DK1361882T3 - 4-fluor-N-indan-2-ylbenzamid og dets anvendelse som farmaceutisk middel - Google Patents

4-fluor-N-indan-2-ylbenzamid og dets anvendelse som farmaceutisk middel

Info

Publication number: DK1361882T3
Authority: DK; Denmark
Prior art keywords: indan; fluoro; benzamide; pharmaceutical; synthase
Prior art date: 2001-02-13

Application number

DK02722066T

Other languages

English (en)

Inventor

Paulus Wohlfart

Armin Walser

Hartmut Strobel

Teri Suzuki

Ramalinga M Dharanipragada

Alena Safarova

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-13

Filing date

2002-02-12

Publication date

2007-03-12

2002-02-12 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2007-03-12 Application granted granted Critical

2007-03-12 Publication of DK1361882T3 publication Critical patent/DK1361882T3/da

Links

BOFMSBVSYVESTM-UHFFFAOYSA-N n-(2,3-dihydro-1h-inden-2-yl)-4-fluorobenzamide Chemical compound C1=CC(F)=CC=C1C(=O)NC1CC2=CC=CC=C2C1 BOFMSBVSYVESTM-UHFFFAOYSA-N 0.000 title abstract 2
241000124008 Mammalia Species 0.000 abstract 1
102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
230000003511 endothelial effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK02722066T 2001-02-13 2002-02-12 4-fluor-N-indan-2-ylbenzamid og dets anvendelse som farmaceutisk middel DK1361882T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01102852		2001-02-13
PCT/EP2002/001443 WO2002064146A1 (en)	2001-02-13	2002-02-12	4-fluoro-n-indan-2-yl benzamide and its use as pharmaceutical

Publications (1)

Publication Number	Publication Date
DK1361882T3 true DK1361882T3 (da)	2007-03-12

Family

ID=8176423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02722066T DK1361882T3 (da)	2001-02-13	2002-02-12	4-fluor-N-indan-2-ylbenzamid og dets anvendelse som farmaceutisk middel

Country Status (33)

Country	Link
US (3)	US6617359B2 (da)
EP (1)	EP1361882B1 (da)
JP (1)	JP4317689B2 (da)
KR (1)	KR101017531B1 (da)
CN (1)	CN100553631C (da)
AT (1)	ATE344669T1 (da)
AU (1)	AU2002253009B2 (da)
BG (1)	BG66065B1 (da)
BR (1)	BR0207178A (da)
CA (1)	CA2437966C (da)
CY (1)	CY1106278T1 (da)
CZ (1)	CZ20032154A3 (da)
DE (1)	DE60215919T2 (da)
DK (1)	DK1361882T3 (da)
EE (1)	EE05302B1 (da)
ES (1)	ES2274025T3 (da)
HR (1)	HRP20030646A2 (da)
HU (1)	HUP0302845A3 (da)
IL (2)	IL157208A0 (da)
MX (1)	MXPA03006841A (da)
MY (1)	MY135778A (da)
NO (1)	NO333522B1 (da)
NZ (1)	NZ527469A (da)
PE (1)	PE20020884A1 (da)
PL (1)	PL363452A1 (da)
PT (1)	PT1361882E (da)
RS (1)	RS51645B (da)
RU (1)	RU2308946C2 (da)
SI (1)	SI1361882T1 (da)
SK (1)	SK286513B6 (da)
TW (1)	TWI241190B (da)
WO (1)	WO2002064146A1 (da)
ZA (1)	ZA200305412B (da)

