11-24	1997-05-28	Hoechst Ag	Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de)	1995-11-28	1997-06-05	Hoechst Ag	Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE69625623T2 (de)	1996-01-31	2003-11-06	Sumitomo Bakelite Co. Ltd., Tokio/Tokyo	Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
DE19607239A1 (de)	1996-02-27	1997-08-28	Behringwerke Ag	Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
DE19944870A1 (de) *	1999-09-18	2001-03-29	Aventis Pharma Gmbh	Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
DE10033195A1 (de) *	2000-07-07	2002-03-21	Aventis Pharma Gmbh	Bifunktionale Fusionsproteine aus Hirudin und TAP
US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
JP2006096668A (ja) *	2002-11-08	2006-04-13	Ono Pharmaceut Co Ltd	エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
RU2435858C2 (ru) *	2009-10-23	2011-12-10	Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН	РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pER-Hir, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК, СПОСОБНЫЙ К АВТОКАТАЛИТИЧЕСКОМУ РАСЩЕПЛЕНИЮ С ОБРАЗОВАНИЕМ [Leu1, Thr2]-63-ДЕСУЛЬФАТОГИРУДИНА, ШТАММ Escherichia coli ER2566/pER-Hir-ПРОДУЦЕНТ УКАЗАННОГО БЕЛКА И СПОСОБ ПОЛУЧЕНИЯ ГЕННО-ИНЖЕНЕРНОГО [Leu1, Thr2]-63-ДЕСУЛЬФАТОГИРУДИНА

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.

1989
- 1989-01-11 IL IL8892589A patent/IL88925A/en active IP Right Grant
- 1989-01-11 AT AT89710003T patent/ATE87938T1/de active
- 1989-01-11 ES ES89710003T patent/ES2055149T3/es not_active Expired - Lifetime
- 1989-01-11 FI FI890127A patent/FI96956C/fi not_active IP Right Cessation
- 1989-01-11 EP EP89710003A patent/EP0324712B1/de not_active Expired - Lifetime
- 1989-01-11 DE DE8989710003T patent/DE58903988D1/de not_active Expired - Lifetime
- 1989-01-11 DE DE19775033C patent/DE19775033I2/de active Active
- 1989-01-12 DK DK013189A patent/DK172350B1/da not_active IP Right Cessation
1997
- 1997-07-23 NL NL970027C patent/NL970027I2/nl unknown
- 1997-08-20 LU LU90127C patent/LU90127I2/fr unknown

Also Published As

Publication number	Publication date
NL970027I1 (nl)	1997-10-01
ATE87938T1 (de)	1993-04-15
DK13189D0 (da)	1989-01-12
FI890127L (fi)	1989-07-14
EP0324712A3 (en)	1990-07-04
EP0324712B1 (de)	1993-04-07
LU90127I2 (fr)	1997-10-06
IL88925A (en)	1995-11-27
FI96956C (fi)	1996-09-25
DE58903988D1 (de)	1993-05-13
NL970027I2 (nl)	1998-04-01
EP0324712A2 (de)	1989-07-19
DE19775033I2 (de)	2011-01-20
DK172350B1 (da)	1998-04-06
ES2055149T3 (es)	1994-08-16
FI890127A0 (fi)	1989-01-11
FI96956B (fi)	1996-06-14

Legal Events

Date	Code	Title	Description
1998-04-06	B1	Patent granted (law 1993)
1999-08-16	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1998 00017, 19980520, EXPIRES: 20120313
2006-10-09	CTFG	Supplementary protection certificate (spc) issued	Spc suppl protection certif: CA 1998 00017
2009-02-02	PUP	Patent expired

Publication	Publication Date	Title
DK13189A (da)	1989-07-14	Hirudin-derivat, dets fremstilling og anvendelse
NO168059C (no)	1992-01-08	Metall-matriks-kompositt, fremgangsmaate og et middel (preform) til fremstilling derav.
NO892834L (no)	1990-01-09	Imidoperoksikarboksylsyrer, dens fremstilling og anvendelse.
NO852306L (no)	1985-12-09	Slitasje-resistent artikkel og fremgangmaate til fremstilling derav.
NO854165L (no)	1986-04-21	Stol.
DE3871538D1 (de)	1992-07-09	Kraftanlage mit c02 als arbeitsfluidum.
NO882385L (no)	1988-12-02	Polypeptid og produksjon derav.
NO882858L (no)	1988-12-30	Silikapartikler, fremstilling og anvendelse derav.
DK0433117T3 (da)	1997-11-03	Nye polypeptider, DNA-sekvenser, som muliggør ekspression deraf, samt fremstilling og anvendelse deraf.
DK55089D0 (da)	1989-02-07	Perhydroazacycloalka oe1,2-aaa imidazolderivat, fremgangsmaade til fremstilling deraf samt mellemprodikter til brug i fremgangsmaaden og fremgangsmaader til fremstilling af mellemprodikterne.
EP0190346A4 (en)	1987-01-22	Novel composite ceramics with improved toughness.
DK186486A (da)	1986-10-28	Fremgangsmaade til fremstilling af alfa-interferon
NO168225C (no)	1992-01-29	Produkt med hylster, samt fremgangsmaate for dets fremstilling.
DE3870764D1 (de)	1992-06-11	Anilinophenylthioharnstoffe, -isothioharnstoffe und -carbodiimide, ihre herstellung und verwendung in der schaedlingsbekaempfung.
IT8522017A0 (it)	1985-08-30	Pressa, in particolare pressa pneumatica, orizzontale per uva.
DK125087D0 (da)	1987-03-11	Efomycin g., dets fremstilling og anvendelse
NO885687D0 (no)	1988-12-21	Opploeselig rekombinant fcepsilon - reseptor, fremstilling og anvendelse derav.
TR25221A (tr)	1992-11-26	ISLAH EDILMIS YUMUSAKLIGA SAHIP YAGLANMIS DERILER VE BUNLARIN üRETILMESINE MAHSUS USUL.
DE3880853D1 (de)	1993-06-17	Stromversorgungsgeraet mit negativer rueckkopplung.
NO862613L (no)	1986-06-27	Nye polypeptider med vekstfaktoraktivitet og nukleinsyresekvenser som koder for polypeptidene.
DK587588A (da)	1989-06-14	Polypeptid, dets anvendelse og fremstilling
IT8719643A0 (it)	1987-03-10	Trasparente. procedimento ed apparecchiatura per inglobare anelli, bracciali esimili in un corpo plastico
IT8409364A0 (it)	1984-03-29	Macchina per la produzione dicatene ornamentali,in particolare di tipo accoppiato
IT8521112V0 (it)	1985-03-15	Cassone-tavolino, trasformabile in letto.
DK73787D0 (da)	1987-02-13	5-hydroxydihydrofusarubin, dets fremstilling og anvendelse, samt til fremstillingen anvendelig mikroorganisme