DK1341764T3 - Ortho-substituerede, nitrogenholdige bisarylforbindelser til anvendelse som inhibitorer for kaliumkanaler - Google Patents

Ortho-substituerede, nitrogenholdige bisarylforbindelser til anvendelse som inhibitorer for kaliumkanaler

Info

Publication number: DK1341764T3
Authority: DK; Denmark
Prior art keywords: ortho; potassium channel; substituted nitrogen; channel inhibitors; bisaryl compounds
Prior art date: 2000-12-07

Application number

DK01999558T

Other languages

Danish (da)

English (en)

Inventor

Horst Hemmerle

Stefan Peukert

Joachim Brendel

Heinz-Werner Kleemann

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-07

Filing date

2001-11-24

Publication date

2005-10-17

2001-11-24 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2005-10-17 Application granted granted Critical

2005-10-17 Publication of DK1341764T3 publication Critical patent/DK1341764T3/da

Links

102000004257 Potassium Channel Human genes 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
108020001213 potassium channel Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK01999558T 2000-12-07 2001-11-24 Ortho-substituerede, nitrogenholdige bisarylforbindelser til anvendelse som inhibitorer for kaliumkanaler DK1341764T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10060807A DE10060807A1 (de)	2000-12-07	2000-12-07	Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013680 WO2002046162A1 (de)	2000-12-07	2001-11-24	Ortho-substituierte stickstoffhaltige bisarylverbindungen zur verwendung als kalium-kanal-inhibitoren

Publications (1)

Publication Number	Publication Date
DK1341764T3 true DK1341764T3 (da)	2005-10-17

Family

ID=7666129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01999558T DK1341764T3 (da)	2000-12-07	2001-11-24	Ortho-substituerede, nitrogenholdige bisarylforbindelser til anvendelse som inhibitorer for kaliumkanaler

Country Status (30)

Country	Link
US (1)	US6794377B2 (cs)
EP (1)	EP1341764B1 (cs)
JP (1)	JP4445198B2 (cs)
KR (1)	KR100815070B1 (cs)
CN (1)	CN1237052C (cs)
AR (1)	AR033408A1 (cs)
AT (1)	ATE297897T1 (cs)
AU (2)	AU2002221892B2 (cs)
BR (1)	BR0116005A (cs)
CA (1)	CA2436891C (cs)
CZ (1)	CZ301923B6 (cs)
DE (2)	DE10060807A1 (cs)
DK (1)	DK1341764T3 (cs)
EE (1)	EE05220B1 (cs)
ES (1)	ES2242792T3 (cs)
HR (1)	HRP20030448B1 (cs)
HU (1)	HUP0302762A3 (cs)
IL (2)	IL156312A0 (cs)
MX (1)	MXPA03004966A (cs)
NO (1)	NO325297B1 (cs)
NZ (1)	NZ526294A (cs)
PL (1)	PL207057B1 (cs)
PT (1)	PT1341764E (cs)
RU (1)	RU2275360C2 (cs)
SI (1)	SI1341764T1 (cs)
SK (1)	SK286056B6 (cs)
TW (1)	TWI242005B (cs)
WO (1)	WO2002046162A1 (cs)
YU (1)	YU40203A (cs)
ZA (1)	ZA200303931B (cs)

