DK1379253T3 - Fremgangsmåde til fremstilling og anvendelse af farmaceutiske formuleringer omfattende 7alfa, 11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-on og 17-estere heraf - Google Patents

Fremgangsmåde til fremstilling og anvendelse af farmaceutiske formuleringer omfattende 7alfa, 11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-on og 17-estere heraf

Info

Publication number: DK1379253T3
Authority: DK; Denmark
Prior art keywords: dien; esters; dimethyl; preparation; 7alpha
Prior art date: 2001-03-30

Application number

DK02728620T

Other languages

English (en)

Inventor

Pemmaraju Narasimha Rao

Carmie Kirk Acosta

Richard P Blye

Hyun K Kim

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-30

Filing date

2002-03-29

Publication date

2006-06-26

2001-03-30 Priority claimed from PCT/US2001/010293 external-priority patent/WO2001074839A2/en

2002-03-29 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2006-06-26 Application granted granted Critical

2006-06-26 Publication of DK1379253T3 publication Critical patent/DK1379253T3/da

Links

238000000034 method Methods 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
DLGDQYMGFBOCRG-LHHMISFZSA-N (8r,9r,10r,13s)-13-(hydroxymethyl)-2,6,7,8,9,10,11,12,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1C1=CCC[C@@]1(CO)CC2 DLGDQYMGFBOCRG-LHHMISFZSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000001794 hormone therapy Methods 0.000 abstract 1
239000006186 oral dosage form Substances 0.000 abstract 1
239000006201 parenteral dosage form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0029—Ethers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK02728620T 2001-03-30 2002-03-29 Fremgangsmåde til fremstilling og anvendelse af farmaceutiske formuleringer omfattende 7alfa, 11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-on og 17-estere heraf DK1379253T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2001/010293 WO2001074839A2 (en)	2000-03-31	2001-03-30	Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha, 11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use

Publications (1)

Publication Number	Publication Date
DK1379253T3 true DK1379253T3 (da)	2006-06-26

Family

ID=21742454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02728620T DK1379253T3 (da)	2001-03-30	2002-03-29	Fremgangsmåde til fremstilling og anvendelse af farmaceutiske formuleringer omfattende 7alfa, 11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-on og 17-estere heraf

Country Status (7)

Country	Link
EP (1)	EP1379253B1 (da)
JP (1)	JP2005510541A (da)
AT (1)	ATE321557T1 (da)
DE (1)	DE60210268T2 (da)
DK (1)	DK1379253T3 (da)
ES (1)	ES2261665T3 (da)
WO (1)	WO2003045398A1 (da)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA712312B (en) *	1970-04-28	1972-01-26	Ochsner Med Found Alton	4,14-estradiene compounds
TW548277B (en) *	1999-07-16	2003-08-21	Akzo Nobel Nv	Orally active androgens

2002
- 2002-03-29 DK DK02728620T patent/DK1379253T3/da active
- 2002-03-29 DE DE60210268T patent/DE60210268T2/de not_active Expired - Lifetime
- 2002-03-29 WO PCT/US2002/009886 patent/WO2003045398A1/en not_active Ceased
- 2002-03-29 EP EP02728620A patent/EP1379253B1/en not_active Expired - Lifetime
- 2002-03-29 JP JP2003546900A patent/JP2005510541A/ja active Pending
- 2002-03-29 AT AT02728620T patent/ATE321557T1/de active
- 2002-03-29 ES ES02728620T patent/ES2261665T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2261665T3 (es)	2006-11-16
DE60210268T2 (de)	2006-12-07
EP1379253B1 (en)	2006-03-29
JP2005510541A (ja)	2005-04-21
EP1379253A1 (en)	2004-01-14
WO2003045398A8 (en)	2004-02-19
ATE321557T1 (de)	2006-04-15
DE60210268D1 (de)	2006-05-18
WO2003045398A1 (en)	2003-06-05

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