DK1361895T3 - Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disse - Google Patents
Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disseInfo
- Publication number
- DK1361895T3 DK1361895T3 DK02709573T DK02709573T DK1361895T3 DK 1361895 T3 DK1361895 T3 DK 1361895T3 DK 02709573 T DK02709573 T DK 02709573T DK 02709573 T DK02709573 T DK 02709573T DK 1361895 T3 DK1361895 T3 DK 1361895T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymeric
- end group
- linkers
- conjugates containing
- group branched
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 abstract 3
- 239000000651 prodrug Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27251101P | 2001-02-20 | 2001-02-20 | |
| PCT/US2002/004780 WO2002066066A1 (fr) | 2001-02-20 | 2002-02-19 | Lieurs polymeriques a ramification terminale et conjugues polymeriques contenant ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1361895T3 true DK1361895T3 (da) | 2008-02-18 |
Family
ID=23040108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02709573T DK1361895T3 (da) | 2001-02-20 | 2002-02-19 | Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disse |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20020161052A1 (fr) |
| EP (1) | EP1361895B1 (fr) |
| JP (1) | JP2004530736A (fr) |
| AT (1) | ATE378071T1 (fr) |
| CA (1) | CA2437986A1 (fr) |
| DE (1) | DE60223496T2 (fr) |
| DK (1) | DK1361895T3 (fr) |
| MX (1) | MXPA03007391A (fr) |
| WO (1) | WO2002066066A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624142B2 (en) * | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| EP1533385A1 (fr) * | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Composés à matrice pour la génération de molécules codées et procédés dirigés utilisant ces derniers |
| JP4820758B2 (ja) | 2004-09-22 | 2011-11-24 | 日本化薬株式会社 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
| HUE025208T2 (en) | 2005-06-16 | 2016-03-29 | Nektar Therapeutics | Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates |
| US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
| RU2447095C2 (ru) | 2006-05-18 | 2012-04-10 | Ниппон Каяку Кабусики Кайся | Высокомолекулярный конъюгат подофиллотоксинов |
| CA2658100A1 (fr) * | 2006-07-19 | 2008-01-24 | Nippon Kayaku Kabushiki Kaisha | Conjugue de combretastatines a poids moleculaire eleve |
| US8334364B2 (en) | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
| JP5548365B2 (ja) | 2006-11-08 | 2014-07-16 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| JP5349318B2 (ja) | 2007-09-28 | 2013-11-20 | 日本化薬株式会社 | ステロイド類の高分子結合体 |
| CN101977631A (zh) | 2008-03-18 | 2011-02-16 | 日本化药株式会社 | 生理活性物质的高分子量偶联物 |
| JP5366940B2 (ja) | 2008-05-08 | 2013-12-11 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
| JP5544357B2 (ja) | 2009-05-15 | 2014-07-09 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
| KR20140024833A (ko) | 2010-11-17 | 2014-03-03 | 니폰 가야꾸 가부시끼가이샤 | 신규한 시티딘계 대사길항제의 고분자 유도체 |
| CN103874722B (zh) | 2011-09-11 | 2016-06-29 | 日本化药株式会社 | 嵌段共聚物的制造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| AU4406793A (en) * | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
-
2002
- 2002-02-19 MX MXPA03007391A patent/MXPA03007391A/es active IP Right Grant
- 2002-02-19 CA CA002437986A patent/CA2437986A1/fr not_active Abandoned
- 2002-02-19 US US10/078,649 patent/US20020161052A1/en not_active Abandoned
- 2002-02-19 WO PCT/US2002/004780 patent/WO2002066066A1/fr not_active Ceased
- 2002-02-19 DK DK02709573T patent/DK1361895T3/da active
- 2002-02-19 AT AT02709573T patent/ATE378071T1/de not_active IP Right Cessation
- 2002-02-19 JP JP2002565624A patent/JP2004530736A/ja active Pending
- 2002-02-19 DE DE60223496T patent/DE60223496T2/de not_active Expired - Lifetime
- 2002-02-19 EP EP02709573A patent/EP1361895B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20020161052A1 (en) | 2002-10-31 |
| EP1361895B1 (fr) | 2007-11-14 |
| DE60223496D1 (de) | 2007-12-27 |
| ATE378071T1 (de) | 2007-11-15 |
| JP2004530736A (ja) | 2004-10-07 |
| EP1361895A1 (fr) | 2003-11-19 |
| MXPA03007391A (es) | 2003-12-04 |
| EP1361895A4 (fr) | 2005-01-19 |
| WO2002066066A1 (fr) | 2002-08-29 |
| WO2002066066A9 (fr) | 2003-10-16 |
| CA2437986A1 (fr) | 2002-08-29 |
| DE60223496T2 (de) | 2008-10-02 |
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