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EP1923062A1 (en)	2006-11-16	2008-05-21	sanofi-aventis	Imidazo[2,1-b]thiazoles and their use as pharmaceuticals
KR101349187B1 (ko) *	2006-12-05	2014-01-10	(주)아모레퍼시픽	지방대사 이상질환의 치료 및 예방용 약학 조성물
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US20130178475A1 (en)	2010-03-17	2013-07-11	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
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US7186735B2 (en) *	2002-08-07	2007-03-06	Sanofi-Aventis Deutschland Gmbh	Acylated arylcycloalkylamines and their use as pharmaceuticals
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2002
- 2002-02-08 TW TW091102292A patent/TWI241190B/zh not_active IP Right Cessation
- 2002-02-11 MY MYPI20020481A patent/MY135778A/en unknown
- 2002-02-12 KR KR1020037010490A patent/KR101017531B1/ko not_active Expired - Fee Related
- 2002-02-12 NZ NZ527469A patent/NZ527469A/xx not_active IP Right Cessation
- 2002-02-12 RU RU2003127750/15A patent/RU2308946C2/ru not_active IP Right Cessation
- 2002-02-12 AU AU2002253009A patent/AU2002253009B2/en not_active Ceased
- 2002-02-12 WO PCT/EP2002/001443 patent/WO2002064146A1/en not_active Ceased
- 2002-02-12 EP EP02722066A patent/EP1361882B1/en not_active Expired - Lifetime
- 2002-02-12 HU HU0302845A patent/HUP0302845A3/hu unknown
- 2002-02-12 RS YU61703A patent/RS51645B/sr unknown
- 2002-02-12 CZ CZ20032154A patent/CZ20032154A3/cs unknown
- 2002-02-12 AT AT02722066T patent/ATE344669T1/de active
- 2002-02-12 SI SI200230443T patent/SI1361882T1/sl unknown
- 2002-02-12 IL IL15720802A patent/IL157208A0/xx unknown
- 2002-02-12 PT PT02722066T patent/PT1361882E/pt unknown
- 2002-02-12 PL PL02363452A patent/PL363452A1/xx not_active Application Discontinuation
- 2002-02-12 ES ES02722066T patent/ES2274025T3/es not_active Expired - Lifetime
- 2002-02-12 DE DE60215919T patent/DE60215919T2/de not_active Expired - Lifetime
- 2002-02-12 CN CNB028048636A patent/CN100553631C/zh not_active Expired - Fee Related
- 2002-02-12 DK DK02722066T patent/DK1361882T3/da active
- 2002-02-12 BR BR0207178-9A patent/BR0207178A/pt not_active Application Discontinuation
- 2002-02-12 SK SK1011-2003A patent/SK286513B6/sk not_active IP Right Cessation
- 2002-02-12 MX MXPA03006841A patent/MXPA03006841A/es active IP Right Grant
- 2002-02-12 HR HR20030646A patent/HRP20030646A2/hr not_active Application Discontinuation
- 2002-02-12 EE EEP200300368A patent/EE05302B1/xx not_active IP Right Cessation
- 2002-02-12 JP JP2002563939A patent/JP4317689B2/ja not_active Expired - Fee Related
- 2002-02-12 CA CA2437966A patent/CA2437966C/en not_active Expired - Fee Related
- 2002-02-13 US US10/073,330 patent/US6617359B2/en not_active Expired - Lifetime
- 2002-02-13 PE PE2002000123A patent/PE20020884A1/es not_active Application Discontinuation
2003
- 2003-07-14 ZA ZA200305412A patent/ZA200305412B/xx unknown
- 2003-07-15 BG BG107994A patent/BG66065B1/bg unknown
- 2003-07-22 US US10/623,775 patent/US6812253B2/en not_active Expired - Lifetime
- 2003-08-03 IL IL157208A patent/IL157208A/en not_active IP Right Cessation
- 2003-08-11 NO NO20033546A patent/NO333522B1/no not_active IP Right Cessation
2004
- 2004-08-18 US US10/920,395 patent/US7202278B2/en not_active Expired - Lifetime
2006
- 2006-12-06 CY CY20061101753T patent/CY1106278T1/el unknown

Also Published As

Publication number	Publication date
EP1361882B1 (en)	2006-11-08
CA2437966C (en)	2011-06-14
MXPA03006841A (es)	2003-11-13
ZA200305412B (en)	2004-09-02
US20040019114A1 (en)	2004-01-29
CN1496264A (zh)	2004-05-12
US7202278B2 (en)	2007-04-10
KR20030074809A (ko)	2003-09-19
IL157208A (en)	2009-09-22
HRP20030646A2 (en)	2005-06-30
PE20020884A1 (es)	2002-11-25
HK1062140A1 (en)	2004-10-21
IL157208A0 (en)	2004-02-19
ES2274025T3 (es)	2007-05-16
DE60215919D1 (de)	2006-12-21
US6812253B2 (en)	2004-11-02
ATE344669T1 (de)	2006-11-15
CA2437966A1 (en)	2002-08-22
BR0207178A (pt)	2004-03-30
CY1106278T1 (el)	2011-10-12
HUP0302845A2 (hu)	2003-12-29
RS51645B (sr)	2011-10-31
CZ20032154A3 (cs)	2004-05-12
TWI241190B (en)	2005-10-11
RU2308946C2 (ru)	2007-10-27
BG66065B1 (bg)	2011-01-31
RS61703A (sr)	2006-12-15
EE05302B1 (et)	2010-06-15
NO333522B1 (no)	2013-07-01
BG107994A (bg)	2004-08-31
EP1361882A1 (en)	2003-11-19
US6617359B2 (en)	2003-09-09
US20030022939A1 (en)	2003-01-30
JP4317689B2 (ja)	2009-08-19
SK286513B6 (sk)	2008-12-05
EE200300368A (et)	2003-10-15
AU2002253009B2 (en)	2006-09-14
CN100553631C (zh)	2009-10-28
SI1361882T1 (sl)	2007-02-28
KR101017531B1 (ko)	2011-02-28
HUP0302845A3 (en)	2005-11-28
JP2004518713A (ja)	2004-06-24
NZ527469A (en)	2005-04-29
NO20033546D0 (no)	2003-08-11
PT1361882E (pt)	2007-01-31
SK10112003A3 (sk)	2004-01-08
MY135778A (en)	2008-06-30
WO2002064146A1 (en)	2002-08-22
DE60215919T2 (de)	2007-05-31
US20050054729A1 (en)	2005-03-10
RU2003127750A (ru)	2005-03-10
NO20033546L (no)	2003-09-24
PL363452A1 (en)	2004-11-15

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