DK134982A - Fremgangsmaade til fremstilling af guanidinopyrimidiner - Google Patents

Fremgangsmaade til fremstilling af guanidinopyrimidiner Download PDF

Info

Publication number: DK134982A
Authority: DK; Denmark
Prior art keywords: guanidinopyrimidines; procedure; preparation; guanidino; halo
Prior art date: 1981-03-24

Application number

DK134982A

Other languages

English (en)

Other versions

DK155284C (da

DK155284B (da

Inventor

D L Ladd

Original Assignee

Smithkline Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-24

Filing date

1982-03-24

Publication date

1982-09-25

1982-03-24 Application filed by Smithkline Corp filed Critical Smithkline Corp

1982-09-25 Publication of DK134982A publication Critical patent/DK134982A/da

1989-03-20 Publication of DK155284B publication Critical patent/DK155284B/da

1989-07-31 Application granted granted Critical

1989-07-31 Publication of DK155284C publication Critical patent/DK155284C/da

Links

QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
FRQBQBUHPNYTGS-UHFFFAOYSA-N 2-pyrimidin-2-ylguanidine Chemical class NC(N)=NC1=NC=CC=N1 FRQBQBUHPNYTGS-UHFFFAOYSA-N 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK134982A 1981-03-24 1982-03-24 Analogifremgangsmaade til fremstilling af guanidinopyrimidiner DK155284C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/247,048 US4336254A (en)	1981-03-24	1981-03-24	Guanidinopyrimidine compounds, compositions and method of using as a diuretic
US24704881		1981-03-24

Publications (3)

Publication Number	Publication Date
DK134982A true DK134982A (da)	1982-09-25
DK155284B DK155284B (da)	1989-03-20
DK155284C DK155284C (da)	1989-07-31

Family

ID=22933338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK134982A DK155284C (da)	1981-03-24	1982-03-24	Analogifremgangsmaade til fremstilling af guanidinopyrimidiner

Country Status (8)

Country	Link
US (1)	US4336254A (da)
EP (1)	EP0062439B1 (da)
JP (1)	JPS57169471A (da)
AT (1)	ATE12228T1 (da)
DE (1)	DE3262592D1 (da)
DK (1)	DK155284C (da)
GR (1)	GR75536B (da)
IE (1)	IE52634B1 (da)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2422887A (en) *		1947-06-24		Pyrimidine compound and processes
US2295563A (en) *	1941-07-30	1942-09-15	Gen Electric	Diazine derivatives
BE490235A (da) *	1948-07-21
CH408026A (de)	1961-07-02	1966-02-28	Wilhelm Jun Dr Kraus	Verfahren zur Herstellung von Pyrimidin-Derivaten
US3284188A (en) *	1963-04-12	1966-11-08	Toyo Koatsu Ind Inc	Method and composition for suppressing the nitrification of ammonium nitrogen in soil

1981
- 1981-03-24 US US06/247,048 patent/US4336254A/en not_active Expired - Fee Related
1982
- 1982-03-18 JP JP57044426A patent/JPS57169471A/ja active Granted
- 1982-03-22 GR GR67668A patent/GR75536B/el unknown
- 1982-03-23 DE DE8282301476T patent/DE3262592D1/de not_active Expired
- 1982-03-23 EP EP82301476A patent/EP0062439B1/en not_active Expired
- 1982-03-23 IE IE665/82A patent/IE52634B1/en unknown
- 1982-03-23 AT AT82301476T patent/ATE12228T1/de not_active IP Right Cessation
- 1982-03-24 DK DK134982A patent/DK155284C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3262592D1 (en)	1985-04-25
IE52634B1 (en)	1988-01-06
DK155284C (da)	1989-07-31
EP0062439B1 (en)	1985-03-20
DK155284B (da)	1989-03-20
US4336254A (en)	1982-06-22
EP0062439A1 (en)	1982-10-13
JPS57169471A (en)	1982-10-19
ATE12228T1 (de)	1985-04-15
JPH0416467B2 (da)	1992-03-24
GR75536B (da)	1984-07-27
IE820665L (en)	1982-09-24

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Legal Events

Date	Code	Title	Description
1985-10-14	PBP	Patent lapsed