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GB0124934D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124939D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124931D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124941D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124938D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124933D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124936D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
BRPI0307351B8 (pt)	2002-02-12	2021-05-25	Smithkline Beecham Corp	composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto
GB0217757D0 (en)	2002-07-31	2002-09-11	Glaxo Group Ltd	Novel compounds
GB0308185D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0315950D0 (en)	2003-06-11	2003-08-13	Xention Discovery Ltd	Compounds
DE10341233A1 (de) *	2003-09-08	2005-03-24	Aventis Pharma Deutschland Gmbh	Kombination von Phenylcarbonsäureamiden mit beta-Adrenozeptoren-Blockern und deren Verwendung zur Behandlung von Vorhofarrhythmien
US20050054673A1 (en) *	2003-09-08	2005-03-10	Aventis Pharma Deutschland Gmbh	Combination of phenylcarboxylic acid amides with beta-adrenoreceptor blockers and their use for the treatment of atrial arrhythmias
GB0402143D0 (en) *	2004-01-30	2004-03-03	Smithkline Beecham Corp	Novel compounds
GB0412986D0 (en)	2004-06-10	2004-07-14	Xention Discovery Ltd	Compounds
US7569589B2 (en)	2004-07-29	2009-08-04	Merck & Co., Inc.	Potassium channel inhibitors
US20080051416A1 (en) *	2004-10-05	2008-02-28	Smithkline Beecham Corporation	Novel Compounds
US7419962B2 (en) *	2004-12-07	2008-09-02	Enanta Pharmaceuticals, Inc.	3,6-bicyclolides
US7576212B2 (en)	2004-12-09	2009-08-18	Xention Limited	Thieno[2,3-B] pyridines as potassium channel inhibitors
GB0512429D0 (en) *	2005-06-17	2005-07-27	Smithkline Beecham Corp	Novel compound
WO2007015775A2 (en) *	2005-07-22	2007-02-08	Merck & Co., Inc.	Potassium channel inhibitors
GB0525164D0 (en)	2005-12-09	2006-01-18	Xention Discovery Ltd	Compounds
RU2436577C2 (ru) *	2006-04-27	2011-12-20	Санофи-Авентис Дойчланд Гмбх	Ингибиторы ионных task-1 и task-3 каналов
GB0815784D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815782D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
GB0815781D0 (en)	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
CA2768396A1 (en)	2009-07-30	2011-02-03	F. Hoffmann-La Roche Ag	Dihydropyrimidone amides as p2x7 modulators
GB201105659D0 (en)	2011-04-01	2011-05-18	Xention Ltd	Compounds
NO3175985T3 (cs)	2011-07-01	2018-04-28
NZ627942A (en)	2012-01-27	2016-03-31	Gilead Sciences Inc	Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
EP3263559A1 (en) *	2013-01-22	2018-01-03	Technische Universität Graz	Lipase inhibitors
WO2014183221A1 (en) *	2013-05-17	2014-11-20	The Centre For Drug Research And Development	Resveratrol analogs and therapeutic uses thereof
TWI773657B (zh)	2015-12-18	2022-08-11	美商亞德利克斯公司	作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
US12084472B2 (en)	2015-12-18	2024-09-10	Ardelyx, Inc.	Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
EP3558992A4 (en)	2016-12-15	2020-12-02	ONO Pharmaceutical Co., Ltd.	TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
MD3762368T2 (ro)	2018-03-08	2022-07-31	Incyte Corp	Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

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US4616002A (en) *	1984-11-09	1986-10-07	Ciba-Geigy Corporation	Dihydro pyridine compounds, compositions and use
US5196537A (en) *	1991-03-21	1993-03-23	G. D. Searle & Co.	5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
GB9307527D0 (en) *	1993-04-13	1993-06-02	Fujisawa Pharmaceutical Co	New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
DE4430638A1 (de) *	1994-08-29	1996-03-07	Bayer Ag	Verwendung von substituierten 4-Phenyl-6-amino-nicotinsäurederivaten als Arzneimittel
US5670504A (en)	1995-02-23	1997-09-23	Merck & Co. Inc.	2,6-diaryl pyridazinones with immunosuppressant activity
US6083986A (en) *	1996-07-26	2000-07-04	Icagen, Inc.	Potassium channel inhibitors
US5935945A (en)	1996-10-31	1999-08-10	Merck & Co., Inc.	Methods of treating or preventing cardiac arrhythmia
US5969017A (en)	1996-10-31	1999-10-19	Merck & Co., Inc.	Methods of treating or preventing cardiac arrhythmia
US6333337B1 (en) *	1998-01-27	2001-12-25	Icagen, Inc.	Potassium channel inhibitors
JP2002517385A (ja)	1998-06-05	2002-06-18	イカゲンインク．	カリウムチャネル阻害剤
CA2341678C (en) *	1998-09-01	2009-10-13	Bristol-Myers Squibb Company	Potassium channel inhibitors and method
DE19947457A1 (de) *	1999-10-02	2001-04-05	Aventis Pharma Gmbh	2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
DE10059418A1 (de) *	2000-11-30	2002-06-20	Aventis Pharma Gmbh	Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen

2000
- 2000-12-07 DE DE10060807A patent/DE10060807A1/de not_active Withdrawn
2001
- 2001-11-24 KR KR1020037007552A patent/KR100815070B1/ko not_active Expired - Fee Related
- 2001-11-24 IL IL15631201A patent/IL156312A0/xx unknown
- 2001-11-24 EP EP01999558A patent/EP1341764B1/de not_active Expired - Lifetime
- 2001-11-24 SK SK687-2003A patent/SK286056B6/sk not_active IP Right Cessation
- 2001-11-24 CA CA2436891A patent/CA2436891C/en not_active Expired - Fee Related
- 2001-11-24 YU YU40203A patent/YU40203A/sh unknown
- 2001-11-24 WO PCT/EP2001/013680 patent/WO2002046162A1/de not_active Ceased
- 2001-11-24 NZ NZ526294A patent/NZ526294A/en unknown
- 2001-11-24 JP JP2002547901A patent/JP4445198B2/ja not_active Expired - Fee Related
- 2001-11-24 HU HU0302762A patent/HUP0302762A3/hu unknown
- 2001-11-24 DK DK01999558T patent/DK1341764T3/da active
- 2001-11-24 AT AT01999558T patent/ATE297897T1/de active
- 2001-11-24 AU AU2002221892A patent/AU2002221892B2/en not_active Ceased
- 2001-11-24 RU RU2003120080/04A patent/RU2275360C2/ru not_active IP Right Cessation
- 2001-11-24 CZ CZ20031564A patent/CZ301923B6/cs not_active IP Right Cessation
- 2001-11-24 ES ES01999558T patent/ES2242792T3/es not_active Expired - Lifetime
- 2001-11-24 SI SI200130385T patent/SI1341764T1/xx unknown
- 2001-11-24 AU AU2189202A patent/AU2189202A/xx active Pending
- 2001-11-24 DE DE50106549T patent/DE50106549D1/de not_active Expired - Lifetime
- 2001-11-24 PT PT01999558T patent/PT1341764E/pt unknown
- 2001-11-24 BR BR0116005-2A patent/BR0116005A/pt not_active Application Discontinuation
- 2001-11-24 MX MXPA03004966A patent/MXPA03004966A/es active IP Right Grant
- 2001-11-24 EE EEP200300225A patent/EE05220B1/xx not_active IP Right Cessation
- 2001-11-24 PL PL365318A patent/PL207057B1/pl not_active IP Right Cessation
- 2001-11-24 HR HR20030448A patent/HRP20030448B1/xx not_active IP Right Cessation
- 2001-11-24 CN CNB018201814A patent/CN1237052C/zh not_active Expired - Fee Related
- 2001-12-05 US US10/002,326 patent/US6794377B2/en not_active Expired - Fee Related
- 2001-12-05 AR ARP010105665A patent/AR033408A1/es active IP Right Grant
- 2001-12-05 TW TW090130040A patent/TWI242005B/zh active
2003
- 2003-05-21 ZA ZA200303931A patent/ZA200303931B/en unknown
- 2003-06-02 NO NO20032488A patent/NO325297B1/no not_active IP Right Cessation
- 2003-06-04 IL IL156312A patent/IL156312A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1341764A1 (de)	2003-09-10
SK286056B6 (sk)	2008-02-05
ATE297897T1 (de)	2005-07-15
AU2189202A (en)	2002-06-18
CA2436891C (en)	2011-01-11
JP4445198B2 (ja)	2010-04-07
HUP0302762A3 (en)	2010-03-29
KR20030081344A (ko)	2003-10-17
MXPA03004966A (es)	2003-09-25
CA2436891A1 (en)	2002-06-13
KR100815070B1 (ko)	2008-03-20
TWI242005B (en)	2005-10-21
ZA200303931B (en)	2004-03-24
NO20032488D0 (no)	2003-06-02
HRP20030448A2 (en)	2005-04-30
NZ526294A (en)	2005-04-29
IL156312A (en)	2009-05-04
PL207057B1 (pl)	2010-10-29
CZ301923B6 (cs)	2010-07-28
HK1066539A1 (en)	2005-03-24
YU40203A (sh)	2006-05-25
PL365318A1 (en)	2004-12-27
EE200300225A (et)	2003-08-15
SI1341764T1 (en)	2005-10-31
US20030060470A1 (en)	2003-03-27
AU2002221892B2 (en)	2006-07-13
SK6872003A3 (en)	2004-02-03
WO2002046162A1 (de)	2002-06-13
AR033408A1 (es)	2003-12-17
HUP0302762A2 (hu)	2003-11-28
JP2004515493A (ja)	2004-05-27
EE05220B1 (et)	2009-10-15
ES2242792T3 (es)	2005-11-16
NO20032488L (no)	2003-08-04
NO325297B1 (no)	2008-03-17
DE10060807A1 (de)	2002-06-20
RU2275360C2 (ru)	2006-04-27
CN1537102A (zh)	2004-10-13
US6794377B2 (en)	2004-09-21
DE50106549D1 (de)	2005-07-21
EP1341764B1 (de)	2005-06-15
PT1341764E (pt)	2005-09-30
IL156312A0 (en)	2004-01-04
CZ20031564A3 (cs)	2003-09-17
HRP20030448B1 (en)	2006-06-30
BR0116005A (pt)	2004-01-06
CN1237052C (zh)	2006-01-18

Publication	Publication Date	Title
NO20032488L (no)	2003-08-04	Orto-substituerte nitrogen-inneholdende bisarylforbindelser anvendt som kaliumkanalinhibitorer
AU2002221892A1 (en)	2002-08-22	Ortho-substituted nitrogen-containing bisaryl compounds used as potassium channel inhibitors
DK1383731T3 (da)	2009-12-07	Biarylforbindelser som serinproteaseinhibitorer
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BR0102329B1 (pt)	2010-09-21	aparelho para cortar peças.
NO20022649L (no)	2002-06-06	Heterocykliske dihydropyrimidiner som kaliumkanal inhibitorer
DK2253620T3 (da)	2014-03-31	Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
ATE308544T1 (de)	2005-11-15	N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren
ATE304015T1 (de)	2005-09-15	Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren
NO20030135D0 (no)	2003-01-10	Piperidinforbindelser for bruk som CCR-3 inhibitorer
NO20052884D0 (no)	2005-06-14	Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
DK1210326T3 (da)	2004-06-21	Hydroxamsyreforbindelser, der er nyttige som matrixmetalloproteinaseinhibitorer
ES1047158Y (es)	2001-08-16	Dispositivo para encofrar, mejorado.
IL180846A0 (en)	2007-06-03	1,1,2,2-tetra (hetero) arylethanes or 1,1,2-tri (hetero) aryl-2-heterocyclylethanes as potassium channel inhibitors
ES1045582Y (es)	2001-03-16	Reja para canaleta.
ITMI20020548A0 (it)	2002-03-15	Modulatore per gascromatografia
ES1046802Y (es)	2001-07-01	Canalon para cultivo hidroponico.
ES1054531Y (es)	2003-11-16	Envase para bastoncillos.
ES1045373Y (es)	2001-02-16	Cinta para fruncidos.
BR0105256B1 (pt)	2009-01-13	cartucho para conexço de ferramentas.
ES1053641Y (es)	2003-08-16	Selector-manipulador, para botoneras de telemando
ES1049353Y (es)	2002-04-16	Brandilla guarda-cuerpos para edificios.
ES1046507Y (es)	2001-06-01	Collarin para trabajos de peluqueria mejorado.
ES1047338Y (es)	2001-08-16	Montacargas para andamios.
ES1047366Y (es)	2001-09-01	Bloque para vallado.